Ligand-dependent Inhibition of CD1d-restricted NKT Cell Development in Mice Transgenic for the Activating Receptor Ly49D

In addition to their CD1d-restricted T cell receptor (TCR), natural killer T (NKT) cells express various receptors normally associated with NK cells thought to act, in part, as modulators of TCR signaling. Immunoreceptor-tyrosine activation (ITAM) and inhibition (ITIM) motifs associated with NK receptors may augment or attenuate perceived TCR signals respectively, potentially influencing NKT cell development and function. ITIM-containing Ly49 family receptors expressed by NKT cells are proposed to play a role in their development and function. We have produced mice transgenic for the ITAM-associated Ly49D and ITIM-containing Ly49A receptors and their common ligand H2-Dd to determine the importance of these signaling interplays in NKT cell development. Ly49D/H2-Dd transgenic mice had selectively and severely reduced numbers of thymic and peripheral NKT cells, whereas both ligand and Ly49D transgenics had normal numbers of NKT cells. CD1d tetramer staining revealed a blockade of NKT cell development at an early precursor stage. Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics, presumably due to attenuation of ITAM signaling. Thus, Ly49D-induced ITAM signaling is incompatible with the early development of cells expressing semi-invariant CD1d-restricted TCRs and appropriately harmonized ITIM–ITAM signaling is likely to play an important role in the developmental program of NKT cells

Study of W boson production in pPb collisions at √sNN = 5.02 TeV

The first study of W boson production in pPb collisions is presented, for bosons decaying to a muon or electron, and a neutrino. The measurements are based on a data sample corresponding to an integrated luminosity of 34.6 nb−1 at a nucleon–nucleon centre-of-mass energy of View the MathML source, collected by the CMS experiment. The W boson differential cross sections, lepton charge asymmetry, and forward–backward asymmetries are measured for leptons of transverse momentum exceeding 25 GeV/c , and as a function of the lepton pseudorapidity in the |ηlab|<2.4 range. Deviations from the expectations based on currently available parton distribution functions are observed, showing the need for including W boson data in nuclear parton distribution global fits.BMWF ; FWF ; FNRS ; FWO ; CNPq ; CAPES ; FAPERJ ; FAPESP ; MES ; CERN ; CAS ; MoST ; NSFC ; COLCIENCIAS ; MSES ; RPF ; MoER ; ERDF ; Academy of Finland ; MEC ; HIP ; CEA ; CNRS ; BMBF ; DFG ; HGF ; GSRT ; OTKA ; NKTH ; DAE ; DST ; IPM ; SFI ; INFN ; NRF ; WCU ; LAS ; CINVESTAV ; CONACYT ; UASLP-FAI ; MSI ; PAEC ; MSHE ; NSC ; FCT ; JINR ; MON ; RosAtom ; RAS ; RFBR ; MESTD ; SEIDI ; CPAN ; Swiss Funding Agencies ; NSC ; ThEPCenter ; IPST ; STAR ; NSTDA ; TUBITAK ; TAEK ; NASU ; STFC ; DOE ; NSF.publisher versio

Feasibility of low energy radiative capture experiments at the LUNA underground accelerator facility

The LUNA (Laboratory Underground for Nuclear Astrophysics) facility has been designed to study nuclear reactions of astrophysical interest. It is located deep underground in the Gran Sasso National Laboratory, Italy. Two electrostatic accelerators, with 50 and 400 kV maximum voltage, in combination with solid and gas target setups allowed to measure the total cross sections of the radiative capture reactions $^2$H(p,$\gamma$)3He and $^{14}$N(p,$\gamma$)$^{15}$O within their relevant Gamow peaks. We report on the gamma background in the Gran Sasso laboratory measured by germanium and bismuth germanate detectors, with and without an incident proton beam. A method to localize the sources of beam induced background using the Doppler shift of emitted gamma rays is presented. The feasibility of radiative capture studies at energies of astrophysical interest is discussed for several experimental scenarios.Comment: Submitted to Eur. Phys. J.

Evidence of time-dependent CP violation in the decay B0 to D*+D*-

We report a measurement of the CP-odd fraction and the time-dependent CP violation in B0 to D*+D*- decays, using 657.10^6 BBbar events collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. We measure a CP-odd fraction of Rperp=0.125+/-0.043(stat)+/-0.023(syst). From the distributions of the proper-time intervals between a B0to D*+D*- decay and the other B meson in the event, we obtain evidence of CP violation with measured parameters AD*+D*-=0.15+/-0.13(stat)+/-0.04(syst) and SD*+D*-=-0.96+/-0.25(stat)-0.16+0.13(syst).Comment: Published in PR

First measurement of the 14N(p,gamma)15O cross section down to 70 keV

In stars with temperatures above 20*10^6 K, hydrogen burning is dominated by the CNO cycle. Its rate is determined by the slowest process, the 14N(p,gamma)15O reaction. Deep underground in Italy's Gran Sasso laboratory, at the LUNA 400 kV accelerator, the cross section of this reaction has been measured at energies much lower than ever achieved before. Using a windowless gas target and a 4pi BGO summing detector, direct cross section data has been obtained down to 70 keV, reaching a value of 0.24 picobarn. The Gamow peak has been covered by experimental data for several scenarios of stable and explosive hydrogen burning. In addition, the strength of the 259 keV resonance has been remeasured. The thermonuclear reaction rate has been calculated for temperatures 90 - 300 *10^6 K, for the first time with negligible impact from extrapolations

Measurements of Charmless Hadronic b->s Penguin Decays in the pi+pi-K+pi- Final State and First Observation of B0 -> rho0K+pi-

We report measurements of charmless hadronic B^0 decays into the pi+pi-K+pi+ final state. The analysis uses a sample of 657x10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider at the Y(4S) resonance. The decay B^0 -> rho0 Kpi is observed for the first time; the significance is 5.0sigma and the corresponding partial branching fraction for M_Kpi in (0.75,1.20) GeV/c^2 is [2.8 +- 0.5(stat) +-0.5(syst)] x 10^{-6}. We also obtain the first evidence for B^0 -> f0Kpi with 3.5sigma significance and for B^0 -> pi+pi-K*0 with 4.5sigma significance. For the two-body decays B^0 -> rho0K*0 and B^0 -> f0K*0, the significances are 2.7sigma and 2.5sigma, respectively, and the upper limits on the branching fractions are 3.4x10^{-6} and 2.2x10^{-6} at 90% confidence level.Comment: 6 pages, 3 figures. accepted by PRD(RC

Observation of B+ -> Dbar*0 tau+ nu_tau and Evidence for B+ -> Dbar^0 tau+ nu_tau at Belle

We present measurements of B+ -> Dbar*0 tau+ nu_tau and B+ -> Dbar^0 tau+ nu_tau decays in a data sample of 657 x 10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We find 446^{+58}_{-56} events of the decay B+ -> Dbar*0 tau+ nu_tau with a significance of 8.1 standard deviations, and 146^{+42}_{-41} events of the decay B+ -> Dbar0 tau+ nu_tau with a significance of 3.5 standard deviations. The latter signal provides the first evidence for this decay mode. The measured branching fractions are B(B+ -> Dbar*0 tau+ nu_tau)=(2.12^{+0.28}_{-0.27} (stat) +- 0.29 (syst)) % and B(B+ -> Dbar0 tau+ nu_tau)=(0.77 +- 0.22 (stat) +- 0.12 (syst)) %.Comment: 6 pages, 4 figures, submitted to Phys. Rev. Let

Evidence for B to K eta' gamma Decays at Belle

We present the results of a search for the radiative decay (B -> K eta' gamma) and find evidence for (B^+ -> K^+ eta' gamma) decays at the 3.3 standard deviation level with a partial branching fraction of (3.6 +/- 1.2 +/- 0.4) x 10e-6, where the first error is statistical and the second systematic. This measurement is restricted to the region of combined (K eta') invariant mass less than 3.4GeVc^2. A 90% confidence level upper limit of 6.4 x 10e-6 is obtained for the decay (B^0 -> K^0 eta' gamma) in the same (K eta') invariant mass region. These results are obtained from a 605 fb^-1 data sample containing 657 x 10e6 B anti-B pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^+e^- collider.Comment: 5 pages, 4 figures. Submitted to PRD-RC on 6/8/0

Improved search for D^0 mixing using semileptonic decays at Belle

A search for mixing in the neutral D meson system has been performed using semileptonic D0 -> K(*)- e+ \nu and D0 -> K(*)- \mu+ \nu decays. Neutral D mesons from D*+ -> D0 \pi_s^+ decays are used and the flavor at production is tagged by the charge of the slow pion. The measurement is performed using 492 fb^-1 of data recorded by the Belle detector. From the yield of right-sign and wrong-sign decays arising from non-mixed and mixed events, respectively, we measure the ratio of the time-integrated mixing rate to the unmixed rate to be R_M = (1.3 +- 2.2 +- 2.0) x 10^-4. This corresponds to an upper limit of R_M < 6.1 x 10^-4 at the 90% C.L.Comment: 20 pages, 16 figures, 8 tables; accepted by PRD; changes from previous version: minor rewording