The effect of green kiwifruit on gas transit and tolerance in healthy humans

Altres ajuts: This work has been performed as part of the doctoral thesis in medicine of Dr Caballero at the Autonomous University of Barcelona. Dr Serra has received research funds from Salvat, Zespri, and Bayer and acted as consulter/speaker for AB-biotics, Allergan, Bayer, Norgine, Cassen-Recordati, Zespri, and Reckitt Benkiser. Juliet Ansell is enployed by Zespri. Noemi Caballero and Bouchra Benslaiman have nothing to disclouse.Green kiwifruit is a fiber-rich fruit that has been shown effective for treatment of constipation. However, fermentation of fibers by colonic bacteria may worsen commonly associated gas-related abdominal symptoms. Aim: To determine the effect of green kiwifruit on transit and tolerance to intestinal gas in humans. In 11 healthy individuals, two gas challenge tests were performed (a) after 2 weeks on a low-flatulogenic diet and daily intake of 2 green kiwifruits and (b) after 2 weeks on a similar diet without intake of kiwifruits. The gas challenge test consisted in continuous infusion of a mixture of gases into the jejunum at 12 mL/min for 2 hours while measuring rectal gas evacuation, abdominal symptoms, and abdominal distension. During the 2 weeks prior to each gas challenge test (on-kiwifruit and off-kiwifruit), the number and consistency of stools, and abdominal symptoms were registered. Intake of kiwifruits was associated with more bowel movements per day (1.8 ± 0.1 vs 1.5 ± 0.1 off-kiwifruit; P =.001) and somewhat looser stools (Bristol score 3.3 ± 0.2 vs 2.8 ± 0.1 off-kiwifruit; P =.072) without relevant abdominal symptoms. Gas infusion produced similar gas evacuation (1238 ± 254 mL and 1172 ± 290 mL; P =.4355), perception of symptoms (score 1.2 ± 0.2 and 1.3 ± 0.3; P =.2367), and abdominal distension (17 ± 7 mm and 17 ± 6 mm; P =.4704) while on-kiwifruit or off-kiwifruit. In healthy subjects, green kiwifruit increases stool frequency without relevant effects on intestinal gas transit and tolerance. If confirmed in patients, these fruits may provide a natural and well-tolerated treatment alternative for constipation. In a cross-over, randomized study in healthy subjects, intake of the fibre-rich green kiwifruit increased bowel movements without effects on gas transit and tolerance in response to a gas challenge test. If confirmed in patients, these fruits may provide a natural and well tolerated treatment alternative for constipation

The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees) : Las Bellostas section

Acknowledgement. This paper represents our modest tribute to Pep Serra-Kiel for his inspiring work, his sharp intelligence, his working tenacity, his always fruitful discussions and his camaraderie and friendship. This work was financed by the Sobrarbe County Research fellow-UNESCO Global Geopark (ARP) and by some projects from the Spanish Science National Plan (UKRIA4D- PID2019--I00/CTA, DR3AM. CGL2014 54118-C2-2-R and MAGIBER-II. CGL2017-90632-REDT). We are also very grateful to the laboratories of the universities of Burgos (Juanjo Villalaín) and Zaragoza (Teresa Román and Sylvia Gracia), Sergio Arruej Gil for the field support and Pablo Calvin and Vicky Burriel for the Burgos logistic support. Very warm acknowledged is given to Alejandro and Pablo from "Casa Molinero" in Las Bellostas for their hospitality, friendship and human warmth during all these years. Finally, we sincerely acknowledge the thorough and constructive reviews done by Miguel Garcés, Josep Tosquella and the editor Carles Martín-Closas.Despite the large number of magnetostratigraphic studies in the South Pyrenean Basin aiming to calibrate the basin chronostratigraphy and the biostratigraphic scales, the South Eastern Jaca Basin remains unexplored from this perspective, and its relation with the Ainsa Basin is not fully understood. In this work we contribute with new magnetostratigraphic data from the 950m thick Las Bellostas section, located in the northern hinge of the Balzes anticline. Well-proven primary signal (positive fold test and two pseudo-antiparallel polarities) supported by numerous primary data in the surroundings allow us building a reliable local polarity sequence of eight magnetozones (from R1 to N4). Additionally, seven new biostratigraphic samples (Nummulites and Assilina) in the lower part of the section (marine environment) allows tightening the section to the Geomagnetic Polarity Time Scale (GPTS) and proposing a refined age model for the southeastern Jaca Basin. The section starts in the Boltaña Fm., of Cuisian age (Shallow Benthic Zone, SBZ11), is followed by a sedimentary gap from C22n to C20n as witnessed by biostratigraphic data (SBZ11 underneath the hiatus and SBZ16 just atop). The deltaic Sobrarbe Fm can be tracked until the C19n (Late Lutetian). From this point (200m) until the top of the section (950m), at least, the entire C18n chron can be recognized within the molassic Campodarbe Fm (C18n.2n-C18n.1r and C18n.1n) (Bartonian) equivalent to the West to the prodeltaic Arguis marls Fm. The Middle Cusian (SBZ11) to Middle Lutetian (SBZ15) stratigraphic hiatus is, in part, enhanced by the structural position at the hinge of the Balzes anticline. These new chronostratigraphic constraints help refining the W-E and N-S stratigraphic relationships in the eastern Jaca Basin and in the Ainsa Basin. This section also allows us to accurately refine the kinematics of the rotational activity in the eastern External Sierras. The significant difference in magnetic declination along the section and neighboring paleomagnetic data from the Balzes anticline (from ≈70º clockwise at the base of the stratigraphic section to non-significant at the top) together with the new age model for the Eastern Jaca Basin help characterizing the rotational activity of the Balzes thrust sheet. The rotation took place between chrons C20r (Middle Lutetian; 45Ma) and C17 (Lower Priabonian 37-38Ma) in agreement to nearby structures (Boltaña, Pico del Aguila anticlines) but clearly diachronic to western ones (Santo Domingo anticline). Besides, the rotational activity seems to follow a linear and continuous pattern (velocity 9-11º/Ma, R: 0.83-0.96) in contrast to closer structures that show two distinct rotational velocities (i.e. Boltaña). These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust

The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees): Las Bellostas section

Despite the large number of magnetostratigraphic studies in the South Pyrenean Basin aiming to calibrate the basin chronostratigraphy and the biostratigraphic scales, the South Eastern Jaca Basin remains unexplored from this perspective, and its relation with the Ainsa Basin is not fully understood. In this work we contribute with new magnetostratigraphic data from the 950m thick Las Bellostas section, located in the northern hinge of the Balzes anticline. Well-proven primary signal (positive fold test and two pseudo-antiparallel polarities) supported by numerous primary data in the surroundings allow us building a reliable local polarity sequence of eight magnetozones (from R1 to N4). Additionally, seven new biostratigraphic samples (Nummulites and Assilina) in the lower part of the section (marine environment) allows tightening the section to the Geomagnetic Polarity Time Scale (GPTS) and proposing a refined age model for the southeastern Jaca Basin. The section starts in the Boltaña Fm., of Cuisian age (Shallow Benthic Zone, SBZ11), is followed by a sedimentary gap from C22n to C20n as witnessed by biostratigraphic data (SBZ11 underneath the hiatus and SBZ16 just atop). The deltaic Sobrarbe Fm. can be tracked until the C19n (Late Lutetian). From this point (200m) until the top of the section (950m), at least, the entire C18n chron can be recognized within the molassic Campodarbe Fm. (C18n.2n-C18n.1r and C18n.1n) (Bartonian) equivalent to the West to the prodeltaic Arguis marls Fm. The Middle Cusian (SBZ11) to Middle Lutetian (SBZ15) stratigraphic hiatus is, in part, enhanced by the structural position at the hinge of the Balzes anticline. These new chronostratigraphic constraints help refining the W-E and N-S stratigraphic relationships in the eastern Jaca Basin and in the Ainsa Basin. This section also allows us to accurately refine the kinematics of the rotational activity in the eastern External Sierras. The important difference in magnetic declination along the section and neighboring paleomagnetic data from the Balzes anticline (from ≈70º clockwise at the base of the stratigraphic section to non-significant at the top) together with the new age model for the Eastern Jaca Basin help characterizing the rotational activity of the Balzes thrust sheet. The rotation took place between chrons C20r (Middle Lutetian; 45Ma) and C17 (Lower Priabonian 37-38Ma) in agreement to nearby structures (Boltaña, Picodel Aguila anticlines) but clearly diachronic to western ones (Santo Domingo anticline). Besides, the rotational activity seems to follow a linear and continuous pattern (velocity 9-11º/Ma, R: 0.83-0.96) in contrast to closer structures that show two distinct rotational velocities (i.e. Boltaña). These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust

The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees): Las Bellostas section

Despite the large number of magnetostratigraphic studies in the South Pyrenean Basin aiming to calibrate the basin chronostratigraphy and the biostratigraphic scales, the South Eastern Jaca Basin remains unexplored from this perspective, and its relation with the Ainsa Basin is not fully understood. In this work we contribute with new magnetostratigraphic data from the 950m thick Las Bellostas section, located in the northern hinge of the Balzes anticline. Well-proven primary signal (positive fold test and two pseudo-antiparallel polarities) supported by numerous primary data in the surroundings allow us building a reliable local polarity sequence of eight magnetozones (from R1 to N4). Additionally, seven new biostratigraphic samples (Nummulites and Assilina) in the lower part of the section (marine environment) allows tightening the section to the Geomagnetic Polarity Time Scale (GPTS) and proposing a refined age model for the southeastern Jaca Basin. The section starts in the Boltaña Fm., of Cuisian age (Shallow Benthic Zone, SBZ11), is followed by a sedimentary gap from C22n to C20n as witnessed by biostratigraphic data (SBZ11 underneath the hiatus and SBZ16 just atop). The deltaic Sobrarbe Fm. can be tracked until the C19n (Late Lutetian). From this point (200m) until the top of the section (950m), at least, the entire C18n chron can be recognized within the molassic Campodarbe Fm. (C18n.2n-C18n.1r and C18n.1n) (Bartonian) equivalent to the West to the prodeltaic Arguis marls Fm. The Middle Cusian (SBZ11) to Middle Lutetian (SBZ15) stratigraphic hiatus is, in part, enhanced by the structural position at the hinge of the Balzes anticline. These new chronostratigraphic constraints help refining the W-E and N-S stratigraphic relationships in the eastern Jaca Basin and in the Ainsa Basin. This section also allows us to accurately refine the kinematics of the rotational activity in the eastern External Sierras. The important difference in magnetic declination along the section and neighboring paleomagnetic data from the Balzes anticline (from ≈70º clockwise at the base of the stratigraphic section to non-significant at the top) together with the new age model for the Eastern Jaca Basin help characterizing the rotational activity of the Balzes thrust sheet. The rotation took place between chrons C20r (Middle Lutetian; 45Ma) and C17 (Lower Priabonian 37-38Ma) in agreement to nearby structures (Boltaña, Picodel Aguila anticlines) but clearly diachronic to western ones (Santo Domingo anticline). Besides, the rotational activity seems to follow a linear and continuous pattern (velocity 9-11º/Ma, R: 0.83-0.96) in contrast to closer structures that show two distinct rotational velocities (i.e. Boltaña). These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust

The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees): Las Bellostas section

Despite the large number of magnetostratigraphic studies in the South Pyrenean Basin aiming to calibrate the basin chronostratigraphy and the biostratigraphic scales, the South Eastern Jaca Basin remains unexplored from this perspective, and its relation with the Ainsa Basin is not fully understood. In this work we contribute with new magnetostratigraphic data from the 950m thick Las Bellostas section, located in the northern hinge of the Balzes anticline. Well-proven primary signal (positive fold test and two pseudo-antiparallel polarities) supported by numerous primary data in the surroundings allow us building a reliable local polarity sequence of eight magnetozones (from R1 to N4). Additionally, seven new biostratigraphic samples (Nummulites and Assilina) in the lower part of the section (marine environment) allows tightening the section to the Geomagnetic Polarity Time Scale (GPTS) and proposing a refined age model for the southeastern Jaca Basin. The section starts in the Boltaña Fm., of Cuisian age (Shallow Benthic Zone, SBZ11), is followed by a sedimentary gap from C22n to C20n as witnessed by biostratigraphic data (SBZ11 underneath the hiatus and SBZ16 just atop). The deltaic Sobrarbe Fm can be tracked until the C19n (Late Lutetian). From this point (200m) until the top of the section (950m), at least, the entire C18n chron can be recognized within the molassic Campodarbe Fm (C18n.2n-C18n.1r and C18n.1n) (Bartonian) equivalent to the West to the prodeltaic Arguis marls Fm. The Middle Cusian (SBZ11) to Middle Lutetian (SBZ15) stratigraphic hiatus is, in part, enhanced by the structural position at the hinge of the Balzes anticline. These new chronostratigraphic constraints help refining the W-E and N-S stratigraphic relationships in the eastern Jaca Basin and in the Ainsa Basin. This section also allows us to accurately refine the kinematics of the rotational activity in the eastern External Sierras. The significant difference in magnetic declination along the section and neighboring paleomagnetic data from the Balzes anticline (from ≈70º clockwise at the base of the stratigraphic section to non-significant at the top) together with the new age model for the Eastern Jaca Basin help characterizing the rotational activity of the Balzes thrust sheet. The rotation took place between chrons C20r (Middle Lutetian; 45Ma) and C17 (Lower Priabonian 37-38Ma) in agreement to nearby structures (Boltaña, Pico del Aguila anticlines) but clearly diachronic to western ones (Santo Domingo anticline). Besides, the rotational activity seems to follow a linear and continuous pattern (velocity 9-11º/Ma, R: 0.83-0.96) in contrast to closer structures that show two distinct rotational velocities (i.e. Boltaña). These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust

Systematics of Lutetian larger foraminifera and magneto-biostratigraphy from the South Pyrenean Basin (Sierras Exteriores, Spain)

A systematic description of the Eocene larger foraminifera recorded in the South Pyrenean Basin (Sierras Exteriores) is presented herein. The large dataset provided in this work includes Nummulites and Alveolina species, along with a variety of other porcellaneous and hyaline taxa with lesser biostratigraphic relevance. Most of the larger foraminifera described in this work correspond to the Lutetian (SBZ13 to SBZ16 biozones) interval, but late Ypresian (SBZ11, Cuisian) and early Bartonian (SBZ17) shallow benthic zones have also been identified. A new species, Idalinaosquetaensis, is described. The systematic revision of middle to late Lutetian alveolines led to a reassessment of Alveolinafusiformis and the finding of two new precursor forms, described as Alveolina aff. fragilis and Alveolina aff. elongata. The new taxa fill in the gap existing so far in the middle to late Lutetian alveolinid biostratigraphy. Despite not being exclusive to SBZ16, these forms provide realiable biostratigraphic information in facies where Nummulites are not present. This realibility lies on the correlation of Nummulitesand Alveolina biostratigraphic markers in the same sections and their calibration to the global time scale through magnetostratigraphy. Magnetostratigraphic calibration of described taxa is provided, along with an update of the SBZ calibration to the Geological Time Scale (Gradstein et al., 2012).&nbsp

Systematics of Lutetian larger foraminifera and magneto-biostratigraphy from the South Pyrenean Basin (Sierras Exteriores, Spain)

An extense systematic description of the Eocene larger foraminiferal faunas recorded in the South Pyrenean Basin (Sierras Exteriores) is presented herein. The large dataset provided in this work includes both Nummulites and Alveolina species, along with a variety of other porcellaneous and hyaline taxa with lesser biostratigraphic relevance, are represented. The larger foraminifera described in this work correspond mainly to the Lutetian (SBZ13 to SBZ16 biozones) interval, but late Ypresian (SBZ11, Cuisian) and Bartonian (SBZ17) shallow benthic zones have also been identified. As one of the most relevant results of this systematic analysis, a new species, Idalina osquetaensis, is described. The systematic revision of middle to late Lutetian alveolines led to a reassessment of A. fusiformis and the finding of two new precursor forms, described as affinis of their corresponding species, A. aff. fragilis and A. aff. elongata. The new forms A. aff. elongata and A. aff. fragilis fill the gap in the middle to late Lutetian alveolinid biostratigraphy. Despite not being exclusive to SBZ16, these new forms provide realiable biostratigraphic information where Nummulites are not present. This realibility lies on the correlation of Nummulites and Alveolina biomarkers in the same sections and their calibration to the global time scale through magnetostratigraphy. In fact, magnetostratigraphic calibration of all described taxa is also provided, along with an update of the SBZ calibration to the current Geologic Time Scale (Gradstein et al., 2012)

Aplicaciones del láser al análisis y tratamiento de obras de arte

Peer Reviewe

The early/middle Eocene transition at the Ésera valley (South Central Pyrenees): Implications in Shallow Benthic Zones (SBZ)

An integrated study including magnetostratigraphy, larger benthic foraminifera and calcareous nannofossil biostratigraphy is presented herein. This work was performed in shallow marine siliciclastics rich in larger foraminifera, around the Ypresian/Lutetian boundary in the Ésera valley (South-Central Pyrenees). Although the calcareous nannofossil content in the studied interval is low, not allowing a precise Y/L boundary to be recognised, the taxa found are enough to support the chronostratigraphic attribution. Data obtained in the Ésera valley section has improved the knowledge of larger benthic foraminifera (Nummulites and Assilina) distribution through chron C21. SBZ 11 to SBZ 12 transition took place at the lowermost C21r, as shown in previous works. SBZ 12 assemblages extend into C21n, where the SBZ 12 to SBZ 13 boundary occurs. These data, obtained in shallow marine siliciclastic facies, with in situ fauna, results in a shift of the SBZ 12/SBZ 13 boundary to the Lower Lutetian, younger than previously believed. Accordingly, the Ypresian/Lutetian boundary occurs in SBZ 12

The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees) : Las Bellostas section

Acknowledgement. This paper represents our modest tribute to Pep Serra-Kiel for his inspiring work, his sharp intelligence, his working tenacity, his always fruitful discussions and his camaraderie and friendship. This work was financed by the Sobrarbe County Research fellow-UNESCO Global Geopark (ARP) and by some projects from the Spanish Science National Plan (UKRIA4D- PID2019--I00/CTA, DR3AM. CGL2014 54118-C2-2-R and MAGIBER-II. CGL2017-90632-REDT). We are also very grateful to the laboratories of the universities of Burgos (Juanjo Villalaín) and Zaragoza (Teresa Román and Sylvia Gracia), Sergio Arruej Gil for the field support and Pablo Calvin and Vicky Burriel for the Burgos logistic support. Very warm acknowledged is given to Alejandro and Pablo from "Casa Molinero" in Las Bellostas for their hospitality, friendship and human warmth during all these years. Finally, we sincerely acknowledge the thorough and constructive reviews done by Miguel Garcés, Josep Tosquella and the editor Carles Martín-Closas.Despite the large number of magnetostratigraphic studies in the South Pyrenean Basin aiming to calibrate the basin chronostratigraphy and the biostratigraphic scales, the South Eastern Jaca Basin remains unexplored from this perspective, and its relation with the Ainsa Basin is not fully understood. In this work we contribute with new magnetostratigraphic data from the 950m thick Las Bellostas section, located in the northern hinge of the Balzes anticline. Well-proven primary signal (positive fold test and two pseudo-antiparallel polarities) supported by numerous primary data in the surroundings allow us building a reliable local polarity sequence of eight magnetozones (from R1 to N4). Additionally, seven new biostratigraphic samples (Nummulites and Assilina) in the lower part of the section (marine environment) allows tightening the section to the Geomagnetic Polarity Time Scale (GPTS) and proposing a refined age model for the southeastern Jaca Basin. The section starts in the Boltaña Fm., of Cuisian age (Shallow Benthic Zone, SBZ11), is followed by a sedimentary gap from C22n to C20n as witnessed by biostratigraphic data (SBZ11 underneath the hiatus and SBZ16 just atop). The deltaic Sobrarbe Fm. can be tracked until the C19n (Late Lutetian). From this point (200m) until the top of the section (950m), at least, the entire C18n chron can be recognized within the molassic Campodarbe Fm. (C18n.2n-C18n.1r and C18n.1n) (Bartonian) equivalent to the West to the prodeltaic Arguis marls Fm. The Middle Cusian (SBZ11) to Middle Lutetian (SBZ15) stratigraphic hiatus is, in part, enhanced by the structural position at the hinge of the Balzes anticline. These new chronostratigraphic constraints help refining the W-E and N-S stratigraphic relationships in the eastern Jaca Basin and in the Ainsa Basin. This section also allows us to accurately refine the kinematics of the rotational activity in the eastern External Sierras. The important difference in magnetic declination along the section and neighboring paleomagnetic data from the Balzes anticline (from ≈70º clockwise at the base of the stratigraphic section to non-significant at the top) together with the new age model for the Eastern Jaca Basin help characterizing the rotational activity of the Balzes thrust sheet. The rotation took place between chrons C20r (Middle Lutetian; 45Ma) and C17 (Lower Priabonian 37-38Ma) in agreement to nearby structures (Boltaña, Picodel Aguila anticlines) but clearly diachronic to western ones (Santo Domingo anticline). Besides, the rotational activity seems to follow a linear and continuous pattern (velocity 9-11º/Ma, R: 0.83-0.96) in contrast to closer structures that show two distinct rotational velocities (i.e. Boltaña). These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust