128 research outputs found
Growth and Characterization of Ce- Substituted Nd2Fe14B Single Crystals
Single crystals of (Nd1-xCex)2Fe14B are grown out of Fe-(Nd,Ce) flux.
Chemical and structural analysis of the crystals indicates that
(Nd1-xCex)2Fe14B forms a solid solution until at least x = 0.38 with a
Vegard-like variation of the lattice constants with x. Refinements of single
crystal neutron diffraction data indicate that Ce has a slight site preference
(7:3) for the 4g rare earth site over the 4f site. Magnetization measurements
show that for x = 0.38 the saturation magnetization at 400 K, a temperature
important to applications, falls from 29.8 for the parent Nd2Fe14B to 27.6
(mu)B/f.u., the anisotropy field decreases from 5.5 T to 4.7 T, and the Curie
temperature decreases from 586 to 543 K. First principles calculations carried
out within density functional theory are used to explain the decrease in
magnetic properties due to Ce substitution. Though the presence of the
lower-cost and more abundant Ce slightly affects these important magnetic
characteristics, this decrease is not large enough to affect a multitude of
applications. Ce-substituted Nd2Fe14B is therefore a potential high-performance
permanent magnet material with substantially reduced Nd content.Comment: 11 Pages, 8 figures, 5 table
The effect of food and formulation on the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL-17822 in healthy male volunteers
We aimed to characterise the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL-17822 in healthy males and explore the effect of food and formulation on the oral absorption of DRL-17822 in 4 phase I studies. DRL-17822 was dosed orally (2-1000 mg) in 2 different drug formulations (nanocrystal formulation and amorphous solid dispersion formulation) after either an overnight fast, or a low-fat, continental or high-fat breakfast. A 2-compartment model with 6 transit absorption compartments best characterised the data. Additionally, a strong interaction of food and formulation on bioavailability was observed and parsimoniously characterised in the model by binning combinations of food state and formulation with similar bio-availabilities. The final model adequately characterised the pharmacokinetic data of DRL-17822 in healthy males including the complex interaction of food and drug formulation. The amorphous solid dispersion formulation has a lower food effect on bioavailability compared with the nanocrystal formulation.Pharmacolog
Enhancement of Friction between Carbon Nanotubes: An Efficient Strategy to Strengthen Fibers
Interfacial friction plays a crucial role in the mechanical properties of
carbon nanotube based fibers, composites, and devices. Here we use molecular
dynamics simulation to investigate the pressure effect on the friction within
carbon nanotube bundles. It reveals that the intertube frictional force can be
increased by a factor of 1.5 ~ 4, depending on tube chirality and radius, when
all tubes collapse above a critical pressure and when the bundle remains
collapsed with unloading down to atmospheric pressure. Furthermore, the overall
cross-sectional area also decreases significantly for the collapsed structure,
making the bundle stronger. Our study suggests a new and efficient way to
reinforce nanotube fibers, possibly stronger than carbon fibers, for usage at
ambient conditions.Comment: revtex, 5 pages, accepted by ACS Nano 10 Dec 200
Gate-tunable giant nonreciprocal charge transport in noncentrosymmetric oxide interfaces
A polar conductor, where inversion symmetry is broken, may exhibit directional propagation of itinerant electrons, i.e., the rightward and leftward currents differ from each other, when time-reversal symmetry is also broken. This potential rectification effect was shown to be very weak due to the fact that the kinetic energy is much higher than the energies associated with symmetry breaking, producing weak perturbations. Here we demonstrate the appearance of giant nonreciprocal charge transport in the conductive oxide interface, LaAlO3/SrTiO3, where the electrons are confined to two-dimensions with low Fermi energy. In addition, the Rashba spin???orbit interaction correlated with the sub-band hierarchy of this system enables a strongly tunable nonreciprocal response by applying a gate voltage. The observed behavior of directional response in LaAlO3/SrTiO3 is associated with comparable energy scales among kinetic energy, spin???orbit interaction, and magnetic field, which inspires a promising route to enhance nonreciprocal response and its functionalities in spin orbitronics
Blast phase myeloproliferative neoplasm: Mayo-AGIMM study of 410 patients from two separate cohorts
A total of 410 patients with blast phase myeloproliferative neoplasm (MPN-BP) were retrospectively reviewed: 248 from the
Mayo Clinic and 162 from Italy. Median survival was 3.6 months, with no improvement over the last 15 years. Multivariable
analysis performed on the Mayo cohort identified high risk karyotype, platelet count < 100 × 109
/L, age > 65 years and
transfusion need as independent risk factors for survival. Also in the Mayo cohort, intensive chemotherapy resulted in complete
remission (CR) or CR with incomplete count recovery (CRi) rates of 35 and 24%, respectively; treatment-specified 3-year/5-year
survival rates were 32/10% for patients receiving allogeneic stem cell transplant (AlloSCT) (n = 24), 19/13% for patients
achieving CR/CRi but were not transplanted (n = 24), and 1/1% in the absence of both AlloSCT and CR/CRi (n = 200) (p <
0.01). The survival impact of AlloSCT (HR 0.2, 95% CI 0.1–0.3), CR/CRi without AlloSCT (HR 0.3, 95% CI 0.2–0.5), high risk
karyotype (HR 1.6, 95% CI 1.1–2.2) and platelet count < 100 × 109
/L (HR 1.6, 95% CI 1.1–2.2) were confirmed to be interindependent. Similar observations were made in the Italian cohort. The current study identifies the setting for improved short-term
survival in MPN-BP, but also highlights the limited value of current therapy, including AlloSCT, in securing long-term survival
Towards colloidal spintronics through Rashba spin-orbit interaction in lead sulphide nanosheets
Employing the spin degree of freedom of charge carriers offers the
possibility to extend the functionality of conventional electronic devices,
while colloidal chemistry can be used to synthesize inexpensive and tuneable
nanomaterials. In order to benefit from both concepts, Rashba spin-orbit
interaction has been investigated in colloidal lead sulphide nanosheets by
electrical measurements on the circular photo-galvanic effect. Lead sulphide
nanosheets possess rock salt crystal structure, which is centrosymmetric. The
symmetry can be broken by quantum confinement, asymmetric vertical interfaces
and a gate electric field leading to Rashba-type band splitting in momentum
space at the M points, which results in an unconventional selection mechanism
for the excitation of the carriers. The effect, which is supported by
simulations of the band structure using density functional theory, can be tuned
by the gate electric field and by the thickness of the sheets. Spin-related
electrical transport phenomena in colloidal materials open a promising pathway
towards future inexpensive spintronic devices.Comment: 25 pages, 4 figure
Pretransplantation use of the second-generation tyrosine kinase inhibitors has no negative impact on the HCT outcome
Management of temporomandibular disorders with transcutaneous electrical nerve stimulation: A systematic review
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