Non-symmetric liquid crystal dimer containing a carbohydrate-based moiety

Peer reviewedPublisher PD

Dielectric resonances of ordered passive arrays

The electrical and optical properties of ordered passive arrays, constituted of inductive and capacitive components, are usually deduced from Kirchhoff's rules. Under the assumption of periodic boundary conditions, comparable results may be obtained via an approach employing transfer matrices. In particular, resonances in the dielectric spectrum are demonstrated to occur if all eigenvalues of the transfer matrix of the entire array are unity. The latter condition, which is shown to be equivalent to the habitual definition of a resonance in impedance for an array between electrodes, allows for a convenient and accurate determination of the resonance frequencies, and may thus be used as a tool for the design of materials with a specific dielectric response. For the opposite case of linear arrays in a large network, where periodic boundary condition do not apply, several asymptotic properties are derived. Throughout the article, the derived analytic results are compared to numerical models, based on either Exact Numerical Renormalisation or the spectral method.Comment: 12 pages, 12 figure

Calculation of the Phase Behavior of Lipids

The self-assembly of monoacyl lipids in solution is studied employing a model in which the lipid's hydrocarbon tail is described within the Rotational Isomeric State framework and is attached to a simple hydrophilic head. Mean-field theory is employed, and the necessary partition function of a single lipid is obtained via a partial enumeration over a large sample of molecular conformations. The influence of the lipid architecture on the transition between the lamellar and inverted-hexagonal phases is calculated, and qualitative agreement with experiment is found.Comment: to appear in Phys.Rev.

Ultra-high-resolution software-defined photonic terahertz spectroscopy

A novel technique for high-resolution 1.5 µm photonics-enabled terahertz (THz) spectroscopy using software control of the illumination spectral line shape (SLS) is presented. The technique enhances the performance of a continuous-wave THz spectrometer to reveal previously inaccessible details of closely spaced spectral peaks. We demonstrate the technique by performing spectroscopy on LiYF4:Ho3+, a material of interest for quantum science and technology, where we discriminate between inhomogeneous Gaussian and homogeneous Lorentzian contributions to absorption lines near 0.2 THz. Ultra-high-resolution (<100 Hz full-width at half maximum) frequency-domain spectroscopy with quality factor Q > 2 × 109 is achieved using an exact frequency spacing comb source in the optical communications band, with a custom uni-traveling-carrier photodiode mixer and coherent down-conversion detection. Software-defined time-domain modulation of one of the comb lines is demonstrated and used to resolve the sample SLS and to obtain a magnetic field-free readout of the electronuclear spectrum for the Ho3+ ions in LiYF4:Ho3+. In particular, homogeneous and inhomogeneous contributions to the spectrum are readily separated. The experiment reveals previously unmeasured information regarding the hyperfine structure of the first excited state in the 5 I8 manifold complementing the results reported in Phys. Rev. B 94, 205132 (2016)

New type of microengine using internal combustion of hydrogen and oxygen

Microsystems become part of everyday life but their application is restricted by lack of strong and fast motors (actuators) converting energy into motion. For example, widespread internal combustion engines cannot be scaled down because combustion reactions are quenched in a small space. Here we present an actuator with the dimensions 100x100x5 um^3 that is using internal combustion of hydrogen and oxygen as part of its working cycle. Water electrolysis driven by short voltage pulses creates an extra pressure of 0.5-4 bar for a time of 100-400 us in a chamber closed by a flexible membrane. When the pulses are switched off this pressure is released even faster allowing production of mechanical work in short cycles. We provide arguments that this unexpectedly fast pressure decrease is due to spontaneous combustion of the gases in the chamber. This actuator is the first step to truly microscopic combustion engines.Comment: Paper and Supplementary Information (to appear in Scientific Reports

Microfluidic generation of droplet interface bilayer networks incorporating real-time size sorting in linear and non-linear configurations

In this study, a novel droplet based microfluidic method for the generation of different sized droplet interface bilayers is reported. A microfluidic platform was designed, which allows the generation and packing of picoliter lipid coated water droplets. Droplets were generated by hydrodynamic focusing coupled with selective transport along grooves according to their size. A trapping structure at the end of the groove and a fine control of the flow pressures allowed for the droplets to be successfully trapped and aligned on demand. This technology facilitates the fine control of droplet size production as well as the generation of extended networks from a variety of lipids including 1,2-diphytanoyl-sn-glycero-3-phosphocholine and 1,2-dioleoyl-sn-glycero-3-phosphocholine in linear and non-linear configurations, which is vital to the application of Droplet Interface Bilayers to biological network construction on-chip

Human cytomegalovirus immunoglobulin G response and pulmonary tuberculosis in adolescents: a case-control study

Background Emerging evidence suggests a link between infection with herpes viruses, particularly human cytomegalovirus (HCMV) and Epstein Barr Virus (EBV), and progression to tuberculosis (TB) disease. Methods An unmatched case-control study was conducted amongst adolescents aged 10-19 years enrolled in an observational study (Teen TB), between November 2020 and November 2021, in Cape Town, South Africa. Fifty individuals with pulmonary TB and 51 healthy TB-exposed individuals without TB were included. Demographics and clinical data were obtained, and serum samples collected at enrolment were tested for HCMV IgG and EBV Nuclear Antigen (EBNA) IgG using two automated enzyme immunoassays. Odds ratios (ORs) were estimated using unconditional logistic regression. Results The median age of 101 participants was 15 years (interquartile range [IQR] 13 to 17); 55 (54%) were female. All participants were HCMV IgG seropositive and 95% were EBNA IgG seropositive. Individuals with TB had higher HCMV IgG titres than healthy controls (p=0.04). Individuals with upper tertile HCMV IgG titres had a 3.7 times greater odds of pulmonary TB compared to those with IgG titres in the lower tertile (95%CI: 1.05–12.84; p=0.04). There was a trend for increasing odds of pulmonary TB with increasing titres of HCMV IgG (p=0.04). In contrast, there was no association between TB and higher EBNA IgG values. Conclusions There is a high prevalence of sensitisation to HCMV and EBV amongst adolescents in this high-TB burden setting. Higher HCMV IgG titres were associated with pulmonary TB in adolescents

Drug design for ever, from hype to hope

In its first 25 years JCAMD has been disseminating a large number of techniques aimed at finding better medicines faster. These include genetic algorithms, COMFA, QSAR, structure based techniques, homology modelling, high throughput screening, combichem, and dozens more that were a hype in their time and that now are just a useful addition to the drug-designers toolbox. Despite massive efforts throughout academic and industrial drug design research departments, the number of FDA-approved new molecular entities per year stagnates, and the pharmaceutical industry is reorganising accordingly. The recent spate of industrial consolidations and the concomitant move towards outsourcing of research activities requires better integration of all activities along the chain from bench to bedside. The next 25 years will undoubtedly show a series of translational science activities that are aimed at a better communication between all parties involved, from quantum chemistry to bedside and from academia to industry. This will above all include understanding the underlying biological problem and optimal use of all available data