Mısır Koçan Kurdu, Sesamia nonagrioides Lefebvre (Lepidoptera: Noctuidae)’in Farklı Gelişme Evrelerinde Toplam Protein, Karbohidrat ve Lipit Miktarı Üzerine Araştırma

Tarım zararlılarına karşı aşırı kimyasal kullanımına alternatif olarak biyolojik mücadele yöntemleri oldukça önemlidir. Alternatif yöntemlerin denenmesinde ve geliştirilmesinde zararlı böceklerin birçok özelliklerinin bilinmesi, laboratuvarda kitle üretimi yapmayı kolaylaştırması mümkündür. Bu çalışmada S. nonagrioides’in farklı evrelerinde protein, karbohidrat ve lipit miktarlarının değişimleri incelenmiştir. Protein, karbohidrat ve lipit içerikleri pupa evresinde azalırken, erginlerde özellikle erkek bireylerde artış gösterdiği belirlenmiştir. Elde edilen bu değerlerin S. nonagrioides’in laboratuvar şartlarında kitle üretiminin yapılmasına katkı sağlayarak, alternatif yöntemlerin geliştirilmesine katkı sağlayacağı kanısındayız

Effect of Turkish pollen and propolis extracts on caspase-3 activity in myeloid cancer cell lines

Purpose: To investigate the apoptosis-inducing capacity of dimethyl sulfoxide (DMSO) extracts of bee pollen and propolis in HL-60 Myeloid Cancer Cell Lines.Methods: DMSO extracts of pollen and propolis were incubated separately with HL-60 cells, and caspase-3 activity evaluated. In order to determine the cell cycle characteristics of HL-60 cells with and without extracts of pollen and propolis, the cells were analysed using flow cytometry.Results: The DMSO extract of propolis (0.5 mg/mL) increased apoptosis from undetectable levels to 60.1 %, while maintaining cell viability. The DMSO extract of pollen (2 mg/ml) increased apoptosis from undetectable levels to 52.2 % while decreasing cell viability by 62 %. Caspase-3 activity in HL-60 cells incubated with DMSO extracts of pollen and propolis were 3.6- to 12-fold higher than in controls.Conclusion: Turkish pollen and propolis individually increase apoptosis and the activity of caspase-3 in HL-60 cells. This finding indicates that bee products may have beneficial effects in the treatment of cancer.Keywords: Pollen, Propolis, Apoptosis, Caspase-3, Myeloid Cance

Prognostic impact of BCL2, BCL6 and MYC status in de novo diffuse large B-cell lymphoma: a regional study of 43 patients

Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma with marked biologic heterogeneity. We aimed to evaluate the status of MYC, BCL2, BCL6 in patients with DLBCL.Methods: Herein, we have investigated the prognostic relevance of MYC, BCL2 and BCL6 from 43 de novo DLBCL patients.Results: In this study, protein overexpression of BCL2 and BCL6 was encountered in 46.5% (n=20) and 27.9% (n=12) of the tumors, respectively.  Rearrangements in MYC, BCL6, and BCL2 were detected in 9.3% (n=4), 25.6% (n=11), and 4.7% (n=2) of the cases, respectively. Any statistically significant difference could not be found between Bcl-2, Bcl-6 expression, C-MYC rearrangement and the survival.Conclusions: We concluded that C-MYC and BCL2 may contribute to aggressive transformation, so more mechanism-based therapy should be explored. A larger study is warranted to better understand the immunophenotypic and molecular features of DLBCL and their respective impact on patient survival

Intraocular pressure assessment in pediatric cases receiving long-term seasonal allergic conjunctivitis treatment

Amaç: Mevsimsel alerjik konjonktivit (MAK) tanısı ile takip ve tedavi edilen pediatrik yaş grubu hastalarda, dönemsel olarak kullanılan ilaçların uzun dönemde göz içi basıncı (GİB) üzerine olan etkisini araştırmak. Gereç ve Yöntemler: Çalışmaya 16 yaş altında, 5 yıl veya daha fazla süredir MAK tedavisi alan 230 olgu (Grup I) ve kontrol grubuna 16 yaş altında sağlıklı 255 olgu (Grup II) dahil edildi. Hastaların GİB ölçümleri non-kontakt tonometri ile yapıldı. Her iki grubun ortalama GİB değerleri istatistiksel olarak kıyaslandı. Bulgular: Çalışmaya alınan olguların yaş ortalaması grup I'de 9.3±2.0, grup II'de 9.1±2.1 bulundu. Grup I'de hastaların MAK nedeni ile tedavi aldıkları süre ortalama 5.3±0.7 yıldı. Grup I'de ortalama GİB sağ gözde 13.7±3.1 mmHg, sol gözde 13.7±2.8 mmHg bulunurken, grup II'de ortalama GİB sağ gözde 13.8±3.1 mmHg, sol gözde 13.9±3.0 mmHg olarak bulundu. İki grubun ortalama GİB değerleri arasında istatistiksel olarak anlamlı fark olmadığı görüldü (P>0.05). Grup I'de 11 hastada (% 4.8) tedavi esnasında kortikosteroid kullanımına bağlı geçici GİB yükselmesi olduğu gözlendi. Bu hastaların tümünde kortikosteroid kesildikten sonra GİB normale döndü. Sonuç: Pediatrik olgularda MAK tanısıyla dönemsel olarak verilen medikal tedavinin uzun dönemde GİB üzerine kalıcı bir etkisinin olmadığı görüldü. Bu hastalarda olası akut GİB yükselmesini fark etmek için yakın takibin önemli olduğunu düşünmekteyiz.Objective: To investigate the effect of seasonal drugs on intraocular pressure (IOP) in the long term in pediatric age group who are followed up and treated with seasonal allergic conjunctivitis (SAC) diagnosis. Materials and Methods: The study included 230 cases under the age of 16 who received SAC treatment for 5 years or more (Group I), and 255 healthy cases under the age of 16 in the control group (Group II). IOP measurements of the patients were made with non-contact tonometry. Mean IOP values of both groups were statistically compared. Results: The mean age of the patients included in the study was 9.3±2.0 in group I and 9.1±2.1 in group II. The mean duration of treatment in SAC patients was 5.3±0.7 years. In group I, the mean IOP was 13.7±3.1 mmHg in the right eye, 13.7±2.8 mmHg in the left eye, while in group II the mean IOP was 13.8±3.1 mmHg in the right eye and 13.9±3.0 mmHg in the left eye. There was no statistically significant difference between the mean IOP values of two groups (P>0.05). Temporary IOP elevation due to corticosteroid treatment was observed in 11 patients (4.8%) in group I. In all these patients, IOP lowered to normal limits after corticosteroid treatment discontinued. Conclusion: It was observed that medical treatment, which is given periodically with the diagnosis of SAC in pediatric cases, does not have a permanent effect on IOP in the long term. We think that close follow-up is important to realize possible acute IOP elevation in these patients

Examination of perception dimension of engineering technology and ergonomics principles in terms of healthcare personnel: a scale development study

In general terms, ergonomics is the conformity of human and equipment. Unconformity between human and equipment is more likely to give harm either to the equipment or to human. This conformity may go for both daily domestic tasks and work life. Domestic furniture and equipment are designed by taking average features of individuals into consideration. For example; chairs, tables, beds and similar things are manufactured with the measurements which are accepted as standard all over the world. People spend most of their time at their homes and workplaces. Similarly, the ergonomics considered in the manufacture of domestic furniture takes an important place in working life, as well. This is highly significant in terms of both health of workers and efficiency of the work done. On the other hand, ergonomics possesses importance in terms of patients except from workers and work efficiency in health sector. Working in non-ergonomic settings may both endanger health of healthcare personnel and cause decrease in work efficiency as well as posing negative effects for recovery of the patients. From this point of view, ergonomics in health sector becomes more important in many aspects. In this study, it was aimed to develop a scale with regard to finding out perceptions of the healthcare personnel on engineering technologies and ergonomics principles

The association of anti-CCP antibodies with disease activity in rheumatoid arthritis

Antibodies to citrullinated proteins have been described in patients with rheumatoid arthritis (RA) and these appear to be the most specific markers of the disease. Our objective was to determine the frequency of antibodies to cyclic citrullinated peptides (CCPs) in patients with RA and the association of anti-CCP antibodies with disease activity, radiological erosions and HLA DR genotype. Forty patients with RA and 38 patients with fibromyalgia were included in this study. Serum samples were collected from both patient groups with RA and fibromyalgia. Anti-CCP was measured by the corresponding enzyme-linked immunosorbent assay. Additionally, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), disease activity score (DAS), visual analog scala (VAS), HLA genotype and radiographic information were determined in patients with RA. The rate of sensitivity and specificity of anti-CCP reactivity for the diagnosis RA were measured (sensitivity 50%, specificity100%). There is no significant difference between anti-CCP (+) and anti-CCP (−) RA patients for DAS28, VAS, ESR, CRP, disease duration, HLA genotype, and radiological assessment of hand. However, there was a significant difference between anti-CCP (+) and anti-CCP (−) RA patients for RF and the radiological assessment of left and right wrists (respectively, P < 0.05, P = 0.04, P = 0.01). There was no significant correlation between anti-CCP antibody and ESR, CRP, VAS, DAS 28 or radiological assessment. A small but significant correlation was found between RF and anti-CCP antibody (P = 0.02, r = 0.35)

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Determination of The Public Green Space Usage Habits of Elementary Age Children: Sample of Çanakkale

Yoğun ve hızlı tempolu kent yaşamı çocukların doğal çevreler ile bağlantılarının kopmasına neden olmakta ve yetişkinler gibi onlar da daha çok iç mekânlarda zaman geçirmeye yönelik pasif hayat tarzlarını gittikçe daha çok benimsemektedirler. Oysaki dış mekânda açık-yeşil alanlarda zaman geçirmenin ve aktivitelere katılmanın fiziksel ve ruhsal gelişim üzerine birçok olumlu etkisi bulunmaktadır. Bu nedenle araştırmada ilköğretim çağındaki 6-12 yaş grubu çocukların açık-yeşil alan kullanım alışkanlıklarının belirlenmesi hedeflenmiştir. Çalışma kapsamında Çanakkale kent merkezinde bulunan ilköğretim okullarında anket çalışmaları yapılarak, çocukların ve ebeveynlerinin açık-yeşil alanları kullanım alışkanlıkları saptanmıştır. Çalışmanın sonucunda çocukların serbest zamanlarında iç mekânda gerçekleştirilen aktivitelere daha çok katıldıkları ve dış mekanda ise kamusal açık-yeşil alanlar yerine yaşadıkları konutların bahçelerini kullandıkları belirlenmiştir. Ebeveynlerin güvenlik kaygılarının çocukların açık-yeşil alan kullanımları üzerine etkileri olduğu saptanmıştır. Çocukların cinsiyet ya da yaşadıkları konut tipinin açık-yeşil alan kullanım desenleri üzerine bir etkisi bulunmadığı belirlenmiştir. Ayrıca hem çocuklar, hem de ebeveynler mevcut açık- yeşil alanlarındaki oyun elemanlarının ve olanaklarının çeşitliliğini yetersiz olarak değerlendirmişlerdir. Sonuç olarak, çocukların açık-yeşil alan kullanımlarını arttırmak için farklı yaş gruplarına hitap edecek çeşitlilikte ve kent bütününde oyun alanlarının tasarlanmasına ve açık-yeşil alan kullanımının çocukların yetiştirilmesi ve eğitilmesindeki ilgili paydaşlar tarafından teşvik edilmesine gerek duyulmaktadır.Intense and fast-paced city life with the natural surrounds of children and adults, such as disconnections causing them to spend more time indoors increasingly inactive lifestyles are adopted. However, spending time in outer space and open green space to participate in activities on the physical and mental development has many positive effects. In this study of primary school age children in the 6-12 age group, open - green space is to determine usage patterns Working under the Dardanelles, surveys made in the central district, open - green space for children and their parents has been identified patterns of use. As a result of the study carried out indoors in children's free time activities and when they go out more if they attend public open green spaces instead of - use is determined that the garden of the house they live. Security concerns of parents of children on the use of open - green space effects are thought to be. Children's gender or the type of housing they live open - green space that have an impact on patterns of usage is determined. In addition, both children and parents at the game elements in the current open - green space and the variety of facilities were evaluated as unsatisfactory. As a result, children's open - green space utilization to increase the different age groups that will cater to diversity and the city as a whole play area for the design of open green space utilization of the children's upbringing and training mAsIndAki by relevant stakeholders to promote is needed

Golden eyed lacewings, general characteristics and the importance in biological control (Neuroptera: Chrysopidae)

Chrysopidae’ler, Neuroptera takımının ikinci büyük familyası olmakla birlikte, ekonomik olarak da en önemli familyası durumundadır. Bu familyanın larvaları ve bir kısım erginleri predatör olup, afit, koşnil, yaprak zararlısı, beyaz sinek, psillit, trips ve diğer yumuşak vücutlu böcekleri avlayarak beslenirler. Bu nedenle bazı türleri çeşitli tarım alanlarında pestisitlerle mücadelede biyolojik mücadele ajanı olarak başarıyla kullanılmaktadırlar. Familya içerisindeki yeşil dantela kanatlılar, Kuzey Amerika ve Avrupa’da Chrysoperla carnea (Stephens) genusu ve Chrysopa Leach 1815 genusuna ait bazı türler biyolojik mücadele proğramlarında yoğunluklu olarak kullanılmaktadır. Bu çalışmanın amacı Chrysopidae familyası hakkındaki bilgilerin derlenmesidirThe Chrysopidae is one of the secondlargest and economically most important families of the Neuroptera. The larvae and a few of adult of this family are predaceous and feed with hunting on aphids, coccids, leafhoppers, whiteflies, psyllids (Homoptera), thrips (Thysanoptera), and other soft-bodied insects. For this reason some species successfully used forthe biological control of agricultural pests. Among all the green lacewing species in family, some species of Chrysopa Leach 1815 and Chrysoperla carnea genera are the most commonly used in biological control programs in North America and Europe. The aim of this study was to review on Chrysopidae family