Worked bone from the site of La Montesita (Aguascalientes, México)

Presentamos el estudio de la industria ósea del sitio arqueológico de La Montesita (Aguascalientes, México). Este asentamiento es objeto de estudio del proyecto dirigido por el Dr. Schulze y el Dr. Pérez Roldán. El sitio se localiza en el estado de Aguascalientes; fechado aproximadamente para el Epiclásico, del 600 al 900 d.C. La distribución del asentamiento es de tipo semidisperso, donde la mayoría de las unidades habitacionales se encuentran sobre el cerro La Montesita, de ahí el nombre del sitio. Se presenta un conjunto de 24 piezas realizadas sobre hueso. Dentro del conjunto destaca la presencia de punzones. Nuestro análisis se enfocará tanto en su clasificación tipológica, como en su análisis tecnológico y funcional mediante la observación de visu de las piezas, el estudio microscópico y su comparación. Asimismo, enfatizaremos en la distribución de los útiles en los diferentes contextos espaciales del asentamiento. Todo ello nos permitirá obtener una visión global de la industria del hueso recuperada hasta el momento en el sitio de La Montesita y, por tanto, a través de esta cultura material, acercarnos a una comprensión más detallada de los distintos modos de vida en este asentamiento del centro-norte de México, una región de gran valor arqueológico a la que se ha prestado menor atención por parte de los investigadores.We present a study of the bone industry from the archaeological site of La Montesita (Aguascalientes, Mexico). This settlement is being studied in the project led by Dr. Schulze and Dr. Pérez Roldán. La Montesita is located in the state of Aguascalientes, and it dates back approximately to the Epiclassic period, from 600-900 AD. The settlement has a semi-sparce distribution, where most of the housing units are located on the Montesita hill, hence the name. We analyzed a set of 24 objects made of bone. Within the set, the presence of awls stands out. Our analysis will focus on both its typological classification and a technological and functional analysis through the observation de visu of the pieces, a microscopic study and their comparison. Likewise, we emphasize the distribution of the bone tools in the different spatial contexts of the settlement. This allows us to obtain a global view of the recovered bone industry at the Montesita site, and thus reach a better understanding of the material culture in the North-Center of Mexico —a region of great archaeological value to which little attention has been paid by researchers

Mechanisms of action and processes of yoga-based group intervention for inpatients with schizophrenia spectrum disorders–A longitudinal qualitative study

Background: Research exploring the effects of yoga therapy (YT) on individuals with schizophrenia spectrum disorders (SSD) is scarce. Therefore, the current study aimed to explore possible mechanisms of actions and processes, as well as adverse effects of a novel yoga-based group intervention (YoGI) for in-patients with SSD in a German university hospital setting. Material and methods: A longitudinal qualitative study was integrated into a rater-blinded randomized controlled trial, exploring the impact of a 4-week YoGI as add-on treatment. In-depth interviews were conducted with participants receiving YoGI (n = 19) in addition to treatment as usual (TAU) and a control group (n = 14) which only received TAU. Interviews were conducted at baseline (n = 33) and 4 weeks post-intervention (N = 28) to assess the participant's experiences and how they changed over time. The interviews (N = 61) were audio-taped, translated, coded, and analyzed by means of inductive thematic analysis. Separate case summaries were prepared for each participant to analyze longitudinal changes within subjects. The research team members collaboratively discussed the final list of themes and subcodes. Rater-based questionnaires, such as the Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), and Personal and Social Performance Scale (PSP) were administered at baseline to assess clinical outcomes. Results: At baseline, participants reported a desire to improve their stress- and symptom management. A minority of participants expressed reservations toward yoga, and several psychosocial barriers were named, including worries about symptom exacerbation. At post-intervention, four mechanisms of change became evident from the interviews: (1) acquiring competence in relaxation, (2) increased interoceptive awareness, (3) feeling connected, and (4) a sense of spiritual wellbeing. A small number of participants reported difficulties with YoGI. Conclusion: Generally, YoGI positively influenced participants' experiences of their inpatient stay, regarding distress, self- and body awareness, social connectedness, and spiritual wellbeing. However, participants also illuminated necessary adjustments to improve the intervention. YoGI will therefore be adapted and further developed in an iterative process based on a participant involvement approach. The efficacy regarding outcomes and processes needs to be investigated in a future larger-scaled randomized controlled trial

Coatings of different carbon nanotubes on platinum electrodes for neuronal devices: Preparation, cytocompatibility and interaction with spiral ganglion cells

Cochlear and deep brain implants are prominent examples for neuronal prostheses with clinical relevance. Current research focuses on the improvement of the long-term functionality and the size reduction of neural interface electrodes. A promising approach is the application of carbon nanotubes (CNTs), either as pure electrodes but especially as coating material for electrodes. The interaction of CNTs with neuronal cells has shown promising results in various studies, but these appear to depend on the specific type of neurons as well as on the kind of nanotubes. To evaluate a potential application of carbon nanotube coatings for cochlear electrodes, it is necessary to investigate the cytocompatibility of carbon nanotube coatings on platinum for the specific type of neuron in the inner ear, namely spiral ganglion neurons. In this study we have combined the chemical processing of as-delivered CNTs, the fabrication of coatings on platinum, and the characterization of the electrical properties of the coatings as well as a general cytocompatibility testing and the first cell culture investigations of CNTs with spiral ganglion neurons. By applying a modification process to three different as-received CNTs via a reflux treatment with nitric acid, long-term stable aqueous CNT dispersions free of dispersing agents were obtained. These were used to coat platinum substrates by an automated spray-coating process. These coatings enhance the electrical properties of platinum electrodes, decreasing the impedance values and raising the capacitances. Cell culture investigations of the different CNT coatings on platinum with NIH3T3 fibroblasts attest an overall good cytocompatibility of these coatings. For spiral ganglion neurons, this can also be observed but a desired positive effect of the CNTs on the neurons is absent. Furthermore, we found that the well-established DAPI staining assay does not function on the coatings prepared from single-wall nanotubes. © 2016 Burblies et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.DFG/EXC 1077/1 “Hearing4all

Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure

Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. However, the impact of enhanced adipose triacylglycerol hydrolysis mediated by adipose triglyceride lipase (ATGL) on cardiac function is unclear. To investigate the role of adipose tissue lipolysis during heart failure, we generated mice with tissue-specific deletion of ATGL (atATGL-KO). atATGL-KO mice were subjected to transverse aortic constriction (TAC) to induce pressure-mediated cardiac failure. The cardiac mouse lipidome and the human plasma lipidome from healthy controls (n = 10) and patients with systolic heart failure (HFrEF, n = 13) were analyzed by MS-based shotgun lipidomics. TAC-induced increases in left ventricular mass (LVM) and diastolic LV inner diameter were significantly attenuated in atATGL-KO mice compared to wild type (wt) -mice. More importantly, atATGL-KO mice were protected against TAC-induced systolic LV failure. Perturbation of lipolysis in the adipose tissue of atATGL-KO mice resulted in the prevention of the major cardiac lipidome changes observed after TAC in wt-mice. Profound changes occurred in the lipid class of phosphatidylethanolamines (PE) in which multiple PE-species were markedly induced in failing wt-hearts, which was attenuated in atATGL-KO hearts. Moreover, selected heart failure-induced PE species in mouse hearts were also induced in plasma samples from patients with chronic heart failure. TAC-induced cardiac PE induction resulted in decreased PC/PE-species ratios associated with increased apoptotic marker expression in failing wt-hearts, a process absent in atATGL-KO hearts. Perturbation of adipose tissue lipolysis by ATGL-deficiency ameliorated pressure-induced heart failure and the potentially deleterious cardiac lipidome changes that accompany this pathological process, namely the induction of specific PE species. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure

A Macroecological Analysis of SERA Derived Forest Heights and Implications for Forest Volume Remote Sensing

Individual trees have been shown to exhibit strong relationships between DBH, height and volume. Often such studies are cited as justification for forest volume or standing biomass estimation through remote sensing. With resolution of common satellite remote sensing systems generally too low to resolve individuals, and a need for larger coverage, these systems rely on descriptive heights, which account for tree collections in forests. For remote sensing and allometric applications, this height is not entirely understood in terms of its location. Here, a forest growth model (SERA) analyzes forest canopy height relationships with forest wood volume. Maximum height, mean, H100, and Lorey's height are examined for variability under plant number density, resource and species. Our findings, shown to be allometrically consistent with empirical measurements for forested communities world-wide, are analyzed for implications to forest remote sensing techniques such as LiDAR and RADAR. Traditional forestry measures of maximum height, and to a lesser extent H100 and Lorey's, exhibit little consistent correlation with forest volume across modeled conditions. The implication is that using forest height to infer volume or biomass from remote sensing requires species and community behavioral information to infer accurate estimates using height alone. SERA predicts mean height to provide the most consistent relationship with volume of the height classifications studied and overall across forest variations. This prediction agrees with empirical data collected from conifer and angiosperm forests with plant densities ranging between 102–106 plants/hectare and heights 6–49 m. Height classifications investigated are potentially linked to radar scattering centers with implications for allometry. These findings may be used to advance forest biomass estimation accuracy through remote sensing. Furthermore, Lorey's height with its specific relationship to remote sensing physics is recommended as a more universal indicator of volume when using remote sensing than achieved using either maximum height or H100

Quantum Information and Variants of Interactive Proof Systems

For nearly three decades, the model of interactive proof systems and its variants have been central to many important and exciting developments in computational complexity theory such as exact characterization of some well known complexity classes, development of probabilistically checkable proof systems and theory of hardness of approximation, and formalization of fundamental cryptographic primitives. On the other hand, the theory of quantum information, which is primarily concerned with harnessing quantum mechanical features for algorithmic, cryptographic, and information processing tasks has found many applications. In the past three decades, quantum information has been used to develop unconditionally secure quantum cryptography protocols, efficient quantum algorithms for certain problems that are believed to be intractable in classical world, and communication efficient protocols. In this thesis, we study the impact of quantum information on the models of interactive proof systems and their multi-prover variants. We study various quantum models and explore two questions. The first question we address pertains to the expressive power of such models with or without resource constraints. The second question is related to error reduction technique of such proof systems via parallel repetition. The question related to the expressive power of models of quantum interactive proof systems and their variants lead us to the following results. (1) We show that the expressive power of quantum interactive proof systems is exactly PSPACE, the class of problems that can be solved by a polynomial-space deterministic Turing machines and that also admit a classical interactive proof systems. This result shows that in terms of complexity-theoretic characterization, both the models are equivalent. The result is obtained using an algorithmic technique known as the matrix multiplicative weights update method to solve a semidefinite program that characterizes the success probability of the quantum prover. (2) We show that polynomially many logarithmic-size unentangled quantum proofs are no more powerful than a classical proof if the verifier has the ability to process quantum information. This result follows from an observation that logarithmic-size quantum states can be efficiently represented classically and such classical representation can be used to efficiently generate the quantum state. (3) We also establish that the model of multi-prover quantum Merlin Arthur proof system, where the verifier is only allowed to apply nonadaptive unentangled measurement on each proof and then a quantum circuit on the classical outcomes, is no more powerful than QMA under the restriction that there are only polynomial number of outcomes per proof. This result follows from showing that such proof systems also admit a QMA verification procedure. The question related to error reduction via parallel repetition lead us to following results on a class of two-prover one-round games with quantum provers and a class of multi-prover QMA proof systems. (1) We establish that for a certain class of two-prover one-round games known as XOR games, admit a perfect parallel repetition theorem in the following sense. When the provers play a collection of XOR games, an optimal strategy of the provers is to play each instance of the collection independently and optimally. In particular, the success probability of the quantum provers in the n-fold repetition of an XOR game G with quantum value w(G) is exactly (w(G))^n. (2) We show a parallel repetition theorem for two-prover one-round unique games. More specifically, we prove that if the quantum value of a unique game is 1-e, then the quantum value of n-fold repetition of the game is at most (1-e^2/49)^n. We also establish that for certain class of unique games, the quantum value of the n-fold repetition of the game is at most (1-e/4)^n. For the special case of XOR games, our proof technique gives an alternate proof of result mentioned above. 3. Our final result on parallel repetition is concerned with SepQMA(m) proof systems, where the verifier receives m unentangled quantum proofs and the measurement operator corresponding to outcome "accept" is a fully separable operator. We give an alternate proof of a result of Harrow and Montanaro [HM10] that states that perfect parallel repetition theorem holds for such proof systems. The first two results follow from the duality of semidefinite programs and the final result follows from cone programming duality

Examining the generalizability of research findings from archival data

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples