Bifurcations of Relative Equilibria Sets of a Massive Point on Rough Rotating Surfaces

Dynamics of a massive point on a rotating wire or surface under dry friction force action is considered. Existence, stability and bifurcations of non-isolated relative equilibria sets of the point located on a sphere uniformly rotating about an inclined fixed axis; on a thin circular hoop rotating about an inclined fixed axis; on a paraboloidal bowl uniformly rotating about its axis are studied. The results are represented in the form of bifurcation diagrams

Stochastic analysis of an elastic 3D half-space respond to random boundary displacements : exact results and Karhunen-Loéve expansion

A stochastic response of an elastic 3D half-space to random displacement excitations on the boundary plane is studied. We derive exact results for the case of white noise excitations which are then used to give convolution representations for the case of general finite correlation length fluctuations of displacements prescribed on the boundary. Solutions to this elasticity problem are random fields which appear to be horizontally homogeneous but inhomogeneous in the vertical direction. This enables us to construct explicitly the Karhunen-Loève (K-L) series expansion by solving the eigen-value problem for the correlation operator. Simulation results are presented and compared with the exact representations derived for the displacement correlation tensor. This paper is a complete 3D generalization of the 2D case study we presented in J. Stat. Physics, v.132 (2008), N6, 1071-1095

The impact of war on the development and progression of arterial hypertension and cardiovascular disease: protocol of a prospective study among Ukrainian female refugees.

Growing evidence supports the impact of psychological factors such as traumatic experiences and Post Traumatic Stress Disorder (PTSD) on the incidence of arterial hypertension (HTN) and cardiovascular diseases (CVD). The war in Ukraine is exposing million inhabitants to traumatic experiences and severe stress. Part of Ukrainians (mostly women and children) left the country to escape war. We report the protocol of a prospective study aiming at the assessment of the impact of war-induced stress on HTN and CVD in women Ukrainian refugees who moved to Poland. The study will be conducted in 3 stages. Stage 1 will assess the prevalence of HTN and PTSD among Ukrainian refugees and will estimate the impact of war-related trauma exposure on these parameters. Data on office blood pressure (BP) will be compared to data already collected in STEPS data 2019 and May Measurement Month 2021 in Ukraine, matched for age and sex. Stage 2 will involve subjects diagnosed with HTN and/or PTSD referred for management and follow-up of these conditions. Psychologic targeted therapies will be offered to subjects with confirmed PTSD, with a periodical reassessment of the severity of PTSD-associated symptoms and of its impact on HTN and cardiovascular health. Clinical history and characteristics will be compared among three groups: subjects with HTN and PTSD, with HTN without PTSD, with PTSD but without HTN. Stage 3 will involve a subgroup among those screened in Stage 1, with the objective of investigating the biological mechanisms underlying the relation between HTN and trauma exposure, identifying early signs of subclinical target organ damage in subjects with HTN with/without PTSD. This study will test the hypothesis that trauma exposure and psychological stress contribute to BP elevation and progression of CVD in this population. It will provide new evidence on the effect of an integrated management, including psychological therapy, on BP and cardiovascular risk. Such approach may be further tested and extrapolated to other populations exposed to war and chronic violence, migrants and refugees around the world. number 2022/45/P/NZ5/02812

Features of the Severity of Cardiovascular Remodeling and Metabolic Disorders in Hypertensive Patients with Obesity in the Presence of Two Unfavorable Genotypes of the ADIPOQ and IRS-1 Genes

The results of a number of studies have shown that in arterial hypertension (AH), G/T and T/T genotypes of the adiponectin gene (ADIPOQ) and Gly/Arg and Arg/Arg genotypes of the insulin receptor substrate 1 gene (IRS-1) are associated with a greater severity of metabolic disorders and hemodynamic parameters compared with G/G and Gly/Gly genotypes of these genes. The aim of the study: to evaluate the severity of cardiovascular remodeling and metabolic disorders in hypertensive obese patients in the simultaneous presence of two unfavorable genotypes of the ADIPOQ and IRS-1 genes. Methods: We examined 300 AH patients: 200 patients with AH and obesity, 50 patients with AH and normal body weight, 50 patients with AH and overweight, 40 patients with AH, obesity and type 2 diabetes mellitus (DM2), 30 healthy individuals. The polymorphisms of the ADIPOQ and IRS-1 was assessed by molecular genetic method. Results: It was found that in all groups of hypertensive patients, regardless of body weight and the presence of DM2, the simultaneous presence of two unfavorable genotypes of the ADIPOQ and IRS-1 genes occurred significantly more often than in healthy individuals: in 41% of AH patients with obesity, 30% of AH patients with normal weight, 40% of AH with overweight, 57.5% of AH with obesity and DM2 vs. 13.3% of healthy individuals. In hypertensive patients, in the presence of overweight and obesity, the frequency of combination of the two unfavorable genotypes of these genes was significantly higher than in AH patients with normal body weight. Conducting comparative evaluation of AH patients with obesity depending on the presence of two unfavorable genotypes or two protective genotypes of the ADIPOQ and IRS-1 genes showed that carriers of the combination of the G/T + T/T genotype of the ADIPOQ and the Gly/Arg + Arg/Arg genotype of the IRS-1 had a higher body mass index, more pronounced insulin resistance, cardiovascular remodeling, adipokine imbalance, impaired carbohydrate and lipid metabolism. Conclusions: In AH patients, the frequency of the simultaneous presence of two unfavorable polymorphisms of ADIPOQ and IRS-1 genes was higher than in healthy individuals. In AH patients with overweight and obesity, the frequency of combination of the two unfavorable genotypes of the ADIPOQ and IRS-1 genes was significantly higher than in normal body weight. The presence of a combination of two unfavorable genotypes of the ADIPOQ and IRS-1 genes in patients with AH and obesity was associated with a greater severity of cardiovascular remodeling and metabolic disorders compared with the combination of two protective genotypes of these genes

Визначення залишкових кількостей антибіотиків групи бацитрацинів у продукції птахівництва мікробіологічним методом

Antibiotics are widely used to stimulate the growth of poultry raised for human consumption, as well as therapeutically for the treatment of infectious diseases of poultry. The indiscriminate use of antibiotic growth stimulants in chicken diets continues to pose a threat to human health. However, because the burden of infectious diseases in poultry is high, the abolition of the use of antibiotics without alternatives will lead to the spread of infections that have serious consequences for food safety and human health. One of the priorities of the state policy on nutrition in the field of health care is to ensure food safety. The aim of the study was to determine the residual amount of antibiotics in poultry meat, liver and kidneys. To validate a qualitatively new screening microbiological method to determine the residual amount of the bacitracin group in poultry products. Material and methods. The limits of sensitivity, accuracy and specificity were established by microbiological method for determining the residual amount of the bacitracin group. The study was performed in 20 replicates of meat, liver and kidney samples that do not contain antibiotics, as well as in samples with the addition of antibiotics of the bacitracin group in concentrations ½ MRL and MRL. Results of research and discussion. Pure inhibition zones with growth of Micrococcus flavus ATCC 10240 test culture were found in the samples without the addition of antibiotics, and inhibition zones ranging from 18.03 ± 0.03 mm to 18.08 ± 0.04 mm were present near the standard of antibiotics. It was found that when adding an antibiotic of the bacitracin group to poultry products, were present around the wells of the inhibition zone of the test culture Micrococcus flavus ATCC 10240. The lowest level of residue determination (½MRL) for poultry, kidney and liver is 10.0 μg/kg , MRL 20.0 μg/kg in accordance with the requirements of national legislation by order of the Ministry of Health of Ukraine Poultry meat safety parameters from 06.08.2013 № 695. Conclusions and prospects for further research. The specificity, accuracy and sensitivity of this method is 100 %, which allows to detect ½ maximum permissible levels of residual amounts of antibiotics of the bacitracin group in accordance with the requirements of national legislation.Антибіотики широко використовуються для стимулювання росту птиці, яку вирощують для використання в їжу, а також терапевтично для лікування інфекційних захворювань птиці. Нерозбірливе використання стимуляторів росту антибіотиків у курячих дієтах продовжує становити загрозу здоров’ю людини. Однак, оскільки навантаження на інфекційні захворювання в птахогосподарствах велике, скасування використання антибіотиків без альтернатив призведе до поширення інфекцій, що мають серйозні наслідки для безпеки продуктів харчування та здоров’я людини. Одним із пріоритетних напрямків державної політики щодо харчування в галузі охорони здоров’я є забезпечення безпеки харчових продуктів. Метою роботи було провести дослідження щодо визначення залишкової кількості антибіотиків у м’ясі, печінці та нирках птиці. Провести валідацію якісного нового скринінгового мікробіологічного методу визначення залишкової кількості групи бацитрацинів в продукції птахівництва. Матеріал та методи. Межі чутливості, точності та специфічності були встановлені мікробіологічним методом визначення залишкової кількості групи бацитрацинів. Дослідження проводилось у 20 повторюваностях зразків м’яса, печінки та нирок, які не містять антибіотики, а також у зразках із додаванням антибіотиків групи бацитрацинів у концентраціях ½ МДР та МДР. Результати дослідження та обговорення. Виявили в зразках без додавання антибіотиків чисті зони інгібування з ростом тест-культури Micrococcus flavus АТСС 10240, а біля стандарту антибіотиків присутні зони інгібування, які становили від 18,03 ± 0,03 мм до 18,08 ± 0,04 мм. Встановлено, що при додаванні антибіотика групи бацитрацинів у м’ясо, печінку, нирки про що свідчить присутність навколо луночок зони інгібування тест-культури Micrococcus flavus АТСС 10240 в тестовому агарі. Найнижчий рівень визначення залишків 10,0 мкг/кг (½ МДР) для м’яса птиці, нирок та печінки становить, МДР 20,0 мкг/кг відповідно до вимог національного законодавства від 06.08.2013 року № 695 наказ Міністерства охорони здоров’я України “Параметрів безпечності м’яса птиці” Висновки та перспективи подальших досліджень. Визначено специфічність, точність та чутливість цього методу становить 100 %, що дозволяє виявляти 10 мкг/кг (½ максимально допустимих рівнів) залишкових кількостей антибіотиків групи бацитрацинів відповідно до вимог національного законодавства

The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity

Background: Hereditary component plays a significant role in the formation of insulin resistance (IR) - one of the pathogenetic links of arterial hypertension (AH) and type 2 diabetes mellitus (DM2). However, the genetic predisposition to IR can not be realized and does not manifest itself clinically in the absence of appropriate factors of the environment (excessive nutrition, low physical activity, etc.). Objective: The review summarizes the results of studies which describe the contribution of genetic polymorphism to the formation and progression of AH, DM2 and their comorbidity in various populations. Results: In many studies, it has been established that genetic polymorphism of candidate genes is influenced by the formation, course and complication of AH and DM2. According to research data, the modulating effect of polymorphism of some genetic markers of AH and DM2 on metabolism and hemodynamics has been established. The results of numerous studies have shown a higher frequency of occurrence of AH and DM2, as well as their more severe course with adverse genetic polymorphisms. At the same time, the role of genetic polymorphism in the formation of AH and DM2 differs in different populations. Conclusion: Contradictory data on the influence of gene polymorphisms on the formation of AH and DM2 in different populations, as well as a small number of studies on the combined effects of several polymorphisms on the formation of comorbidity, determine the continuation of research in this direction

Features of metabolic and hemodynamic indicators in obese patients with resistant hypertension

Objective: To establish the features of metabolic and hemodynamic parameters in obese patients with true and pseudo-resistant arterial hypertension (AH)

Hemodynamic and metabolic disorders in obese patients with resistant hypertension

Patients with resistant hypertension differed from hypertensive obese patients without resistance with higher BMI and BP, higher levels of triglycerides, insulin, HbA1c, more pronounced IR, cardiovascular remodeling, imbalance of oxidative stress - antioxidant protection system, higher proinflammatory and RAAS activity. Patients with true resistance differed from pseudo-resistant patients with significantly lower BMI, higher aldosterone levels, more pronounced imbalance of the system of oxidative stress - antioxidant protection and less pronounced adipokines imbalance

Modern approach to complex treatment of diabetic foot syndrome in a surgical hospital

139 patients exposed to surgical interventions concerning the diabetic foot syndrome (DFS) from 2013 to 2015 were analyzed in this article. They were divided in two groups: patients with neuropathic (n=60) and neuroischemic (n=79) types of DFS. The dependence of surgical treatment results from the prevalence of purulent-necrotic processes was evaluated. The tendency of decrease of major amputations was established.В статье проанализированы 139 пациентов, которым выполнены хирургические вмешательства по поводу синдрома диабетической стопы (СДС) в период с 2013-го по 2015 год. Выделены 2 группы: пациенты с нейропатическим (n=60) и нейроишемическим (n=79) типами СДС. В ходе работы была оценена зависимость исходов операций от распространенности гнойно-некротических процессов, а также была установлена тенденция к уменьшению количества больших ампутаций

Experimental Observation of Plasma Wakefield Growth Driven by the Seeded Self-Modulation of a Proton Bunch

We measure the effects of transverse wakefields driven by a relativistic proton bunch in plasma with densities of 2.1 x 10(14) and 7.7 x 10(14) electrons/cm(3). We show that these wakefields periodically defocus the proton bunch itself, consistently with the development of the seeded self-modulation process. We show that the defocusing increases both along the bunch and along the plasma by using time resolved and time-integrated measurements of the proton bunch transverse distribution. We evaluate the transverse wakefield amplitudes and show that they exceed their seed value (< 15 MV/m) and reach over 300 MV/m. All these results confirm the development of the seeded self-modulation process, a necessary condition for external injection of low energy and acceleration of electrons to multi-GeV energy levels