The effect of dry extract of Geranium Palustre herb on coagulation system = Вплив сухого екстракту трави герані болотної на систему зсідання крові

Ostapets M. O., Shevtsov I. I., Karabut L. V., Bereznyakova M. E. The effect of dry extract of Geranium Palustre herb on coagulation system = Вплив сухого екстракту трави герані болотної на систему зсідання крові. Journal of Education, Health and Sport. 2015;5(8):119-125. ISSN 2391-8306. DOI 10.5281/zenodo.27484http://dx.doi.org/10.5281/zenodo.27484http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%288%29%3A119-125https://pbn.nauka.gov.pl/works/605723Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.06.2015. Revised 15.07.2015. Accepted: 25.07.2015. UDC 615.322:582.751:615.273 THE EFFECT OF DRY EXTRACT OF GERANIUM PALUSTRE HERB ON COAGULATION SYSTEMВПЛИВ СУХОГО ЕКСТРАКТУ ТРАВИ ГЕРАНІ БОЛОТНОЇ НА СИСТЕМУ ЗСІДАННЯ КРОВІ M. O. Ostapets, I. I. Shevtsov, L. V. Karabut, M. E. BereznyakovaМ. О. Остапець, І. І. Шевцов, Л. В. Карабут, М. Є. Березнякова National University of Pharmacy, Kharkiv, UkraineНаціональний фармацевтичний університет, Харків, Україна[email protected] AbstractThe article is devoted to the studying of mechanism action on coagulation system the dry extract of Geranium Palustre herb. Established, those during 20-ty days of introduction the investigation extract increasing the activity of platelet’s mechanism of hemostasis (increasing platelet’s amount, their aggregation activity and retraction of blood clotting). On the background of introduction the investigation extract decreasing indicators of I and III phase of coagulation cascade (activated partial thromboplastin time, thrombin time), increasing prothrombin time and level of fibrinogen. Obtaining result suggest about active action the dry extract of Geranium Palustre herb on «external» way activation of hemocoagulation by possibility effect of accelerate the formation of thromboplastin, causing the hypercoagulation.The mechanism of antihemmorhagic action of dry extract of Geranium Palustre herb due to the presence in the composition biological active substances (such as tannins, flavonoids, elagic, galic and ascorbinic organic acids) that acting complex on vascular-platelet and coagulation hemostasis at the expense of increasing the strength and sealing vascular-tissue barriers, P-vitamin activity – it is ability to reduce capillary fragility and permeability and increasing their resistance.Key words: dry extract of Geranium Palustre herb, platelets, coagulation, phenolic compounds.  РефератСтаття присвячена дослідженню механізму дії сухого екстракту трави герані болотної на систему зсідання крові. Встановлено, що протягом 20-ти денного введення досліджуваного екстракту підвищувалася активність тромбоцитарної ланки гемостазу (підвищувалася кількість тромбоцитів, їх агрегаційна здатність та ретракція кров’яного згустку). На фоні введення сухого екстракту трави герані болотної знижувалися показники I та III фази коагуляційного гемостазу (активований частковий тромбопластиновий час, тромбіновий час), підвищувався протромбіновий час та рівень фібриногену. Отримані дані свідчать про вплив сухого екстракту трави герані болотної на «внутрішній» шлях активації зсідання крові за рахунок прискорення формування тромбопластину, що призводить до гіперкоагуляції.Механізм антигеморагічної дії сухого екстракту трави герані болотної обумовлений наявністю у складі біологічно активних речовин (дубильних речовин, флавоноїдів, елагової, галової та аскорбінової органічних кислот), які діють комплексно як на судинно-тромбоцитарний, так і на коагуляційний гемостаз за рахунок ущільнення та збільшення міцності судинно-тканинних бар’єрів, Р-вітамінної активності – здатності зменшувати проникність та ламкість капілярів, підвищувати їх резистентність.Ключові слова: сухий екстракт трави герані болотної, тромбоцити, зсідання крові, фенольні сполуки. РефератВЛИЯНИЕ СУХОГО ЭКСТРАКТА ТРАВЫ ГЕРАНИ БОЛОТНОЙ НА СИСТЕМУ СВЕРТЫВАНИЯ КРОВИ. Статья посвящена исследованию механизма действия сухого экстракта травы герани болотной на систему свертывания крови. Установлено, что на протяжении 20-ти дневного введения исследуемого экстракта повышалась активность тромбоцитарного звена гемостаза (увеличивалось количество тромбоцитов, их агрегационная способность и ретракция кровяного сгустка). На фоне введения сухого экстракта травы герани болотной снижались показатели I и III фазы коагуляционного гемостаза (активированное частичное тромбопластиновое время, тромбиновое время), повышалось  протромбиновое время и уровень фибриногена. Полученные данные свидетельствуют о влиянии сухого экстракта травы герани болотной на «внутренний» путь активации свертывания крови за счет ускорения формирования тромбопластина, что приводит к гиперкоагуляции.Механизм антигеморрагического действия сухого экстракта травы герани болотной обусловлен наличием в составе биологически активных соединений (дубильных веществ, флавоноидов, эллаговой, галловой и аскорбиновой органических кислот), которые действуют комплексно как на сосудисто-тромбоцитарный, так и на коагуляционный гемостаз за счет уплотнения и увеличения прочности сосудисто-тканевых барьеров, Р-витаминной активности – способности уменьшать проницаемость и ломкость капилляров, повышать их резистентность.Ключевые слова: сухой экстракт травы герани болотной, тромбоциты, свертывание крови, фенольные соединения

SuperConga: an open-source framework for mesoscopic superconductivity

We present SuperConga, an open-source framework for simulating equilibrium properties of unconventional and ballistic singlet superconductors, confined to two-dimensional (2D) mesoscopic grains in a perpendicular external magnetic field, at arbitrary low temperature. It aims at being both fast and easy to use, enabling research without access to a computer cluster, and visualization in real-time with OpenGL. The core is written in C++ and CUDA, exploiting the embarrassingly parallel nature of the quasiclassical theory of superconductivity by utilizing the parallel computational power of modern GPUs. The framework self-consistently computes both the superconducting order-parameter and the induced vector potential, and finds the current density, free energy, induced flux density, local density of states, as well as the magnetic moment. A user-friendly Python frontend is provided, enabling simulation parameters to be defined via intuitive configuration files, or via the command-line interface, without requiring a deep understanding of implementation details. For example, complicated geometries can be created with relative ease. The framework ships with simple tools for analyzing and visualizing the results, including an interactive plotter for spectroscopy. An overview of the theory is presented, as well as examples showcasing the framework's capabilities and ease of use. The framework is free to download from https://gitlab.com/superconga/superconga, which also links to the extensive user manual, containing even more examples, tutorials and guides.Comment: Accepted version. Review-style article, 31 pages and link to software at https://gitlab.com/superconga/supercong

Contribution of Alexey Suvorin and His Newspaper Novoye Vremya into Russian Culture of the Second Half of 19th – Early 20th Century’

Novoye Vremya (The New Time) newspaper was considered as the leading daily periodical of the pre-revolutionary Russia. In 1876, Aleksey Suvorin, an outstanding Russian publisher and literary figure, became its owner and chief editor. He turned the newspaper into a source of information, which seriously influenced the public opinion in Russia. Novoye Vremya provoked constant interest among readers of all social levels. It was popular both among high-ranking government officials and people without any ranks, conservatives and liberals, people with higher education and those who did not even graduate a gymnasium. Newspaper stories were apprehensible not only for educated people but for any common person. Young and old, men and women liked Novoye Vremya. It had never forced its opinion and suggested the readers to make personal judgement through its reports. Suvorin managed to form the audience that valued the newspaper and believed in it. Not only Novoye Vremya stood out for its excellent materials on politics, economy, and non-fiction. In its reviews the newspaper gave a fair evaluation of the Russian authors’ works. Moreover, it became famous with the literary works of the top writers, the classics of Russian literature. Therefore, it is not by accident that the author of this article pays special attention to the cooperation between Novoye Vremya and the most known Russian writers of the second half of the 19th century and early 20th century. Thanks to Suvorin, the talent of Anton Chekhov, who started publishing his works in the newspaper under a different name, opened up. Novoye Vremya published the stories which were later included into his collection In the Twilight. Here he also published his famous novella The Duel. Despite the fact that Novoye Vremya was considered to be a newspaper rather than a literary magazine, it worked together with such writers as Leo Tolstoy, Nikolay Nekrasov, Nikolay Leskov, Mikhail Saltykov-Shchedrin, for whom the newspaper was not only a serious periodical but also a source of education and knowledge. In Soviet times the directive was to forget about Suvorin. And when they did remember, they certainly wrote about him as a reactionary, chauvinist, notorious monarchist. And if another major pre-revolutionary publisher I.D. Sytin was recognized by the Soviet government, although he lost his printing house and real estate, then Suvorin was in disgrace

Numerical Simulation of Multicomponent Ion Beam from Ion Sources

A program library for numerical simulation of a multicomponent charged particle beam from ion sources is presented. The library is aimed for simulation of high current, low energy multicomponent ion beam from ion source through beamline and realized under the Windows user interface for the IBM PC. It is used for simulation and optimization of beam dynamics and based on successive and consistent application of two methods: the momentum method of distribution function (RMS technique) and particle in cell method. The library has been used to simulate and optimize the transportation of tantalum ion beam from the laser ion source (CERN) and calcium ion beam from the ECR ion source (JINR, Dubna)

SuperConga: An open-source framework for mesoscopic superconductivity

We present SuperConga, an open-source framework for simulating equilibrium properties of unconventional and ballistic singlet superconductors, confined to two-dimensional (2D) mesoscopic grains in a perpendicular external magnetic field, at arbitrary low temperatures. It aims at being both fast and easy to use, enabling research without access to a computer cluster, and visualization in real-time with OpenGL. The core is written in C++ and CUDA, exploiting the embarrassingly parallel nature of the quasiclassical theory of superconductivity by utilizing the parallel computational power of modern graphics processing units. The framework self-consistently computes both the superconducting order-parameter and the induced vector potential and finds the current density, free energy, induced flux density, local density of states (LDOS), and the magnetic moment. A user-friendly Python frontend is provided, enabling simulation parameters to be defined via intuitive configuration files, or via the command-line interface, without requiring a deep understanding of implementation details. For example, complicated geometries can be created with relative ease. The framework ships with simple tools for analyzing and visualizing the results, including an interactive plotter for spectroscopy. An overview of the theory is presented, as well as examples showcasing the framework\u27s capabilities and ease of use. The framework is free to download from https://gitlab.com/superconga/superconga, which also links to the extensive user manual, containing even more examples, tutorials, and guides. To demonstrate and benchmark SuperConga, we study the magnetostatics, thermodynamics, and spectroscopy of various phenomena. In particular, we study flux quantization in solenoids, vortex physics, surface Andreev bound-states, and a "phase crystal."We compare our numeric results with analytics and present experimental observables, e.g., the magnetic moment and LDOS, measurable with, for example, scanning probes, STM, and magnetometry

SRSF1 modulates the organization of splicing factors in nuclear speckles and regulates transcription

The mammalian cell nucleus is compartmentalized into non-membranous subnuclear domains that regulate key nuclear functions. Nuclear speckles are subnuclear domains that contain pre-mRNA processing factors and non-coding RNAs. Many of the nuclear speckle constituents work in concert to coordinate multiple steps of gene expression, including transcription, pre-mRNA processing and mRNA transport. The mechanism that regulates the formation and maintenance of nuclear speckles in the interphase nucleus is poorly understood. In the present study, we provide evidence for the involvement of nuclear speckle resident proteins and RNA components in the organization of nuclear speckles. SR-family splicing factors and their binding partner, long non-coding MALAT1 RNA, can nucleate the assembly of nuclear speckles in the interphase nucleus. Depletion of SRSF1 in human cells compromises the association of splicing factors to nuclear speckles and influences the levels and activity of other SR proteins. Furthermore, on a stably integrated reporter gene locus, we demonstrate the role for SRSF1 in RNA polymerase II-mediated transcription. Our results suggest that SR proteins mediate the assembly of nuclear speckles and regulate gene expression by influencing both transcriptional and posttranscriptional activities within the cell nucleus

A Tailward Moving Current Sheet Normal Magnetic Field Front Followed by an Earthward Moving Dipolarization Front

A case study is presented using measurements from the Cluster spacecraft and ground-based magnetometers that show a substorm onset propagating from the inner to outer plasma sheet. On 3 October 2005, Cluster, traversing an ion-scale current sheet at the near-Earth plasma sheet, detected a sudden enhancement of Bz, which was immediately followed by a series of flux rope structures. Both the local Bz enhancement and flux ropes propagated tailward. Approximately 5 min later, another Bz enhancement, followed by a large density decrease, was observed to rapidly propagate earthward. Between the two Bz enhancements, a significant removal of magnetic flux occurred, possibly resulting from the tailward moving Bz enhancement and flux ropes. In our scenario, this flux removal caused the magnetotail to be globally stretched so that the thinnest sheet formed tailward of Cluster. The thinned current sheet facilitated magnetic reconnection that quickly evolved from plasma sheet to lobe and generated the later earthward moving dipolarization front (DF) followed by a reduction in density and entropy. Ground magnetograms located near the meridian of Cluster's magnetic foot points show two-step bay enhancements. The positive bay associated with the first Bz enhancement indicates that the substorm onset signatures propagated from the inner to the outer plasma sheet, consistent with the Cluster observation. The more intense bay features associated with the later DF are consistent with the earthward motion of the front. The event suggests that current disruption signatures that originated in the near-Earth current sheet propagated tailward, triggering or facilitating midtail reconnection, thereby preconditioning the magnetosphere for a later strong substorm enhancement

Site-fidelity and spatial movements of western North Pacific gray whales on their summer range off Sakhalin, Russia

The Western North-Pacific (WNP) gray whale feeding grounds are off the northeastern coast of Sakhalin Island, Russia and is comprised of a nearshore and offshore component that can be distinguished by both depth and location. Spatial movements of gray whales within their foraging grounds were examined based on 13 years of opportunistic vessel and shore-based photo-identification surveys. Site fidelity was assessed by examining annual return and resighting rates. Lagged Identification Rates (LIR) analyses were conducted to estimate the residency and transitional movement patterns within the two components of their feeding grounds. In total 243 individuals were identified from 2002-2014, among these were 94 calves. The annual return rate over the period 2002-2014 was 72%, excluding 35 calves only seen one year. Approximately 20% of the individuals identified from 2002-2010 were seen every year after their initial sighting (including eight individuals that returned for 13 consecutive years). The majority (239) of the WNP whales were observed in the nearshore area while only half (122) were found in the deeper offshore area. Within a foraging season, there was a significantly higher probability of gray whales moving from the nearshore to the offshore area. No mother-calf pairs, calves or yearlings were observed in the offshore area, which was increasingly used by mature animals. The annual return rates, and population growth rates that are primarily a result of calf production with little evidence of immigration, suggest that this population is demographically self-contained and that both the nearshore and offshore Sakhalin feeding grounds are critically important areas for their summer annual foraging activities. The nearshore habitat is also important for mother-calf pairs, younger individuals, and recently weaned calves. Nearshore feeding could also be energetically less costly compared to foraging in the deeper offshore habitat and provide more protection from predators, such as killer whales

Трансанальна гемороїдальна деартеріалізація з лазерною абляцією зовнішніх гемороїдальних вузлів – малотравматичний спосіб вирішення проблеми комбінованого геморою в амбулаторних умовах

The presence combined with enlarged hemorrhoids external hemorrhoids limits the performance of minimally invasivetechniques, most focused on internal hemorrhoids. The open hemorrhoidectomy does not satisfy the duration with postoperativerehabilitation. Ultrasound reсtodopleromety made possible to fi nd the most controlled and effi cient surgical solutions in thetreatment of internal hemorrhoids II-III stages. Laser vaporization external hemorrhoids proves effectiveness in the combinedtreatment of hemorrhoids. In our study, we combined two aforementioned surgical techniques for the treatment of chroniccombined hemorrhoids. We analyzed the results of treatment of 52 patients with chronic combined hemorrhoids in 2-3 stages.All patients left the hospital in the fi rst days after surgery. Smaller duration of the operation, minimal postoperative painreaction, a rapid return to normal life, permit to recommend a combination of hemorrhoids dearterializationНаявність комбінованого геморою зі збільшеними зовнішніми гемороїдальними вузлами обмежує виконаннямалоінвазивних методик, які в більшості спрямовані на внутрішній геморой. Відкрита гемороїдектомія не задовольняєтривалістю післяопераційної реконвалесценції. Ультразвукова ректодоплерометрія дозволила знайти найбільш контро-льоване та ефективне хірургічне рішення в лікуванні внутрішнього геморою ІI–ІII стадій. У лікуванні комбінованого ге-морою підтверджує свою ефективність лазерна вапоризація зовнішніх гемороїдальних вузлів. У нашому дослідженні мипоєднали дві вищевказані хірургічні методики для лікування хронічного комбінованого геморою. Проаналізовано резуль-тати лікування 52 пацієнтів із хронічним комбінованим гемороєм 2–3 стадій. Всі пацієнти залишили стаціонар у першу добупісля операції. Менша тривалість операції, мінімальна післяопераційна больова реакція, швидке повернення до звичай-ного способу життя дозволяють рекомендувати поєднання гемороїдальної деартеріалізації під контролем ультразвуковоїдоплерометрії з лазерною вапоризацією в лікуванні хронічного комбінованого геморою в амбулаторних умовах