Chorionic Bump in First-trimester Sonography

Objectives The present research was motivated by providing new insight into early pregnancies with a chorionic bump diagnosis in first-trimester sonography and its impact on live birth rate. Methods To determine the rate of CB, first trimester sonograms of pregnant women referring to Akbarabadi Hospital, which is a treatment and training center affiliated to Iran University of Medical Sciences as well as those referring to a private center were analyzed. The total number of transvaginal sonographies performed was 1900 cases from whom 8 cases of CB were detected. The chorionic bump size and number and history of infertility or coagulation disorders were considered as our independent variables and multiple gestation with pregnancy outcome as dependent ones. Results Overall, the prevalence rate of CB was 0.4 (4 per 1000), with 8 patients diagnosed with CB from 1900 the first trimester pregnant women. Of 8 pregnant women, 5 showed live birth (62.5) and 3 experienced fetal demise (37.5). The chorionic bumps ranged in size from 0.1 cc to 1.8 cc (average, 0.73 cc). No significant relationship was found between history of smoking, coagulopathy, infertility, multiple gestation and the size of CB. Conclusions The main finding was that the frequency of live birth in our sample was 62.5 (5 from 8). The clinical inference is that a chorionic bump on first-trimester sonography does not definitely guarantee a secure prediction. The correlation between bump size and pregnancy outcome is not clear, which warrants further research. © 201

Chorionic Bump in First-trimester Sonography

Objectives The present research was motivated by providing new insight into early pregnancies with a chorionic bump diagnosis in first-trimester sonography and its impact on live birth rate. Methods To determine the rate of CB, first trimester sonograms of pregnant women referring to Akbarabadi Hospital, which is a treatment and training center affiliated to Iran University of Medical Sciences as well as those referring to a private center were analyzed. The total number of transvaginal sonographies performed was 1900 cases from whom 8 cases of CB were detected. The chorionic bump size and number and history of infertility or coagulation disorders were considered as our independent variables and multiple gestation with pregnancy outcome as dependent ones. Results Overall, the prevalence rate of CB was 0.4 (4 per 1000), with 8 patients diagnosed with CB from 1900 the first trimester pregnant women. Of 8 pregnant women, 5 showed live birth (62.5) and 3 experienced fetal demise (37.5). The chorionic bumps ranged in size from 0.1 cc to 1.8 cc (average, 0.73 cc). No significant relationship was found between history of smoking, coagulopathy, infertility, multiple gestation and the size of CB. Conclusions The main finding was that the frequency of live birth in our sample was 62.5 (5 from 8). The clinical inference is that a chorionic bump on first-trimester sonography does not definitely guarantee a secure prediction. The correlation between bump size and pregnancy outcome is not clear, which warrants further research. © 201

Vremenske i prostorne varijacije salaniteta podzemnih voda u ravnici Mazandaran, Iran, tijekom dugogodišnjeg razdoblja od 26 godina

Groundwater resources are one of the main sources of water supply for agricultural sector in Iran. Therefore, this study aimed to investigate the situation of groundwater salinity in Mazandaran for use in agriculture. In this study, statistical analysis of collected data, proper semivariogram model selection, cross validation of predictions and preparing probabilistic and zoning maps using geostatistical tools in the ArcGIS software, were performed. To investigate the spatial variations and preparing zoning maps of water salinity, ordinary kriging (OK) was used and the zoning maps were prepared. Spatial structure of electrical conductivity (EC) assessment showed a moderate spatial dependence in most years. Zoning and probabilistic maps of EC showed that the salinity of groundwater will be added and the most probable salinity is related the lowland areas in the eastern part of the plain. The use of this groundwater for irrigation in the long term can decrease the rice yield and faced rice production with a serious risk. The results of the Mann-Kendall and the Sen tests indicated a decreasing trend in the area of groundwater with EC higher than one dS/m in Mazandaran plain that this expressing an improvement in the quality of groundwater in the plain.Resursi podzemnih voda jedan su od glavnih izvora vodoopskrbe poljoprivrednog sektora u Iranu. Stoga je ova studija usmjerena na istraživanje stanja saliniteta podzemnih voda u Mazandaranu koje se koriste u poljoprivredi. U ovoj studiji provedena je: statistička analiza prikupljenih podataka, odabir pravilnog modela semivariograma, unakrsno potvrđivanje predviđanja i pripremanje probabilističkih i zoniranje karata koristeći geostatističke alate u ArcGIS softveru. Da bi se istražile prostorne varijacije i pripremile karte slanosti vode korišteno je obično krigiranje (OK) i pripremljene su karte zoniranja. Prostorna struktura procjene električne provodljivosti (EC) pokazala je umjerenu prostornu ovisnost u većini godina. Zoniranje i probabilističke karte električne vodljivosti pokazale su da će se dodati slanost podzemnih voda, a najvjerojatnija slanost povezana je s nizinskim područjima u istočnom dijelu ravnice. Korištenje takvih podzemnih voda za navodnjavanje dugoročno može smanjiti prinos riže i proizvodnju s rižom s ozbiljnim rizikom. Rezultati ispitivanja pomoću Mann-Kendall-ovog i Senovog testa ukazali su na trend pada podzemnih voda s električnom vodljivošću 1 dS/m, što upućuje na poboljšanje kvalitete podzemnih voda u ravnici Mazandaran

Effects of Caspian Sea water level fluctuations on existing drains

This study is an attempt to develop an integrated methodology to predict the impact of the Caspian Sea on flooding using Geographic Information Systems (GIS) and hydrodynamic modeling. A rise in the sea level might lead to major flooding events, and have a severe impact on the spatial development of cities and regions. The feasibility of simulating a flood event along a drain channel is evaluated near residential development areas along the Chapakroud drain. The results of the study show that about 2 km of the drain embankments would be influenced by changes in sea water levels. For elevations of -23 m and -24 m, the maximum depths of water in the drain are 3.95 m and 2.94 m. The tail of the backwater reaches 3465 m and 2390 m, respectively, leading to flooded areas of 35.97 ha and 12.88 ha. The study shows that at these elevations environmental and social problems arise with regards to the drain. The results also indicate that GIS is an effective tool for floodplain visualization and analysis. It should be noted that the mixture of salt and soft water, as a result of rising sea water level, is a problem that was not investigated in this study and should be examined in the future

Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue

Exposure to ionizing radiation can cause rapid mineral loss and increase bone-resorbing osteoclasts within metabolically-active, cancellous-bone tissue leading to structural deficits. To better understand mechanisms involved in rapid, radiation-induced bone loss, we determined the influence of total-body irradiation on expression of select cytokines known both to stimulate osteoclastogenesis and contribute to inflammatory bone disease. Adult (16wk), male C57BL/6J mice were exposed to either 2Gy gamma rays (137Cs, 0.8Gy/min) or heavy ions (56Fe, 600MeV, 0.50-1.1Gy/min); this dose corresponds to either a single fraction of radiotherapy (typical total dose is 10Gy) or accumulates over long-duration, interplanetary missions. Serum, marrow, and mineralized tissue were harvested 4hrs-7d later. Gamma irradiation caused a prompt (2.6-fold within 4hrs) and persistent (peaking at 4.1-fold within 1d) rise in the expression of the obligate osteoclastogenic cytokine, receptor activator of nuclear factor kappaB-ligand (Rankl) within marrow cells over controls. Similarly, Rankl expression peaked in marrow cells within 3d of iron exposure (9.2-fold). Changes in Rankl expression induced by gamma irradiation preceded and overlapped with a rise in expression of other pro-osteoclastic cytokines in marrow (e.g., monocyte chemotactic protein-1 increased 11.9-fold, tumor necrosis factor-alpha increased 1.7- fold over controls). Marrow expression of the RANKL decoy receptor, osteoprotegerin (Opg), also rose after irradiation (11.3-fold). The ratio Rankl/Opg in marrow was increased 1.8-fold, a net pro-resorption balance. As expected, radiation increased a serum marker of resorption (tartrate resistant acid phosphatase) and led to cancellous bone loss (16% decrease in bone volume/total volume) through reduced trabecular struts. We conclude that total-body irradiation (gamma or heavy-ion) caused temporal, concerted regulation of gene expression within marrow and mineralized tissue for select cytokines which are responsible for osteoclastogenesis and elevated resorption; this is likely to account for rapid and progressive 52 deterioration of cancellous microarchitecture following exposure to ionizing radiation

Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice

UnlabelledDiabetic obesity is associated with increased fracture risk in adults and adolescents. We find in both adolescent and adult mice dramatically inferior mechanical properties and structural quality of cortical bone, in agreement with the human fracture data, although some aspects of the response to obesity appear to differ by age.IntroductionThe association of obesity with bone is complex and varies with age. Diabetic obese adolescents and adult humans have increased fracture risk. Prior studies have shown reduced mechanical properties as a result of high-fat diet (HFD) but do not fully address size-independent mechanical properties or structural quality, which are important to understand material behavior.MethodsCortical bone from femurs and tibiae from two age groups of C57BL/6 mice fed either HFD or low-fat diet (LFD) were evaluated for structural and bone turnover changes (SEM and histomorphometry) and tested for bending strength, bending stiffness, and fracture toughness. Leptin, IGF-I, and non-enzymatic glycation measurements were also collected.ResultsIn both young and adult mice fed on HFD, femoral strength, stiffness, and toughness are all dramatically lower than controls. Inferior lamellar and osteocyte alignment also point to reduced structural quality in both age groups. Bone size was largely unaffected by HFD, although there was a shift from increasing bone size in obese adolescents to decreasing in adults. IGF-I levels were lower in young obese mice only.ConclusionsWhile the response to obesity of murine cortical bone mass, bone formation, and hormonal changes appear to differ by age, the bone mechanical properties for young and adult groups are similar. In agreement with human fracture trends, adult mice may be similarly susceptible to bone fracture to the young group, although cortical bone in the two age groups responds to diabetic obesity differently

Improving water resources management using different irrigation strategies and water qualities: Field and modelling study

The aim of this study was to investigate the effects of two different irrigation strategies, regulated deficit irrigation, RDI and partial root drying, PRD using surface freshwater (SW) and brackish treated wastewater (TWW) for maize and potato crops. The SALTMED model has been applied using the field measurements of two cropping seasons 2013 and 2014 at the Canale Emiliano Romagnolo, CER’s experimental farm located in Mezzolara di Budrio (Bologna, Italy). In 2013, PRD irrigated potato received 17% less irrigation water than RDI but produced nearly the same yield as under RDI. The water productivity, o naverage, was 11% higher for PRD compared with RDI. For maize 2014 season, the PRD strategy received almost 15% less irrigation water, but produced a yield only 6% lower than that of RDI and gave equal water productivity to RDI. Given that the two strategies received the same amount of rainfall the results favour the PRD over RDI. Had the site not received above average rainfall (258 mm in 2013 and 259 mm during the 2014 growing seasons), PRD might have produced higher yield and water productivity than RDI. In terms of model simulations, overall, the model showed a strong relationship between the observed and the simulated soil moisture and salinity profiles, total dry mater and final yields. This illustrates SALTMED model’s ability to simulate the dry matter and yield of C3 and C4 crops as well as to simulated different water qualities and different water application strategies. Therefore, the model can run with “what if” scenarios depicting several water qualities, crops and irrigation systems and strategies without the need to try them all in the field. This will reduce costs of labour and investment

Alternate partial root-zone irrigation reduces bundle-sheath cell leakage to CO2 and enhances photosynthetic capacity in maize leaves

The physiological basis for the advantage of alternate partial root-zone irrigation (PRI) over common deficit irrigation (DI) in improving crop water use efficiency (WUE) remains largely elusive. Here leaf gas exchange characteristics and photosynthetic CO2–response and light–response curves for maize (Zea mays L.) leaves exposed to PRI and DI were analysed under three N-fertilization rates, namely 75, 150, and 300 mg N kg−1 soil. Measurements of net photosynthetic rate (An) and stomatal conductance (gs) showed that, across the three N-fertilization rates, the intrinsic WUE was significantly higher in PRI than in DI leaves. Analysis of the CO2–response curve revealed that both carboxylation efficiency (CE) and the CO2-saturated photosynthetic rate (Asat) were significantly higher in PRI than in DI leaves across the three N-fertilization rates; whereas the N-fertilization rates did not influence the shape of the curves. The enhanced CE and Asat in the PRI leaves was accompanied by significant decreases in carbon isotope discrimination (Δ13C) and bundle-sheath cell leakiness to CO2 (Φ). Analysis of the light–response curve indicated that, across the three N-fertilization rates, the quantum yield (α) and light-saturated gross photosynthetic rate (Amax) were identical for the two irrigation treatments; whilst the convexity (κ) of the curve was significantly greater in PRI than in DI leaves, which coincided with the greater CE and Asat derived from the CO2–response curve at a photosynthetic photon flux density of 1500 μmol m−2 s−1. Collectively, the results suggest that, in comparison with the DI treatment, PRI improves photosynthetic capacity parameters CE, Asat, and κ of maize leaves and that contributes to the greater intrinsic WUE in those plants

Derivation of irrigation requirements for radiological impact assessments

When assessing the radiological impacts of radioactive waste disposal, irrigation using groundwater contaminated with releases from the disposal system is a principal means of crop and soil contamination. In spite of their importance for radiological impact assessments, irrigation data are scarce and often associated with considerable uncertainty for several reasons including limited obligation to measure groundwater abstraction and differences in measuring methodologies. Further uncertainty arises from environmental (e.g. climate and landscape) change likely to occur during the assessment long time frame. In this paper, we derive irrigation data using the crop growth AquaCrop model relevant to a range of climates, soils and crops for use in radiological impact assessments. The AquaCrop estimates were compared with actual irrigation data reported in the literature and with estimates obtained from simple empirical methods proposed for use in radiological impact assessments. Further, the AquaCrop irrigation data were analysed using mixed effects modelling to investigate the effects of climate, soil and crop type on the irrigation requirement. Irrigation estimates from all models were within a reasonable range of the measured values. The AquaCrop estimates, however, were at the higher end of the range and higher than those from the empirical methods. Nevertheless, they may be more appropriate for conservative radiological assessments. The use of mixed effects modelling allowed for the characterisation of crop-specific variability in the irrigation data, and in contrast to the empirical methods, the AquaCrop and the mixed effects models accounted for the soil effect on the irrigation requirement. The approach presented in this paper is relevant for obtaining irrigation data for a specific site under different climatic conditions as well as for generic dose assessments. To the best of our knowledge, this is one of the most comprehensive analyses of irrigation data in the context of radiological impact assessment currently available

Dried plum diet protects from bone loss caused by ionizing radiation

Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or anti-inflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Thus, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth