18 research outputs found
Neutrino masses: From fantasy to facts
Theory suggests the existence of neutrino masses, but little more. Facts are
coming close to reveal our fantasy: solar and atmospheric neutrino data
strongly indicate the need for neutrino conversions, while LSND provides an
intriguing hint. The simplest ways to reconcile these data in terms of neutrino
oscillations invoke a light sterile neutrino in addition to the three active
ones. Out of the four neutrinos, two are maximally-mixed and lie at the LSND
scale, while the others are at the solar mass scale. These schemes can be
distinguished at neutral-current-sensitive solar & atmospheric neutrino
experiments. I discuss the simplest theoretical scenarios, where the lightness
of the sterile neutrino, the nearly maximal atmospheric neutrino mixing, and
the generation of & all follow
naturally from the assumed lepton-number symmetry and its breaking. Although
the most likely interpretation of the present data is in terms of
neutrino-mass-induced oscillations, one still has room for alternative
explanations, such as flavour changing neutrino interactions, with no need for
neutrino mass or mixing. Such flavour violating transitions arise in theories
with strictly massless neutrinos, and may lead to other sizeable flavour
non-conservation effects, such as , conversion in
nuclei, unaccompanied by neutrino-less double beta decay.Comment: 33 pages, latex, 16 figures. Invited Talk at Ioannina Conference,
Symmetries in Intermediate High Energy Physics and its Applications, Oct.
1998, to be published by Springer Tracts in Modern Physics. Festschrift in
Honour of John Vergados' 60th Birthda
Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer
ABSTRACT Liquid biopsies, examinations of tumor components in body fluids, have shown promise for predicting clinical outcomes. To evaluate tumor-associated genomic and genetic variations in plasma cell-free DNA (cfDNA) and their associations with treatment response and overall survival, we applied whole genome and targeted sequencing to examine the plasma cfDNAs derived from 20 patients with advanced prostate cancer. Sequencing-based genomic abnormality analysis revealed locusspecific gains or losses that were common in prostate cancer, such as 8q gains, AR amplifications, PTEN losses and TMPRSS2-ERG fusions. To estimate tumor burden in cfDNA, we developed a Plasma Genomic Abnormality (PGA) score by summing the most significant copy number variations. Cox regression analysis showed that PGA scores were significantly associated with overall survival (p < 0.04). After androgen deprivation therapy or chemotherapy, targeted sequencing showed significant mutational profile changes in genes involved in androgen biosynthesis, AR activation, DNA repair, and chemotherapy resistance. These changes may reflect the dynamic evolution of heterozygous tumor populations in response to these treatments. These results strongly support the feasibility of using non-invasive liquid biopsies as potential tools to study biological mechanisms underlying therapy-specific resistance and to predict disease progression in advanced prostate cancer