Mixed Reality-Based Simulator for Training on Imageless Navigation Skills in Total Hip Replacement Procedures

Imageless navigation systems (INS) in orthopaedics have been used to improve the outcomes of several orthopaedic procedures such as total hip replacement [1, 2]. However, the increased surgical times and the associate learning curve discourage surgeons from using navigation systems in their theatres [2]. This paper presents a Mixed Reality (MR) simulator that helps surgeons acquire the infrared based navigation skills before performing it in reality. A group of 7 hip surgeons tried the application, expressing their satisfaction with all the features and confirmed that the simulator represents a cheaper and faster option to train surgeons in the use of INS than the current learning methods

Collapse of a semiflexible polymer in poor solvent

We investigate the dynamics and the pathways of the collapse of a single, semiflexible polymer in a poor solvent via 3-D Brownian Dynamics simulations. Earlier work indicates that the condensation of semiflexible polymers generically proceeds via a cascade through metastable racquet-shaped, long-lived intermediates towards the stable torus state. We investigate the rate of decay of uncollapsed states, analyze the preferential pathways of condensation, and describe likelihood and lifespan of the different metastable states. The simulation are performed with a bead-stiff spring model with excluded volume interaction and exponentially decaying attractive potential. The semiflexible chain collapse is studied as functions of the three relevant length scales of the phenomenon, i.e., the total chain length $L$, the persistence length $L_p$ and the condensation length $L_0 = \sqrt{k_B T L_p/u_0}$, where $u_0$ is a measure of the attractive potential per unit length. Two dimensionless ratios, $L/L_p$ and $L_0/L_p$, suffice to describe the decay rate of uncollapsed states, which appears to scale as $(L/L_p)^{1/3} (L_0/L_p)$. The condensation sequence is described in terms of the time series of the well separated energy levels associated with each metastable collapsed state. The collapsed states are described quantitatively through the spatial correlation of tangent vectors along the chain. We also compare the results obtained with a locally inextensible bead-rod chain and with a phantom bead-spring model. Finally, we show preliminary results on the effects of steady shear flow on the kinetics of collapse.Comment: 9 pages, 8 figure

Two-point microrheology and the electrostatic analogy

The recent experiments of Crocker et al. suggest that microrheological measurements obtained from the correlated fluctuations of widely-separatedprobe particles determine the rheological properties of soft, complex materials more accurately than do the more traditional particle autocorrelations. This presents an interesting problem in viscoelastic dynamics. We develop an important, simplifing analogy between the present viscoelastic problem and classical electrostatics. Using this analogy and direct calculation we analyze both the one and two particle correlations in a viscoelastic medium in order to explain this observation

The Wolf-Rayet binaries of the nitrogen sequence in the Large Magellanic Cloud: spectroscopy, orbital analysis, formation, and evolution

Massive Wolf-Rayet (WR) stars dominate the radiative and mechanical energy budget of galaxies and probe a critical phase in the evolution of massive stars prior to core-collapse. It is not known whether core He-burning WR stars (classical WR, cWR) form predominantly through wind-stripping (w-WR) or binary stripping (b-WR). With spectroscopy of WR binaries so-far largely avoided due to its complexity, our study focuses on the 44 WR binaries / binary candidates of the Large Magellanic Cloud (LMC, metallicity Z~0.5 Zsun), identified on the basis of radial velocity variations, composite spectra, or high X-ray luminosities. Relying on a diverse spectroscopic database, we aim to derive the physical and orbital parameters of our targets, confronting evolution models of evolved massive stars at sub-solar metallicity, and constraining the impact of binary interaction in forming them. Spectroscopy is performed using the Potsdam Wolf-Rayet (PoWR) code and cross-correlation techniques. Disentanglement is performed using the code Spectangular or the shift-and-add algorithm. Evolutionary status is interpreted using the Binary Population and Spectral Synthesis (BPASS) code, exploring binary interaction and chemically-homogeneous evolution. No obvious dichotomy in the locations of apparently-single and binary WN stars on the Hertzsprung-Russell diagram is apparent. According to commonly used stellar evolution models (BPASS, Geneva), most apparently-single WN stars could not have formed as single stars, implying that they were stripped by an undetected companion. Otherwise, it must follow that pre-WR mass-loss/mixing (e.g., during the red supergiant phase) are strongly underestimated in standard stellar evolution models.Comment: accepted to A&A on 10.05.2019; 69 pages (25 main paper + 44 appendix); Corrigendum: Shenar et al. 2020, A&A, 641, 2: An unfortunate typo in the implementation of the "transformed radius" caused errors of up to ~0.5dex in the derived mass-loss rates. This has now been correcte

Linear and nonlinear rheology of wormlike micelles

Several surfactant molecules self-assemble in solution to form long, cylindrical, flexible wormlike micelles. These micelles can be entangled with each other leading to viscoelastic phases. The rheological properties of such phases are very interesting and have been the subject of a large number of experimental and theoretical studies in recent years. We shall report on our recent work on the macrorheology, microrheology and nonlinear flow behaviour of dilute aqueous solutions of a surfactant CTAT (Cetyltrimethylammonium Tosilate). This system forms elongated micelles and exhibits strong viscoelasticity at low concentrations ($\sim$ 0.9 wt%) without the addition of electrolytes. Microrheology measurements of $G(\omega)$ have been done using diffusing wave spectroscopy which will be compared with the conventional frequency sweep measurements done using a cone and plate rheometer. The second part of the paper deals with the nonlinear rheology where the measured shear stress $\sigma$ is a nonmonotonic function of the shear rate $\dot{\gamma}$. In stress-controlled experiments, the shear stress shows a plateau for $\dot{\gamma}$ larger than some critical strain rate, similar to the earlier reports on CPyCl/NaSal system. Cates et al have proposed that the plateau is a signature of mechanical instability in the form of shear bands. We have carried out extensive experiments under controlled strain rate conditions, to study the time-dependence of shear stress. The measured time series of shear stress has been analysed in terms of correlation integrals and Lyapunov exponents to show unambiguously that the behaviour is typical of low dimensional dynamical systems.Comment: 15 pages, 10 eps figure

Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children.

Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [NTOTAL=679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood

The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.WT104150/Wellcome Trust (Wellcome)published version, accepted version, submitted versio

VLT/SPHERE deep insight of NGC 3603's core: Segregation or confusion?

We present new near-infrared photometric measurements of the core of the young massive cluster NGC 3603 obtained with extreme adaptive optics. The data were obtained with the SPHERE instrument mounted on ESO Very Large Telescope, and cover three fields in the core of this cluster. We applied a correction for the effect of extinction to our data obtained in the J and K broadband filters and estimated the mass of detected sources inside the field of view of SPHERE/IRDIS, which is 13.5"x13.5". We derived the mass function (MF) slope for each spectral band and field. The MF slope in the core is unusual compared to previous results based on Hubble space telescope (HST) and very large telescope (VLT) observations. The average slope in the core is estimated as -1.06^{+0.26}_{-0.26} for the main sequence stars with 3.5 Msun < M < 120 Msun.Thanks to the SPHERE extreme adaptive optics, 814 low-mass stars were detected to estimate the MF slope for the pre-main sequence stars with 0.6 Msun< M < 3.5 Msun , Gamma = -0.54^{+0.11}_{-0.11} in the K-band images in two fields in the core of the cluster. For the first time, we derive the mass function of the very core of the NGC 3603 young cluster for masses in the range 0.6 - 120 Msun. Previous studies were either limited by crowding, lack of dynamic range, or a combination of both