Subleading-twist effects in single-spin asymmetries in semi-inclusive deep-inelastic scattering on a longitudinally polarized hydrogen target

Single-spin asymmetries in the semi-inclusive production of charged pions in deep-inelastic scattering from transversely and longitudinally polarized proton targets are combined to evaluate the subleading-twist contribution to the longitudinal case. This contribution is significantly positive for (\pi^+) mesons and dominates the asymmetries on a longitudinally polarized target previously measured by \hermes. The subleading-twist contribution for (\pi^-) mesons is found to be small

Measurement of single-spin azimuthal asymmetries in semi-inclusive electroproduction of pions and kaons on a longitudinally polarised deuterium target

Single-spin asymmetries have been measured for semi-inclusive electroproduction of $\pi^+$, $\pi^-$, $\pi^0$ and $K^+$ mesons in deep-inelastic scattering off a longitudinally polarised deuterium target. The asymmetries appear in the distribution of the hadrons in the azimuthal angle $\phi$ around the virtual photon direction, relative to the lepton scattering plane. The corresponding analysing powers in the $\sin \phi$ moment of the cross section are $0.012 \pm 0.002 {(stat.)} \pm 0.002 {(syst.)}$ for $\pi^+$, $0.006 \pm 0.003 {(stat.)} \pm 0.002 {(syst.)}$ for $\pi^-$, $0.021 \pm 0.005 {(stat.)} \pm 0.003 {(syst.)}$ for $\pi^0$ and $0.013 \pm 0.006 {(stat.)} \pm 0.003 {(syst.)}$ for $K^+$. The $\sin 2\phi$ moments are compatible with zero for all particles.Comment: Revised version shortened 9 pages, 3 tables, 7 figure

Quark fragmentation to π±\pi^{\pm}, π0\pi^{0}, K±K^{\pm}, pp and pˉ\bar{p} in the nuclear environment

The influence of the nuclear medium on lepto-production of hadrons was studied in the HERMES experiment at DESY in semi-inclusive deep-inelastic scattering of 27.6 GeV positrons off deuterium, nitrogen and krypton targets. The differential multiplicity for krypton relative to that of deuterium has been measured for the first time for various identified hadrons ($\pi^+$, $\pi^-$, $\pi^0$, $K^+$, $K^-$, $p$ and $\bar{p}$) as a function of the virtual photon energy $\nu$, the fraction $z$ of this energy transferred to the hadron, and the hadron transverse momentum squared $p_t^2$. The multiplicity ratio is strongly reduced in the nuclear medium at low $\nu$ and high $z$, with significant differences among the various hadrons. The distribution of the hadron transverse momentum is broadened towards high $p_t^2$ in the nuclear medium, in a manner resembling the Cronin effect previously observed in collisions of heavy ions and protons with nuclei.Comment: 8 pages, 5 figure

Biomolekulare Wechselwirkungen von Proteinen - Datenbankunterstuetzung fuer das Proteindocking. Teilvorhaben: BIOWEPRO Abschlussbericht

The presently available methods for the one-to-one docking problem are not well suited for the one-to-many docking problem for technical as well as quality reasons. In particular, there is a lack of efficiency when applying the methods to large protein databases. Therefore, new techniques to support the docking search are required. The project aims at the development of efficient methods for similarity search in protein database systems which are applicable as a filter step for the one-to-many docking prediction. As a new approach, we developed the approximation-based similarity measure for 3-D surface segments and successfully applied the model to docking segments in a protein database. For the efficient processing of similarity queries, we identified the ellipsoid query as a new query type which provides a wide and flexible applicability for similarity search in protein database systems. Our new algorithms support efficient processing of ellipsoid queries based on multidimensional index structures. In particular, applied to the filter step of one-to-many protein docking, promising results are obtained. Additional applications of the methods range from large molecular databases to multimedia and CAD database systems. (orig.)SIGLEAvailable from TIB Hannover: DtF QN1(58,34) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Mutations in <em>TTC19</em>: Expanding the molecular, clinical and biochemical phenotype.

BACKGROUND: TTC19 deficiency is a progressive neurodegenerative disease associated with isolated mitochondrial respiratory chain (MRC) complex III deficiency and loss-of-function mutations in the TT19 gene in the few patients reported so far. METHODS: We performed exome sequencing and selective mutational analysis of TTC19, respectively, in patients from three unrelated families presenting with initially unspecific clinical signs of muscular hypotonia and global developmental delay followed by regression, ataxia, loss of speech, and rapid neurological deterioration. One patient showed severe lactic acidosis at the neonatal age and during intercurrent illness. RESULTS: We identified homozygous mutations in all three index cases, in two families novel missense mutations (c.544&nbsp;T&thinsp;&gt;&thinsp;C/p.Leu185Pro; c.917&nbsp;T&thinsp;&gt;&thinsp;C/p.Leu324Pro). The younger sister of the severely affected patient 3 showed only mild delay of motor skills and muscular hypotonia so far but is also homozygous for the same mutation. Notably, one patient revealed normal activities of MRC complex III in two independent muscle biopsies. Neuroimaging of the severely affected patients demonstrated lesions in putamen and caudate nuclei, cerebellar atrophy, and the unusual finding of hypertrophic olivary nuclei degeneration. Reviewing the literature revealed striking similarities regarding neuroimaging and clinical course in pediatric patients with TTC19 deficiency: patterns consistent with Leigh or Leigh-like syndrome were found in almost all, hypertrophic olivary nucleus degeneration in all patients reported so far. The clinical course in pediatric patients is characterized by an initially unspecific developmental delay, followed by regression, progressive signs and symptoms of cerebellar, basal ganglia and brainstem affection, especially loss of speech and ataxia. Subsequently, neurological deterioration leading to a vegetative state occurs. CONCLUSIONS: Our findings add to the phenotypic, genetic, and biochemical spectrum of TTC19 deficiency. However, TTC19 deficient patients do show characteristic clinical and neuroimaging features, which may facilitate diagnosis of this yet rare disorder. Normal MRC complex III activity does not exclude the diagnosis