The dwarf nova SS Cygni: what is wrong?

Since the Fine Guiding Sensor (FGS) on the Hubble Space Telescope (HST) was used to measure the distance to SS Cyg to be $166\pm12$ pc, it became apparent that at this distance the disc instability model fails to explain the absolute magnitude during outburst. It remained, however, an open question whether the model or the distance have to be revised. Recent observations led to a revision of the system parameters of SS Cyg and seem to be consistent with a distance of d\gta 140 pc. We re-discuss the problem taking into account the new binary and stellar parameters measured for SS Cyg. We confront not only the observations with the predictions of the disc instability model but also compare SS Cyg with other dwarf novae and nova-like systems. We assume the disc during outburst to be in a quasi stationary state and use the black-body approximation to estimate the accretion rate during outburst as a function of distance. Using published analysis of the long term light curve we determine the mean mass transfer rate of SS Cyg as a function of distance and compare the result with mass transfer rates derived for other dwarf novae and nova-like systems. At a distance of d\gta 140 pc, both the accretion rate during outburst as well as the mean mass transfer rate of SS Cyg contradict the disc instability model. More important, at such distances we find the mean mass transfer rate of SS Cyg to be higher or comparable to those derived for nova-like systems. Our findings show that a distance to SS Cyg \gta 140 pc contradicts the main concepts developed for accretion discs in cataclysmic variables during the last 30 years. Either our current picture of disc accretion in these systems must be revised or the distance to SS Cyg is $\sim 100$ pcComment: 6 pages, 3 figures, accepted for publication in Astronomy and Astrophysic

Crecimiento y condición de juveniles de lenguado (Solea solea L.) como indicadores de calidad de hábitat en áreas de cría costeras y estuáricas del Golfo de Vizcaya con énfasis en zonas expuestas al vertido del Erika

Indicators of growth and condition were used to compare the habitat quality of nurseries of juvenile sole (Solea solea L.) in the Bay of Biscay, based on one survey in 2000. The four biological indicators are poorly correlated with each other, suggesting that no single measure may give an adequate description of fish health and of its habitat’s quality. Growth indicators showed significant differences between northern and southern areas. Juveniles from the two southernmost nurseries, the Gironde estuary and the Pertuis Antioche, displayed significant lower otolith increment widths and mean sizes. These differences were inversely related to water temperature and unrelated to genetic or age differences, and are unlikely to be due to limiting trophic conditions in the nurseries. Hence, they may be considered in terms of differences in habitat quality and potential anthropogenic impacts. Condition indices do not show this north-south pattern but highlight low condition values in the Pertuis Antioche. Short-term and fluctuating biochemical indicators such as RNA/DNA ratios appeared to be unreliable over a long-term study, while morphometric indices seemed to be relevant, complementary indicators as they integrate the whole juvenile life-history of sole in the nurseries. The growth and condition indices of juveniles in September 2000 from nursery grounds exposed to the Erika oil spill in December 1999 were relatively high. These results lead us to suggest that there was no obvious impact of this event on the health of juvenile sole and on the quality of the exposed nursery grounds a few months after the event.Se usaron indicadores de crecimiento y condición de lenguados juveniles (Solea solea L.) para comparar la calidad del hábitat de áreas de cría en el Golfo de Vizcaya basados en un muestreo de 2000. Los cuatro indicadores biológicos mostraron bajas correlaciones entre sí, lo que sugiere que no existe una medida única para describir adecuadamente el estado de los peces y la calidad de su hábitat. Los indicadores de crecimiento mostraron diferencias significativas entre las áreas septentrionales y meridionales. Los juveniles de las áreas situadas más al sur: el estuario del Garona y Pertuis Antioche mostraron incrementos de otolitos y tamaños medios significativamente inferiores. Estas diferencias están inversamente relacionadas con la temperatura del agua, pero no con diferencias genéticas o de edad, y no es probable que se deba a una condición trófica limitante en las áreas de cría. Por tanto, pueden considerarse en términos de calidad del hábitat y el potencial impacto antropogénico. Los índices de condición no muestras este patrón norte-sur sino que destacan los bajos valores de condición en Pertuis Antioche. Los indicadores bioquímicos variables de corto término como las relaciones RNA/DNA no parecieron fiables para estudios de mayor escala, mientras que los índices morfométricos parecen ser relevantes y complementarios ya que integran toda el período juvenil de la vida de los lenguados en sus áreas de cría. Los valores de crecimiento y condición de juveniles en septiembre de 2000 en áreas de cría expuestas al vertido de crudo del Erika en diciembre de 1999 fueron relativamente elevadas. Estos resultados sugieren que no hubo un impacto obvio de este evento sobre la salud de los juveniles de lenguado ni en la calidad de las áreas de cría expuestas transcurridos unos pocos meses después del vertido

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

AbstractBackground: The Jun N-terminal kinase (JNK) signaling pathway has been implicated in cell proliferation and apoptosis, but its function seems to depend on the cell type and inducing signal. In T cells, JNK has been implicated in both antigen-induced activation and apoptosis.Results: We generated mice lacking the JNK2 isozymes. The mutant mice were healthy and fertile but defective in peripheral T-cell activation induced by antibody to the CD3 component of the T-cell receptor (TCR) complex – proliferation and production of interleukin-2 (IL-2), IL-4 and interferon-γ (IFN-γ) were reduced. The proliferation defect was restored by exogenous IL-2. B-cell activation was normal in the absence of JNK2. Activation-induced peripheral T-cell apoptosis was comparable between mutant and wild-type mice, but immature (CD4+> CD8+) thymocytes lacking JNK2 were resistant to apoptosis induced by administration of anti-CD3 antibody in vivo. The lack of JNK2 also resulted in partial resistance of thymocytes to anti-CD3 antibody in vitro, but had little or no effect on apoptosis induced by anti-Fas antibody, dexamethasone or ultraviolet-C (UVC) radiation.Conclusions: JNK2 is essential for efficient activation of peripheral T cells but not B cells. Peripheral T-cell activation is probably required indirectly for induction of thymocyte apoptosis resulting from administration of anti-CD3 antibody in vivo. JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells

Stellar photometry with Multi Conjugate Adaptive Optics

We overview the current status of photometric analyses of images collected with Multi Conjugate Adaptive Optics (MCAO) at 8-10m class telescopes that operated, or are operating, on sky. Particular attention will be payed to resolved stellar population studies. Stars in crowded stellar systems, such as globular clusters or in nearby galaxies, are ideal test particles to test AO performance. We will focus the discussion on photometric precision and accuracy reached nowadays. We briefly describe our project on stellar photometry and astrometry of Galactic globular clusters using images taken with GeMS at the Gemini South telescope. We also present the photometry performed with DAOPHOT suite of programs into the crowded regions of these globulars reaching very faint limiting magnitudes Ks ~21.5 mag on moderately large fields of view (~1.5 arcmin squared). We highlight the need for new algorithms to improve the modeling of the complex variation of the Point Spread Function across the field of view. Finally, we outline the role that large samples of stellar standards plays in providing a detailed description of the MCAO performance and in precise and accurate colour{magnitude diagrams.Comment: 17 pages, 12 figures, SPIE 201

AGN Emission Line Diagnostics and the Mass-Metallicity Relation up to Redshift z~2: the Impact of Selection Effects and Evolution

Emission line diagnostic diagrams probing the ionization sources in galaxies, such as the Baldwin-Phillips-Terlevich (BPT) diagram, have been used extensively to distinguish AGN from purely star-forming galaxies. Yet, they remain poorly understood at higher redshifts. We shed light on this issue with an empirical approach based on a z~0 reference sample built from ~300,000 SDSS galaxies, from which we mimic selection effects due to typical emission line detection limits at higher redshift. We combine this low-redshift reference sample with a simple prescription for luminosity evolution of the global galaxy population to predict the loci of high-redshift galaxies on the BPT and Mass-Excitation (MEx) diagnostic diagrams. The predicted bivariate distributions agree remarkably well with direct observations of galaxies out to z~1.5, including the observed stellar mass-metallicity (MZ) relation evolution. As a result, we infer that high-redshift star-forming galaxies are consistent with having "normal" ISM properties out to z~1.5, after accounting for selection effects and line luminosity evolution. Namely, their optical line ratios and gas-phase metallicities are comparable to that of low-redshift galaxies with equivalent emission-line luminosities. In contrast, AGN narrow-line regions may show a shift toward lower metallicities at higher redshift. While a physical evolution of the ISM conditions is not ruled out for purely star-forming galaxies, and may be more important starting at z>2, we find that reliably quantifying this evolution is hindered by selections effects. The recipes provided here may serve as a basis for future studies toward this goal. Code to predict the loci of galaxies on the BPT and MEx diagnostic diagrams, and the MZ relation as a function of emission line luminosity limits, is made publicly available.Comment: Main article: 15 pages, 7 figures; Appendix: 13 pages, 11 figures. Revisions: Paper now accepted for publication in the Astrophysical Journal (same scientific content as previous arXiv version). IDL routines to make empirical predictions on the BPT, MEx, and M-Z plane are now released at https://sites.google.com/site/agndiagnostics/home/me

The cuticle mutant eca2 modifies plant defense responses to biotrophic and necrotrophic pathogens and herbivory insects

We isolated previously several Arabidopsis thaliana mutants with constitutive expression of the early microbe-associated molecular pattern–induced gene ATL2, named eca (expresión constitutiva de ATL2). Here, we further explored the interaction of eca mutants with pest and pathogens. Of all eca mutants, eca2 was more resistant to a fungal pathogen (Botrytis cinerea) and a bacterial pathogen (Pseudomonas syringae) as well as to a generalist herbivorous insect (Spodoptera littoralis). Permeability of the cuticle is increased in eca2; chemical characterization shows that eca2 has a significant reduction of both cuticular wax and cutin. Additionally, we determined that eca2 did not display a similar compensatory transcriptional response, compared with a previously characterized cuticular mutant, and that resistance to B. cinerea is mediated by the priming of the early and late induced defense responses, including salicylic acid– and jasmonic acid–induced genes. These results suggest that ECA2-dependent responses are involved in the nonhost defense mechanism against biotrophic and necrotrophic pathogens and against a generalist insect by modulation and priming of innate immunity and late defense responses. Making eca2 an interesting model to characterize the molecular basis for plant defenses against different biotic interactions and to study the initial events that take place in the cuticle surface of the aerial organs

General relativistic Sagnac formula revised

The Sagnac effect is a time or phase shift observed between two beams of light traveling in opposite directions in a rotating interferometer. We show that the standard description of this effect within the framework of general relativity misses the effect of deflection of light due to rotational inertial forces. We derive the necessary modification and demonstrate it through a detailed analysis of the square Sagnac interferometer rotating about its symmetry axis in Minkowski space-time. The role of the time shift in a Sagnac interferometer in the synchronization procedure of remote clocks as well as its analogy with the Aharanov-Bohm effect are revised.Comment: 11 pages, 3 figure

Global FKRP Registry: observations in more than 300 patients with Limb Girdle Muscular Dystrophy R9

Objective The Global FKRP Registry is a database for individuals with conditions caused by mutations in the Fukutin‐Related Protein (FKRP) gene: limb girdle muscular dystrophy R9 (LGMDR9, formerly LGMD2I) and congenital muscular dystrophies MDC1C, Muscle–Eye–Brain Disease and Walker–Warburg Syndrome. The registry seeks to further understand the natural history and prevalence of FKRP‐related conditions; aid the rapid identification of eligible patients for clinical studies; and provide a source of information to clinical and academic communities. Methods Registration is patient‐initiated through a secure online portal. Data, reported by both patients and their clinicians, include: age of onset, presenting symptoms, family history, motor function and muscle strength, respiratory and cardiac function, medication, quality of life and pain. Results Of 663 registered participants, 305 were genetically confirmed LGMDR9 patients from 23 countries. A majority of LGMDR9 patients carried the common mutation c.826C > A on one or both alleles; 67.9% were homozygous and 28.5% were compound heterozygous for this mutation. The mean ages of symptom onset and disease diagnosis were higher in individuals homozygous for c.826C > A compared with individuals heterozygous for c.826C > A. This divergence was replicated in ages of loss of running ability, wheelchair‐dependence and ventilation assistance; consistent with the milder phenotype associated with individuals homozygous for c.826C > A. In LGMDR9 patients, 75.1% were currently ambulant and 24.6%, nonambulant (unreported in 0.3%). Cardiac impairment was reported in 23.2% (30/129). Interpretation The Global FKRP Registry enables the collection of patient natural history data, which informs academics, healthcare professionals and industry. It represents a trial‐ready cohort of individuals and is centrally placed to facilitate recruitment to clinical studies.publishedVersio