1,178 research outputs found
A numerical study of a semi-Lagrangian Parareal method applied to the viscous Burgers equation
This is the author accepted manuscript. The final version is available from Springer via the DOI in this record.This work focuses on the Parareal parallelin-time
method and its application to the viscous Burgers
equation. A crucial component of Parareal is the
coarse time stepping scheme, which strongly impacts
the convergence of the parallel-in-time method. Three
choices of coarse time stepping schemes are investigated
in this work: explicit Runge-Kutta, implicit-explicit
Runge-Kutta, and implicit Runge-Kutta with semiLagrangian
advection.
Manufactured solutions are used to conduct studies,
which provide insight into the viability of each considered
time stepping method for the coarse time step of
Parareal. One of our main findings is the advantageous convergence behavior of the semi-Lagrangian scheme
for advective flows.Schmitt: The work of this author is supported by the ’Excellence
Initiative’ of the German Federal and State Governments
and the Graduate School of Computational Engineering
at Technische Universit¨at Darmstadt
Peixoto: Acknowledges the Sao Paulo Research Foundation
(FAPESP) under the grant number 2016/18445-7 and the National
Science and Technology Development Council (CNPq)
under grant number 441328/2014-
UK science press officers, professional vision and the generation of expectations
Science press officers can play an integral role in helping promote expectations and hype about biomedical research. Using this as a starting point, this article draws on interviews with 10 UK-based science press officers, which explored how they view their role as science reporters and as generators of expectations. Using Goodwin’s notion of ‘professional vision’, we argue that science press officers have a specific professional vision that shapes how they produce biomedical press releases, engage in promotion of biomedical research and make sense of hype. We discuss how these insights can contribute to the sociology of expectations, as well as inform responsible science communication.This project was funded by the Wellcome Trust (Wellcome Trust Biomedical Strategic Award 086034)
Murine model for Fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence
Peer reviewedPublisher PD
Tailoring Three-Point Functions and Integrability III. Classical Tunneling
We compute three-point functions between one large classical operator and two
large BPS operators at weak coupling. We consider operators made out of the
scalars of N=4 SYM, dual to strings moving in the sphere. The three-point
function exponentiates and can be thought of as a classical tunneling process
in which the classical string-like operator decays into two classical BPS
states. From an Integrability/Condensed Matter point of view, we simplified
inner products of spin chain Bethe states in a classical limit corresponding to
long wavelength excitations above the ferromagnetic vacuum. As a by-product we
solved a new long-range Ising model in the thermodynamic limit.Comment: 37 pages, 10 figure
Pathophysiology of acute experimental pancreatitis: Lessons from genetically engineered animal models and new molecular approaches
The incidence of acute pancreatitis is growing and worldwide population-based studies report a doubling or tripling since the 1970s. 25% of acute pancreatitis are severe and associated with histological changes of necrotizing pancreatitis. There is still no specific medical treatment for acute pancreatitis. The average mortality resides around 10%. In order to develop new specific medical treatment strategies for acute pancreatitis, a better understanding of the pathophysiology during the onset of acute pancreatitis is necessary. Since it is difficult to study the early acinar events in human pancreatitis, several animal models of acute pancreatitis have been developed. By this, it is hoped that clues into human pathophysiology become possible. In the last decade, while employing molecular biology techniques, a major progress has been made. The genome of the mouse was recently sequenced. Various strategies are possible to prove a causal effect of a single gene or protein, using either gain-of-function (i.e., overexpression of the protein of interest) or loss-of-function studies (i.e., genetic deletion of the gene of interest). The availability of transgenic mouse models and gene deletion studies has clearly increased our knowledge about the pathophysiology of acute pancreatitis and enables us to study and confirm in vitro findings in animal models. In addition, transgenic models with specific genetic deletion or overexpression of genes help in understanding the role of one specific protein in a cascade of inflammatory processes such as pancreatitis where different proteins interact and co-react. This review summarizes the recent progress in this field. Copyright (c) 2005 S. Karger AG, Basel
Novel insights into host-fungal pathogen interactions derived from live-cell imaging
Acknowledgments The authors acknowledge funding from the Wellcome Trust (080088, 086827, 075470 and 099215) including a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 and FP7-2007–2013 grant agreement HEALTH-F2-2010-260338–ALLFUN to NARG.Peer reviewedPublisher PD
A Hybrid Higgs
We construct composite Higgs models admitting a weakly coupled Seiberg dual
description. We focus on the possibility that only the up-type Higgs is an
elementary field, while the down-type Higgs arises as a composite hadron. The
model, based on a confining SQCD theory, breaks supersymmetry and electroweak
symmetry dynamically and calculably. This simultaneously solves the \mu/B_\mu
problem and explains the smallness of the bottom and tau masses compared to the
top mass. The proposal is then applied to a class of models where the same
confining dynamics is used to generate the Standard Model flavor hierarchy by
quark and lepton compositeness. This provides a unified framework for flavor,
supersymmetry breaking and electroweak physics. The weakly coupled dual is used
to explicitly compute the MSSM parameters in terms of a few microscopic
couplings, giving interesting relations between the electroweak and soft
parameters. The RG evolution down to the TeV scale is obtained and salient
phenomenological predictions of this class of "single-sector" models are
discussed.Comment: 56 pages, 7 figures, v2: discussion on FCNCs and references added,
v3: JHEP versio
Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles
Innovation in Creative Industries: From the Quadruple Helix Model to the Systems Theory
Knowledge and creativity have always played a key role in the economy. Since the 2000s, the relevance of the creative industries, a high growth sector, has been pointed out as long as its strong and positive effects on jobs and economic growth. In the current context of rapid globalization and technological development, the innovation system is getting even more complex because it implies a shift in research focus from the supply to the demand side environment (consumption-driven economy). The authors focus on theoretical approaches coming from management and media studies able to explain the current paradigm shift in innovation and knowledge production and use: the Triple Helix model (and its developments) and Systems Theory. As an interesting case study, the Creative Enterprise Australia (CEA) is analyzed according the theoretical approaches shown. The paper tries to shed new light on the evolving role of knowledge pointing out the overlapping relationships between all the actors involved and the interpenetration of systems, and the prominent appointment of the media as an interpretative framework of the convergence of the depicted theories
Wizard CD Plus and ProTaper Universal: analysis of apical transportation using new software
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