466 research outputs found
Coulomb integrals for the SL(2,R) WZNW model
We review the Coulomb gas computation of three-point functions in the SL(2,R)
WZNW model and obtain explicit expressions for generic states. These amplitudes
have been computed in the past by this and other methods but the analytic
continuation in the number of screening charges required by the Coulomb gas
formalism had only been performed in particular cases. After showing that ghost
contributions to the correlators can be generally expressed in terms of Schur
polynomials we solve Aomoto integrals in the complex plane, a new set of
multiple integrals of Dotsenko-Fateev type. We then make use of monodromy
invariance to analytically continue the number of screening operators and prove
that this procedure gives results in complete agreement with the amplitudes
obtained from the bootstrap approach. We also compute a four-point function
involving a spectral flow operator and we verify that it leads to the one unit
spectral flow three-point function according to a prescription previously
proposed in the literature. In addition, we present an alternative method to
obtain spectral flow non-conserving n-point functions through well defined
operators and we prove that it reproduces the exact correlators for n=3.
Independence of the result on the insertion points of these operators suggests
that it is possible to violate winding number conservation modifying the
background charge.Comment: Improved presentation. New section on spectral flow violating
correlators and computation of a four-point functio
Representations of integers by certain positive definite binary quadratic forms
We prove part of a conjecture of Borwein and Choi concerning an estimate on
the square of the number of solutions to n=x^2+Ny^2 for a squarefree integer N.Comment: 8 pages, submitte
The nonrelativistic limit of the Magueijo-Smolin model of deformed special relativity
We study the nonrelativistic limit of the motion of a classical particle in a
model of deformed special relativity and of the corresponding generalized
Klein-Gordon and Dirac equations, and show that they reproduce nonrelativistic
classical and quantum mechanics, respectively, although the rest mass of a
particle no longer coincides with its inertial mass. This fact clarifies the
meaning of the different definitions of velocity of a particle available in DSR
literature. Moreover, the rest mass of particles and antiparticles differ,
breaking the CPT invariance. This effect is close to observational limits and
future experiments may give indications on its effective existence.Comment: 10 pages, plain TeX. Discussion of generalized Dirac equation and CPT
violation adde
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors
The RNA 6-N-methyladenosine (m6A) demethylase ALKBH5 has been shown to be oncogenic in several cancer types, including leukemia and glioblastoma. We present here the target-tailored development and first evaluation of the antiproliferative effects of new ALKBH5 inhibitors. Two compounds, 2-[(1-hydroxy-2-oxo-2-phenylethyl)sulfanyl]acetic acid (3) and 4-{[(furan-2-yl)methyl]amino}-1,2-diazinane-3,6-dione (6), with IC50 values of 0.84 mu M and 1.79 mu M, respectively, were identified in high-throughput virtual screening of the library of 144 000 preselected compounds and subsequent verification of hits in an m6A antibody-based enzyme-linked immunosorbent assay (ELISA) enzyme inhibition assay. The effect of these compounds on the proliferation of selected target cancer cell lines was then measured. In the case of three leukemia cell lines (HL-60, CCRF-CEM, and K562) the cell proliferation was suppressed at low micromolar concentrations of inhibitors, with IC50 ranging from 1.38 to 16.5 mu M. However, the effect was low or negligible in the case of another leukemia cell line, Jurkat, and the glioblastoma cell line A-172. These results demonstrate the potential of ALKBH5 inhibition as a cancer-cell-type-selective antiproliferative strategy.Peer reviewe
Random matrix theory, the exceptional Lie groups, and L-functions
There has recently been interest in relating properties of matrices drawn at
random from the classical compact groups to statistical characteristics of
number-theoretical L-functions. One example is the relationship conjectured to
hold between the value distributions of the characteristic polynomials of such
matrices and value distributions within families of L-functions. These
connections are here extended to non-classical groups. We focus on an explicit
example: the exceptional Lie group G_2. The value distributions for
characteristic polynomials associated with the 7- and 14-dimensional
representations of G_2, defined with respect to the uniform invariant (Haar)
measure, are calculated using two of the Macdonald constant term identities. A
one parameter family of L-functions over a finite field is described whose
value distribution in the limit as the size of the finite field grows is
related to that of the characteristic polynomials associated with the
7-dimensional representation of G_2. The random matrix calculations extend to
all exceptional Lie groupsComment: 14 page
Advection of vector fields by chaotic flows
We have introduced a new transfer operator for chaotic flows whose leading
eigenvalue yields the dynamo rate of the fast kinematic dynamo and applied
cycle expansion of the Fredholm determinant of the new operator to evaluation
of its spectrum. The theory hs been tested on a normal form model of the vector
advecting dynamical flow. If the model is a simple map with constant time
between two iterations, the dynamo rate is the same as the escape rate of
scalar quantties. However, a spread in Poincar\'e section return times lifts
the degeneracy of the vector and scalar advection rates, and leads to dynamo
rates that dominate over the scalar advection rates. For sufficiently large
time spreads we have even found repellers for which the magnetic field grows
exponentially, even though the scalar densities are decaying exponentially.Comment: 12 pages, Latex. Ask for figures from [email protected]
Some recursive formulas for Selberg-type integrals
A set of recursive relations satisfied by Selberg-type integrals involving
monomial symmetric polynomials are derived, generalizing previously known
results. These formulas provide a well-defined algorithm for computing
Selberg-Schur integrals whenever the Kostka numbers relating Schur functions
and the corresponding monomial polynomials are explicitly known. We illustrate
the usefulness of our results discussing some interesting examples.Comment: 11 pages. To appear in Jour. Phys.
Wigner quantization of some one-dimensional Hamiltonians
Recently, several papers have been dedicated to the Wigner quantization of
different Hamiltonians. In these examples, many interesting mathematical and
physical properties have been shown. Among those we have the ubiquitous
relation with Lie superalgebras and their representations. In this paper, we
study two one-dimensional Hamiltonians for which the Wigner quantization is
related with the orthosymplectic Lie superalgebra osp(1|2). One of them, the
Hamiltonian H = xp, is popular due to its connection with the Riemann zeros,
discovered by Berry and Keating on the one hand and Connes on the other. The
Hamiltonian of the free particle, H_f = p^2/2, is the second Hamiltonian we
will examine. Wigner quantization introduces an extra representation parameter
for both of these Hamiltonians. Canonical quantization is recovered by
restricting to a specific representation of the Lie superalgebra osp(1|2)
The least common multiple of a sequence of products of linear polynomials
Let be the product of several linear polynomials with integer
coefficients. In this paper, we obtain the estimate: as , where is a constant depending on
.Comment: To appear in Acta Mathematica Hungaric
Some extremal functions in Fourier analysis, III
We obtain the best approximation in , by entire functions of
exponential type, for a class of even functions that includes
, where , and , where . We also give periodic versions of these results where the
approximating functions are trigonometric polynomials of bounded degree.Comment: 26 pages. Submitte
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