Candidates for multiple impact craters?: Popigai and Chicxulub as seen by the global high resolution gravitational field model EGM2008

In 2008 the new Earth Gravitational Model (EGM2008) was released. It contains a complete set of spherical harmonic coefficients of the Earth's gravitational potential (Stokes parameters) to degree 2190 and order 2159 and selected orders to degree 2190, that can be used for evaluation of various potential quantities with both the unprecedented accuracy and high spatial resolution. Two such quantities, the gravity anomaly and second-order radial derivative of the disturbing potential, were computed over selected areas with known impact craters. The displays of these derivatives for two such sites clearly show not only the strong circular-like features known to be associated with them but also other symmetrical structures which appear to make them multiple impact sites. At Popigai, Siberia, the series of circular features fall in a line from the "primary crater" in the southeast (SE) direction. At Chicxulub, Yucatán, there appears to be one more crater close to the "primary" in the northeast (NE) direction, as well as possibly others in the vicinity of the main crater (SW). Gravity information alone is not, however, proof of impact craters but it is useful in identifying <i>candidate sites</i> for further study, for examination by geologists and geophysicists. In the case of Chicxulub, a very recent single seismic profile suggests that a more likely explanation for the observed circular like gravity signal from EGM2008 NE of the "primary" is a pre-impact basin

Long-Term Impact of Single Epilepsy Training on Knowledge, Attitude and Practices: Comparison of Trained and Untrained Rwandan Community Health Workers

Objectives: To close the epilepsy treatment gap and reduce related stigma, eradication of misconceptions is importantIn 2014, Community Health Workers (CHWs) from Musanze (Northern Rwanda) were trained on different aspects of epilepsy. This study compared knowledge, attitude and practices (KAPs) towards epilepsy of trained CHWs 3 years after training, to untrained CHWs from Rwamagana (Eastern Rwanda).Methods: An epilepsy KAP questionnaire was administered to 96 trained and 103 untrained CHWs. Demographic and intergroup KAP differences were analysed by response frequencies. A multivariate analyses was performed based on desired and undesired response categories.Results: Epilepsy awareness was high in both groups, with better knowledge levels in trained CHWs. Negative attitudes were lowest in trained CHWs, yet 17% still reported misconceptions. Multivariate analysis demonstrated the impact of the training, irrespective of age, gender and educational level. Knowing someone with epilepsy significantly induced more desired attitudes.Conclusion: Despite demographic differences between trained and untrained CHWs, a single epilepsy training resulted in significant improvement of desired KAPs after 3 years. Nation-wide CHW training programs with focus on training-resistant items, e.g., attitudes, are recommended

A first Alps - dedicated gravity data set - introduction and status of the AlpArray gravity field activities

In this contribution, activities of the AlpArray Gravity Research Group (AAGRG) are introduced. Since 2018, this group in the frame of the AlpArray project (http://www.alparray.ethz.ch/en/home/) prepares gravity and other data sets to support multidisciplinary goals of the project. It is focused on the mantle, plate and surface processes in the Alps-Apennines-Carpathians-Dinarides orogenic system. In 2018, the AAGRG set up its own methodology guidelines and assembled available land-gravity data and digital elevation model (DEM) data from all the participating countries. Our presentation targets especially three goals: 1) to introduce AAGRG activities as an integral part of the AlpArray project for studying Alpine orogeny \u2013 a goal that by definition requires international cooperation, 2) to review the input data and the works accomplished so far, and, 3) to discuss the steps to be taken to produce detailed gravity maps of the region \u2013 the first Alps-dedicated gravity field data set. We plan to prepare gravity grids in a homogeneous processing approach of either 2x2 km or 4x4 km resolution, depending on the coverage and data quality. The final data sets will be made public in late 2019. A special emphasis is put on the calculation of the Bouguer anomaly using ellipsoidal rather tha normal heights. For calculating topographic effects the preference is given to local DEMs, where available, as they often provide higher quality and spatial resolutions. The public gravity data sets are evaluated with the high-resolution geopotential models like EIGEN-6C4 or EGM2008 \u2013 a useful means for identifying biases in the data coming from various countries and campaigns

Strategic research agenda for biomedical imaging

This Strategic Research Agenda identifies current challenges and needs in healthcare, illustrates how biomedical imaging and derived data can help to address these, and aims to stimulate dedicated research funding efforts. Medicine is currently moving towards a more tailored, patient-centric approach by providing personalised solutions for the individual patient. Innovation in biomedical imaging plays a key role in this process as it addresses the current needs for individualised prevention, treatment, therapy response monitoring, and image-guided surgery. The use of non-invasive biomarkers facilitates better therapy prediction and monitoring, leading to improved patient outcomes. Innovative diagnostic imaging technologies provide information about disease characteristics which, coupled with biological, genetic and -omics data, will contribute to an individualised diagnosis and therapy approach. In the emerging field of theranostics, imaging tools together with therapeutic agents enable the selection of best treatments and allow tailored therapeutic interventions. For prenatal monitoring, the use of innovative imaging technologies can ensure an early detection of malfunctions or disease. The application of biomedical imaging for diagnosis and management of lifestyle-induced diseases will help to avoid disease development through lifestyle changes. Artificial intelligence and machine learning in imaging will facilitate the improvement of image interpretation and lead to better disease prediction and therapy planning. As biomedical imaging technologies and analysis of existing imaging data provide solutions to current challenges and needs in healthcare, appropriate funding for dedicated research is needed to implement the innovative approaches for the wellbeing of citizens and patients

Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein

A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton addition to the glycosidic nitrogen N9 of oxoG from the Nε-ammonium of Lys249 residue of hOGG1 that is enabled owing to the N9 pyramidal geometry. The N9-pyramidalization of oxoG is induced within hOGG1 active site. The coordination of N9 nitrogen to the Nε-ammonium of Lys249 unveiled by available crystal structures enables concerted, synchronous substitution of the N9−C1′ bond by the N9−H bond. The reaction is compared with other pathways already proposed by means of calculated activation energies. The ΔG# energy for the newly proposed reaction mechanism calculated with the B3LYP/6-31G(d,p) method 17.0 kcal mol−1 is significantly lower than ΔG# energies for other reactions employing attack of the Nε-amino group to the anomeric carbon C1′ of oxoG and attack of the Nε-ammonium to the N3 nitrogen of oxoG base. Moreover, activation energy for the oxoG cleavage proceeding via N9-pyramidalization is lower than energy calculated for normal G because the electronic state of the five-membered aromatic ring of oxoG is better suited for the reaction. The modification of aromatic character introduced by oxidation to the nucleobase thus seems to be the factor that is checked by hOGG1 to achieve base-specific cleavage

Benchmark forward gravity schemes: the gravity field of a realistic lithosphere model WINTERC-G

Several alternative gravity forward modelling methodologies and associated numerical codes with their own advantages and limitations are available for the solid Earth community. With upcoming state-of-the-art lithosphere density models and accurate global gravity field data sets, it is vital to understand the opportunities and limitations of the various approaches. In this paper, we discuss the four widely used techniques: global spherical harmonics (GSH), tesseroid integration (TESS), triangle integration (TRI), and hexahedral integration (HEX). A constant density shell benchmark shows that all four codes can produce similar precise gravitational potential fields. Two additional shell tests were conducted with more complicated density structures: laterally varying density structures and a crust-mantle interface density. The differences between the four codes were all below 1.5% of the modelled gravity signal suitable for reproducing satellite-acquired gravity data. TESS and GSH produced the most similar potential fields (<0.3 %). To examine the usability of the forward modelling codes for realistic geological structures, we use the global lithosphere model WINTERC-G that was constrained, among other data, by satellite gravity field data computed using a spectral forward modelling approach. This spectral code was benchmarked against the GSH, and it was confirmed that both approaches produce a similar gravity solution with negligible differences between them. In the comparison of the different WINTERC-G-based gravity solutions, again GSH and TESS performed best. Only short-wavelength noise is present between the spectral and tesseroid forward modelling approaches, likely related to the different way in which the spherical harmonic analysis of the varying boundaries of the mass layer is performed. The spherical harmonic basis functions produce small differences compared to the tesseroid elements, especially at sharp interfaces, which introduces mostly short-wavelength differences. Nevertheless, both approaches (GSH and TESS) result in accurate solutions of the potential field with reasonable computational resources. Differences below 0.5% are obtained, resulting in residuals of 0.076 mGal standard deviation at 250 km height. The biggest issue for TRI is the characteristic pattern in the residuals that is related to the grid layout. Increasing the resolution and filtering allow for the removal of most of this erroneous pattern, but at the expense of higher computational loads with respect to the other codes. The other spatial forward modelling scheme, HEX, has more difficulty in reproducing similar gravity field solutions compared to GSH and TESS. These particular approaches need to go to higher resolutions, resulting in enormous computation efforts. The hexahedron-based code performs less than optimal in the forward modelling of the gravity signature, especially with a laterally varying density interface. Care must be taken with any forward modelling software as the approximation of the geometry of the WINTERC-G model may deteriorate the gravity field solution

Benchmark forward gravity schemes: the gravity field of a realistic lithosphere model WINTERC-G

Several alternative gravity forward modelling methodologies and associated numerical codes with their own advantages and limitations are available for the solid Earth community. With upcoming state-of-the-art lithosphere density models and accurate global gravity field data sets, it is vital to understand the opportunities and limitations of the various approaches. In this paper, we discuss the four widely used techniques: global spherical harmonics (GSH), tesseroid integration (TESS), triangle integration (TRI), and hexahedral integration (HEX). A constant density shell benchmark shows that all four codes can produce similar precise gravitational potential fields. Two additional shell tests were conducted with more complicated density structures: laterally varying density structures and a crust-mantle interface density. The differences between the four codes were all below 1.5% of the modelled gravity signal suitable for reproducing satellite-acquired gravity data. TESS and GSH produced the most similar potential fields (<0.3 %). To examine the usability of the forward modelling codes for realistic geological structures, we use the global lithosphere model WINTERC-G that was constrained, among other data, by satellite gravity field data computed using a spectral forward modelling approach. This spectral code was benchmarked against the GSH, and it was confirmed that both approaches produce a similar gravity solution with negligible differences between them. In the comparison of the different WINTERC-G-based gravity solutions, again GSH and TESS performed best. Only short-wavelength noise is present between the spectral and tesseroid forward modelling approaches, likely related to the different way in which the spherical harmonic analysis of the varying boundaries of the mass layer is performed. The spherical harmonic basis functions produce small differences compared to the tesseroid elements, especially at sharp interfaces, which introduces mostly short-wavelength differences. Nevertheless, both approaches (GSH and TESS) result in accurate solutions of the potential field with reasonable computational resources. Differences below 0.5% are obtained, resulting in residuals of 0.076 mGal standard deviation at 250 km height. The biggest issue for TRI is the characteristic pattern in the residuals that is related to the grid layout. Increasing the resolution and filtering allow for the removal of most of this erroneous pattern, but at the expense of higher computational loads with respect to the other codes. The other spatial forward modelling scheme, HEX, has more difficulty in reproducing similar gravity field solutions compared to GSH and TESS. These particular approaches need to go to higher resolutions, resulting in enormous computation efforts. The hexahedron-based code performs less than optimal in the forward modelling of the gravity signature, especially with a laterally varying density interface. Care must be taken with any forward modelling software as the approximation of the geometry of the WINTERC-G model may deteriorate the gravity field solution

Réalisation et caractérisation de dépôts microniques de composés à haut indice de réfraction,à base de sels de zinc,sur des particules de carbonate de calcium

STRASBOURG-Sc. et Techniques (674822102) / SudocSudocFranceF