Selected reliability studies for the NERVA program

An investigation was made into certain methods of reliability analysis that are particularly suitable for complex mechanisms or systems in which there are many interactions. The methods developed were intended to assist in the design of such mechanisms, especially for analysis of failure sensitivity to parameter variations and for estimating reliability where extensive and meaningful life testing is not feasible. The system is modeled by a network of interconnected nodes. Each node is a state or mode of operation, or is an input or output node, and the branches are interactions. The network, with its probabilistic and time-dependent paths is also analyzed for reliability and failure modes by a Monte Carlo, computerized simulation of system performance

Incorporating inventories into supply and demand analysis

While the paper lacks a formal abstract, it draws the important distinction between stocks and flows in supply and demand to better understand the business cycle

Comment on the "Coupling Constant and Quark Loop Expansion for Corrections to the Valence Appeoximation" by Lee and Weingarten

Lee and Weingarten have recently criticized our calculation of quarkonium and glueball scalars as being "incomplete" and "incorrect". Here we explain the relation of our calculations to full QCD.Comment: 5 pages,2 epsfigs. Submitted to the Comment section of Phys. Rev. D 28th April 199

Incorporating inventories into supply and demand analysis

While the paper lacks a formal abstract, it draws the important distinction between stocks and flows in supply and demand to better understand the business cycle.Inventories; supply and demand; business cycles; stocks versus flows

Providing Feedback Following Leadership Walkrounds is Associated with Better Patient Safety Culture, Higher Employee Engagement and Lower Burnout

Background There is a poorly understood relationship between Leadership WalkRounds (WR) and domains such as safety culture, employee engagement, burnout and work-life balance. Methods This cross-sectional survey study evaluated associations between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture, employee engagement, burnout and work-life balance, across 829 work settings. Results 16 797 of 23 853 administered surveys were returned (70.4%). 5497 (32.7% of total) reported that they had participated in WR, and 4074 (24.3%) reported that they participated in WR with feedback. Work settings reporting more WR with feedback had substantially higher safety culture domain scores (first vs fourth quartile Cohen’s d range: 0.34–0.84; % increase range: 15–27) and significantly higher engagement scores for four of its six domains (first vs fourth quartile Cohen’s d range: 0.02–0.76; % increase range: 0.48–0.70). Conclusion This WR study of patient safety and organisational outcomes tested relationships with a comprehensive set of safety culture and engagement metrics in the largest sample of hospitals and respondents to date. Beyond measuring simply whether WRs occur, we examine WR with feedback, as WR being done well. We suggest that when WRs are conducted, acted on, and the results are fed back to those involved, the work setting is a better place to deliver and receive care as assessed across a broad range of metrics, including teamwork, safety, leadership, growth opportunities, participation in decision-making and the emotional exhaustion component of burnout. Whether WR with feedback is a manifestation of better norms, or a cause of these norms, is unknown, but the link is demonstrably potent

Glueball calculations in large-N_c gauge theory

We use the light-front Hamiltonian of transverse lattice gauge theory to compute from first principles the glueball spectrum and light-front wavefunctions in the leading order of the 1/N_c colour expansion. We find 0^{++}, 2^{++}, and 1^{+-} glueballs having masses consistent with N_c=3 data available from Euclidean lattice path integral methods. The wavefunctions exhibit a light-front constituent gluon structure.Comment: 4 pages, 2 figures, uses macro boxedeps.tex, minor corrections in revised versio

Quaternary faulting in the New Madrid seismic zone in southernmost Illinois

U.S. Geological Survey, Department of the Interior, under USGS award number 1434-95-G-2525Ope

Graphical Reasoning in Compact Closed Categories for Quantum Computation

Compact closed categories provide a foundational formalism for a variety of important domains, including quantum computation. These categories have a natural visualisation as a form of graphs. We present a formalism for equational reasoning about such graphs and develop this into a generic proof system with a fixed logical kernel for equational reasoning about compact closed categories. Automating this reasoning process is motivated by the slow and error prone nature of manual graph manipulation. A salient feature of our system is that it provides a formal and declarative account of derived results that can include `ellipses'-style notation. We illustrate the framework by instantiating it for a graphical language of quantum computation and show how this can be used to perform symbolic computation.Comment: 21 pages, 9 figures. This is the journal version of the paper published at AIS

Improved Tumor Contrast Achieved by Single Time Point Dual-Reporter Fluorescence Imaging

In this study, we demonstrate a method to quantify biomarker expression that uses an exogenous dual-reporter imaging approach to improve tumor signal detection. The uptake of two fluorophores, one nonspecific and one targeted to the epidermal growth factor receptor (EGFR), were imaged at 1 h in three types of xenograft tumors spanning a range of EGFR expression levels (n  =  6 in each group). Using this dual-reporter imaging methodology, tumor contrast-to-noise ratio was amplified by \u3e6 times at 1 h postinjection and \u3e2 times at 24 h. Furthermore, by as early as 20 min postinjection, the dual-reporter imaging signal in the tumor correlated significantly with a validated marker of receptor density (P  \u3c  0.05, r  =  0.93). Dual-reporter imaging can improve sensitivity and specificity over conventional fluorescence imaging in applications such as fluorescence-guided surgery and directly approximates the receptor status of the tumor, a measure that could be used to inform choices of biological therapies

Mixing of scalar glueballs and flavour-singlet scalar mesons

We discuss in detail the extraction of hadronic mixing strengths from lattice studies. We apply this to the mixing of a scalar glueball and a scalar meson in the quenched approximation. We also measure correlations appropriate for flavour-singlet scalar mesons using dynamical quark configurations from UKQCD. This enables us to compare the results from the quenched study of the mixing with the direct determination of the mixed spectrum. Improved methods of evaluating the disconnected quark diagrams are also presented.Comment: 23 pages, 5 postscript figure