Adjoint Computation for Hypersurfaces Using Formal Desingularizations

We show how to use formal desingularizations (defined earlier by the first author) in order to compute the global sections (also called adjoints) of twisted pluricanonical sheaves. These sections define maps that play an important role in the birational classification of schemes.Comment: 10 page

Lattice polygons and families of curves on rational surfaces

First we solve the problem of finding minimal degree families on toric surfaces by reducing it to lattice geometry. Then we describe how to find minimal degree families on, more generally, rational complex projective surfaces

First Steps Towards Radical Parametrization of Algebraic Surfaces

We introduce the notion of radical parametrization of a surface, and we provide algorithms to compute such type of parametrizations for families of surfaces, like: Fermat surfaces, surfaces with a high multiplicity (at least the degree minus 4) singularity, all irreducible surfaces of degree at most 5, all irreducible singular surfaces of degree 6, and surfaces containing a pencil of low-genus curves. In addition, we prove that radical parametrizations are preserved under certain type of geometric constructions that include offset and conchoids.Comment: 31 pages, 7 color figures. v2: added another case of genus

Counting Realizations of Laman Graphs on the Sphere

We present an algorithm that computes the number of realizations of a Laman graph on a sphere for a general choice of the angles between the vertices. The algorithm is based on the interpretation of such a realization as a point in the moduli space of stable curves of genus zero with marked points, and on the explicit description, due to Keel, of the Chow ring of this space

Zero-Sum Cycles in Flexible Non-triangular Polyhedra

Finding necessary conditions for the geometry of flexible polyhedra is a classical problem that has received attention also in recent times. For flexible polyhedra with triangular faces, we showed in a previous work the existence of cycles with a sign assignment for their edges, such that the signed sum of the edge lengths along the cycle is zero. In this work, we extend this result to flexible non-triangular polyhedra

Combinatorics of Bricard's octahedra

We re-prove the classification of motions of an octahedron — obtained by Bricard at the beginning of the XX century — by means of combinatorial objects satisfying some elementary rules. The explanations of these rules rely on the use of a well-known creation of modern algebraic geometry, the moduli space of stable rational curves with marked points, for the description of configurations of graphs on the sphere. Once one accepts the objects and the rules, the classification becomes elementary (though not trivial) and can be enjoyed without the need of a very deep background on the topic

Metabolomics: is it useful for inflammatory bowel diseases?

Purpose of Review: The assessment of metabolite profiles in biofluids has become a powerful method for the detection of biomarker molecules and disease mechanisms. This review outlines the recent advances in the use of metabolomic techniques to study inflammatory bowel diseases (IBDs). Recent findingsThe last few years have seen an increase in the studies of experimental and human IBD focusing on the search for small metabolites, such as amino acids, bases, and tricarboxylic acid cycle intermediates. Experimental methods for the screening of metabolites in serum, urine, fecal extracts, and colon tissue include H-1 NMR spectroscopy, gas chromatography-mass spectrometry, and liquid chromatography methods. Several studies demonstrate that IBD patients and healthy individuals, as well as the IBD subtypes, can be distinguished using metabolic profiling. Metabolomic data of fecal extracts and urine have revealed disruptions in bacterial populations, findings that are indicative of a possible involvement of the microbiome in the development of IBDs. SummaryMetabolites from biofluids can be detected in IBDs by different experimental methods that allow successful separation of IBD subtypes from healthy cohorts. Knowledge of a unique metabolomic fingerprint in IBDs could be useful for diagnosis, treatment, and detection of disease mechanisms

Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice

Background/Aims: Compounds of Cannabis sativa are known to exert anti-inflammatory properties, some of them without inducing psychotropic side effects. Cannabidiol (CBD) is such a side effect-free phytocannabinoid that improves chemically induced colitis in rodents when given intraperitoneally. Here, we tested the possibility whether rectal and oral application of CBD would also ameliorate colonic inflammation, as these routes of application may represent a more appropriate way for delivering drugs in human colitis. Methods: Colitis was induced in CD1 mice by trinitrobenzene sulfonic acid. Individual groups were either treated with CBD intraperitoneally (10 mg/kg), orally (20 mg/kg) or intrarectally (20 mg/kg). Colitis was evaluated by macroscopic scoring, histopathology and the myeloperoxidase (MPO) assay. Results: Intraperitoneal treatment of mice with CBD led to improvement of colonic inflammation. Intrarectal treatment with CBD also led to a significant improvement of disease parameters and to a decrease in MPO activity while oral treatment, using the same dose as per rectum, had no ameliorating effect on colitis. Conclusion: The data of this study indicate that in addition to intraperitoneal application, intrarectal delivery of cannabinoids may represent a useful therapeutic administration route for the treatment of colonic inflammation. Copyright (C) 2012 S. Karger AG, Base

Mobile Icosapods

Pods are mechanical devices constituted of two rigid bodies, the base and the platform, connected by a number of other rigid bodies, called legs, that are anchored via spherical joints. It is possible to prove that the maximal number of legs of a mobile pod, when finite, is 20. In 1904, Borel designed a technique to construct examples of such 20-pods, but could not constrain the legs to have base and platform points with real coordinates. We show that Borel’s construction yields all mobile 20-pods, and that it is possible to construct examples where all coordinates are real