The Link between Genetic Factors in Children with Febrile Convulsions Appearance

The aim of this research paper is to reflect the link between genetic factors and presenting children with febrile convulsions.Keywords: febrile seizures, genetic factor, the pediatric clinic

Economic Diversification and the Urban Image; Changing the Narrative on Street Vending

Street vending is a dynamic phenomenon of network of events, socio-economic and cultural factors while remaining a narration of place. At the metropolitan level, the narrative is negatively skewed towards street vending and its aesthetic reality, contemporaneously exploring hostile environmental interventions within the informal sector. This paper attempted to explore a counter-narrative asking; based on aesthetic experience, can the “desired” urban image be achieved by allowing street vendors proliferate in public spaces? This question was asked within the scope of the political-economy of diversification in Nigeria. Mapping over google satellite images over critical periods leading to demolitions and/or developments, this paper documented the spatial distribution of vendors to determine the urban centres that are hostile to vending activities and those that were not. The paper argued that, around public spaces such as parks and sidewalks, the precarious nature of vending activities lead to their diffidence in upgrades to stalls, tables and kiosks. With pictures from spaces that appear to approve of street vending tacitly, a pattern of upgrades in vending apparatus and kiosks were established. This paper proposes an integrative model of passive, active and tacit support that is required to influence the discourse of vending activities within the context of urban images produced in Nigerian. In conclusion and using sing Gouverneur (2014) concepts of receptors and transformers, this paper revealed that potential existing parks within a dense urban area could serve as transformers, creating an urban image that defies that “out of place” narrative associated with vendors

Socioeconomic determinants of psychological well-being: the role of income, income change, and income sources during the course of 29 years

http://deepblue.lib.umich.edu/bitstream/2027.42/61251/1/Kaplan_2008_Annals-of-Epidemiology.pd

Energy efficiency in residential buildings using nano-wood composite materials

Wood is one of the conventional building materials in the world, due to its availability and sustainability in nature. The electric and thermal conductivity of wood have made it exceptional among the other conventional construction materials. Nevertheless, wood has deficiencies such as deterioration as a result of fungal and insect attack, vulnerability to fire and dimensional variability to water absorption. Nanotechnology has been in use in other scientific and technological fields for long period of time, but it is still fresh to some extent in architecture. When nanotechnology is applied to the conventional wood, a nono-wood composite will be produce with enhanced properties such as mechanical strength, fire resistance, durability, water immersion. This paper is aimed at examining how wood as a conventional building material can be enhanced using nanotechnology. It further consıders the conservation of energy in residential buildings through the building integrated nano-wood technology

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin

Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs). It is not known whether a failure to silence transcription flanking DSBs has any impact on DNA repair efficiency or whether chromatin remodelers contribute to the process. Here, we show that the PBAF remodeling complex is important for DSB-induced transcriptional silencing and promotes repair of a subset of DNA DSBs at early time points, which can be rescued by inhibiting transcription globally. An ATM phosphorylation site on BAF180, a PBAF subunit, is required for both processes. Furthermore, we find that subunits of the PRC1 and PRC2 polycomb group complexes are similarly required for DSB-induced silencing and promoting repair. Cancer-associated BAF180 mutants are unable to restore these functions, suggesting PBAF's role in repressing transcription near DSBs may contribute to its tumor suppressor activity

Regulation of gene expression is associated with tolerance of the Arctic copepod Calanus glacialis to CO2-acidified sea water

publishedVersio

Research Blogs and the Discussion of Scholarly Information

The research blog has become a popular mechanism for the quick discussion of scholarly information. However, unlike peer-reviewed journals, the characteristics of this form of scientific discourse are not well understood, for example in terms of the spread of blogger levels of education, gender and institutional affiliations. In this paper we fill this gap by analyzing a sample of blog posts discussing science via an aggregator called ResearchBlogging.org (RB). ResearchBlogging.org aggregates posts based on peer-reviewed research and allows bloggers to cite their sources in a scholarly manner. We studied the bloggers, blog posts and referenced journals of bloggers who posted at least 20 items. We found that RB bloggers show a preference for papers from high-impact journals and blog mostly about research in the life and behavioral sciences. The most frequently referenced journal sources in the sample were: Science, Nature, PNAS and PLoS One. Most of the bloggers in our sample had active Twitter accounts connected with their blogs, and at least 90% of these accounts connect to at least one other RB-related Twitter account. The average RB blogger in our sample is male, either a graduate student or has been awarded a PhD and blogs under his own name

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Here, we report on the identification of amiloride-based small molecules that potently inhibit OC43 and SARS-CoV-2 replication through targeting of conserved structured elements within the viral 5′-end. Nuclear magnetic resonance–based structural studies revealed specific amiloride interactions with stem loops containing bulge like structures and were predicted to be strongly bound by the lead amilorides in retrospective docking studies. Amilorides represent the first antiviral small molecules that target RNA structures within the 5′ untranslated regions and proximal region of the CoV genomes. These molecules will serve as chemical probes to further understand CoV RNA biology and can pave the way for the development of specific CoV RNA–targeted antivirals