Assessing product portfolios from a production logistics perspective

The increasing individualization and the growing customer demand for product variety leads to a constant shortening of product life cycles and to the necessity of periodically rationalizing product portfolios. For this reason, approaches to product portfolio assessment offer methods that allow a financial or market-oriented valuation of existing products in portfolios. When assessing products in product portfolios, conventional approaches do not explicitly take the logistical impact of products on the logistics performance or costs of the production into account. The consequence of neglecting the logistical assessment dimension to product portfolios is that products, that have a negative impact on the logistics performance of a company, are not part of a critical examination. This paper therefore presents an approach that aims at developing a methodology to assess product portfolios both from a logistical as well as from financial or market-oriented perspectives. To this end, the approach initially works the influence of individual products and product characteristics on the logistics performance and logistics costs of production out. The consolidation of these findings with further evaluation variables then enables a product portfolio optimization with explicit consideration of a logistic assessment dimension

Why a Systematic Investigation of Production Planning and Control Procedures is Needed for the Target-oriented Configuration of PPC

The target-oriented configuration of production planning and control (PPC) confronts companies with major challenges. While there are already many publications dealing with the effect of specific procedures of PPC tasks on the logistic objectives, there is still a lack of a framework allowing a comprehensive and relatively simple examination of the target conformity of PPC configuration on the level of procedures. Furthermore, such a framework would thereby also enable companies to position their PPC among conflicting production and logistic objectives. This contribution presents the current state of knowledge on target-oriented and holistic PPC configuration and points out why a systematic investigation of the generally valid interdependencies of PPC procedures with each other as well as the impact on the most important objectives is necessary. Further, it is outlined which future research activities are planned and with a demonstrative example illustrated how complex cause-effect relationships within PPC on the level of procedures arise. © 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Deutsche Forschungsgemeinschaft (DFG)/Systematische Untersuchung der Wirkung von Verfahren der Produktionsplanung und der Produktionssteuerung auf logistische Zielgrößen/434659386/E

Integrated Concept for Acquisition and Utilization of Production Feedback Data to Support Production Planning and Control in the Age of Digitalization

Digitalization is changing industrial production and is offering huge potential for producing companies. One effect resulting from the increasing presence of information and communication technology in production is the increasing quantity and quality of production feedback data. However, only collecting large amounts of data of data does not lead to high logistical performance and low logistical costs. It is essential to acquire the right data with as little operating expenses as possible, to analyze the acquired data target-oriented and to present the results user-oriented, so that concrete actions can be derived. In practice, this is a challenge for producing companies. To demonstrate the opportunities in this field of action, a concept was developed at the Institute of Production Systems and Logistics (IFA) (Hannover, Germany) and, furthermore, implemented in the IFA learning factory. This paper starts with a short introduction of the IFA learning factory. After that, the paper presents the developed concept in detail, describing the PPC system, the data acquisition using RFID, an order processing support system using ESL and the (real-time) data analysis. In the end a summarizing conclusion is given underlining the importance of an integrated concept for data acquisition and utilization

Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3

AIMS: Clinical observations in patients with long QT syndrome carrying sodium channel mutations (LQT3) suggest that bradycardia caused by parasympathetic stimulation may provoke torsades de pointes (TdP). beta-Adrenoceptor blockers appear less effective in LQT3 than in other forms of the disease. METHODS AND RESULTS: We studied effects of autonomic modulation on arrhythmias in vivo and in vitro and quantified sympathetic innervation by autoradiography in heterozygous mice with a knock-in deletion (DeltaKPQ) in the Scn5a gene coding for the cardiac sodium channel and increased late sodium current (LQT3 mice). Cholinergic stimulation by carbachol provoked bigemini and TdP in freely roaming LQT3 mice. No arrhythmias were provoked by physical stress, mental stress, isoproterenol, or atropine. In isolated, beating hearts, carbachol did not prolong action potentials per se, but caused bradycardia and rate-dependent action potential prolongation. The muscarinic inhibitor AFDX116 prevented effects of carbachol on heart rate and arrhythmias. beta-Adrenoceptor stimulation suppressed arrhythmias, shortened rate-corrected action potential duration, increased rate, and minimized difference in late sodium current between genotypes. beta-Adrenoceptor density was reduced in LQT3 hearts. Acute beta-adrenoceptor blockade by esmolol, propranolol or chronic propranolol in vivo did not suppress arrhythmias. Chronic flecainide pre-treatment prevented arrhythmias (all P < 0.05). CONCLUSION: Cholinergic stimulation provokes arrhythmias in this model of LQT3 by triggering bradycardia. beta-Adrenoceptor density is reduced, and beta-adrenoceptor blockade does not prevent arrhythmias. Sodium channel blockade and beta-adrenoceptor stimulation suppress arrhythmias by shortening repolarization and minimizing difference in late sodium current.status: publishe

Temporal trends in fetal mortality at and beyond term and induction of labor in Germany 2005-2012 : data from German routine perinatal monitoring

Purpose: While a variety of factors may play a role in fetal and neonatal deaths, postmaturity as a cause of stillbirth remains a topic of debate. It still is unclear, whether induction of labor at a particular gestational age may prevent fetal deaths. Methods: A multidisciplinary working group was granted access to the most recent set of relevant German routine perinatal data, comprising all 5,291,011 hospital births from 2005 to 2012. We analyzed correlations in rates of induction of labor (IOL), perinatal mortality (in particular stillbirths) at different gestational ages, and fetal morbidity. Correlations were tested with Pearson's product-moment analysis (α = 5 %). All computations were performed with SPSS version 22. Results: Induction rates rose significantly from 16.5 to 21.9 % (r = 0.98; p \ 0.001). There were no significant changes in stillbirth rates (0.28-0.35 per 100 births; r = 0.045; p = 0.806). Stillbirth rates 2009-2012 remained stable in all gestational age groups irrespective of induction. Fetal morbidity (one or more ICD-10 codes) rose significantly during 2005–2012. This was true for both children with (from 33 to 37 %, r = 0.784, p \ 0.001) and without (from 25 to 31 %, (r = 0.920, p \ 0.001) IOL. Conclusions: An increase in IOL at term is not associated with a decline in perinatal mortality. Perinatal morbidity increased with and without indiction of labor

Beiträge zum 28. Darmstädter Geotechnik-Kolloquium am 09. März 2022

Themenschwerpunkte: 1. Modell- und Feldversuche 2. Digitalisierung und künstliche Intelligenz in der Geotechnik 3. Nationale und internationale Großprojekte 4. Normung und Rechtliche

Beiträge zum 28. Darmstädter Geotechnik-Kolloquium am 09. März 2022

Themenschwerpunkte: 1. Modell- und Feldversuche 2. Digitalisierung und künstliche Intelligenz in der Geotechnik 3. Nationale und internationale Großprojekte 4. Normung und Rechtliche