Advancing Torpor Inducing Transfer Habitats for Human Stasis to Mars

SpaceWorks Enterprises, Inc. (SEI) has conducted an evaluation of an advanced habitat system designed to transportcrews between the Earth and Mars. This new and innovative habitat concept is capable of placing crew members ininactive, torpor states during transit phases of a deep space mission. This substantially reduces the mass and size ofthe habitat, which ultimately leads to significant reductions in the overall architecture size.Our approach for achieving this is based on extending the current and evolving medical practice of TherapeuticHypothermia (TH) - a proven and effective treatment for various traumatic injuries. TH is a medical treatment thatlowers a patient's body temperature by just 5 to 10 degrees Fahrenheit causing human metabolic rate to decreasesignificantly and the body to enter an unconscious state. This method avoids the intractable challenges often associatedwith cell metabolic cessation through cryogenic freezing and other highly speculative approaches.The initial results obtained from the research and analysis conducted in the Phase I effort warranted further study ofthis concept and technology. The specific objectives of the continued work include:1. Addressing critical medical aspects and risks for inducing torpor via Therapeutic Hypothermia and theapproach for providing nutrition and hydration for the crew during torpor. 2. Focusing on mitigation aspects and technology potential for solving key human spaceflight challenges. 3. Addressing critical engineering aspects of the design that may impact the initial performance and cost resultsobtained in Phase I. 4. Examining the broader extensibility and enabling capabilities of this concept through applicability toadditional exploration missions beyond Mars. 5. Establishing a technology development roadmap, addressing both medical and engineering aspects, thatindicate a logical and scientifically achievable path forward for maturation of this technology

Dynamic factor analysis of surface water management impacts on soil and bedrock water contents in Southern Florida Lowlands

As part of the C111 spreader canal project, structural and operational modifications involving incremental raises in canal stage are planned along one of the major canals (i.e., C111) separating Everglades National Park and agricultural production areas to the east of the park. This study used Dynamic Factor Analysis (DFA) as an alternative tool to physically based models to explore the relationship between different hydrologic variables and the effect of proposed changes in surface water management on soil and bedrock water contents in south Florida. To achieve the goal, objectives were to: (1) use DFA to identify the most important factors affecting temporal variation in soil and bedrock water contents, (2) develop a simplified DFA based regression model for predicting soil and bedrock water contents as a function of canal stage and (3) assess the effect of the proposed incremental raises in canal stage on soil and bedrock water contents. DFA revealed that 5 common trends were the minimum required to describe unexplained variation in the 11 time series studied. Introducing canal stage, water table evaporation and net recharge resulted in lower Akaike information criterion (AIC) and higher Nash-Sutcliffe (C[subscript eff]) values. Results indicated that canal stage significantly (t > 2) drives temporal variation in soil and bedrock water contents, which was represented as scaled frequency while net surface recharge was significant in 7 out of the 11 time series analyzed. The effect of water table evaporation was not significant at all sites. Results also indicated that the most important factor influencing temporal variation in soil and bedrock water contents in terms of regression coefficient magnitude was canal stage. Based on DFA results, a simple regression model was developed to predict soil and bedrock water contents at various elevations as a function of canal stage and net recharge. The performance of the simple model ranged from good (C[subscript eff] ranging from 0.56 to 0.74) to poor (C[subscript eff] ranging from 0.10 to 0.15), performance was better at sites with smaller depths to water table (< 1 m) highlighting the effect of micro-topography on soil and bedrock water content dynamics. Assessment of the effect of 6, 9 and 12 cm increases in canal stage using the simple regression model indicated that changes in temporal variation in soil and bedrock water contents were negligible (average<1.0% average change) at 500 to 2000 m from C111 (or low elevations) which may be attributed to the near saturation conditions already occurring at these sites. This study used DFA to explore the relationship between soil and bedrock water dynamics and surface water stage in shallow water table environments. This approach can be applied to any system in which detailed physical modeling would be limited by inadequate information on parameters or processes governing the physical system

The heats of formation of the haloacetylenes XCCY [X, Y = H, F, Cl]: basis set limit ab initio results and thermochemical analysis

The heats of formation of haloacetylenes are evaluated using the recent W1 and W2 ab initio computational thermochemistry methods. These calculations involve CCSD and CCSD(T) coupled cluster methods, basis sets of up to spdfgh quality, extrapolations to the one-particle basis set limit, and contributions of inner-shell correlation, scalar relativistic effects, and (where relevant) first-order spin-orbit coupling. The heats of formation determined using W2 theory are: \hof(HCCH) = 54.48 kcal/mol, \hof(HCCF) = 25.15 kcal/mol, \hof(FCCF) = 1.38 kcal/mol, \hof(HCCCl) = 54.83 kcal/mol, \hof(ClCCCl) = 56.21 kcal/mol, and \hof(FCCCl) = 28.47 kcal/mol. Enthalpies of hydrogenation and destabilization energies relative to acetylene were obtained at the W1 level of theory. So doing we find the following destabilization order for acetylenes: FCCF $>$ ClCCF $>$ HCCF $>$ ClCCCl $>$ HCCCl $>$ HCCH. By a combination of W1 theory and isodesmic reactions, we show that the generally accepted heat of formation of 1,2-dichloroethane should be revised to -31.8$\pm$0.6 kcal/mol, in excellent agreement with a very recent critically evaluated review. The performance of compound thermochemistry schemes such as G2, G3, G3X and CBS-QB3 theories has been analyzed.Comment: Mol. Phys., in press (E. R. Davidson issue

Millimeter and sub-millimeter atmospheric performance at Dome C combining radiosoundings and ATM synthetic spectra

The reliability of astronomical observations at millimeter and sub-millimeter wavelengths closely depends on a low vertical content of water vapor as well as on high atmospheric emission stability. Although Concordia station at Dome C (Antarctica) enjoys good observing conditions in this atmospheric spectral windows, as shown by preliminary site-testing campaigns at different bands and in, not always, time overlapped periods, a dedicated instrument able to continuously determine atmospheric performance for a wide spectral range is not yet planned. In the absence of such measurements, in this paper we suggest a semi-empirical approach to perform an analysis of atmospheric transmission and emission at Dome C to compare the performance for 7 photometric bands ranging from 100 GHz to 2 THz. Radiosoundings data provided by the Routine Meteorological Observations (RMO) Research Project at Concordia station are corrected by temperature and humidity errors and dry biases and then employed to feed ATM (Atmospheric Transmission at Microwaves) code to generate synthetic spectra in the wide spectral range from 100 GHz to 2 THz. To quantify the atmospheric contribution in millimeter and sub-millimeter observations we are considering several photometric bands in which atmospheric quantities are integrated. The observational capabilities of this site at all the selected spectral bands are analyzed considering monthly averaged transmissions joined to the corresponding fluctuations. Transmission and pwv statistics at Dome C derived by our semi-empirical approach are consistent with previous works. It is evident the decreasing of the performance at high frequencies. We propose to introduce a new parameter to compare the quality of a site at different spectral bands, in terms of high transmission and emission stability, the Site Photometric Quality Factor.Comment: accepted to MNRAS with minor revision

Degree of explanation

Partial explanations are everywhere. That is, explanations citing causes that explain some but not all of an effect are ubiquitous across science, and these in turn rely on the notion of degree of explanation. I argue that current accounts are seriously deficient. In particular, they do not incorporate adequately the way in which a cause’s explanatory importance varies with choice of explanandum. Using influential recent contrastive theories, I develop quantitative definitions that remedy this lacuna, and relate it to existing measures of degree of causation. Among other things, this reveals the precise role here of chance, as well as bearing on the relation between causal explanation and causation itself

Priority monism and part/whole dependence

Priority monism is the view that the cosmos is the only independent concrete object. The paper argues that, pace its proponents, Priority monism is in conflict with the dependence of any whole on any of its parts: if the cosmos does not depend on its parts, neither does any smaller composit

Direct visualization of degradation microcompartments at the ER membrane

To promote the biochemical reactions of life, cells can compartmentalize molecular interaction partners together within separated non-membrane-bound regions. It is unknown whether this strategy is used to facilitate protein degradation at specific locations within the cell. Leveraging in situ cryo-electron tomography to image the native molecular landscape of the unicellular alga Chlamydomonas reinhardtii, we discovered that the cytosolic protein degradation machinery is concentrated within similar to 200-nm foci that contact specialized patches of endoplasmic reticulum (ER) membrane away from the ER-Golgi interface. These non-membrane-bound microcompartments exclude ribosomes and consist of a core of densely clustered 265 proteasomes surrounded by a loose cloud of Cdc48. Active proteasomes in the microcompartments directly engage with putative substrate at the ER membrane, a function canonically assigned to Cdc48. Live-cell fluorescence microscopy revealed that the proteasome clusters are dynamic, with frequent assembly and fusion events. We propose that the microcompartments perform ER-associated degradation, colocalizing the degradation machinery at specific ER hot spots to enable efficient protein quality control

Five Ws and an H: Digital Challenges in Newspaper Newsrooms and Boardrooms

It is no news to anyone involved with the media, from the newsroom to the boardroom to the classroom, that journalism is at a crossroads as an occupation, a business, a content form, and a public good. This is perhaps particularly true of journalism in the traditional news medium of record, the newspaper, where enormous uncertainty surrounds virtually every facet of the enterprise as it adjusts to being part of a digital network. This essay uses a framework familiar to journalists and journalism educators -- the traditional “five Ws and an H” of who, what, when, where, why, and how -- to address some of the significant issues facing corporate and newsroom managers, as well as journalists themselves