Terrestrialization in the Ordovician

This contribution reviews the evidence for terrestrial organisms during the Ordovician (microbial, land plant, fungal, animal) and for the nature of the terrestrial biota. The evidence regarding the origin and early diversification of land plants combines information from both fossils and living organisms. Extant plants can be utilized in: (1) phylogenetic analyses to provide evidence for the nature of the algal–land plant transition and the characteristics of the most basal land plants; (2) evolutionary developmental biology studies of the characters that enabled the invasion of the land; (3) molecular clock analysis to provide evidence regarding timing of the origin and diversification of land plants. We conclude that the Ordovician was a critical period during the terrestrialization of planet Earth that witnessed the transition from a microbial terrestrial biota to one dominated by a vegetation of the most basal land plants

Cryptospores from the Katian (Upper Ordovician) of the Tungus basin: The first evidence for early land plants from the Siberian paleocontinent

© 2015 Elsevier B.V.A diverse assemblage of cryptospores is reported for the first time from the Upper Ordovician of Siberia. It was discovered during a palynological study of a sedimentary succession of about 100 m, exposed along the Bolshaya Nirunda River, a right tributary of the Podkamennaya Tunguska River. The succession is located on the southern margin of the extensive epicontinental Tungus basin on the Siberian Platform between the Katanga and Yenisei land masses. The cryptospore assemblage was recovered from the siliciclastic-carbonate Dolbor Formation and scarcely from the overlying more carbonate Bur Formation. Both formations belong to the Katian Global Stage (Upper Ordovician). The cryptospores occur together with marine remnants (acritarchs, prasinophytes, chitinozoans, scolecodonts). It is similar to all known Upper Ordovician cryptospore assemblages in comprising naked and envelope-enclosed monads, dyads, tetrads and polyads. Although preservation is moderate to poor, the cryptospore taxa Velatitetras laevigata, Tetrahedraletes medinensis, Abditusdyadus laevigatus, Dyadospora murusdensa, Pseudodyadospora laevigata, Segestrespora laevigata and Sphaerasaccus glabellus can be identified. This report represents the first record of spores of the earliest land plants from the paleocontinent Siberia and therefore extends the global paleogeographical coverage of Late Ordovician cryptospores

The Ordovician System: From overlapping unit stratotypes to Global Boundary Stratotype Sections and Points

For nearly a century the Ordovician System was hidden as Murchison and Sedgwick tussled over the overlapping ground between their Silurian and Cambrian systems. The Ordovician is, in fact, one of the longest of the geological periods, characterised by major magmatic and plate tectonic activity; the roles of microcontinents and volcanic archipelagos were significant in shaping the Ordovician planet and the evolution of its biotas, associated with an immense biodiversification, significant fluctuations in climate and sea levels, and the first Phanerozoic mass extinction of marine invertebrates. The period was unique in being thalassocratic; epicontinental seas had a wider reach than during any other geological period. The land areas were restricted to isolated microblocks of archipelagos of various sizes with low relief, with rivers traversing gentle gradients, carrying sparse terrigenous material seaward. It is an ancient world with few parallels elsewhere in the Phanerozoic, and little in common with Holocene ecosystems and environments. The Ordovician System was introduced by Charles Lapworth as a solution to the stratotypes of overlapping units loosely defined by Adam Sedgwick for the Cambrian and by Roderick Murchison for the Silurian. Following a period of intensive research into all the key regions of the globe, unit stratotypes in the type areas of England and Wales have been replaced by seven global stages and three series based on Global Boundary Stratotype Sections and Points, enhancing the definition of these chronostratigraphic units and facilitating global correlation. As a consequence, the biological and geological events during the period can be recognised, and the magnitude and significance of originations and extinctions understood. A global synthesis of successions in Europe (Geological Society, London, Special Publications, 532) and the rest of the world (Geological Society, London, Special Publications, 533) has emphasised the importance of a universal language for Ordovician chronostratigraphy and its dividends

Metal-induced malformations in early Palaeozoic plankton are harbingers of mass extinction

Glacial episodes have been linked to Ordovician–Silurian extinction events, but cooling itself may not be solely responsible for these extinctions. Teratological (malformed) assemblages of fossil plankton that correlate precisely with the extinction events can help identify alternate drivers of extinction. Here we show that metal poisoning may have caused these aberrant morphologies during a late Silurian (Pridoli) event. Malformations coincide with a dramatic increase of metals (Fe, Mo, Pb, Mn and As) in the fossils and their host rocks. Metallic toxins are known to cause a teratological response in modern organisms, which is now routinely used as a proxy to assess oceanic metal contamination. Similarly, our study identifies metal-induced teratology as a deep-time, palaeobiological monitor of palaeo-ocean chemistry. The redox-sensitive character of enriched metals supports emerging ‘oceanic anoxic event’ models. Our data suggest that spreading anoxia and redox cycling of harmful metals was a contributing kill mechanism during these devastating Ordovician–Silurian palaeobiological events

Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy

Background: Duchenne muscular dystrophy (DMD) is a lethal muscle disease detected in approximately 1:5000 male births. DMD is caused by mutations in the DMD gene, encoding a critical protein that links the cytoskeleton and the extracellular matrix in skeletal and cardiac muscles. The primary consequence of the disrupted link between the extracellular matrix and the myofibre actin cytoskeleton is thought to involve sarcolemma destabilization, perturbation of Ca homeostasis, activation of proteases, mitochondrial damage, and tissue degeneration. A recently emphasized secondary aspect of the dystrophic process is a progressive metabolic change of the dystrophic tissue; however, the mechanism and nature of the metabolic dysregulation are yet poorly understood. In this study, we characterized a molecular mechanism of metabolic perturbation in DMD. Methods: We sequenced plasma miRNA in a DMD cohort, comprising 54 DMD patients treated or not by glucocorticoid, compared with 27 healthy controls, in three groups of the ages of 4–8, 8–12, and 12–20 years. We developed an original approach for the biological interpretation of miRNA dysregulation and produced a novel hypothesis concerning metabolic perturbation in DMD. We used the mdx mouse model for DMD for the investigation of this hypothesis. Results: We identified 96 dysregulated miRNAs (adjusted P-value <0.1), of which 74 were up-regulated and 22 were down-regulated in DMD. We confirmed the dysregulation in DMD of Dystro-miRs, Cardio-miRs, and a large number of the DLK1-DIO3 miRNAs. We also identified numerous dysregulated miRNAs yet unreported in DMD. Bioinformatics analysis of both target and host genes for dysregulated miRNAs predicted that lipid metabolism might be a critical metabolic perturbation in DMD. Investigation of skeletal muscles of the mdx mouse uncovered dysregulation of transcription factors of cholesterol and fatty acid metabolism (SREBP-1 and SREBP-2), perturbation of the mevalonate pathway, and the accumulation of cholesterol in the dystrophic muscles. Elevated cholesterol level was also found in muscle biopsies of DMD patients. Treatment of mdx mice with Simvastatin, a cholesterol-reducing agent, normalized these perturbations and partially restored the dystrophic parameters. Conclusions: This investigation supports that cholesterol metabolism and the mevalonate pathway are potential therapeutic targets in DMD. 2

The Ordovician of France and neighbouring areas of Belgium and Germany

The Ordovician successions of France and neighbouring areas of Belgium and Germany are reviewed and correlated based on international chronostratigraphic and regional biostratigraphic charts. The same three megasequences related to the rift, drift and docking of Avalonia with Baltica can be tracked in Belgium and neighbouring areas (Brabant Massif and Ardenne inliers), western (Rhenish Massif) and northeastern Germany (Rügen). The remaining investigated areas were part of Gondwana in the Ordovician. The Armorican Massif shares with the Iberian Peninsula a Furongian–Early Ordovician gap (Toledanian or Norman gap), and a continuous Mid–Late Ordovician shelf sedimentation. The Occitan Domain (Montagne Noire and Mouthoumet massifs), eastern Pyrenees and northwestern Corsica share with southwestern Sardinia continuous shelf sedimentation in the Early Ordovician, and a Mid Ordovician ‘Sardic gap’. In the Ordovician, the Maures Massif probably belonged to the same Sardo-Occitan domain. The Vosges and Schwarzwald massifs display compa-rable, poorly preserved Ordovician successions, suggesting affinities with the Teplá-Barrandian and/or Molda-nubian zones of Central Europe.This paper is a contribution to the International Geoscience Programme (IGCP) projects 653 "The onset of the Great Ordovician Biodiversification Event" and 735 “Rocks and the Rise of Ordovician Life: Filling knowledge gaps in the Early Palaeozoic Biodiversification". The authors are particularly grateful to Annalisa Ferretti, David A.T. Harper and Petr Kraft for their careful and constructive reviews, comments and suggestions, which greatly improved the quality and relevance of the paper