8 research outputs found
Informed consent in biobank research: A deliberative approach to the debate
As acknowledged in the literature, public consultation related to biobanks has been largely oriented to assuring and informing rather than seeking considered input. In April and May of 2007, the authors participated in running a deliberative public engagement event in British Columbia, Canada, which sought to enhance public input related to the governance of biobanks. The topic of the event was 'Biobanking in British Columbia (BC)' and at the event a random-digit dialed demographically stratified sample of 21 participants deliberated on what values and interests ought to be considered in the regulation and use of biobanks for health research. In this paper, we report results related to debate over the place of informed consent in biobank research. Drawing on a pre/post-survey and qualitative analysis of event transcripts, we show that participants indicated strong support for biobanks, for a general reduction in concern for withdrawal of samples, and placed a strong emphasis on the need for review of biobanks research that is independent of funders and researchers. In this context, there was persistent disagreement about when consent was required for new research activities.Informed consent Biobanks Public engagement Deliberative democracy Canada
The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG
Dictyostelium RasG has been implicated in the regulation of a variety of cellular processes, including the initiation of development, cell movement, and cytokinesis, but the molecular components of the signaling pathways involved are largely unknown. We used a tetracycline-regulated protein expression system to study the effect of activated RasG, RasG(G12T), expression on the phosphorylation state of Dictyostelium proteins. Over 70 vegetative phosphoprotein components were resolved by two-dimensional (2-D) immunoblot analysis and of these 16 phosphothreonine and three phosphotyrosine protein components were found to reproducibly change upon RasG(G12T) expression. Thirteen of these were recovered from 2-D gels and identified by mass spectrometry of in-gel tryptic digestions. The proteins identified include the signaling proteins RasGEF-R and protein kinase B, the adhesion protein DdCAD-1, the cytoskeletal protein actin, the mitochondrial division protein FtsZA, and proteins involved in translation and metabolism. In addition to the direct demonstration of the phosphorylation of putative downstream targets of RasG activation, these findings reveal previously undetected phosphorylation of several proteins
Responsible innovation: an approach for extracting public values concerning advanced biofuels
<div><p>The objective of our study was to test an approach for extracting public values concerning a virtually unknown and scientifically complex topic, namely advanced lignocellulosic biofuels, in order to foster responsible innovation of this novel technology in Canada as early on in the policy-making process as possible. As advanced lignocellulosic biofuels are currently an emerging form of liquid fuel for transport, it may be beneficial to open the development of this technology to “upstream” public input. We thereby explore how a deliberative mini-public views the need for advanced lignocellulosic biofuels and their recommendations for supporting or opposing its development and production. Participants of the study engaged in four days of deliberation on their value-based considerations concerning the social acceptability of this technology. On the final day, they developed a series of collective recommendations on three participant-generated agenda items: economic sustainability, unknown environmental and health impacts, and governance issues related to responsibility for advanced biofuels policy. The results provide a novel input into interdisciplinary research aimed at better understanding what may be driving public values on wider, sometimes controversial, issues related to biofuels.</p></div
Avoiding catastrophes: seeking synergies among the public health, environmental protection, and human security sectors
Global health catastrophes have complex origins, often rooted in social disruption, poverty, conflict, and environmental collapse. Avoiding them will require a new integrative analysis of the links between disease, armed conflict, and environmental degradation within a socioecological vulnerability and human security context. Exploring these connections was the aim of Avoiding Catastrophe: Linking Armed Conflict, Harm to Ecosystems, and Public Health, an expert workshop held in May 4–6, 2016, at Concordia University in Montreal, QC, Canada