Molecular Lines in Bok Globules and Around Herbig Ae/be Stars

This paper is intended as part of a more extensive molecular line survey in star forming regions along the evolutionary track of a collapsing cloud toward a young stellar object. We have studied a sample of seven small dark clouds (Bok globules) and eight Herbig Ae/Be stars in the J=1->0 transition of HCO$^{+}$, H$^{13}$CO$^{+}$, HCN and H$^{13}$CN. The choice of these molecules is determined by the simple chemistry and the predicted high abundance of the reactants leading to their formation. The isotopically substituted species (isotopomers), H$^{13}$CO$^{+}$ and H$^{13}$CN, were observed in order to determine, whenever possible, the optical thickness of the main species. The most abundant isotopomers were found in almost all the sources (detection rate 70-90\%). Those sources which exhibited the strongest signals were also searched for the $^{13}$C isotopomers. H$^{13}$CO$^{+}$ was found in one dark cloud and around three Herbig Ae/Be stars, while H$^{13}$CN around only one star. The column densities for each species and the physical conditions of the objects were derived whenever the observational data allowed it.Comment: 16 pages plus 6 figures available in hardcopy from [email protected] LaTEX ver. 2.09, BAP 11-1993-036-DD

Tracing the evolutionary stage of Bok globules: CCS and NH3

We pursue the investigation of a previously proposed correlation between chemical properties and physical evolutionary stage of isolated low-mass star-forming regions. In the past, the NH3/CCS abundance ratio was suggested to be a potentially useful indicator for the evolutionary stage of cloud cores. We aim to study its applicability for isolated Bok globules. A sample of 42 Bok globules with and without signs of current star formation was searched for CCS(2-1) emission, the observations were complemented with NH3 measurements available in the literature and own observations. The abundance ratio of both molecules is discussed with respect to the evolutionary stage of the objects and in the context of chemical models. The NH3/CCS ratio could be assessed for 18 Bok globules and is found to be moderately high and roughly similar across all evolutionary stages from starless and prestellar cores towards internally heated cores harbouring protostars of Class 0, Class I or later. Bok globules with extremely high CCS abundance analogous to carbon-chain producing regions in dark cloud cores are not found. The observed range of NH3/CCS hints towards a relatively evolved chemical state of all observed Bok globules.Comment: 12 pages, 6 figures, accepted for publication in Astronomy & Astrophysic

Nuevas citas en la familia Brassicaceae para la provincia de San Luis (Argentina)

In the present paper, 11 native and 5 introduced taxa belonging to Brassicaceae, and distributed among 7 genera are recorded for first time for San Luis province, Argentina, Common names, illustrations, habitat, distribution and herbarium specimens as a reference are provided tor each taxon. Also, a key to indentify species of the genus Lepidium are given.En la presente contribución se citan por primera vez para la provincia de San Luis, Argentina, 16 taxones pertenecientes a la familia Brassicaceae, 11 nativos y 5 introducidos distribuidos en 7 géneros. Se describen brevemente, se ilustran y se proporciona al menos un ejemplar de herbario como referencia para cada taxón. Se informa sobre características de hábitat y distribución en la provincia de San Luis y se proporcionan los nombres vulgares y datos de usos e importancia agronómica de cada uno de ellos. Para el g6nero Lepidium se provee una clave para identificar las especies

A sensitive survey for water maser emission towards Bok globules using the Robledo 70m antenna

We report the most sensitive water maser survey towards Bok globules to date, using NASA's 70m antenna in Robledo de Chavela (Spain). We observed 207 positions within the CB catalog with a higher probability of harboring a young star, using as selection criteria the presence of radio continuum emission (from submillimeter to centimeter wavelengths), geometrical centers of molecular outflows, peaks in maps of high-density gas tracers (NH3 or CS), and IRAS point sources. We have obtained 7 maser detections, 6 of which (in CB 34, CB 54, CB 65, CB 101, CB 199, and CB 232) are reported for the first time here. Most of the water masers we detected are likely to be associated with young stellar objects (YSOs), except for CB 101 (probably an evolved object) and CB 65 (uncertain nature). The water maser in CB 199 shows a relatively high shift (~30 km/s) of its velocity centroid with respect to the cloud velocity, which is unusual for low-mass YSOs. We speculate that high-velocity masers in this kind of object could be related with episodes of energetic mass-loss in close binaries. Alternatively, the maser in CB 199 could be pumped by a protoplanetary or a young planetary nebula. CB 232 is the smallest Bok globule (~0.6 pc) known to be associated with water maser emission, although it would be superseded by the cases of CB 65 (~0.3 pc) and CB 199 (~0.5 pc) if their association with YSOs is confirmed. All our selection criteria have statistically compatible detection rates, except for IRAS sources, which tend to be a somewhat worse predictor for the presence of maser emission.Comment: 42 pages, 7 figures. Accepted by The Astronomical Journal. Corrected typos in Tables 1 &

CPX-351 treatment in secondary acute myeloblastic leukemia is effective and improves the feasibility of allogeneic stem cell transplantation: results of the Italian compassionate use program

Secondary acute myeloid leukemia (sAML) poorly responds to conventional treatments and allogeneic stem cell transplantation (HSCT). We evaluated toxicity and efficacy of CPX-351 in 71 elderly patients (median age 66 years) with sAML enrolled in the Italian Named (Compassionate) Use Program. Sixty days treatment-related mortality was 7% (5/71). The response rate at the end of treatment was: CR/CRi in 50/71 patients (70.4%), PR in 6/71 (8.5%), and NR in 10/71 (19.7%). After a median follow-up of 11 months relapse was observed in 10/50 patients (20%) and 12 months cumulative incidence of relapse (CIR) was 23.6%. Median duration of response was not reached. In competing risk analysis, CIR was reduced when HSCT was performed in first CR (12 months CIR of 5% and 37.4%, respectively, for patients receiving (=20) or not (=30) HSCT, p = 0.012). Twelve-months OS was 68.6% (median not reached). In landmark analysis, HSCT in CR1 was the only significant predictor of longer survival (12 months OS of 100 and 70.5%, for patients undergoing or not HSCT in CR1, respectively, p = 0.011). In conclusion, we extend to a real-life setting, the notion that CPX is an effective regimen for high risk AML patients and may improve the results of HSCT

The 9.7 and 18 um silicate absorption profiles towards diffuse and molecular cloud lines-of-sight

Studying the composition of dust in the interstellar medium (ISM) is crucial in understanding the cycle of dust in our galaxy. The mid-infrared spectral signature of amorphous silicates, the most abundant dust species in the ISM, is studied in different lines-of-sight through the Galactic plane, thus probing different conditions in the ISM. We have analysed 10 spectra from the Spitzer archive, of which 6 lines-of-sight probe diffuse interstellar medium material and 4 probe molecular cloud material. The 9.7 um silicate absorption features in 7 of these spectra were studied in terms of their shape and strength. In addition, the shape of the 18 um silicate absorption features in 4 of the diffuse sightline spectra were analysed. The 9.7 um silicate absorption bands in the diffuse sightlines show a strikingly similar band shape. This is also the case for all but one of the 18 um silicate absorption bands observed in diffuse lines-of-sight. The 9.7 um bands in the 4 molecular sightlines show small variations in shape. These modest variations in the band shape are inconsistent with the interpretation of the large variations in {\tau}_9.7/E(J-K) between diffuse and molecular sightlines in terms of silicate grain growth. Instead, we suggest that the large changes in {\tau}_9.7 / E(J-K) must be due to changes in E(J-K).Comment: 14 pages, 19 figures, accepted for publication in A&

Incidence, treatment and outcome of central nervous system relapse in adult acute lymphoblastic leukaemia patients treated front-line with paediatric-inspired regimens: A retrospective multicentre Campus ALL study

Within the Campus ALL network we analyzed the incidence, characteristics, treatment and outcome of a central nervous system (CNS) relapse in 1035 consecutive adult acute lymphoblastic leukemia (ALL) patients treated frontline with pediatric-inspired protocols between 2009 and 2020. Seventy-one patients (6.8%) experienced a CNS recurrence, more frequently in T- (28/278; 10%) than in B-ALL (43/757; 5.7%) (p = 0.017). An early CNS relapse—< 12 months from diagnosis—was observed in 41 patients. In multivariate analysis, risk factors for early CNS relapse included T-cell phenotype (p = <0.001), hyperleucocytosis >100 × 109/L (p<0.001) and male gender (p = 0.015). Treatment was heterogeneous, including chemotherapy, radiotherapy, intrathecal therapy and novel agents. A complete remission (CR) was obtained in 39 patients (55%) with no differences among strategies. After CR, 26 patients underwent an allogenic transplant, with a significant overall survival benefit compared to non-transplanted patients (p = 0.012). After a median observation of 8 months from CNS relapse, 23 patients (32%) were alive. In multivariate analysis, the time to CNS relapse was the strongest predictor of a lower 2-year post-relapse survival (p<0.001). In conclusion, in adult ALL the outcome after a CNS relapse remains very poor. Effective CNS prophylaxis remains the best approach and allogenic transplant should be pursued when possible

High-resolution observations of water masers in Bok globules

We present Very Large Array observations at 1.3 cm of several water maser detections obtained by previous single-dish studies of Bok globules in the Clemens & Barvainis (1988; CB) catalog. We report water maser emission in CB 3 (CB3-mm), CB 54 (IRAS 07020-1618), CB 101 (IRAS 17503-0833), and CB 232 (IRAS 21352+4307), and non-detection towards CB 65 (IRAS 16277-2332) and CB 205 (IRAS 19433+2743). These are the first reported interferometric observations of water masers in Bok globules of the CB catalog. We also present single-dish observations of millimeter and centimeter spectral lines towards CB 101 (IRAS 17503-0833) and CB 65 (IRAS 16277-2332). All the maser emission seems to be associated with star forming regions hosting bipolar molecular outflows, except IRAS 17503-0833 in CB 101, which we suggest to be a possible Mira evolved star, and IRAS 16277-2332 in CB 65, of unknown nature. We have used the precise position of the maser emission to derive information about the powering source of the masers. By analyzing the spatio-kinematical distribution of the water masers, we confirm the millimeter source CB 3-mm as the most likely powering source of the CB 3 masers. We propose the near-IR source CB 232 YC1-I as the best candidate for pumping the maser emission observed in CB 232, while in CB 54, we suggest that the pumping source of the masers could be located at the position of an elongated feature observed in near-infrared maps.Comment: 29 pages, 6 figures. Accepted by The Astronomical Journa

Sympathetic cooling and detection of molecular ions in a Penning trap

Published versio

High resolution optical spectroscopy of an LBV-candidate inside the CygOB2 association

For the first time, we obtained the high-resolution (R=15000 and 60000) optical spectra for the extremely luminous star No.12, associated with the IR-source IRAS20308+4104, a member of the CygOB2 association. We have found about 200 spectral features in range 4552-7939AA, including the interstellar NaI, KI lines and numerous DIBs, which are the strongest absorption lines in the spectrum, along with the HeI, CII, and SiII lines. A two-dimensional spectral classification indicates that the spectral type is B5+/-0.5 Ia+. Our analysis of the Vr data shows the presence of a Vr gradient in the stellar atmosphere, caused by the infall of matter onto the star. The strong Halpha emission displays broad Thompson wings and time-variable core absorption, providing evidence that the stellar wind is inhomogeneous, and a slightly blue-shifted PCyg type absorption profile. We concluded that the wind is variable in time.Comment: 20 pages, 5 figures, 2 table