Man's exploration of space

Apollo spacecraft developmen

Further development of a charged liquid colloid source for electrostatic propulsion Final report

Performance characteristics of charged liquid droplet electrostatic propulsion syste

Empirical model for the Earth's cosmic ray shadow at 400 KM: Prohibited cosmic ray access

The possibility to construct a unit sphere of access that describes the cosmic radiation allowed to an Earth-orbiting spacecraft is discussed. It is found that it is possible to model the occluded portion of the cosmic ray sphere of access as a circular projection with a diameter bounded by the satellite-Earth horizon. Maintaining tangency at the eastern edge of the spacecraft-Earth horizon, this optically occluded area is projected downward by an angle beta which is a function of the magnetic field inclination and cosmic ray arrival direction. This projected plane, corresponding to the forbidden area of cosmic ray access, is bounded by the spacecraft-Earth horizon in easterly directions, and is rotated around the vertical axis by an angle alpha from the eastern direction, where the angle alpha is a function of the offset dipole latitude of the spacecraft

Forecasting basketball players’ performance using sparse functional data

Statistics and analytic methods are becoming increasingly important in basketball. In particular, predicting players’ performance using past observations is a considerable challenge. The purpose of this study is to forecast the future behavior of basketball players. The available data are sparse functional data, which are very common in sports. So far, however, no forecasting method designed for sparse functional data has been used in sports. A methodology based on two methods to handle sparse and irregular data, together with the analogous method and functional archetypoid analysis is proposed. Results in comparison with traditional methods show that our approach is competitive and additionally provides prediction intervals. The methodology can also be used in other sports when sparse longitudinal data are available

Re-evaluation of cosmic ray cutoff terminology

The study of cosmic ray access to locations inside the geomagnetic field has evolved in a manner that has led to some misunderstanding and misapplication of the terminology originally developed to describe particle access. This paper presents what is believed to be a useful set of definitions for cosmic ray cutoff terminology for use in theoretical and experimental cosmic ray studies

An assessment of the isoniazid preventive therapy programme for children in a busy primary healthcare clinic in Nelson Mandela Bay Health District, Eastern Cape Province, South Africa

Background. Tuberculosis (TB) is a significant contributor to the international and national burden of disease. Global estimates suggest that there were 10.4 million new cases of TB in 2015. Children accounted for ~10% of these cases, although in South Africa (SA) this figure is thought to be higher. Despite clear evidence that isoniazid preventive therapy (IPT) can reduce the risk of progression from TB infection to disease in TB contacts, IPT has been poorly implemented in SA national TB control programmes.Objectives. To determine current practices regarding the identification and management of child contacts (<5 years of age) at a primary care clinic in the Nelson Mandela Bay Health District, Eastern Cape Province, SA.Methods. A cross-sectional descriptive study was conducted using a retrospective record review of infectious TB index patients aged ≥15 years. Folders of index patients with bacteriologically confirmed pulmonary TB, who started TB treatment between 21 October 2011 and 28 February 2014, were included. A sample size of 246 child contacts was required to obtain adequate power. A 95% confidence interval (CI) was used to determine statistically significant results.Results. Index patient records (N=491) were assessed and 261 child contacts identified. In a high percentage of index patient folders (87.5%; n=430), contacts were documented, although only 0.53 child contacts were identified per index patient. Of the 261 child contacts identified, 184 (70.5%) were screened for TB, 2 started TB treatment and 108/184 (58.7%) started IPT. For the remaining 74 (40.2%) children, there was no documentation of further management. Only 4 (3.7%) children completed the 24-week IPT course. Male patients reported fewer child contacts (χ2 =7.31; p=0.01; odds ratio (OR) 0.6; 95% CI 0.42 - 0.86) and were less likely to bring contacts for screening (χ2=8.98; p=0.003; OR 0.41; 95% CI 0.24 - 0.72). Retreatment index patients were also less likely to bring contacts for screening (χ2=6.37; p=0.01; OR 0.45; 95% CI 0.25 - 0.81) and those who were screened were less likely to initiate IPT (χ2=4.05; p=0.04; OR 0.54; 95% CI 0.3 - 0.95).Conclusion. Despite contacts being well documented, child contacts were poorly identified. The fall-out of children at each step from identification to IPT completion was unacceptably high. Contacts of male patients and retreatment index patients were at greater risk of poor management. Recommendations to improve IPT delivery at national and local level include a review of the national IPT guidelines, considering the relative success of shorter courses of TB prophylaxis, the use of standardised IPT stationery, staff training and the involvement of community health workers in contact management

Neurofilaments form flexible bundles during neuritogenesis in culture and in mature axons in situ

Neurofilaments (NFs) undergo cation-dependent phospho-mediated associations with each other and other cytoskeletal elements that support axonal outgrowth. Progressive NF-NF associations generate a resident, bundled population that undergoes exchange with transporting NFs. We examined the properties of bundled NFs. Bundles did not always display a fully linear profile but curved and twisted at various points along the neurite length. Bundles retracted faster than neurites and retracted bundles did not expand following extraction with Triton, indicating that they coiled passively rather than due to pressure from the cell. Bundles consisted of helically wound NFs, which may provide flexibility necessary for turning of growing axons during pathfinding. Interactions between NFs and other cytoskeletal elements may be disrupted en masse during neurite retraction or regionally during remodeling. It is suggested that bundles within long axons that cannot be fully retracted into the soma could provide maintain proximal support yet still allow more distal flexibility for remodeling and changing direction during pathfinding

Evidence of Rapid Phenocryst Growth of Olivine During Ascent in Basalts From the Big Pine Volcanic Field: Application of Olivine‐Melt Thermometry and Hygrometry at the Liquidus

The Quaternary Big Pine (BP) volcanic field in eastern California is notable for the occurrence of mantle xenoliths in several flows. This points to rapid ascent of basalt through the crust and precludes prolonged storage in a crustal reservoir. In this study, the hypothesis of phenocryst growth during ascent is tested for several basalts (13–7 wt% MgO) and shown to be viable. Phenocrysts of olivine and clinopyroxene frequently display diffusion‐limited growth textures, and clinopyroxene compositions are consistent with polybaric crystallization. When the most Mg‐rich olivine in each sample is paired with the whole‐rock composition, resulting Fe2+‐MgKD(olivine‐melt) values (0.31–0.36) match those calculated from literature models (0.32–0.36). Application of a Mg‐ and a Ni‐based olivine‐melt thermometer from the literature, both calibrated on the same experimental data set, leads to two sets of temperatures that vary linearly with whole‐rock MgO wt%. Because the Ni thermometer is independent of water content, it provides the actual temperature at the onset of olivine crystallization (1247–1097°C), whereas the Mg thermometer gives the temperature under anhydrous conditions and thus allows ΔT (=TMg − TNi = depression of liquidus due to water) to be obtained. The average ΔT for all samples is ~59°C, which is consistent with analyzed water contents of 1.5–3.0 wt% in olivine‐hosted melt inclusions from the literature. Because the application of olivine‐melt thermometry/hygrometry at the liquidus only requires microprobe analyses of olivine combined with whole‐rock compositions, it can be used to obtain large global data sets of the temperature and water contents of basalts from different tectonic settings.Plain Language SummaryBasaltic lavas are a window into their mantle source regions, which is why it is important to determine their temperatures and water contents. In this study, a new approach that allows these two parameters to be quantified is demonstrated for basalts from the Big Pine volcanic field, CA. They were targeted because many contain chunks of dense mantle rocks, which precludes storage in a crustal magma chamber and points to direct ascent from the mantle to the surface along fractures. Two hypotheses are proposed, tested, and shown to be viable in this study: (1) olivine crystallized in the basalts during ascent, and (2) the most Mg‐rich olivine analyzed in each basalt represents the first olivine to grow during ascent. This enables the most Mg‐rich olivine to be paired with the whole‐rock composition in the application of olivine‐melt thermometry and hygrometry. The results match those from published, independent studies. The success of this approach paves the way for the attainment of large, high‐quality data sets for basalts from a wide variety of tectonic settings. This, in turn, may allow global variations in mantle temperature and volatile content to be mapped in greater detail and better understood.Key PointsRapid phenocryst growth occurs during ascent in Mg‐rich basalts (some carry mantle xenoliths) from the Big Pine volcanic field, CAThe most Mg‐rich olivine can be paired with the whole‐rock composition to apply olivine‐melt thermometry/hygrometry at the liquidusLarge, high‐quality data sets on the temperature and water content of basalts from various tectonic settings can be obtained by this methodPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163434/3/ggge22329-sup-0001-2020GC009264-SI.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163434/2/ggge22329.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163434/1/ggge22329_am.pd

A point process framework for modeling electrical stimulation of the auditory nerve

Model-based studies of auditory nerve responses to electrical stimulation can provide insight into the functioning of cochlear implants. Ideally, these studies can identify limitations in sound processing strategies and lead to improved methods for providing sound information to cochlear implant users. To accomplish this, models must accurately describe auditory nerve spiking while avoiding excessive complexity that would preclude large-scale simulations of populations of auditory nerve fibers and obscure insight into the mechanisms that influence neural encoding of sound information. In this spirit, we develop a point process model of the auditory nerve that provides a compact and accurate description of neural responses to electric stimulation. Inspired by the framework of generalized linear models, the proposed model consists of a cascade of linear and nonlinear stages. We show how each of these stages can be associated with biophysical mechanisms and related to models of neuronal dynamics. Moreover, we derive a semi-analytical procedure that uniquely determines each parameter in the model on the basis of fundamental statistics from recordings of single fiber responses to electric stimulation, including threshold, relative spread, jitter, and chronaxie. The model also accounts for refractory and summation effects that influence the responses of auditory nerve fibers to high pulse rate stimulation. Throughout, we compare model predictions to published physiological data and explain differences in auditory nerve responses to high and low pulse rate stimulation. We close by performing an ideal observer analysis of simulated spike trains in response to sinusoidally amplitude modulated stimuli and find that carrier pulse rate does not affect modulation detection thresholds.Comment: 1 title page, 27 manuscript pages, 14 figures, 1 table, 1 appendi