Interstellar Bubbles in Two Young H II Regions

peer reviewedMassive stars are expected to produce wind-blown bubbles in the interstellar medium; however, ring nebulae, suggesting the existence of bubbles, are rarely seen around main-sequence O stars. To search for wind-blown bubbles around main-sequence O stars, we have obtained high-resolution Hubble Space Telescope WFPC2 images and high-dispersion echelle spectra of two pristine H II regions, N11B and N180B, in the Large Magellanic Cloud. These H II regions are ionized by OB associations that still contain O3 stars, suggesting that the H II regions are young and have not hosted any supernova explosions. Our observations show that wind-blown bubbles in these H II regions can be detected kinematically, but not morphologically, because their expansion velocities are comparable to or only slightly higher than the isothermal sound velocity in the H II regions. Bubbles are detected around concentrations of massive stars, individual O stars, and even an evolved red supergiant (a fossil bubble). Comparisons between the observed bubble dynamics and model predictions show a large discrepancy (1-2 orders of magnitude) between the stellar wind luminosity derived from bubble observations and models and that derived from observations of stellar winds. The number and distribution of bubbles in N11B differ from those in N180B, which can be explained by the difference in the richness of stellar content between these two H II regions. Most of the bubbles observed in N11B and N180B show a blister structure, indicating that the stars were formed on the surfaces of dense clouds. Numerous small dust clouds, similar to Bok globules or elephant trunks, are detected in these H II regions, and at least one of them hosts on-going star formation

Islet Adaptations in Fetal Sheep Persist Following Chronic Exposure to High Norepinephrine

Complications in pregnancy elevate fetal norepinephrine (NE) concentrations. Previous studies in NE-infused sheep fetuses revealed that sustained exposure to high NE resulted in lower expression of α2-adrenergic receptors in islets and increased insulin secretion responsiveness after acutely terminating the NE infusion. In this study, we determined if the compensatory increase in insulin secretion following chronic elevation of NE is independent of hyperglycemia in sheep fetuses and whether it is persistent in conjunction with islet desensitization to NE. Following an initial assessment of glucose-stimulated insulin secretion (GSIS) at 129±1 days of gestation, fetuses were continuously infused for seven days with NE and maintained at euglycemia with a maternal insulin infusion. Fetal GSIS studies were again performed on days 8 and 12. Adrenergic sensitivity was determined in pancreatic islets collected at day 12. NE infusion increased (P\u3c0.01) fetal plasma NE concentrations and lowered (P\u3c0.01) basal insulin concentrations compared to vehicle-infused controls. GSIS was 1.8-fold greater (P\u3c0.05) in NE-infused fetuses compared to controls at both one and five days after discontinuing the infusion. Glucose-potentiated arginine-induced insulin secretion was also enhanced (P\u3c0.01) in NE-infused fetuses. Maximum GSIS in islets isolated from NE-infused fetuses was 1.6-fold greater (P\u3c0.05) than controls, but islet insulin content and intracellular calcium signaling were not different between treatments. The half-maximal inhibitory concentration for NE was 2.6-fold greater (P\u3c0.05) in NE-infused islets compared to controls. These findings show that chronic NE exposure and not hyperglycemia produce persistent adaptations in pancreatic islets that augment β-cell responsiveness in part through decreased adrenergic sensitivity

The NN scattering 3S1-3D1 mixing angle at NNLO

The 3S1-3D1 mixing angle for nucleon-nucleon scattering, epsilon_1, is calculated to next-to-next-to-leading order in an effective field theory with perturbative pions. Without pions, the low energy theory fits the observed epsilon_1 well for momenta less than $\sim 50$ MeV. Including pions perturbatively significantly improves the agreement with data for momenta up to $\sim 150$ MeV with one less parameter. Furthermore, for these momenta the accuracy of our calculation is similar to an effective field theory calculation in which the pion is treated non-perturbatively. This gives phenomenological support for a perturbative treatment of pions in low energy two-nucleon processes. We explain why it is necessary to perform spin and isospin traces in d dimensions when regulating divergences with dimensional regularization in higher partial wave amplitudes.Comment: 17 pages, journal versio

Defining Well Clear Separation for Unmanned Aircraft Systems Operating with Non-Cooperative Aircraft

Detect-and-Avoid (DAA) systems are essential to the safe operations of Unmanned Aircraft Systems, and have the objectives of mitigating collisions with and remaining Well Clear of manned aircraft. This paper analyzes four candidate DAA Well Clear definitions for non-cooperative aircraft using mitigated performance metrics of DAA systems. These DAA Well Clear definitions were proposed in previous work based on their unmitigated collision risk and maneuver initiation range. In this work they are evaluated using safety and operational suitability metrics computed from a large number of representative encounters. Results suggest that although the four candidate DAA Well Clear definitions provide comparable safety, the alerting characteristics give preference for the DAA Well Clear definition without a temporal parameter

Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction

In pregnancies complicated by placental insufficiency and intrauterine growth restriction (IUGR), fetal glucose and oxygen concentrations are reduced, whereas plasma norepinephrine and epinephrine concentrations are elevated throughout the final third of gestation. Here we study the effects of chronic hypoxemia and hypercatecholaminemia on β-cell function in fetal sheep with placental insufficiency-induced IUGR that is produced by maternal hyperthermia. IUGR and control fetuses underwent a sham (intact) or bilateral adrenal demedullation (AD) surgical procedure at 0.65 gestation. As expected, AD-IUGR fetuses had lower norepinephrine concentrations than intact-IUGR fetuses despite being hypoxemic and hypoglycemic. Placental insufficiency reduced fetal weights, but the severity of IUGR was less with AD. Although 2 basal plasma insulin concentrations were lower in intact-IUGR and AD-IUGR fetuses compared with intact-controls, glucose-stimulated insulin concentrations were greater in AD-IUGR fetuses compared with intact-IUGR fetuses. Interestingly, AD-controls had lower glucose- and arginine-stimulated insulin concentrations than intact-controls, but AD-IUGR and AD-control insulin responses were not different. To investigate chronic hypoxemia in the IUGR fetus, arterial oxygen tension was increased to normal levels by increasing the maternal inspired oxygen fraction. Oxygenation of IUGR fetuses enhanced glucose-stimulated insulin concentrations 3.3-fold in intact-IUGR and 1.7-fold in AD-IUGR fetuses but did not lower norepinephrine and epinephrine concentrations. Together these findings show that chronic hypoxemia and hypercatecholaminemia have distinct but complementary roles in the suppression of β-cell responsiveness in IUGR fetuses. Placental insufficiency restricts the supply of oxygen and nutrients to the fetus and causes intrauterine growth restriction (IUGR) (1, 2). The resulting fetal hypoxemia and hypoglycemia provoke endocrine responses that lower plasma insulin concentrations (3,–5). High norepinephrine and epinephrine concentrations are a hallmark of both human and animal IUGR fetuses (6,–11). These high concentrations of catecholamines inhibit insulin secretion from pancreatic β-cells and may contribute to very low insulin concentrations in the IUGR fetus (12, 13). In addition, chronic elevation of norepinephrine has been shown to slow fetal growth and induce asymmetric growth of fetal tissues (14, 15)

Gene content evolution in the arthropods

Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome. Dissection of the genomic record of sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods. Using 76 whole genome sequences representing 21 orders spanning more than 500 million years of arthropod evolution, we document changes in gene and protein domain content and provide temporal and phylogenetic context for interpreting these innovations. We identify many novel gene families that arose early in the evolution of arthropods and during the diversification of insects into modern orders. We reveal unexpected variation in patterns of DNA methylation across arthropods and examples of gene family and protein domain evolution coincident with the appearance of notable phenotypic and physiological adaptations such as flight, metamorphosis, sociality, and chemoperception. These analyses demonstrate how large-scale comparative genomics can provide broad new insights into the genotype to phenotype map and generate testable hypotheses about the evolution of animal diversity

Effects of Language Context on Ratings of Shy and Unsociable Behaviors in English Language Learning Children

Purpose The primary goal of this study was to explore the effect of the language context on the socially withdrawn behaviors of school aged-children who are English Language Learners (ELLs) from middle to high SES backgrounds. This is one of the first studies to address the frequently confused concepts of shyness and unsociability as independent constructs within the ELL population. This study also investigated the feasibility of an experimental parent and child questionnaire that examines shyness and unsociability across native and English speaking contexts. Method Children and parents (34 ELL and 37 native English speaking) were administered an experimental questionnaire examining shy and unsociable behavior in native language and English-speaking contexts. Results Parents and children from the ELL group reported significantly higher ratings of shy behavior in English versus native language contexts, whereas unsociable ratings did not differ across language contexts. Conclusions Shyness and unsociability are distinguishable behaviors in ELL children and these constructs should be considered when examining withdrawal. Additionally, examining ELL children’s behavior across language contexts provides a valuable method for investigating language influenced behavioral problems. This study demonstrates the need for service providers to evaluate behavior across subtype and language context before pathologizing withdrawal in ELL children

HD 100453: A Link Between Gas-Rich Protoplanetary Disks and Gas-Poor Debris Disks

HD 100453 has an IR spectral energy distribution (SED) which can be fit with a power law plus a blackbody. Previous analysis of the SED suggests that the system is a young Herbig Ae star with a gas-rich, flared disk. We reexamine the evolutionary state of the HD 100453 system by refining its age (based on a candidate low-mass companion) and by examining limits on the disk extent, mass accretion rate, and gas content of the disk environment. We confirm that HD 100453B is a common proper motion companion to HD 100453A, with a spectral type of M4.0V-M4.5V, and derive an age of 10 ± 2 Myr. We find no evidence of mass accretion onto the star. Chandra ACIS-S imagery shows that the Herbig Ae star has L x/L bol and an X-ray spectrum similar to nonaccreting β Pic Moving Group early F stars. Moreover, the disk lacks the conspicuous Fe II emission and excess FUV continuum seen in spectra of actively accreting Herbig Ae stars, and from the FUV continuum, we find the accretion rate is \u3c 1.4 × 10–9 M ☉ yr–1. A sensitive upper limit to the CO J = 3–2 intensity indicates that the gas in the outer disk is likely optically thin. Assuming a [CO]/[H2] abundance of 1 × 10–4 and a depletion factor of 103, we find that the mass of cold molecular gas is less than ~0.33 M J and that the gas-to-dust ratio is no more than ~4:1 in the outer disk. The combination of a high fractional IR excess luminosity, a relatively old age, an absence of accretion signatures, and an absence of detectable circumstellar molecular gas suggests that the HD 100453 system is in an unusual state of evolution between a gas-rich protoplanetary disk and a gas-poor debris disk

Data access for the 1,000 Plants (1KP) project

© 2014 Matasci et al.; licensee BioMed Central Ltd. The 1,000 plants (1KP) project is an international multi-disciplinary consortium that has generated transcriptome data from over 1,000 plant species, with exemplars for all of the major lineages across the Viridiplantae (green plants) clade. Here, we describe how to access the data used in a phylogenomics analysis of the first 85 species, and how to visualize our gene and species trees. Users can develop computational pipelines to analyse these data, in conjunction with data of their own that they can upload. Computationally estimated protein-protein interactions and biochemical pathways can be visualized at another site. Finally, we comment on our future plans and how they fit within this scalable system for the dissemination, visualization, and analysis of large multi-species data sets