Tetravalent Chromium (Cr(4+)) as Laser-Active Ion for Tunable Solid-State Lasers

During 10/31/92 - 3/31/93, the following summarizes our major accomplishments: (1) the self-mode-locked operation of the Cr:forsterite laser was achieved; (2) synchronous pumping was used to mode lock the forsterite laser resulting in picosecond pulses, which in turn provided the starting mechanism for self-mode-locking; and (3) the pulses generated had a FWHW of 105 fs and were tunable between 1230 - 1270 nm

Tetravalent Chromium (Cr(4+)) as Laser-Active Ion for Tunable Solid-State Lasers

During 10/31/91 - 3/31/92, the following summarizes are major accomplishments: (1) numerical modeling of the four mirror astigmatically compensated, Z-fold cavity was performed; and (2) the simulation revealed several design parameters to be used for the construction of a femtosecond forsterite laser

Tetravalent chromium (Cr(4+)) as laser-active ion for tunable solid-state lasers

Major accomplishments under NASA grant NAG-1-1346 are summarized. (1) numerical modeling of the four mirror astigmatically compensated, Z-fold cavity was performed and several design parameters to be used for the construction of a femtosecond forsterite laser were revealed by simulation. (2) femtosecond pulses from a continuous wave mode-locked chromium doped forsterite laser were generated. The forsterite laser was actively mode-locked using an acousto-optic modulator operating at 78 MHz with two Brewster high dispersion glass prisms for intra-cavity chirp compensation. Transform-limited sub-100-fs pulses were routinely generated in the TEM(sub 00) mode with 85 mW of continuous power tunable over 1230-1280 nm. The shortest pulses of 60-fs pulsewidth were measured. (3) Self-mode-locked operation of the Cr:forsterite laser was achieved. Synchronous pumping was used to mode lock the forsterite laser resulting in picosecond pulses, which in turn provided the starting mechanism for self-mode-locking. The pulses generated had an FWHM of 105 fs and were tunable between 1230-1270 nm. (4) Numerical calculations indicated that the pair of SF 14 prisms used in the cavity compensated for quadratic phase but introduced a large cubic phase term. Further calculations of other optical glasses indicated that a pair of SFN 64 prisms can introduce the same amount of quadratic phase as SF 14 prisms but introduce a smaller cubic phase. When the SF 14 prisms were replaced by SFN 64 prisms the pulsewidth was reduced to 50 fs. Great improvement was observed in the stability of the self mode-locked forsterite laser and in the ease of achieving mode locking. Using the same experimental arrangement and a new forsterite crystal with improved FOM the pulse width was reduced to 36 fs

Tetravalent chromium (Cr(4+)) as laser-active ion for tunable solid-state lasers

Generation of femtosecond pulses from a continuous-wave mode-locked chromium-doped forsterite (Cr(4+):Mg2SiO4) laser has been accomplished. The forsterite laser was actively mode-locked using an acousto-optic modulator operating at 78 MHz with two Brewster high-dispersion glass prisms for intra-cavity chirp compensation. Transform-limited sub-100-fs pulses were routinely generated in the TEM(sub 00) mode with 85 mW of continuous power (with 1 percent output coupler), tunable over 1230-1280 nm. The shortest pulses of 60-fs pulsewidth were measured

Prevalence, risk factors, and treatment outcomes of isoniazid- and rifampicin-mono-resistant pulmonary tuberculosis in Lima, Peru

Background : Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes. Methods : A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB from 34 health facilities in a northern district of Lima, Peru, from March 2010 through December 2011. Participants were interviewed and a sputum sample was cultured on Lowenstein-Jensen (LJ) media. Drug susceptibility testing was performed using the proportion method. Medication regimens were documented for each patient. Our primary outcomes were treatment outcome at the end of treatment. The secondary outcome included recurrent episodes among cured patients within two years after completion of the treatment. Results : Of 1292 patients enrolled, 1039 (80%) were culture-positive. From this subpopulation, isoniazid mono-resistance was present in 85 (8%) patients and rifampicin mono-resistance was present in 24 (2%) patients. In the multivariate logistic regression model, isoniazid mono-resistance was associated with illicit drug use (adjusted odds ratio (aOR) = 2.10; 95% confidence interval (CI): 1.1-4.1), and rifampicin mono-resistance was associated with HIV infection (aOR = 9.43; 95% CI: 1.9-47.8). Isoniazid mono-resistant patients had a higherrisk of poor treatment outcomes including treatment failure (2/85, 2%, p-value<0.01) and death (4/85, 5%, p<0.02). Rifampicin mono-resistant patients had a higher risk of death (2/24,8%, p<0.01). Conclusion : A high prevalence of isoniazid and rifampicin mono-resistance was found among TB patients in our low HIV burden setting which were similar to regions with high HIV burden. Patients with isoniazid and rifampicin mono-resistance had an increased risk of poor treatment outcomes

Optical Communications Systems for NASA's Human Space Flight Missions

The Laser-Enhanced Mission Communications Navigation and Operational Services (LEMNOS) office at Goddard Space Flight Center (GSFC) manages two NASA optical communication related projects, the Orion EM-2 Optical Communications Terminal (O2O) and the Integrated Laser Communications Relay Demonstration (LCRD) Low-Earth Orbit (LEO) User Modem and Amplifier Terminal (ILLUMA-T) projects. The main goal of LEMNOS is the advancement and implementation of optical communications systems and technologies for NASA missions. The O2O mission is sponsored by NASA's Human Exploration and Operations (HEO) Mission Directorate. The O2O project will provide optical communications capability to the Orion series of spacecraft, starting with the demonstration of operational utility on EM-2. It will be the first time a human exploration mission will rely on optical communications for its high-bandwidth link. ILLUMA-T is sponsored by the Space Communications and Navigation (SCaN) Program Office. It is destined for the International Space Station (ISS) as an external payload attached to the Japanese Experiment Module - Exposed Facility (JEM-EF). The ILLUMA-T project is developing an optical communications user terminal to demonstrate high bandwidth data transfer between LEO and the ground through the geosynchronous LCRD relay. ILLUMA-T will be the first demonstration of a LEO user of the LCRD system, pointing and tracking from a moving spacecraft at LEO to GEO satellite and vice versa, end-to-end operational utility of optical communications, and 51 Mbps forward link to ISS from ground. Both projects are collaborations between GSFC, Massachusetts Institute of Technology " Lincoln Laboratory (MIT-LL), and a number of contractors

Optical Communication Activities Through the Laser-Enhanced Mission Communications Navigation and Operational Services (LEMNOS) Office

The Laser-Enhanced Mission Communications Navigation and Operational Services (LEMNOS) office at Goddard Space Flight Center (GSFC) manages two NASA optical communication related projects, the Orion EM-2 Optical Communications Terminal (O2O) and the Integrated Laser Communications Relay Demonstration (LCRD) Low-Earth Orbit (LEO) User Modem and Amplifier Terminal (ILLUMA-T) projects. The main goal of LEMNOS project is to implement optical communications technologies on NASA missions starting with demonstrations of operational utility on Orion EM-2 and the International Space Station

Multi-Watt Average Power Nanosecond Microchip Laser and Power Scalability Estimates

We demonstrated up to 2 W average power, CW-pumped, passively- Q-switched, 1.5 ns monolithic MCL with single-longitudinal mode-operation. We discuss laser design issues to bring the average power to 5-1 OW and beyond

The long-term and interannual variability of summer fresh water storage over the eastern Siberian shelf: Implication for climatic change

A time series of summer fresh water content anomalies (FWCA) over the Laptev and East Siberian sea shelves was constructed from historical hydrographic records for the period from 1920 to 2005. Results from a multiple regression between FCWA and various atmospheric and oceanic indices show that the fresh water content on the shelves is mainly controlled by atmospheric vorticity on quasi-decadal timescales. When the vorticity of the atmosphere on the shelves is antycyclonic, approximately 500 km3 of fresh water migrates from the eastern Siberian shelf to the Arctic Ocean through the northeastern Laptev Sea. When the vorticity of the atmosphere is cyclonic, this fresh water remains on the southern Laptev and East Siberian sea shelves. This FWCA represents approximately 35% of the total fresh water inflow provided by river discharge and local sea-ice melt, and is about ten times larger than the standard deviation of the Lena River summer long-term mean discharge. However, the large interannual and spatial variability in the fresh water content of the shelves, as well as the spatial coverage of the hydrographic data, makes it difficult to detect the long-term tendency of fresh water storage associated with climate change