478 research outputs found
Superlattice with hot electron injection: an approach to a Bloch oscillator
A semiconductor superlattice with hot electron injection into the miniband is
considered. The injection changes the stationary distribution function and
results in a qualitative change of the frequency behaviour of the differential
conductivity. In the regime with Bloch oscillating electrons and injection into
the upper part of the miniband the region of negative differential conductivity
is shifted from low frequencies to higher frequencies. We find that the dc
differential conductivity can be made positive and thus the domain instability
can be suppressed. At the same time the high-frequency differential
conductivity is negative above the Bloch frequency. This opens a new way to
make a Bloch oscillator operating at THz frequencies.Comment: RevTeX, 8 pages, 2 figures, to be published in Phys. Rev. B, 15
Januar 200
Direct measurement of decoherence for entanglement between a photon and stored atomic excitation
Violations of a Bell inequality are reported for an experiment where one of
two entangled qubits is stored in a collective atomic memory for a user-defined
time delay. The atomic qubit is found to preserve the violation of a Bell
inequality for storage times up to 21 microseconds, 700 times longer than the
duration of the excitation pulse that creates the entanglement. To address the
question of the security of entanglement-based cryptography implemented with
this system, an investigation of the Bell violation as a function of the
cross-correlation between the generated nonclassical fields is reported, with
saturation of the violation close to the maximum value allowed by quantum
mechanics.Comment: 4 pages, 3 figures. Minor changes. Published versio
Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia
Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc and manganese, have previously been linked to pre-eclampsia at time of disease. Our aims were to investigate whether maternal plasma micronutrient concentrations and related antioxidant enzyme activities are altered prior to pre-eclampsia onset and to examine the dependence on genetic variations in these antioxidant enzymes.
Methods: Pre-disease plasma samples (15+1 weeks’ gestation) were obtained from women enrolled in the international SCreening fOr Pregnancy Endpoints (SCOPE) study who subsequently developed pre-eclampsia (n=244), and age- and BMI-matched normotensive controls (n=472). Micronutrient concentrations were measured by inductively coupled plasma mass spectrometry; associated antioxidant enzyme activities, selenoprotein-P, caeruloplasmin concentrations and activities, antioxidant capacity and markers of oxidative stress were measured by colorimetric assays. Sixty four tagSNPs within genes encoding the antioxidant enzymes and selenoprotein-P were genotyped using allele-specific competitive PCR.
Results: Plasma copper and caeruloplasmin concentrations were modestly, but significantly elevated in women who subsequently developed pre-eclampsia (both P<0.001) compared to controls (median [IQR], copper: 1957.4 [1787, 2177.5] vs. 1850.0 [1663.5, 2051.5] µg/L; caeruloplasmin: 2.5[1.4, 3.2] vs. 2.2[1.2, 3.0] µg/ml). There were no differences in other micronutrients or enzymes between groups. No relationship was observed between genotype for single nucleotide polymorphisms (SNPs) and antioxidant enzyme activity.
Conclusions: This analysis of a prospective cohort study reports maternal micronutrient concentrations in combination with associated antioxidant enzymes and SNPs in their encoding genes in women at 15 weeks’ gestation that subsequently developed pre-eclampsia. The modest elevation in copper may contribute to oxidative stress, later in pregnancy, in those women that go on to develop pre-eclampsia. The lack of evidence to support the hypothesis that functional SNPs influence antioxidant enzyme activity in pregnant women argues against a role for these genes in the aetiology of pre-eclampsia
Conditional control of the quantum states of remote atomic memories for quantum networking
Quantum networks hold the promise for revolutionary advances in information
processing with quantum resources distributed over remote locations via
quantum-repeater architectures. Quantum networks are composed of nodes for
storing and processing quantum states, and of channels for transmitting states
between them. The scalability of such networks relies critically on the ability
to perform conditional operations on states stored in separated quantum
memories. Here we report the first implementation of such conditional control
of two atomic memories, located in distinct apparatuses, which results in a
28-fold increase of the probability of simultaneously obtaining a pair of
single photons, relative to the case without conditional control. As a first
application, we demonstrate a high degree of indistinguishability for remotely
generated single photons by the observation of destructive interference of
their wavepackets. Our results demonstrate experimentally a basic principle for
enabling scalable quantum networks, with applications as well to linear optics
quantum computation.Comment: 10 pages, 8 figures; Minor corrections. References updated. Published
at Nature Physics 2, Advanced Online Publication of 10/29 (2006
Вибір та обґрунтування параметрів технології підтримки стінок стовбура свердловини в осадових породах
Практичне значення роботи полягає в досліджені широкого кола властивостей різних хімічних сполук, покликаних збільшити ступінь стійкості осадових порід в стінках стовбура свердловини; застосування досліджених речовин приведе до істотного підвищення продуктивності бурових робіт, скорочення часу на роботи, пов’язані із ліквідацією ускладнень і аварій в свердловині, або повного виключення останніх, загального зростання ефективності і економічності процесу спорудження свердловин.Мета дипломної роботи: встановлення закономірностей фізико-хімічних процесів, що протікають в стовбурі свердловини, споруджуваної в товщі осадових гірських порід, при циркуляції промивальних рідин і формулюванні на їх основі адекватних технологічних заходів гідравлічної програми промивання свердловини, реалізація якої дозволить надати процесу спорудження свердловин достатньо високу міру продуктивності і економічності
Spontaneous DC Current Generation in a Resistively Shunted Semiconductor Superlattice Driven by a TeraHertz Field
We study a resistively shunted semiconductor superlattice subject to a
high-frequency electric field. Using a balance equation approach that
incorporates the influence of the electric circuit, we determine numerically a
range of amplitude and frequency of the ac field for which a dc bias and
current are generated spontaneously and show that this region is likely
accessible to current experiments. Our simulations reveal that the Bloch
frequency corresponding to the spontaneous dc bias is approximately an integer
multiple of the ac field frequency.Comment: 8 pages, Revtex, 3 Postscript figure
Selenoprotein gene nomenclature
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4 and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine-R-sulfoxide reductase 1) and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15 kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV) and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates
ModBase, a database of annotated comparative protein structure models, and associated resources
ModBase (http://salilab.org/modbase) is a database of annotated comparative protein structure models. The models are calculated by ModPipe, an automated modeling pipeline that relies primarily on Modeller for fold assignment, sequence–structure alignment, model building and model assessment (http://salilab.org/modeller/). ModBase currently contains 10 355 444 reliable models for domains in 2 421 920 unique protein sequences. ModBase allows users to update comparative models on demand, and request modeling of additional sequences through an interface to the ModWeb modeling server (http://salilab.org/modweb). ModBase models are available through the ModBase interface as well as the Protein Model Portal (http://www.proteinmodelportal.org/). Recently developed associated resources include the SALIGN server for multiple sequence and structure alignment (http://salilab.org/salign), the ModEval server for predicting the accuracy of protein structure models (http://salilab.org/modeval), the PCSS server for predicting which peptides bind to a given protein (http://salilab.org/pcss) and the FoXS server for calculating and fitting Small Angle X-ray Scattering profiles (http://salilab.org/foxs)
Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase
Selenium is an essential trace element incorporated into selenoproteins as selenocysteine. Selenocysteine (Sec) lyases (SCLs) and cysteine (Cys) desulfurases (CDs) catalyze the removal of selenium or sulfur from Sec or Cys, respectively, and generally accept both substrates. Intriguingly, human SCL (hSCL) is specific for Sec even though the only difference between Sec and Cys is a single chalcogen atom
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