1,006 research outputs found

    Learning away from neoliberalism: Lines of connection towards other worlds

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    In this essay, I envision the university, not simply as a discreet institution with formal boundaries to attend to and defend from neoliberal and conservative assaults, but as a location of possibility from which to locate and advance projects that connect students and ourselves to the possibility of other economic worlds.In this essay, I envision the university, not simply as a discreet institution with formal boundaries to attend to and defend from neoliberal and conservative assaults, but as a location of possibility from which to locate and advance projects that connect students and ourselves to the possibility of other economic worlds

    Making the green economy: politics, desire, and economic possibility

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    The green economy is put forward as an apposite remedy to both economic crisis and ecological devastation. Policy makers, academics, corporate interests and activists are advancing their goals as part of and through the green economy, a discursive terrain full of circulating and competing ideas about, dispositions towards, and desires for the economy. In Massachusetts, broad-based coalitions involving labor, environmentalists and community groups have emerged to capture funding, influence policy and launch their own economic initiatives. This paper explores and compares the activities of two green economy coalitions. I investigate how social actors, including myself, have been negotiating, responding to, and producing the meaning of the green economy, and the meaning of "the economy" writ-large, through our political efforts. I aim to move beyond a project that only critiques capitalism or maps out capitalist hegemony. Instead, taking inspiration and drawing from J.K. Gibson-Graham I look to theorize and amplify non-capitalist initiatives and enterprises. I am particularly interested in thinking about the ways in which the expression of different desires for economy can lead to openings, or closures, for the construction of non-capitalist relationships, initiatives, and enterprises Key words: green economy, economic subjectivity, Gibson-Graham, non-capitalism, fantas

    Single- and multi-photon excited fluorescence from serotonin complexed with B-cyclodextrin

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    The fluorescence of serotonin on binding with B-cyclodextrin has been studied using both steady-state and time-resolved methods. Steady state fluorescence intensity of serotonin at 340 nm showed ~ 30% increase in intensity on binding with Ka ~ 60 dm3 mol 1 and the fluorescence lifetimes showed a corresponding increase. In contrast, the characteristic green fluorescence (‘hyperluminescence’) of serotonin observed upon multiphoton near-infrared excitation with sub-picosecond pulses was resolved into two lifetime components assigned to free and bound serotonin. The results are of interest in relation to selective imaging and detection of serotonin using the unusual hyperluminescence emission and in respect to recent determinations of serotonin by capillary electrophoresis in the presence of cyclodextrin. The results also suggest that hyperluminescence occurs from multiphoton excitation of a single isolated serotonin molecule

    Cognitive-Behavior Therapy (CBT) for Panic Disorder: Relationship of Anxiety and Depression Comorbidity with Treatment Outcome

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    Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The current study examined the relationship of comorbid depression and anxiety to treatment outcome in a large-scale, multi-site clinical trial for cognitive-behavior therapy (CBT) for panic disorder. Comorbidity was associated with more severe panic disorder symptoms, although comorbid diagnoses were not associated with treatment response. Comorbid generalized anxiety disorder (GAD) and major depressive disorder (MDD) were not associated with differential improvement on a measure of panic disorder severity, although only rates of comorbid GAD were significantly lower at posttreatment. Treatment responders showed greater reductions on measures of anxiety and depressive symptoms. These data suggest that comorbid anxiety and depression are not an impediment to treatment response, and successful treatment of panic disorder is associated with reductions of comorbid anxiety and depressive symptoms. Implications for treatment specificity and conceptual understandings of comorbidity are discussed

    Comparative safety and benefit-risk profile of biologics and oral treatment for moderate-to-severe plaque psoriasis: A network meta-analysis of clinical trial data

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    Background The comparative safety and benefit-risk profiles of moderate-to-severe psoriasis treatment have not been well studied. Objective To compare the short-term (12-16 weeks) and long-term (48-56 weeks) safety and benefit-risk profiles of moderate-to-severe psoriasis treatments. Methods A systematic literature review of phase II-IV randomized controlled trials of moderate-to-severe psoriasis treatments was conducted (cutoff: July 1, 2020). Any adverse events (AEs), any serious AEs, and AEs leading to treatment discontinuation were compared using Bayesian network meta-analyses (NMAs). Results Fifty-two and 7, respectively, randomized controlled trials were included in the short- and long-term NMAs, respectively. In the short-term NMA, the rates of any AEs were the lowest for tildrakizumab (posterior median: 46.0%), certolizumab (46.2%), and etanercept (49.1%). The rates of any serious AE were the lowest for certolizumab (0.8%), risankizumab (1.2%), and etanercept (1.6%). The rates of AEs leading to treatment discontinuation were the lowest for risankizumab (0.5%), tildrakizumab (1.0%), and guselkumab (1.5%). In the long-term NMA, risankizumab had the lowest rates of all 3 outcomes (67.5%, 4.4%, and 1.0%, respectively) and the most favorable benefit-risk profile. Limitations The results may not be generalizable to real-world populations. Conclusions Anti–interleukin 23 agents were associated with low rates of safety events. Risankizumab had the most favorable benefit-risk profile in the long term

    Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children

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    OBJECTIVES: To report clinical course, etiology, management, and long-term outcomes of children suffering from Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). METHODS: We conducted a study of all pediatric patients with SJS or TEN admitted between 2000 and 2007 to the Hospital for Sick Children and Children's Hospital Boston, and particular attention was paid to clinical manifestations, etiology, mortality, and long-term outcomes. RESULTS: We identified 55 cases of SJS (n = 47), TEN (n = 5), or SJS/TEN overlap syndrome (n - 3). Drugs were identified as the most likely etiologic agent in 29 children (53%); antiepileptic drugs were the most common agents (n = 16), followed by sulfonamide antibiotics (n = 7) and chemotherapy drugs (n = 2). Acute Mycoplasma pneumoniae infection was confirmed in 12 children (22%), and herpes simplex virus was confirmed in 5 children (9%). Treatment regimens differed significantly between participating sites and included systemic antimicrobial agents (67%), systemic corticosteroids (40%), and antiviral drugs (31%). Intravenous immunoglobulin was administered to 21 children (38%), of whom 8 received concomitant systemic corticosteroids. Ten children (18%) had recurrence of SJS up to 7 years after the index episode, and 3 experienced multiple recurrences. Twenty-six children (47%) suffered long-term sequelae that mostly involved the skin and eyes. CONCLUSIONS: Mortality rate in children was lower than that reported in adults, but half of affected children suffered long-term complications. The recurrence rate of SJS was high (1 in 5), which suggests vulnerability and potential genetic predisposition. In the absence of standardized management guidelines for these conditions, treatment regimens differed significantly between participating institutions.Fil: Finkelstein, Yaron. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; CanadáFil: Soon, Gordon S.. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; CanadáFil: Acuna, Patrick. Children's Hospital Boston; Estados UnidosFil: George, Mathew. Children's Hospital Boston; Estados UnidosFil: Pope, Elena. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; CanadáFil: Ito, Shinya. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; CanadáFil: Shear, Neil H.. University of Toronto; Canadá. University Of Toronto. Hospital For Sick Children; CanadáFil: Koren, Gideon. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; CanadáFil: Shannon, Michael W.. Children's Hospital Boston; Estados UnidosFil: Garcia Bournissen, Facundo. University of Toronto; Canadá. University Of Toronto. Hospital For Sick Children; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

    Einstein equations in the null quasi-spherical gauge

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    The structure of the full Einstein equations in a coordinate gauge based on expanding null hypersurfaces foliated by metric 2-spheres is explored. The simple form of the resulting equations has many applications -- in the present paper we describe the structure of timelike boundary conditions; the matching problem across null hypersurfaces; and the propagation of gravitational shocks.Comment: 12 pages, LaTeX (revtex, amssymb), revision 18 pages, contains expanded discussion and explanations, updated references, to appear in CQ
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