A Di Pietro

A Reuben

AL Martinez-Rocha

Antonio Di Pietro

B Musher

BE de Pauw

CS Foster

CY Low

David R. Andes

DB Jones

DC Sheppard

Donna MacCallum

E Anaissie

E Mayayo

EI Boutati

FC Odds

FM Polack

FP Silveira

GM Gonzalez

GP Bodey

HC Gugnani

IL Stevenson

J Guarro

KA Marr

Katja Schäfer

M Nucci

M Ortoneda

MC Dignani

MJ Bharathi

MS Lopez-Berges

NA Rotowa

Neil A. R. Gow

PE Nelson

RC Prados-Rosales

TF Patterson

TJ Liesegang

TJ Walsh

Y Couteaudier

Y Fan

Y Ishibashi

Y Kono

Y Zhao

PLoS ONE

English

PubMed

Schäfer Katja

Di Pietro Antonio

Gow Neil A. R.

MacCallum Donna

Public Library of Science (PLOS)

 Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence

Crossref

Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence

The soil-borne plant pathogen Fusarium oxysporum causes life-threatening invasive fusariosis in immunocompromised individuals. The mechanism of infection in mammalian hosts is largely unknown. In the present study we show that the symptoms of disseminated fusariosis caused by F. oxysporum in immunosuppressed mice are remarkably similar to those reported in humans. Distinct fungal structures were observed inside the host, depending on the infected organ. Invasive hyphae developed in the heart and kidney, causing massive colonization of the organs. By contrast, chlamydospore-like survival structures were found in lung, spleen and liver. Systemically infected mice also developed skin and eye infections, as well as thrombosis and necrosis in the tail. We further show that F. oxysporum can disseminate and persist in the organs of immunocompetent animals, and that these latent infections can lead to lethal systemic fusariosis if the host is later subjected to immunosuppressive treatment

Schäfer, Katja

Di Pietro, Antonio

Gow, Neil A. R.

MacCallum, Donna

Repositorio Institucional de la Universidad de Córdoba

Schafer, Katja

Gow, Neil A R

The Open University

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Murine model for Fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence

Neil A R Gow

Directory of Open Access Journals

Murine model for Fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence.

http://helvia.uco.es/xmlui/bitstream/10396/15490/3/dipietro4.pdf

Murine model for Fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence

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Public Library of Science (PLOS)

Crossref

Repositorio Institucional de la Universidad de Córdoba

The Open University

Directory of Open Access Journals