Fluorescence in nanostructured fulleride films

Applied Physics Letters, 89Nanostructuring of fullerene C60 beam deposited films is achieved by electrochemical reduction in a potassium hydroxide aqueous solution. Alkali fulleride clusters are formed at the electrode, as it is illustrated by cyclic voltammetry, x-ray diffraction, and scanning tunneling microscopy. Fluorescence emission from fluorophore doped fullerene reduced films was investigated by fluorescence spectroscopy and scanning near-field optical microscopy. These techniques lead to results which also fit such nanometer-sized fulleride cluster interpretation. In particular, the fluorophore fluorescence lifetime decreases as long as aggregation in the film is more effective,which occurs with the increase of film thickness

Hyperprolinemia as a clue in the diagnosis of a patient with psychiatric manifestations

Lately, microdeletions of the 22q region, responsible for DiGeorge syndrome or velocardiofacial syndrome, have been increasingly related to neuropsychiatric disorders including schizophrenia and bipolar disorder. These manifestations seem to be related to certain genes located in the hemideleted region such as the proline dehydrogenase (PRODH) and the catechol-o-methyltransferase (COMT) genes. We describe a teenager who started his adolescent psychiatric care presenting cognitive impairment, irritable mood and aggressive behaviour with schizophrenia-like symptoms that scored 153 in the Positive and Negative Symptoms Scale (PANSS) assessment. Worsening of symptoms when the patient was treated with valproic acid, and plasma aminoacids showing an increase in alanine and proline, suggested a mitochondrial involvement of the proline metabolic pathway. Mild dysmorphic features also suggested a possible 22q11 deletion syndrome that was confirmed. A mutation for Hyperprolinemia type I was also detected. Knowledge of the correct diagnosis was crucial for an adequate treatment.info:eu-repo/semantics/publishedVersio

Biomechanical Comparison of Open versus Percutaneous Techniques for Primary Mid-Substance Achilles Tendon Repair: A Meta-Analysis

poste

Complications Associated with Proximal Hamstring Tendon Repair: A Systematic Review

poste

Estudo da infeccão por...

A taxa de infecção por "B. bigemina" foi estudada em bovinos de diferentes grupos genéticos e em teleóginas de "B. microplus". Amostras de sangue foram obtidas de 15 vacas e 15 bezerros dos grupos genéticos: Nelore, Canchim/Nelore, Angus/Nelore e Simental/Nelore. Essas amostras foram utilizadas para confecção de esfregaços de sangue, para extração de DNA e determinação do volume globular. Todas as amostras de DNA foram submetidas a amplificação pela técnica da Reação em Cadeia da Polimerase (PCR) e Nested-PCR usando \\\'primers\\\' específicos para \\\'B. bigemina\\\'. Simultâneamente foram colhidas teleóginas de vacas e bezerros, a fim de se verificar a taxa de infecção por \\\'Babesia bigemina\\\' (por meio de exame direto da hemolinfa e por N-PCR). A amplificação do DNA de "B. bigemina" (N-PCR) detectou que 100% dos animais são positivos em todos os grupos genéticos estudados. Nos bezerros foi possível detectar parasitemias por meio da reação de PCR (primeira reação), fato que mostra que esses animais aparesentam maior disponibilidade de DNA de "B. bigemina", quando comparado aos adultos. Os bezerros apresentaram menor nível de hematócrito, quando comparado às vacas. Por meio de N-PCR foi possível detectar 186 (16,9%) carrapatos infectados por "B. bigemina" distribuidos em todos os grupos genéticos e categorias de idades. Porém, novamente foi verificada uma forte associação entre idade e taxa de infecção dos carrapatos, mas não houve diferenças significativas entre os grupos genética

Quality of life in caregivers of patients with multiple myeloma

Objectives: This study aimed to assess the relationship between sociodemographic, clinical, and psychological variables with quality of life (QoL) and the moderating role of caregivers' age and caregiving duration in caregivers of patients with Multiple Myeloma.Method: The sample included 118 caregivers who completed questionnaires that assessed psychological morbidity, satisfaction with social support, coping, burden, unmet needs, and QoL.Results: High psychological morbidity, burden and information, financial and emotional unmet needs were associated with lower QoL, while higher satisfaction with social support and more effective use of coping strategies were associated with better QoL. Women caregivers reported more satisfaction with social support and those who did not choose to care reported greater financial unmet needs and more use of coping strategies. The relationship between caregivers' psychological morbidity/social support and QoL was mediated by emotional needs and double mediated by coping and burden. The caregivers' age moderated the relationship between psychological morbidity/social support and emotional needs.Conclusion: Interventions to support the caregiver's emotional needs to promote their QoL are needed. These should be particularly tailored for older caregivers reporting greater psychological morbidity and younger caregivers less satisfied with their social support, as they have a negative indirect impact on their QoL.Portuguese Associations of Portuguese Association against Leukemia and the PortugueseAssociation of Leukemias and Lymphoma