Reflections of the past

Taha Toros Arşivi, Dosya No: 190-MüzelerUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

Bilateral intracerebral hemorrhage of basal ganglion: a case report

Serebral kanamanın en sık gözlendigi bölgeler putamen, temporal lob, parietal lob veya frontal lobların santral maddesi, thalamus, serebllar hemisfer ve beyin sapında ponstur. Bazal ganglionlar hipertansiyona baglı intraserebral hemorajinin (ISH) en yaygın gözlendigi bölgedir. Etyolojisinde hipertansiyon, vasküler anomaliler, vaskülopatiler, hematolojik bozukluklar, tümörler, antikoagülanlar, ilaçlar rol oynar. Bilateral intraserebral hemoraji (BIH) gelisiminde hipertansiyondan baska metanol intoksikasyonu, etilen glikol intoksikasyonu, neonatal asfiksi, migren ve hiperglisemik hiperosmolar koma ile iliskili vakalar da bildirilmistir. Hipertansiyona baglı olarak bilateral bazal ganglion kanaması az rastlanılan bir tablodur. Bu olgu sunumunda, sol hemiparezisi olan, risk faktörü olarak hipertansiyon ve diabeti bulunan ve hipertansiyona baglı bilateral intraserebral hemoraji gelisen bir hastadan bahsedecegiz.Cerebral hemorrhages are mainly seen in the area of the central matter of putamen, temporal lobe, parietal lobe or frontal lobe, thalamus, cerebellar hemisphere and pons in the brainstem. Hypertension related intracranial hemorrhages are most commonly seen in basal ganglia. The etiology of the hemorrhages are hypertension, vascular anomalies, vasculopaties, hematological disease, tumors, anticoagulant drugs. Besides hypertension, methanol or ethylene glycol intoxication, neonatal asphyxia, migraine and hyperglycemic hyperosmolar coma are also related with this condition. In this case report we discuss a patient with hypertension and diabetes mellitus who developed bilateral intracerebral hemorrhages of the basal ganglia

COVID-19 in pediatric nephrology centers in Turkey

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10–15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients’ susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage

ACOUSTICAL ANALYSIS OF A THEATRE: İSTANBUL METROPOLITAN MUNICIPALITY BEYOĞLU THEATRE AS A CASE STUDY

Bu tez çalışmasında, özellikle işitsel açıdan önemli olan mekanların tasarımıyla ilgilenenlere konu hakkında bilgiler sunulmuş, bir tiyatro salonunun hacim akustiği açısından incelenmesinde kullanılabilecek performans kriterleri geliştirilerek, seçilen bir salon, akustik konfor koşulları açısından değerlendirilmiştir. Bu bağlamda, araştırma için İstanbul Büyükşehir Belediyesi'nin açtığı Beyoğlu Sahnesi yarışmasında birincilik ödülünü alan, tez danışmanım Sayın Prof. Dr. Füsun Demirel'in de projede akustik danışman olarak görev aldığı proje, örnek olarak seçilmiştir. Projede yer alan üç salondan büyük salonun akustik konforunu ortaya koyan çınlama süresi (RT), erken sönümleme süresi (EDT), berraklık (C80), belirginlik (D50), erken yanal yansıma oranı (LF80), konuşma iletim indisi (STI) gibi performans kriterleri, ODEON bilgisayar yazılımı aracılığı ile analiz edilerek ortaya konmuştur.This thesis aims to uncover the performance criteria regarding acoustic comfort of theatre halls and the effects of these criteria on sound quality in these halls. As the case, the project, which recieved the first prize from İstanbul Metropolitan Municipality at Beyoğlu Scene quest and to which my thesis supervisor Prof. Dr. Füsun Demirel contributed as the acoustics advisor, is depicted. Among the three halls of the Project, the Grand hall is analyzed using ODEON software in terms of performance criteria regarding reverberation time (RT), early decay time (EDT), clarity (C80), definition (D50), early lateral fraction (LF80), speech transmission index ( STI)

The role of molds in the relation between indoor environment and atopy in asthma patients

The effect of mold fungi to allergic sensitization is not well-known. We aimed to evaluate the role of molds in the relation between indoor environment and atopy in asthmatics. Materials and Methods: The air samples obtained from 66 stable asthmatics and 35 control subject's houses were sprayed into Sabouraud dextrose agar. Allergy skin testing were performed in both groups. The temperature and humidity of each house were measured. Results: The incidence of atopy was similar in cases (59.1%) and controls (51.4%). The average amount of mold was 35.9 CFU/m3 and 34.3 CFU/m3, respectively. The number of household residents was positively correlated with the amount of molds. There was no difference in the amount of mold with respect to dosage of inhaler corticosteroids as well as symptom levels in asthmatics. The most frequently encountered allergens were Dermatophagoides farinae/Dermatophagoides pteronyssinus, grass/weeds and molds. Spending childhood in a village was more common among atopics. Conclusion: Living environment during the childhood might affect atopy and asthma. Based on the identification of molds as the second most frequent allergen after mites in our study population, assessment of mold sensitization as well as in forming patients about ways to avoid them seem likely to contribute to the effective management of uncontrolled asthma

Rituximab treatment for difficult-to-treat nephrotic syndrome in children: A multicenter, retrospective study

Background/aim: This study aimed to evaluate the efficacy of rituximab in children with difficult-to-treat nephrotic syndrome, considering the type of disease (steroid-sensitive or -resistant) and the dosing regimen. Materials and methods: This multicenter retrospective study enrolled children with difficult-to-treat nephrotic syndrome on rituximab treatment from 13 centers. The patients were classified based on low (single dose of 375 mg/m(2)) or high (2-4 doses of 375 mg/m(2)) initial dose of rituximab and the steroid response. Clinical outcomes were compared. Results: Data from 42 children [20 steroid-sensitive (frequent relapsing / steroid-dependent) and 22 steroid-resistant nephrotic syndrome, aged 1.9-17.3 years] were analyzed. Eleven patients with steroid-sensitive nephrotic syndrome (55%) had a relapse following initial rituximab therapy, with the mean time to first relapse of 8.4 +/- 5.2 months. Complete remission was achieved in 41% and 36% of steroid-resistant patients, with the median remission time of 3.65 months. At Year 2, eight patients in steroid-sensitive group (40%) and four in steroid-resistant group (18%) were drug-free. Total cumulative doses of rituximab were higher in steroid-resistant group (p = 001). Relapse rates and time to first relapse in steroid-sensitive group or remission rates in steroid-resistant group did not differ between the low and high initial dose groups. Conclusion: The current study reveals that rituximab therapy may provide a lower relapse rate and prolonged relapse-free survival in the steroid-sensitive group, increased remission rates in the steroid-resistant group, and a significant number of drug-free patients in both groups. The optimal regimen for initial treatment and maintenance needs to be determined