Control of Drosophila adult pattern by extradenticle

The homeobox gene extradenticle (exd) acts as a cofactor of the homeotic genes in the specification of larval patterns during embryogenesis. To study its role in adult patterns, we have generated clones of mutant exd- cells and examined their effect on the different body parts. In some regions, exd- clones exhibit homeotic transformations similar to those produced by known homeotic mutations such as Ultrabithorax (Ubx), labial (lab), spineless-aristapedia (ssa) or Antennapedia (Antp). In other regions, the lack of exd causes novel homeotic transformations producing ectopic eyes and legs. Moreover, exd is also required for functions normally not associated with homeosis, such as the maintenance of the dorsoventral pattern, the specification of subpatterns in adult appendages or the arrangement of bristles in the mesonotum and genitalia. Our findings indicate that exd is critically involved in adult morphogenesis, not only in the homeotic function but also in several other developmental processes.This work was supported by grants from the Dirección General de Investigación Científica y Técnica and the Human Frontier Science Program Organization and an institutional grant from the Fundación Ramón ArecesPeer Reviewe

Dynamic, ecological, accessible and 3D Virtual Worlds-based Libraries using OpenSim and Sloodle along with mobile location and NFC for checking in

This paper proposes the implementation of a 3D virtual library, using open platforms such as OpenSimulator and Sloodle, applied to the integration of virtual learning environments. It also proposes their application to the creation of open libraries to share and disseminate the new dynamic nature of knowledge, in the understanding that 3D virtual worlds may contribute to the future of libraries as part of green initiatives to achieve an ecologic and sustainable planet

Using clustering methods to deal with high number of alternatives on Group Decision Making

Novel Group Decision Making methods and Web 2.0 have augmented the quantity of data that experts have to discuss about. Nevertheless, experts are only capable of dealing with a reduced set of information. In this paper, a novel method for dealing with decision environments that include a large set of alternatives is presented. By the use of clustering methods, the available alternatives are combined into clusters according to their similarity. Afterwards, one Group Decision Making process is employed for choosing a cluster and another one for selecting the final alternative.The authors would like to thank the FEDER financial support for the Project TIN2016-75850-P by the Spanish Ministry of Science, Innovation and Universities

A Sparse-Bayesian Approach for the Design of Robust Digital Predistorters Under Power-Varying Operation

"Early access"In this article, a sparse-Bayesian treatment is proposed to solve the crucial questions posed by power amplifier (PA) and digital predistorter (DPD) modeling. To learn a model, the advanced Bayesian framework includes a group of specific processes that maximize the likelihood of the measured data: regressor pursuit and identification, coefficient estimation, stopping criterion, and regressor deselection. The relevance vector machine (RVM) method is reformulated theoretically to be implemented in complex-valued linear regression. In essence, given an initial set of candidate regressors, the result of this sparse-Bayesian learning approach is the most likely model. Experimental results are provided for the linearization of class AB and class J PAs driven by a 30-MHz fifth-generation new radio signal for a fixed average power, where the evolution of the figures of merit versus the number of active coefficients is examined for the proposed sparse-Bayesian pursuit (SBP) algorithm in comparison to other greedy algorithms. The SBP presents a good performance in terms of linearization capabilities and computational cost. Furthermore, the proposed Bayesian framework enabled the design of a DPD model structure, deselect regressors, and readjust coefficients in a direct learning architecture, demonstrating the robustness to changes in the power level over a 10-dB range.Ministerio de Ciencia e Innovación 10.13039/501100011033Junta de Andalucía - Fondos FEDER US-126499

Impulsivity in fatal suicide behaviour: A systematic review and meta-analysis of psychological autopsy studies

Our aim is to review and perform a meta-analysis on the role of impulsivity in fatal suicide behaviour. We included papers who used psychological autopsy methodology, assessed adult death by suicide, and included assessment of impulsivity. We excluded papers about assisted suicide, terrorist suicide, or other cause of death other than suicide or postmortem diagnosis made only from medical records or database. 97 articles were identified. 33 were included in the systematic review and nine in the meta-analysis. We found that people who die by suicide with high impulsivity are associated with younger age, substance abuse, and low intention to die, whereas those with low impulsivity were associated with older age, depression, schizophrenia, high intention to die and low social support. In the meta-analysis, suicide cases had higher impulsivity scores than living controls (Hedges' g = 0.59, 95 % CI [0.28, 0.89], p=.002). However, studies showed heterogeneity (Q = 90.86, p<.001, I2=89.0 %). Impulsivity-aggressiveness interaction was assessed through meta-regression (β=0.447, p=.045). Individuals with high impulsivity would be exposed to a higher risk of fatal suicide behaviour, aggressiveness would play a mediating role. People who die by suicide with high and low impulsivity display distinct characteristics, which may reflect different endophenotypes leading to suicide by different pathways

The influence of gender and academic training in the entrepreneurial intention of physical activity and sport sciences students

Objeto: El objetivo del presente artículo es conocer si existen diferencias en las variables que explican la intención de emprender de los estudiantes universitarios de Ciencias de la Actividad Física y el Deporte atendiendo a la formación y al género de éstos. Diseño/metodología/enfoque: Para conocer las intenciones de emprender y las distintas variables relacionadas con el emprendimiento se utilizó un cuestionario previamente validado. Éste fue administrado a 578 estudiantes pre-graduados (1er - 4º curso) y post-graduados de Ciencias de la Actividad Física y el Deporte de Valencia. Aportaciones y resultados: Se encontraron diferencias significativas (p≤0.05) en las variables que predicen la intención de emprender según género y formación de los estudiantes. En ambos géneros la actitud y el control percibido resultaron ser las variables predictoras de la intención de emprender, y en los hombres también la norma subjetiva. Limitaciones: La muestra de estudiantes sólo pertenece a la titulación de Ciencias de la Actividad Física y el Deporte de Valencia, por lo que los resultados no son extrapolables a toda la población de estudiantes. Implicaciones prácticas: Para favorecer el espíritu emprendedor y de esta manera formar graduados más preparados para su inserción en el mundo laboral se deben crear programas que fomenten la actitud hacia la conducta del emprendimiento y el control del comportamiento percibido. Implicaciones sociales: Aumentar el número de emprendedores en el sector deportivo, reduciendo la brecha de género, así como mejorar la calidad del emprendimiento, ya que éste es un aspecto clave debido al impacto positivo que este fenómeno genera sobre la economía. Originalidad / Valor añadido: Conocer si existen diferencias en función de la formación y el género debido a la masiva incorporación de la mujer al mundo laboral deportivo y su baja intención de emprender, con el objetivo de formar tanto a graduados como graduadas con habilidades emprendedoras.Purpose: The objective of this article is to know if there are differences in the variables that explain the entrepreneurial intention of the Physical Activity and Sport Science students addressing academic training and gender of them. Design/methodology: To know entrepreneurial intentions and the different variables related to entrepreneurship, a questionnaire previously validated was used. The questionnaire was provided to 578 students pre-graduated (1st-4th course) and post-graduate of Physical Activity and Sport Science degree of Valencia. Findings: Statistically significant differences (p ≤ 0.05) in the variables that predict entrepreneurial intention of Physical Activity and Sport Science students by gender and training were found. In both genders, the attitude towards entrepreneurship and the perceived behavior control were the predictors of entrepreneurial intentions and in men also the subjective norms. Research limitations/implications: The students sample belongs only to the Physical Activity and Sport Science degree of Valencia, so the results cannot be extrapolated to the entire population. Practical implications: It should be developing the attitude toward the behavior of entrepreneurship and perceived behavioral control to promote entrepreneurship. In this way, the graduates will be more prepare for insertion into the working world. Social implications: To increase the number of entrepreneurs (male and female) in the sports sector throughout the education, reducing the gender gap in entrepreneurship and improve the quality of entrepreneurship, as this is a key issue because of the positive impact that this phenomenon generates on the economy Originality/value: It is interesting to know the predictor variables of entrepreneurial intentions, and to know if there are differences based on education and gender due to the massive entry of women into the sport workplaces and low intention to undertake of the. So it is quite important training in the best way, both graduates (male and female) with entrepreneurial skills.Peer Reviewe

ESIT Virtual Museum as a resource for teaching-learning in Technology and Design areas

[ES] El Museo Virtual ESIT, es producto de un Proyecto de Innovación Educativa (PIE) ocupado de promover acciones bajo la perspectiva STEAM, apoyándose en la metodología Learning by doing en áreas de ingeniería, para que la creatividad y la tecnología se complementen en la búsqueda y aplicación de una solución funcional, real y bella. Y que, además, coloca al estudiante en el centro de su experiencia formativa en la que también pueda experimentar situaciones reales a la hora de presentarse a convocatorias de concurso, oportunidades laborales altamente competitivas o convocatorias públicas o privadas que concedan financiación para el desarrollo de un proyecto determinado. El proyecto Museo Virtual ESIT es un proyecto, a través del cual, se genera un espacio arquitectónico utilizando la herramienta Unity, que hace posible centrarse en la creación de un metamodelo de mundo virtual. En este caso se emula las distintas salas de un museo o galería de arte, donde exponer las soluciones producidas por la actividad formativa desarrolla en el área de Diseño de la Escuela Superior de Ingeniería y Tecnología (ESIT) de la Universidad Internacional de la Rioja (UNIR).[EN] The ESIT Virtual Museum is the product of an educational innovation project which offers some actions under the STEAM perspective, supporting on the "Learning by doing" methodology in engineering areas, so that creativity and technology complement each other in the search and application of functional, real and aesthetic solution. The student is placed at the center of their formative experience, in which they can also experience real situations in terms of appearing in competitive exams, highly competitive job opportunities or public or private calls that grant financing for the development of a specific project. The ESIT Virtual Museum is an architectural space project with the Unity tool to develop a metamodel of the virtual world. In this case, the solutions produced by the training activity are developed in the Design area of the Higher School of Engineering and Technology (ESIT) of the International University of La Rioja (UNIR) are exposed in the different rooms of a museum or an art gallery.De Miguel, L.; Rúas Ruiz-De Infante, J.; Ríos Aguilar, S.; González Crespo, R. (2019). El Museo Virtual ESIT como recurso para la enseñanza-aprendizaje en áreas de diseño y tecnología. En IV Congreso Internacional de investigación en artes visuales: ANIAV 2019 Imagen [N] visible. Editorial Universitat Politècnica de València. 213-220. https://doi.org/10.4995/ANIAV.2019.2019.9000OCS21322

Impact of COVID-19 on people with intellectual and developmental disabilities, their families, support professionals and organizations

Our world has been transformed by the coronavirus and the infection it causes. The severity of the disease and the consequences of the state of alarm do not affect everyone equally, being people with intellectual and developmental disabilities one of the most vulnerable groups. INICO and Plena inclusion conducted a study to analyze the impact of COVID-19 and lockdown on people with intellectual and developmental disabilities, their families, direct support professionals, and disability organizations. To address this goal, four online surveys were developed and completed by almost 1.500 participants from all the Spanish regions. The results indicate that, despite the efforts made by the third sector, the health crisis has unveiled the deficiencies of our support system, which leads us to reflect on three fundamental aspects: the degree to which the development and maintenance of natural support networks is carried out when the person lives in a specific environment; the extent to which the support offered from the third sector reaches individuals outside the disability services network; and the role of our educational system in guaranteeing the right to education for people with special support needs.Nuestro mundo se ha visto transformado por el coronavirus y la infección que provoca. La gravedad de la enfermedad y las consecuencias del estado de alarma no afectan a todos por igual, siendo las personas con discapacidad intelectual y del desarrollo uno de los colectivos más vulnerables. El INICO y Plena inclusión realizaron un estudio con la finalidad de analizar el impacto de la COVID-19 y el confinamiento durante la primera ola en 2020 en las personas con discapacidad intelectual y del desarrollo, sus familiares, personal de atención directa y organizaciones. Para ello, se elaboraron y aplicaron en España cuatro encuestas en línea, participando cerca de 1.500 personas. Los resultados indican que, a pesar del esfuerzo realizado por el tercer sector, la crisis sanitaria ha dejado al descubierto las carencias de nuestro sistema de apoyos, lo que lleva a reflexionar sobre tres aspectos fundamentales: el grado en que se trabaja en el desarrollo y mantenimiento de redes naturales de apoyo cuando la persona vive en un entorno específico; la medida en que los apoyos ofrecidos desde el tercer sector llegan a contextosque se encuentran fuera de la red de servicios ofertados por el movimiento asociativo; y el papel de nuestro sistema educativo a la hora de garantizar el derecho a la educación de personas con necesidades especiales de apoyo

La influencia del género y de la formación académica en la intención de emprender de los estudiantes de ciencias de la actividad física y el deporte

Objeto: El objetivo del presente artículo es conocer si existen diferencias en las variables que explican la intención de emprender de los estudiantes universitarios de Ciencias de la Actividad Física y el Deporte atendiendo a la formación y al género de éstos. Diseño/metodología: Para conocer las intenciones de emprender y las distintas variables relacionadas con el emprendimiento se utilizó un cuestionario previamente validado. Éste fue administrado a 578 estudiantes pre-graduados (1er - 4º curso) y post-graduados de Ciencias de la Actividad Física y el Deporte de Valencia. Aportaciones y resultados: Se encontraron diferencias significativas (p≤0.05) en las variables que predicen la intención de emprender según género y formación de los estudiantes. En ambos géneros la actitud y el control percibido resultaron ser las variables predictoras de la intención de emprender, y en los hombres también la norma subjetiva. Limitaciones: La muestra de estudiantes sólo pertenece a la titulación de Ciencias de la Actividad Física y el Deporte de Valencia, por lo que los resultados no son extrapolables a toda la población de estudiantes. Implicaciones prácticas: Para favorecer el espíritu emprendedor y de esta manera formar graduados más preparados para su inserción en el mundo laboral se deben crear programas que fomenten la actitud hacia la conducta del emprendimiento y el control del comportamiento percibido. Implicaciones sociales: Aumentar el número de emprendedores en el sector deportivo, reduciendo la brecha de género, así como mejorar la calidad del emprendimiento, ya que éste es un aspecto clave debido al impacto positivo que este fenómeno genera sobre la economía. Valor añadido: Conocer si existen diferencias en función de la formación y el género debido a la masiva incorporación de la mujer al mundo laboral deportivo y su baja intención de emprender, con el objetivo de formar tanto a graduados como graduadas con habilidades emprendedoras.Purpose: The objective of this article is to know if there are differences in the variables that explain the entrepreneurial intention of the Physical Activity and Sport Science students addressing academic training and gender of them. Design/methodology/approach: To know entrepreneurial intentions and the different variables related to entrepreneurship, a questionnaire previously validated was used. The questionnaire was provided to 578 students pre-graduated (1st-4th course) and post-graduate of Physical Activity and Sport Science degree of Valencia. Findings: Statistically significant differences (p ≤ 0.05) in the variables that predict entrepreneurial intention of Physical Activity and Sport Science students by gender and training were found. In both genders, the attitude towards entrepreneurship and the perceived behavior control were the predictors of entrepreneurial intentions and in men also the subjective norms. Research limitations/implications: The students sample belongs only to the Physical Activity and Sport Science degree of Valencia, so the results cannot be extrapolated to the entire population. Practical implications: It should be developing the attitude toward the behavior of entrepreneurship and perceived behavioral control to promote entrepreneurship. In this way, the graduates will be more prepare for insertion into the working world. Social implications: To increase the number of entrepreneurs (male and female) in the sports sector throughout the education, reducing the gender gap in entrepreneurship and improve the quality of entrepreneurship, as this is a key issue because of the positive impact that this phenomenon generates on the economy Originality/value: It is interesting to know the predictor variables of entrepreneurial intentions, and to know if there are differences based on education and gender due to the massive entry of women into the sport workplaces and low intention to undertake of the. So it is quite important training in the best way, both graduates (male and female) with entrepreneurial skills.Ciencias de la Actividad Física y del Deport