Power spectra of solar brightness variations at different inclinations

Magnetic features on the surfaces of cool stars cause variations of their brightness. Such variations have been extensively studied for the Sun. Recent planet-hunting space telescopes allowed measuring brightness variations in hundred thousands of other stars. The new data posed the question of how typical is the Sun as a variable star. Putting solar variability into the stellar context suffers, however, from the bias of solar observations being made from its near-equatorial plane, whereas stars are observed at all possible inclinations. We model solar brightness variations at timescales from days to years as they would be observed at different inclinations. In particular, we consider the effect of the inclination on the power spectrum of solar brightness variations. The variations are calculated in several passbands routinely used for stellar measurements. We employ the Surface Flux Transport Model (SFTM) to simulate the time-dependent spatial distribution of magnetic features on both near- and far-sides of the Sun. This distribution is then used to calculate solar brightness variations following the SATIRE (Spectral And Total Irradiance REconstruction) approach. We have quantified the effect of the inclination on solar brightness variability at timescales down to a day. Thus, our results allow making solar brightness records directly comparable to those obtained by the planet-hunting space telescopes. Furthermore, we decompose solar brightness variations into the components originating from the solar rotation and from the evolution of magnetic features

Testing for Network and Spatial Autocorrelation

Testing for dependence has been a well-established component of spatial statistical analyses for decades. In particular, several popular test statistics have desirable properties for testing for the presence of spatial autocorrelation in continuous variables. In this paper we propose two contributions to the literature on tests for autocorrelation. First, we propose a new test for autocorrelation in categorical variables. While some methods currently exist for assessing spatial autocorrelation in categorical variables, the most popular method is unwieldy, somewhat ad hoc, and fails to provide grounds for a single omnibus test. Second, we discuss the importance of testing for autocorrelation in data sampled from the nodes of a network, motivated by social network applications. We demonstrate that our proposed statistic for categorical variables can both be used in the spatial and network setting

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse.

A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225 patients with glioblastoma multiforme at first relapse. Primary objectives were to determine progression-free survival (PFS) at 6 months and safety for TMZ and PCB in adult patients who failed conventional treatment. Secondary objectives were to assess overall survival and health-related quality of life (HRQL). TMZ was given orally at 200 mg/m(2)/day or 150 mg/m(2)/day (prior chemotherapy) for 5 days, repeated every 28 days. PCB was given orally at 150 mg/m(2)/day or 125 mg/m(2)/day (prior chemotherapy) for 28 days, repeated every 56 days. HRQL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30 [+3]) and the Brain Cancer Module 20 (BCM20). The 6-month PFS rate for patients who received TMZ was 21%, which met the protocol objective. The 6-month PFS rate for those who received PCB was 8% (P = 0.008, for the comparison). Overall PFS significantly improved with TMZ, with a median PFS of 12.4 weeks in the TMZ group and 8.32 weeks in the PCB group (P = 0.0063). The 6-month overall survival rate for TMZ patients was 60% vs. 44% for PCB patients (P = 0.019). Freedom from disease progression was associated with maintenance of HRQL, regardless of treatment received. TMZ had an acceptable safety profile; most adverse events were mild or moderate in severity

Future aspects of renal transplantation

New and exciting advances in renal transplantation are continuously being made, and the horizons for organ transplantation are bright and open. This article reviews only a few of the newer advances that will allow renal transplantation to become even more widespread and successful. The important and exciting implications for extrarenal organ transplantation are immediately evident. © 1988 Springer-Verlag

Connecting measurements of solar and stellar brightness variations

Context. A comparison of solar and stellar brightness variations is hampered by the difference in spectral passbands that are used in observations, and also by the possible difference in the inclination of the solar and stellar rotation axes from the line of sight. Aims. We calculate the rotational variability of the Sun as it would be measured in passbands used for stellar observations. In particular, we consider the filter systems used by the CoRoT, Kepler, TESS, and Gaia space missions. We also quantify the effect of the inclination of the rotation axis on the solar rotational variability. Methods. We employed the spectral and total irradiance reconstruction (SATIRE) model to calculate solar brightness variations in different filter systems as observed from the ecliptic plane. We then combined the simulations of the surface distribution of the magnetic features at different inclinations using a surface flux transport model with the SATIRE calculations to compute the dependence of the variability on the inclination. Results. For an ecliptic-bound observer, the amplitude of the solar rotational variability, as observed in the total solar irradiance (TSI), is 0.68 mmag (averaged over solar cycles 21–24). We obtained corresponding amplitudes in the Kepler (0.74 mmag), CoRoT (0.73 mmag), TESS (0.62 mmag), Gaia G (0.74 mmag), Gaia GRP (0.62 mmag), and Gaia GBP (0.86 mmag) passbands. Decreasing the inclination of the rotation axis decreases the rotational variability. For a sample of randomly inclined stars, the variability is on average 15% lower in all filter systems we considered. This almost compensates for the difference in amplitudes of the variability in TSI and Kepler passbands, making the amplitudes derived from the TSI records an ideal representation of the solar rotational variability for comparison to Kepler stars with unknown inclinations. Conclusions. The TSI appears to be a relatively good measure of solar variability for comparisons with stellar measurements in the CoRoT, Kepler, TESS Gaia G, and Gaia GRP filters. Whereas the correction factors can be used to convert the variability amplitude from solar measurements into the values expected for stellar missions, the inclination affects the shapes of the light curves so that a much more sophisticated correction than simple scaling is needed to obtain light curves out of the ecliptic for the Sun

Assessment of a self-reported Drinks Diary for the estimation of drinks intake by care home residents: Fluid Intake Study in the Elderly (FISE)

Objectives: We evaluated the accuracy of a newly developed self-completed Drinks Diary in care home residents and compared it with direct observation and fluid intake charts. Design: Observational study. Setting: Residential care homes in Norfolk, UK. Participants: 22 elderly people (18 women, mean age 86.6 years SD 8.6, 12 with MMSE scores <27). Measurements: Participants recorded their own drinks intake over 24 hours using the Drinks Diary while care staff used the homes’ usual fluid intake chart to record drinks intake. These records were compared with drinks intake assessed by researcher direct observation (reference method), during waking hours (6am to 10pm), while drinks taken from 10pm to 6am were self-reported and checked with staff. Results: Drinks intake assessed by the Drinks Diary was highly correlated with researcher direct observation (Pearson correlation coefficient r=0.93, p<0.001, mean difference -163ml/day) while few staff-completed fluid charts were returned and correlation was low (r=0.122, p=0.818, mean difference 702ml/day). The Drinks Diary classified 19 of 22 participants correctly as drinking enough or not using both the European Food Safety Authority and US recommendations. Conclusion: The Drinks Diary estimate of drinks intake was comparable with direct observation and more accurate (and reliably completed) than staff records. The Drinks Diary can provide a reliable estimate of drinks intake in elderly care home residents physically and cognitively able to complete it. It may be useful for researchers, care staff and practitioners needing to monitor drinks intake of elderly people, to help them avoid dehydration

First-principles design and subsequent synthesis of a material to search for the permanent electric dipole moment of the electron

We describe the first-principles design and subsequent synthesis of a new material with the specific functionalities required for a solid-state-based search for the permanent electric dipole moment of the electron. We show computationally that perovskite-structure europium barium titanate should exhibit the required large and pressure-dependent ferroelectric polarization, local magnetic moments, and absence of magnetic ordering even at liquid helium temperature. Subsequent synthesis and characterization of Eu$_{0.5}$Ba$_{0.5}$TiO$_3$ ceramics confirm the predicted desirable properties.Comment: Nature Materials, in pres

Alpha-band rhythms in visual task performance: phase-locking by rhythmic sensory stimulation

Oscillations are an important aspect of neuronal activity. Interestingly, oscillatory patterns are also observed in behaviour, such as in visual performance measures after the presentation of a brief sensory event in the visual or another modality. These oscillations in visual performance cycle at the typical frequencies of brain rhythms, suggesting that perception may be closely linked to brain oscillations. We here investigated this link for a prominent rhythm of the visual system (the alpha-rhythm, 8-12 Hz) by applying rhythmic visual stimulation at alpha-frequency (10.6 Hz), known to lead to a resonance response in visual areas, and testing its effects on subsequent visual target discrimination. Our data show that rhythmic visual stimulation at 10.6 Hz: 1) has specific behavioral consequences, relative to stimulation at control frequencies (3.9 Hz, 7.1 Hz, 14.2 Hz), and 2) leads to alpha-band oscillations in visual performance measures, that 3) correlate in precise frequency across individuals with resting alpha-rhythms recorded over parieto-occipital areas. The most parsimonious explanation for these three findings is entrainment (phase-locking) of ongoing perceptually relevant alpha-band brain oscillations by rhythmic sensory events. These findings are in line with occipital alpha-oscillations underlying periodicity in visual performance, and suggest that rhythmic stimulation at frequencies of intrinsic brain-rhythms can be used to reveal influences of these rhythms on task performance to study their functional roles

Universality, limits and predictability of gold-medal performances at the Olympic Games

Inspired by the Games held in ancient Greece, modern Olympics represent the world's largest pageant of athletic skill and competitive spirit. Performances of athletes at the Olympic Games mirror, since 1896, human potentialities in sports, and thus provide an optimal source of information for studying the evolution of sport achievements and predicting the limits that athletes can reach. Unfortunately, the models introduced so far for the description of athlete performances at the Olympics are either sophisticated or unrealistic, and more importantly, do not provide a unified theory for sport performances. Here, we address this issue by showing that relative performance improvements of medal winners at the Olympics are normally distributed, implying that the evolution of performance values can be described in good approximation as an exponential approach to an a priori unknown limiting performance value. This law holds for all specialties in athletics-including running, jumping, and throwing-and swimming. We present a self-consistent method, based on normality hypothesis testing, able to predict limiting performance values in all specialties. We further quantify the most likely years in which athletes will breach challenging performance walls in running, jumping, throwing, and swimming events, as well as the probability that new world records will be established at the next edition of the Olympic Games.Comment: 8 pages, 3 figures, 1 table. Supporting information files and data are available at filrad.homelinux.or