Structured robust stability and boundedness of nonlinear hybrid delay systems

Taking different structures in different modes into account, the paper has developed a new theory on the structured robust stability and boundedness for nonlinear hybrid stochastic differential delay equations (SDDEs) without the linear growth condition. A new Lyapunov function is designed in order to deal with the effects of different structures as well as those of different parameters within the same modes. Moreover, a lot of effort is put into showing the almost sure asymptotic stability in the absence of the linear growth condition

Delay dependent stability of highly nonlinear hybrid stochastic systems

There are lots of papers on the delay dependent stability criteria for differential delay equations (DDEs), stochastic differential delay equations (SDDEs) and hybrid SDDEs. A common feature of these existing criteria is that they can only be applied to delay equations where their coefficients are either linear or nonlinear but bounded by linear functions (namely, satisfy the linear growth condition). In other words, there is so far no delay-dependent stability criterion on nonlinear equations without the linear growth condition (we will refer to such equations as highly nonlinear ones). This paper is the first to establish delay dependent criteria for highly nonlinear hybrid SDDEs. It is therefore a breakthrough in the stability study of highly nonlinear hybrid SDDE

Boundedness and stability of highly nonlinear neutral stochastic systems with multiple delays

This paper reports the boundedness and stability of highly nonlinear hybrid neutral stochastic differential delay equations (NSDDEs) with multiple delays. Without imposing linear growth condition, the boundedness and exponential stability of the exact solution are investigated by Lyapunov functional method. In particular, using the M-matrix technique, the mean square exponential stability is obtained. Finally, three examples are presented to verify our results

Exponential stability of highly nonlinear neutral pantograph stochastic differential equations

In this paper, we investigate the exponential stability of highly nonlinear hybrid neutral pantograph stochastic differential equations(NPSDEs). The aim of this paper is to establish exponential stability criteria for a class of hybrid NPSDEs without the linear growth condition. The methods of Lyapunov functions and M-matrix are used to study exponential stability and boundedness of the hybrid NPSDEs

Stability of highly nonlinear neutral stochastic differential delay equations

Stability criteria for neutral stochastic differential delay equations (NSDDEs) have been studied intensively for the past several decades. Most of these criteria can only be applied to NSDDEs where their coefficients are either linear or nonlinear but bounded by linear functions. This paper is concerned with the stability of hybrid NSDDEs without the linear growth condition, to which we will refer as highly nonlinear ones. The stability criteria established in this paper will be dependent on delays

An elastic-viscoplastic creep model for describing creep behavior of layered rock

To describe the full-stage creep behavior of layered rock accurately, a new elastic-viscoplastic creep model is proposed based on fractional order theory in this manuscript, which consists of a Hooke elastomer, a fractional Abel dashpot, a Kelvin body, and a new non-linear visco-plastic component. The non-linear creep model can not only describe the changes in three creep stages (primary creep, steady-state creep and accelerating creep) but also reflect the influence of different bedding angles of rock. The constitutive equations of the non-linear creep model are deduced by the empirical model method and plastic theory method, respectively. The parameters of the non-linear creep model are identified using the Levenberg-Marquardt algorithm from Origin. It shows that the creep model in this paper are highly consistent with the experimental data under different load levels, creep stages and bedding angles, and the accuracy and rationality of the model are verified. Moreover, the creep constitutive equations for layered rock derived by the two methods have the same fitting effect on the same set of experimental data

Stability analysis of highly nonlinear hybrid multiple-delay stochastic differential equations

Stability criteria for stochastic differential delay equation (SDDE) have been studied intensively for the past few decades. However, most of these criteria can only be applied to delay equations where their coefficients are either linear or nonlinear but bounded by linear functions. Recently, the stability of highly nonlinear hybrid stochastic differential equations with a single delay is investigated in [Fei, Hu, Mao and Shen, Automatica, 2017], whose work, in this paper, is extended to highly nonlinear hybrid stochastic differential equations with variable multiple delays. In other words, this paper establishes the stability criteria of highly nonlinear hybrid variable multiple-delay stochastic differential equations. We also discuss an example to illustrate our results

Stability of highly nonlinear hybrid stochastic integro-differential delay equations

For the past few decades, the stability criteria for the stochastic differential delay equations (SDDEs) have been studied intensively. Most of these criteria can only be applied to delay equations where their coefficients are either linear or nonlinear but bounded by linear functions. Recently, the stability criterion for highly nonlinear hybrid stochastic differential equations is investigated in Fei et al. (2017). In this paper, we investigate a class of highly nonlinear hybrid stochastic integro-differential delay equations (SIDDEs). First, we establish the stability and boundedness of hybrid stochastic integro-differential delay equations. Then the delay-dependent criteria of the stability and boundedness of solutions to SIDDEs are studied. Finally, an illustrative example is provided

Somatic SF3B1 hotspot mutation in prolactinomas.

The genetic basis and corresponding clinical relevance of prolactinomas remain poorly understood. Here, we perform whole genome sequencing (WGS) on 21 patients with prolactinomas to detect somatic mutations and then validate the mutations with digital polymerase chain reaction (PCR) analysis of tissue samples from 227 prolactinomas. We identify the same hotspot somatic mutation in splicing factor 3 subunit B1 (SF3B1R625H) in 19.8% of prolactinomas. These patients with mutant prolactinomas display higher prolactin (PRL) levels (p = 0.02) and shorter progression-free survival (PFS) (p = 0.02) compared to patients without the mutation. Moreover, we identify that the SF3B1R625H mutation causes aberrant splicing of estrogen related receptor gamma (ESRRG), which results in stronger binding of pituitary-specific positive transcription factor 1 (Pit-1), leading to excessive PRL secretion. Thus our study validates an important mutation and elucidates a potential mechanism underlying the pathogenesis of prolactinomas that may lead to the development of targeted therapeutics