Leaders of Reform: Progressive Republicans in Kansas, 1900-1916

Robert Sherman La Forte was professor of history at the University of North Texas, where he taught for thirty years. In addition to this book, he coauthored three books on World War II history and the authorized history of the University of North Texas. With a New Foreword by Charles Delgadillo. Charles Delgadillo is lecturer in history at the California State Polytechnic University, Pomona, and Norco College, in California. He is the author of Crusader for Democracy: The Political Life of William Allen White.This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.In Leaders of Reform Robert Sherman La Forte examines the intricacies of shifting factions within the state majority party over a two decade period, from the Boss-Busters and political machines of the early 1900s through the formation of a new party behind Theodore Roosevelt in 1913. He discusses the motives, activities, accomplishments, and failures of the progressive Republicans. He provides excellent vignettes of major leaders such as William Allen White, Arthur Capper, Joseph L. Bristow, and Charles Curtis, as well as lesser-known characters such as Walter Roscoe Stubbs, Edward H. Hoch, and Cy Leland, Jr. In providing a detailed analysis of virtually all Kansas progressive Republican leaders during the era, La Forte has made a valuable contribution to both state and national political history

Leaders of Reform: Progressive Republicans in Kansas, 1900-1916

In Leaders of Reform Robert Sherman La Forte examines the intricacies of shifting factions within the state majority party over a two decade period, from the Boss-Busters and political machines of the early 1900s through the formation of a new party behind Theodore Roosevelt in 1913. He discusses the motives, activities, accomplishments, and failures of the progressive Republicans. He provides excellent vignettes of major leaders such as William Allen White, Arthur Capper, Joseph L. Bristow, and Charles Curtis, as well as lesser-known characters such as Walter Roscoe Stubbs, Edward H. Hoch, and Cy Leland, Jr. In providing a detailed analysis of virtually all Kansas progressive Republican leaders during the era, La Forte has made a valuable contribution to both state and national political history. Description Robert Sherman La Forte was professor of history at the University of North Texas, where he taught for thirty years. In addition to this book, he coauthored three books on World War II history and the authorized history of the University of North Texas. With a New Foreword by Charles Delgadillo. Charles Delgadillo is lecturer in history at the California State Polytechnic University, Pomona, and Norco College, in California. He is the author of Crusader for Democracy: The Political Life of William Allen White. This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.https://digitalcommons.pittstate.edu/kansas_open_books/1038/thumbnail.jp

Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms

Hyaluronan is an extracellular glycosaminoglycan polymer consisting of linear disaccharide units containing alternating glucuronate and N-acetylglucosamine.Many cell types make hyaluronan, which unlike most other macromolecules is assembled at the plasmamembrane and concurrently translocated through the hyaluronan synthase enzyme. The normal function of large hyaluronan polymers (\u3e1MDa) in tissue cushioning, hydration, and lubrication is well established. The aberrant accumulation and degradation of hyaluronan and the receptor-mediated signaling of smaller hyaluronan fragments have also been extensively implicated in a variety of pathological states including inflammation and cancer. More recently, the discovery that hyaluronan can either be a structural matrix component or appear as smaller processed polymers and oligomers that differentially engage a diverse range of signaling receptors has created an exciting paradigm shift and reenergized hyaluronan research in a broad range of fields. In this special issue, eight review articles focus on summarizing the latest contributions to understanding hyaluronan synthesis and catabolism and the regulation of hyaluronan functions. Seven novel primary research articles also investigate multiple roles of hyaluronan in disease progression and targeting

Sistema de clasificación de huevos mediante un algoritmo de visión artificial

Desarrollar un sistema de clasificación de huevos mediante un algoritmo de visión artificial.El presente trabajo muestra el desarrollo de un algoritmo de visión artificial basado en código abierto que permite clasificar distintos huevos de gallina mediante la estimación del peso a través de una imagen en 2D; para lograr el objetivo en este trabajo el peso se calcula tomando en consideración únicamente dos factores geométricos que son el ancho y alto del producto. El algoritmo inicia con la adquisición de la imagen, para posteriormente realizar el procesamiento de la imagen, detectar los contornos, analizar las dimensiones y finalizar calculando el peso y clasificando el producto. El funcionamiento del algoritmo se basa en una escena de pruebas el cual se trata de un ambiente controlado que consta de una cámara web Genius FaceCam 1000X y una fuente de luz ubicadas de manera frontal a la base. Los criterios de clasificación se basan en la norma técnica ecuatoriana para ovoproductos NTE INEN 1973. Para validar el funcionamiento del algoritmo se realizó las respectivas pruebas con 21 huevos de gallina seleccionados al azar obteniendo 19 coincidencias, teniendo como resultado una eficiencia de 90,47% en la clasificación, y un 97,32% de eficiencia en la estimación del peso.Ingenierí

Is the test of senior friendly ⁄child resistant packaging ethical?

Research has documented the drastic reduction of unintentional poisonings of children since the introduction of child resistant (CR) packaging. However, studies also indicate that consumers report difficulty using CR packages, in part because tests which determine the ‘senior friendliness’ of CR designs that are used throughout the world disallow people with ‘overt or obvious’ disabilities from being test subjects. Our review of drug package usability suggests that the current tests of CR packaging can and should be revised to correct this problem. We use US legislation, regulation and data to exemplify these points, but the conclusions are applicable to all protocols that include the exclusionary provision

Template for Developing Guidelines for the Evaluation of the Clinical Efficacy of Psychophysiological Interventions

An essential function of both the Association for Applied Psychophysiology and Biofeedback (AAPB) and the Society for Neuronal Regulation (SNR) is the systematic evaluation of psychophysiological interventions that have been developed for the treatment of medical and psychiatric disorders. In order to address scientific concerns regarding the efficacy of specific clinical applications of biofeedback, these two societies formed and Efficacy Task Force. The process to be used in the assessment of treatment efficacy, specificity and clinical utility is presented in the form of a template that will serve as the foundation for a series of scientific reviews and practice guidlines to be published by both societies

Risk factors for race-day fatality in flat racing Thoroughbreds in Great Britain (2000 to 2013)

A key focus of the racing industry is to reduce the number of race-day events where horses die suddenly or are euthanased due to catastrophic injury. The objective of this study was therefore to determine risk factors for race-day fatalities in Thoroughbred racehorses, using a cohort of all horses participating in flat racing in Great Britain between 2000 and 2013. Horse-, race- and course-level data were collected and combined with all race-day fatalities, recorded by racecourse veterinarians in a central database. Associations between exposure variables and fatality were assessed using logistic regression analyses for (1) all starts in the dataset and (2) starts made on turf surfaces only. There were 806,764 starts in total, of which 548,571 were on turf surfaces. A total of 610 fatalities were recorded; 377 (61.8%) on turf. In both regression models, increased firmness of the going, increasing racing distance, increasing average horse performance, first year of racing and wearing eye cover for the first time all increased the odds of fatality. Generally, the odds of fatality also increased with increasing horse age whereas increasing number of previous starts reduced fatality odds. In the ‘all starts’ model, horses racing in an auction race were at 1.46 (95% confidence interval (CI) 1.06–2.01) times the odds of fatality compared with horses not racing in this race type. In the turf starts model, horses racing in Group 1 races were at 3.19 (95% CI 1.71–5.93) times the odds of fatality compared with horses not racing in this race type. Identification of novel risk factors including wearing eye cover and race type will help to inform strategies to further reduce the rate of fatality in flat racing horses, enhancing horse and jockey welfare and safety

Complexity of the microglial activation pathways that drive innate host responses during lethal alphavirus encephalitis in mice

Microglia express multiple TLRs (Toll-like receptors) and provide important host defence against viruses that invade the CNS (central nervous system). Although prior studies show these cells become activated during experimental alphavirus encephalitis in mice to generate cytokines and chemokines that influence virus replication, tissue inflammation and neuronal survival, the specific PRRs (pattern recognition receptors) and signalling intermediates controlling microglial activation in this setting remain unknown. To investigate these questions directly in vivo, mice ablated of specific TLR signalling molecules were challenged with NSV (neuroadapted Sindbis virus) and CNS viral titres, inflammatory responses and clinical outcomes followed over time. To approach this problem specifically in microglia, the effects of NSV on primary cells derived from the brains of wild-type and mutant animals were characterized in vitro. From the standpoint of the virus, microglial activation required viral uncoating and an intact viral genome; inactivated virus particles did not elicit measurable microglial responses. At the level of the target cell, NSV triggered multiple PRRs in microglia to produce a broad range of inflammatory mediators via non-overlapping signalling pathways. In vivo, disease survival was surprisingly independent of TLR-driven responses, but still required production of type-I IFN (interferon) to control CNS virus replication. Interestingly, the ER (endoplasmic reticulum) protein UNC93b1 facilitated host survival independent of its known effects on endosomal TLR signalling. Taken together, these data show that alphaviruses activate microglia via multiple PRRs, highlighting the complexity of the signalling networks by which CNS host responses are elicited by these infections

Efficacy of acupuncture for chronic low back pain: protocol for a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Chronic back pain is a major public health problem and the primary reason patients seek acupuncture treatment. Therefore, an objective assessment of acupuncture efficacy is critical for making informed decisions about its appropriate role for patients with this common condition. This study addresses methodological shortcomings that have plagued previous studies evaluating acupuncture for chronic low back pain.</p> <p>Methods and Design</p> <p>A total of 640 participants (160 in each of four arms) between the ages of 18 and 70 years of age who have low back pain lasting at least 3 months will be recruited from integrated health care delivery systems in Seattle and Oakland. They will be randomized to one of two forms of Traditional Chinese Medical (TCM) acupuncture needling (individualized or standardized), a "control" group (simulated acupuncture), or to continued usual medical care. Ten treatments will be provided over 7 weeks. Study participants and the "Diagnostician" acupuncturists who evaluate participants and propose individualized treatments will be masked to the acupuncture treatment actually assigned each participant. The "Therapist" acupuncturists providing the treatments will not be masked but will have limited verbal interaction with participants. The primary outcomes, standard measures of dysfunction and bothersomeness of low back pain, will be assessed at baseline, and after 8, 26, and 52 weeks by telephone interviewers masked to treatment assignment. General health status, satisfaction with back care, days of back-related disability, and use and costs of healthcare services for back pain will also be measured. The primary analysis comparing outcomes by randomized treatment assignment will be analysis of covariance adjusted for baseline value. For both primary outcome measures, this trial will have 99% power to detect the presence of a minimal clinically significant difference among all four treatment groups and over 80% power for most pairwise comparisons. Secondary analyses will compare the proportions of participants in each group that improve by a clinically meaningful amount.</p> <p>Conclusion</p> <p>Results of this trial will help clarify the value of acupuncture needling as a treatment for chronic low back pain.</p> <p>Trial registration</p> <p>Clinical Trials.gov NCT00065585.</p