The influence of tobacco smoking on adhesion molecule profiles

Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. We review the evidence that tobacco smoking dysregulates specific components of the adhesion cascade, which may be a common factor in several smoking-induced diseases. Smoking causes inappropriate leukocyte activation, leukocyte-endothelial adhesion, and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction. Appropriate inflammatory reactions may thus be compromised. In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. This evidence is discussed herein

Clinical presentation, diagnostic findings and outcome of dogs with presumptive spinal-only meningoencephalomyelitis of unknown origin

Objectives: To summarise clinical presentation, diagnostic findings and long-term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone. Methods: Medical records were reviewed for dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin between 2006 and 2015. Results: 21 dogs were included; the majority presented with an acute (43%) or chronic (52%) onset of neurological signs. Ambulatory paresis was the most common neurological presentation (67%). Neurological examination most commonly revealed a T3-L3 myelopathy, and spinal hyperaesthesia was a common finding (71%). A spinal cord lesion was visible in 90% of cases on magnetic resonance imaging. Eighteen lesions (86%) showed parenchymal contrast enhancement and 17 lesions (81%) showed contrast enhancement of overlying meninges. All dogs were treated with immunosuppressive doses of glucocorticosteroids, sometimes combined with cytosine arabinoside. At time of data capture, 10/21 dogs (48%) had died or been euthanased because of the condition. Overall median survival time was 669 days. Clinical Significance: Meningoencephalomyelitis of unknown origin should be considered in the differential diagnosis of dogs presenting with a progressive myelopathy. Magnetic resonance imaging features can possibly help to distinguish presumptive meningoencephalomyelitis of unknown origin from other more common spinal diseases. Overall, long-term survival is guarded, approximately 50% of dogs will die or be euthanased despite appropriate therapy

Correlation length scalings in fusion edge plasma turbulence computations

The effect of changes in plasma parameters, that are characteristic near or at an L-H transition in fusion edge plasmas, on fluctuation correlation lengths are analysed by means of drift-Alfven turbulence computations. Scalings by density gradient length, collisionality, plasma beta, and by an imposed shear flow are considered. It is found that strongly sheared flows lead to the appearence of long-range correlations in electrostatic potential fluctuations parallel and perpendicular to the magnetic field.Comment: Submitted to "Plasma Physics and Controlled Fusion

Fast Community Identification by Hierarchical Growth

A new method for community identification is proposed which is founded on the analysis of successive neighborhoods, reached through hierarchical growth from a starting vertex, and on the definition of communities as a subgraph whose number of inner connections is larger than outer connections. In order to determine the precision and speed of the method, it is compared with one of the most popular community identification approaches, namely Girvan and Newman's algorithm. Although the hierarchical growth method is not as precise as Girvan and Newman's method, it is potentially faster than most community finding algorithms.Comment: 6 pages, 5 figure

Quantum electric-dipole liquid on a triangular lattice

Geometric frustrations and quantum mechanical fluctuations may prohibit the formation of long-range ordering even at the lowest temperature, and therefore liquid-like ground states could be expected. A good example is the quantum spin liquid in frustrated magnets that represents an exotic phase of matter and is attracting enormous interests. Geometric frustrations and quantum fluctuations can happen beyond magnetic systems. Here we propose that quantum electric-dipole liquids, analogs to quantum spin liquids, could emerge in frustrated dielectrics where antiferroelectrically coupled small electric dipoles reside on a triangular lattice. The quantum paraelectric hexaferrite BaFe12O19, in which small electric dipoles originated from the off-center displacement of Fe3+ in the FeO5 bipyramids constitute a two-dimensional triangular lattice, represents a promising candidate to generate the anticipated electric-dipole liquid. We present a series of experimental evidences, including dielectric permittivity, heat capacity, and thermal conductivity measured down to 66 mK, to reveal the existence of a nontrivial ground state in BaFe12O19, characterized by itinerant low-energy excitations with a small gap, to which we interpret as an exotic liquid-like quantum phase. The quantum electric-dipole liquids in frustrated dielectrics open up a fresh playground for fundamental physics and may find applications in quantum information and computation as well.Comment: 13 pages, 6 figure

Analysis of circulating insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in tobacco smokers and non-smokers

<p>Abstract</p> <p>Background</p> <p>IGF-1 and the major serum IGF-1 binding protein, IGFBP-3, are under extensive investigation as potential prognostic markers of specific malignancies and vascular diseases. However, there is conflicting evidence that tobacco smoking may influence systemic concentrations of IGF-1 and IGFBP-3.</p> <p>Subjects and methods</p> <p>Serum concentrations of IGF-1 and IGFBP-3 were measured in 20 smokers and 20 non-smokers, matched for age and gender. Serum concentrations of cotinine, the major metabolite of nicotine, and ICAM-1, known to exhibit a dose-dependent relationship with cotinine, were also assayed.</p> <p>Results</p> <p>There was no difference between the systemic concentrations of IGF-1 or IGFBP-3 found in smokers and non-smokers (IGF-1: mean [s.d]; 104 <abbrgrp><abbr bid="B29">29</abbr></abbrgrp> vs 101 <abbrgrp><abbr bid="B24">24</abbr></abbrgrp> ng ml^-1, respectively; and IGFBP-3: 2562 [522] vs 2447 [570] ng ml^-1, respectively). Similarly, there was no correlation between serum cotinine and IGF-1 or IGFBP-3 concentrations in smokers. Soluble ICAM-1 concentrations were significantly increased in smokers, compared to non-smokers (mean [s.d]; 258 [60] vs 194 [50] ng ml^-1, respectively; p = 0.002).</p> <p>Conclusion</p> <p>There was no relationship noted between tobacco smoking and either IGF-1 or IGFBP-3. These data suggest that smoking would not appear to be a major confounder of the reported clinical associations between IGF-1, IGFBP-3, or IGF-1/IGFBP-3 ratios and specific disease entities.</p

The role of the Bézier extraction operator for T-splines of arbitrary degree: linear dependencies, partition of unity property, nesting behaviour and local refinement

We determine linear dependencies and the partition of unity property of T-spline meshes of arbitrary degree using the Bézier extraction operator. Local refinement strategies for standard, semi-standard and nonstandard T-splines – also by making use of the Bézier extraction operator – are presented for meshes of even and odd polynomial degrees. A technique is presented to determine the nesting between two T-spline meshes, again exploiting the Bézier extraction operator. Finally, the hierarchical refinement of standard, semi-standard and non-standard T-spline meshes is discussed. This technique utilises the reconstruction operator, which is the inverse of the Bézier extraction operator

Pregnancies and associated events in women receiving Enzyme Replacement Therapy for late onset Glycogen Storage Disease Type II (Pompe disease)

AIM: Glycogen storage disease type II (GSD II or Pompe disease; OMIM; 232 300) is a rare autosomal recessive lysosomal storage disorder resulting from deficiency of α-glucosidase and accumulation of glycogen in muscle. Clinical symptoms include weakness of skeletal and respiratory muscles and, in infants, cardiomyopathy. Patients with GSD II receive infusions of recombinant α-glucosidase (enzyme replacement therapy; ERT), which slow the progression of the disease. ERT is given to male and female patients of all ages but as yet little is documented on the effects of continuing ERT during pregnancy. The aim of this case series was therefore to ascertain the pregnancy outcomes of women with GSD II on ERT and to describe adverse events associated with pregnancy, delivery and therapy. METHODS: The medical records of eight women attending the Royal Free Hospital Lysosomal Storage Disorders Unit were reviewed. Four of the eight women had seven pregnancies over a period of 8 years. RESULTS: In this series GSD II was associated with interventional deliveries but normal neonates. Cessation of ERT in early pregnancy resulted in deterioration of maternal symptoms and emergence of allergic reactions on restarting ERT. CONCLUSION: Individualized care plans are required to ensure the best neonatal and maternal outcomes. Consideration should be given to the potential benefits to mother and fetus of continuing ERT during pregnancy

Bases históricas dos direitos humanos e fundamentais e a necessidade de uma concepção multicultural

The present study focuses on human rights theory and multiculturalism. The general objective is to understand how the conception of multiculturalism has repercussions on an effective universalization of human rights that respects cultural differences between peoples. As a methodology, the proposal is to conduct a literature and documental review through legislative documents and selected theoretical framework. The approach will be hypothetical-deductive. The hypothesis that will be tested is that the conception of multiculturalism is fundamental for a universalization of human rights that respects cultural differences between peoples. Finally, it is concluded that the adoption of human rights as multicultural is a necessary means to make them effective and egalitarian in application worldwide, however, it is important to recognize that we are still far from this ideal.El presente estudio se centra en la teoría de los derechos humanos y el multiculturalismo. El objetivo general es comprender cómo la concepción del multiculturalismo repercute en una efectiva universalización de los derechos humanos que respete las diferencias culturales entre los pueblos. Como metodología, se propone realizar una revisión bibliográfica y documental a través de documentos legislativos y del marco teórico seleccionado. El enfoque será hipotético-deductivo. La hipótesis que se pondrá a prueba es que la concepción del multiculturalismo es fundamental para una universalización de los derechos humanos que respete las diferencias culturales entre los pueblos. Finalmente, se concluye que la adopción de los derechos humanos como multiculturales es un medio necesario para hacerlos efectivos e igualitarios en su aplicación en todo el mundo, sin embargo, es importante reconocer que aún estamos lejos de este ideal.Este artigo centra-se na teoria dos direitos humanos e o multiculturalismo. O objetivo geral é compreender como a concepção do multiculturalismo repercute em uma efetiva universalização dos direitos humanos que respeite as diferenças culturais entre os povos. Como metodologia, propõe-se realizar uma revisão bibliográfica e documental através de documentos legislativos e do marco teórico selecionado. A abordagem será hipotético-dedutiva. A hipótese que se colocará à prova é que a concepção do multiculturalismo é fundamental para uma universalização dos direitos humanos que respeite as diferenças culturais entre os povos. Finalmente, se conclui que a adoção dos direitos humanos como multiculturais é um meio necessário para fazê-los efetivos e igualitários na sua aplicação em todo o mundo, porém, é importante reconhecer que ainda estamos longe desse ideal