Oxidation-induced Cu coating on steel surface

Abstract. Copper is accumulated in recycled steels and is difficult to be removed during steelmaking processes when steel scrap is used as steel sources. Meanwhile, copper characteristics are of importance both to human beings and to animals and plants. In this paper, integrated copper coating was observed on the surface of copper-containing steels when the steels were heated at around 1150℃. However, the copper was separately scattered in and under the surface rust after heating at 1000℃. The forming mechanisms of copper coating are discussed in detail. By choosing a proper descaling reagent, self-generated oxidation-induced copper coating appeared on the steel surface. The method proposed in this work is environmentally friendly for nontoxic chemicals being used. In addition, this provides a new concept for producing protective composite by oxidizing from the substrate directly and there is no bonding problem

Two-stage Supply Chain Model with Uncertain Demand

Based on uncertainty theory, a two-stage supply chain model is presented, where the customers’ demands are characterized as uncertain variables. The objective is to minimize the combined costs incurred in the manufacturing and logistics phases. When these uncertain variables are linear, the objective function and constraints can be converted into crisp equivalents, then can be solved by traditional methods. An example is given to illustrate the model and the converting method

Investigating nonflow contribution subtraction in d-Au collisions with AMPT model

This paper presents research that focuses on nonflow contribution subtraction in heavy-ion collisions, using a multiphase transport model (AMPT). Specifically, the study aims to investigate the behavior of charged particle elliptic flow ($v_{\rm 2}$) in d-Au collisions at a collision energy of $\sqrt{s_{\rm NN}} = 200$ GeV and to determine the impact of nonflow sources, such as jet correlations and resonance decays, in small collision systems. To reduce nonflow effects, the per-trigger yield distribution in peripheral d-Au collisions or pp collisions with the same collision energy is subtracted. Our results show that the nonflow effects in central and mid-central collisions are not strongly dependent on subtracting the per-trigger yield distribution in peripheral d-Au collisions or pp collisions. Furthermore, the elliptic flow of charged particles, after removing nonflow effects through two subtracting methods from this work, exhibits consistency in various collision centrality classes. We also discuss comparisons with measurements from d-Au collisions at $\sqrt{s_{\rm NN}} = 200$ GeV. Overall, this work provides valuable insights and serves as a reference for researchers studying nonflow contribution subtraction in experiments with small collision systems

Using the PALS Architecture to Verify a Distributed Topology Control Protocol for Wireless Multi-Hop Networks in the Presence of Node Failures

The PALS architecture reduces distributed, real-time asynchronous system design to the design of a synchronous system under reasonable requirements. Assuming logical synchrony leads to fewer system behaviors and provides a conceptually simpler paradigm for engineering purposes. One of the current limitations of the framework is that from a set of independent "synchronous machines", one must compose the entire synchronous system by hand, which is tedious and error-prone. We use Maude's meta-level to automatically generate a synchronous composition from user-provided component machines and a description of how the machines communicate with each other. We then use the new capabilities to verify the correctness of a distributed topology control protocol for wireless networks in the presence of nodes that may fail.Comment: In Proceedings RTRTS 2010, arXiv:1009.398

Study of neutron density fluctuation and neutron-proton correlation in Au+Au collisions using PYTHIA8/Angantyr

Utilizing the PYTHIA8 Angantyr model, which incorporates the multiple-parton interactions (MPI) based color reconnection (CR) mechanism, we study the relative neutron density fluctuation and neutron-proton correlation in Au+Au collisions at $\sqrt{s_\text{NN}}$ = 7.7, 11.5, 14.5, 19.6, 27, 39, 62.4, and 200 GeV. In this study, we have not only delved into the dependence of these two remarkable observations on rapidity, centrality, and energy, but also presented an analysis of their interplay with the MPI and CR. Our results have shown that the light nuclei yield ratio of proton, deuteron, and triton, expressed by the elegant expression $N_tN_p/N_d^2$, remains unchanged even as the rapidity coverage and collision centrality increase. Interestingly, we have also revealed that the effect of CR is entirely dependent on the presence of MPI; CR has no impact on the yield ratio if MPI is off. Our findings further demonstrate that the light nuclei yield ratio experiences a slight increase with increasing collision energy as predicted by the PYTHIA8 Angantyr model, but it cannot describe the non-monotonic trend observed by the STAR experiment. Based on the Angantyr model simulation results, it is essential not to overlook the correlation between neutron and proton fluctuations. The Angantyr model is a good baseline for studying collisions in the absence of a Quark-Gluon Plasma (QGP) system, given its lack of flow and jet quenching.Comment: arXiv admin note: text overlap with arXiv:2211.03297 by other author

A review of the design and clinical evaluation of the ShefStim array-based functional electrical stimulation system

Functional electrical stimulation has been shown to be a safe and effective means of correcting foot 12 drop of central neurological origin. Current surface-based devices typically consist of a single channel stimulator, 13 a sensor for determining gait phase and a cuff, within which is housed the anode and cathode. The cuff-mounted 14 electrode design reduces the likelihood of large errors in electrode placement, but the user is still fully responsible 15 for selecting the correct stimulation level each time the system is donned. Researchers have investigated different 16 approaches to automating aspects of setup and/or use, including recent promising work based on iterative learning 17 techniques. This paper reports on the design and clinical evaluation of an electrode array-based FES system for 18 the correction of drop foot, ShefStim. The paper reviews the design process from proof of concept lab-based study, 19 through modelling of the array geometry and interface layer to array search algorithm development. Finally, the 20 paper summarises two clinical studies involving patients with drop foot. The results suggest that the ShefStim 21 system with automated setup produces results which are comparable with clinician setup of conventional systems. 22 Further, the final study demonstrated that patients can use the system without clinical supervision. When used 23 unsupervised, setup time was 14 minutes (9 minutes for automated search plus 5 minutes for donning the 24 equipment), although this figure could be reduced significantly with relatively minor changes to the design

Efficacy of guideline-directed medical treatment in heart failure with mildly reduced ejection fraction.

Heart failure with mildly reduced ejection fraction (HFmrEF) has received increasing attention following the publication of the latest ESC guidelines in 2021. However, it remains unclear whether patients with HFmrEF could benefit from guideline-directed medical treatment (GDMT), referring the combination of ACEI/ARB/ARNI, β-blockers, and MRAs, which are recommended for those with reduced ejection fraction. This study explored the efficacy of GDMT in HFmrEF patients. This was a retrospective cohort study of HFmrEF patients admitted to The First Affiliated Hospital of Dalian Medical University between 1 September 2015 and 30 November 2019. Propensity score matching (1:2) between patients receiving triple-drug therapy (TT) and non-triple therapy (NTT) based on age and sex was performed. The primary outcome was all cause death, cardiac death, rehospitalization from any cause, and rehospitalization due to worsening heart failure. Of the 906 patients enrolled in the matched cohort (TT group, n = 302; NTT group, N = 604), 653 (72.08%) were male, and mean age was 61.1 ± 11.92. Survival analysis suggested that TT group experienced a significantly lower incidence of prespecified primary endpoints than NTT group. Multivariable Cox regression showed that TT group had a lower risk of all-cause mortality (HR 0.656, 95% CI 0.447-0.961, P = 0.030), cardiac death (HR 0.599, 95% CI 0.380-0.946, P = 0.028), any-cause rehospitalization (HR 0.687, 95% CI 0.541-0.872, P = 0.002), and heart failure rehospitalization (HR 0.732, 95% CI 0.565-0.948, P = 0.018). In patients with HFmrEF, combined use of neurohormonal antagonists produces remarkable effects in reducing the occurrence of the primary outcome of rehospitalization and death. Thus, the treatment of HFmrEF should be categorized as HFrEF due to the similar benefit of neurohormonal blocking therapy in HFrEF and HFmrEF. [Abstract copyright: © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

New insights from GWAS for the cleft palate among han Chinese population

Genome wide association studies (GWAS) already have identified tens of susceptible loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, whether these loci associated with nonsyndromic cleft palate only (NSCPO) remains unknown. In this study, we replicated 38 SNPs (Single nucleotide polymorphisms) which has the most significant p values in published GWASs, genotyping by using SNPscan among 144 NSCPO trios from Western Han Chinese. We performed the transmission disequilibrium test (TDT) on individual SNPs and gene-gene (GxG) interaction analyses on the family data; Parent-of-Origin effects were assessed by separately considering transmissions from heterozygous fathers versus heterozygous mothers to affected offspring. Allelic TDT results showed that T allele at rs742071 (PAX7) (p=0.025, ORtransmission=3.00, 95%CI: 1.09-8.25) and G allele at rs2485893 (10kb 3? of SYT14) were associated with NSCPO (p=0.0036, ORtransmission= 0.60, 95%CI: 0.42-0.85). Genotypic TDT based on 3 pseudo controls further confirmed that rs742071 (p-value=0.03, ORtransmission=3.00, 95%CI: 1.09-8.25) and rs2485893 were associated with NSCPO under additive model (p-value= 0.02, ORtransmission= 0.66, 95%CI: 0.47-0.92). Genotypic TDT for epistatic interactions showed that rs4844913 (37kb 3? of DIEXF) interacted with rs11119388 (SYT14) (p-value=1.80E-08) and rs6072081 (53kb 3? of MAFB) interacted with rs6102085 (33kb 3? of MAFB) (p-value=3.60E-04) for NSCPO, suggesting they may act in the same pathway in the etiology of NSCPO. In this study, we found that rs742071 and rs2485893 were associated NSCPO from Han Chinese population; also, interactions of rs4844913:rs11119388 and rs6072081:rs6102085 for NSCPO were identified, gene-gene interactions have been proposed as a potential source of the remaining heritability, these findings provided new insights of the previous GWAS

Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective

Liver disease results from a dynamic pathological process associated with cellular and genetic alterations, which may progress stepwise to liver dysfunction. Commonly, liver disease begins with hepatocyte injury, followed by persistent episodes of cellular regeneration, inflammation, and hepatocyte death that may ultimately lead to nonreversible liver failure. For centuries, herbal remedies have been used for a variety of liver diseases and recent studies have identified the active compounds that may interact with liver disease-associated targets. Further study on the herbal remedies may lead to the formulation of next generation medicines with hepatoprotective, antifibrotic, and anticancer properties. Still, the pharmacological actions of vast majority of herbal remedies remain unknown; thus, extensive preclinical studies are important. In this review, we summarize progress made over the last five years of the most commonly used preclinical models of liver diseases that are used to screen for curative herbal medicines for nonalcoholic fatty liver disease, liver fibrosis/cirrhosis, and liver. We also summarize the proposed mechanisms associated with the observed liver-protective, antifibrotic, and anticancer actions of several promising herbal medicines and discuss the challenges faced in this research field