Coulomb integrals for the SL(2,R) WZNW model

We review the Coulomb gas computation of three-point functions in the SL(2,R) WZNW model and obtain explicit expressions for generic states. These amplitudes have been computed in the past by this and other methods but the analytic continuation in the number of screening charges required by the Coulomb gas formalism had only been performed in particular cases. After showing that ghost contributions to the correlators can be generally expressed in terms of Schur polynomials we solve Aomoto integrals in the complex plane, a new set of multiple integrals of Dotsenko-Fateev type. We then make use of monodromy invariance to analytically continue the number of screening operators and prove that this procedure gives results in complete agreement with the amplitudes obtained from the bootstrap approach. We also compute a four-point function involving a spectral flow operator and we verify that it leads to the one unit spectral flow three-point function according to a prescription previously proposed in the literature. In addition, we present an alternative method to obtain spectral flow non-conserving n-point functions through well defined operators and we prove that it reproduces the exact correlators for n=3. Independence of the result on the insertion points of these operators suggests that it is possible to violate winding number conservation modifying the background charge.Comment: Improved presentation. New section on spectral flow violating correlators and computation of a four-point functio

Representations of integers by certain positive definite binary quadratic forms

We prove part of a conjecture of Borwein and Choi concerning an estimate on the square of the number of solutions to n=x^2+Ny^2 for a squarefree integer N.Comment: 8 pages, submitte

The nonrelativistic limit of the Magueijo-Smolin model of deformed special relativity

We study the nonrelativistic limit of the motion of a classical particle in a model of deformed special relativity and of the corresponding generalized Klein-Gordon and Dirac equations, and show that they reproduce nonrelativistic classical and quantum mechanics, respectively, although the rest mass of a particle no longer coincides with its inertial mass. This fact clarifies the meaning of the different definitions of velocity of a particle available in DSR literature. Moreover, the rest mass of particles and antiparticles differ, breaking the CPT invariance. This effect is close to observational limits and future experiments may give indications on its effective existence.Comment: 10 pages, plain TeX. Discussion of generalized Dirac equation and CPT violation adde

Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors

The RNA 6-N-methyladenosine (m6A) demethylase ALKBH5 has been shown to be oncogenic in several cancer types, including leukemia and glioblastoma. We present here the target-tailored development and first evaluation of the antiproliferative effects of new ALKBH5 inhibitors. Two compounds, 2-[(1-hydroxy-2-oxo-2-phenylethyl)sulfanyl]acetic acid (3) and 4-{[(furan-2-yl)methyl]amino}-1,2-diazinane-3,6-dione (6), with IC50 values of 0.84 mu M and 1.79 mu M, respectively, were identified in high-throughput virtual screening of the library of 144 000 preselected compounds and subsequent verification of hits in an m6A antibody-based enzyme-linked immunosorbent assay (ELISA) enzyme inhibition assay. The effect of these compounds on the proliferation of selected target cancer cell lines was then measured. In the case of three leukemia cell lines (HL-60, CCRF-CEM, and K562) the cell proliferation was suppressed at low micromolar concentrations of inhibitors, with IC50 ranging from 1.38 to 16.5 mu M. However, the effect was low or negligible in the case of another leukemia cell line, Jurkat, and the glioblastoma cell line A-172. These results demonstrate the potential of ALKBH5 inhibition as a cancer-cell-type-selective antiproliferative strategy.Peer reviewe

Random matrix theory, the exceptional Lie groups, and L-functions

There has recently been interest in relating properties of matrices drawn at random from the classical compact groups to statistical characteristics of number-theoretical L-functions. One example is the relationship conjectured to hold between the value distributions of the characteristic polynomials of such matrices and value distributions within families of L-functions. These connections are here extended to non-classical groups. We focus on an explicit example: the exceptional Lie group G_2. The value distributions for characteristic polynomials associated with the 7- and 14-dimensional representations of G_2, defined with respect to the uniform invariant (Haar) measure, are calculated using two of the Macdonald constant term identities. A one parameter family of L-functions over a finite field is described whose value distribution in the limit as the size of the finite field grows is related to that of the characteristic polynomials associated with the 7-dimensional representation of G_2. The random matrix calculations extend to all exceptional Lie groupsComment: 14 page

Advection of vector fields by chaotic flows

We have introduced a new transfer operator for chaotic flows whose leading eigenvalue yields the dynamo rate of the fast kinematic dynamo and applied cycle expansion of the Fredholm determinant of the new operator to evaluation of its spectrum. The theory hs been tested on a normal form model of the vector advecting dynamical flow. If the model is a simple map with constant time between two iterations, the dynamo rate is the same as the escape rate of scalar quantties. However, a spread in Poincar\'e section return times lifts the degeneracy of the vector and scalar advection rates, and leads to dynamo rates that dominate over the scalar advection rates. For sufficiently large time spreads we have even found repellers for which the magnetic field grows exponentially, even though the scalar densities are decaying exponentially.Comment: 12 pages, Latex. Ask for figures from [email protected]

Some recursive formulas for Selberg-type integrals

A set of recursive relations satisfied by Selberg-type integrals involving monomial symmetric polynomials are derived, generalizing previously known results. These formulas provide a well-defined algorithm for computing Selberg-Schur integrals whenever the Kostka numbers relating Schur functions and the corresponding monomial polynomials are explicitly known. We illustrate the usefulness of our results discussing some interesting examples.Comment: 11 pages. To appear in Jour. Phys.

Wigner quantization of some one-dimensional Hamiltonians

Recently, several papers have been dedicated to the Wigner quantization of different Hamiltonians. In these examples, many interesting mathematical and physical properties have been shown. Among those we have the ubiquitous relation with Lie superalgebras and their representations. In this paper, we study two one-dimensional Hamiltonians for which the Wigner quantization is related with the orthosymplectic Lie superalgebra osp(1|2). One of them, the Hamiltonian H = xp, is popular due to its connection with the Riemann zeros, discovered by Berry and Keating on the one hand and Connes on the other. The Hamiltonian of the free particle, H_f = p^2/2, is the second Hamiltonian we will examine. Wigner quantization introduces an extra representation parameter for both of these Hamiltonians. Canonical quantization is recovered by restricting to a specific representation of the Lie superalgebra osp(1|2)

The least common multiple of a sequence of products of linear polynomials

Let $f(x)$ be the product of several linear polynomials with integer coefficients. In this paper, we obtain the estimate: $\log {\rm lcm}(f(1), ..., f(n))\sim An$ as $n\rightarrow\infty$, where $A$ is a constant depending on $f$.Comment: To appear in Acta Mathematica Hungaric

Some extremal functions in Fourier analysis, III

We obtain the best approximation in $L^1(\R)$, by entire functions of exponential type, for a class of even functions that includes $e^{-\lambda|x|}$, where $\lambda >0$, $\log |x|$ and $|x|^{\alpha}$, where $-1 < \alpha < 1$. We also give periodic versions of these results where the approximating functions are trigonometric polynomials of bounded degree.Comment: 26 pages. Submitte