42 research outputs found
As a Matter of Factions: The Budgetary Implications of Shifting Factional Control in Japan’s LDP
For 38 years, the Liberal Democratic Party (LDP) maintained single-party control over the Japanese government. This lack of partisan turnover in government has frustrated attempts to explain Japanese government policy changes using political variables. In this paper, we look for intraparty changes that may have led to changes in Japanese budgetary policy. Using a simple model of agenda-setting, we hypothesize that changes in which intraparty factions “control” the LDP affect the party’s decisions over spending priorities systematically. This runs contrary to the received wisdom in the voluminous literature on LDP factions, which asserts that factions, whatever their raison d’être, do not exhibit different policy preferences. We find that strong correlations do exist between which factions comprise the agenda-setting party “mainstream” and how the government allocates spending across pork-barrel and public goods items
The quantum vacuum at the foundations of classical electrodynamics
In the classical theory of electromagnetism, the permittivity and the
permeability of free space are constants whose magnitudes do not seem to
possess any deeper physical meaning. By replacing the free space of classical
physics with the quantum notion of the vacuum, we speculate that the values of
the aforementioned constants could arise from the polarization and
magnetization of virtual pairs in vacuum. A classical dispersion model with
parameters determined by quantum and particle physics is employed to estimate
their values. We find the correct orders of magnitude. Additionally, our simple
assumptions yield an independent estimate for the number of charged elementary
particles based on the known values of the permittivity and the permeability,
and for the volume of a virtual pair. Such interpretation would provide an
intriguing connection between the celebrated theory of classical
electromagnetism and the quantum theory in the weak field limit.Comment: Accepted in Applied Physics B: Special Issue for the 50 years of the
laser. Comments are welcome
Correlations between the peak flux density and the position angle of inner-jet in three blazars
We aim to investigate the relation between the long-term flux density and the
position angle (PA) evolution of inner-jet in blazars. We have carried out the
elliptic Gaussian model-fit to the `core' of 50 blazars from 15 GHz VLBA data,
and analyzed the variability properties of three blazars from the model-fit
results. Diverse correlations between the long-term peak flux density and the
PA evolution of the major axis of the `core' have been found in 20% of
the 50 sources. Of them, three typical blazars have been analyzed, which also
show quasi-periodic flux variations of a few years (T). The correlation between
the peak flux density and the PA of inner-jet is positive for S5~0716+714, and
negative for S4~1807+698. The two sources cannot be explained with the
ballistic jet models, the non-ballistic models have been analyzed to explain
the two sub-luminal blazars. A correlation between the peak flux density and
the PA (with a T/4 time lag) of inner-jet is found in [HB89]~1823+568, this
correlation can be explained with a ballistic precession jet model. All the
explanations are based mainly on the geometric beaming effect; physical flux
density variations from the jet base would be considered for more complicated
situations in future, which could account for the no or less significance of
the correlation between the peak flux density and the PA of inner-jet in the
majority blazars of our sample.Comment: 6 pages, 7 figures, accepted for publication in Astrophysics and
Space Scienc
Development of a versatile laboratory experiment to teach the metabolic transformation of hydrolysis
In this paper we describe an easy, reliable, versatile and inexpensive laboratory experiment to teach the metabolic transformation of hydrolysis to Pharmacy students. The experiment does not require the sacrifice of any experimental animal, or any work with organs or tissues, and so can be implemented in a typical university chemistry laboratory. We used acetylsalicylic acid (ASA), hexyl salicylate (HS) and two enzymes, a lipase and an esterase. Since both ASS and HS liberate salicylic acid (SA) upon hydrolysis, students can evaluate the different enzymatic transformations by monitoring the amount of SA liberated. The learning outcomes are an enhanced student understanding of: (1) the process of hydrolysis; (2) the application of enzymatic transformations of molecules from food to xenobiotics; (3) the differences between the general specificity of substrate of both enzymes; (4) the concepts of the lipophilic pocket; (5) the catalytic triad and its regioselectivity in relation to the ester bond. A questionnaire was administered to participating students at three points in time: at the beginning of the module, after enzymatic hydrolysis was taught in class, and after the laboratory experiment. From an analysis of the questionnaire data we conclude that this practical helped Pharmacy students to understand these concepts
Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial
We report the first long-term follow-up of a randomized trial (NCT04978259) addressing the effects of remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. Of the 208 patients recruited from 11 Finnish hospitals, 198 survived, of whom 181 (92%) completed follow-up. At one year, self-reported recovery occurred in 85% in remdesivir and 86% in standard of care (SoC) (RR 0.94, 95% CI 0.47-1.90). We infer no convincing difference between remdesivir and SoC in quality of life or symptom outcomes (p > 0.05). Of the 21 potential long-COVID symptoms, patients reported moderate/major bother from fatigue (26%), joint pain (22%), and problems with memory (19%) and attention/concentration (18%). In conclusion, after a one-year follow-up of hospitalized patients, one in six reported they had not recovered well from COVID-19. Our results provide no convincing evidence of remdesivir benefit, but wide confidence intervals included possible benefit and harm.publishedVersionPeer reviewe
Developing manufacturing control software: A survey and critique
The complexity and diversity of manufacturing software and the need to adapt this software to the frequent changes in the production requirements necessitate the use of a systematic approach to developing this software. The software life-cycle model (Royce, 1970) that consists of specifying the requirements of a software system, designing, implementing, testing, and evolving this software can be followed when developing large portions of manufacturing software. However, the presence of hardware devices in these systems and the high costs of acquiring and operating hardware devices further complicate the manufacturing software development process and require that the functionality of this software be extended to incorporate simulation and prototyping.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45542/1/10696_2005_Article_BF01328739.pd
Mitochondrial pseudogenes in insect DNA barcoding: differing points of view on the same issue
Supplementary Material for: High Vitreous Concentration of IL-6 and IL-8, but Not of Adhesion Molecules in Relation to Plasma Concentrations in Proliferative Diabetic Retinopathy
<b><i>Background/Aim:</i></b> Inflammatory markers have been observed in proliferative diabetic retinopathy (PDR). We assessed vitreous concentrations of adhesion molecules and cytokines in PDR and non-diabetic controls and plasma concentrations to differentiate local inflammation from the breakdown of the blood-retina barrier. <b><i>Methods:</i></b> 38 patients with PDR and 16 controls with macular hole or epiretinal membrane underwent vitrectomy. Vitreous and plasma soluble adhesion molecules [sE-selectin, intercellular adhesion molecule (sICAM)-1 and -3, platelet-endothelial cell adhesion molecule (sPECAM)-1, sP-selectin, vascular cell adhesion molecule (sVCAM)-1] and cytokines [interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 (p70), tumour necrosis factor-α and -β, γ-interferon] were detected by the multiplex assay. <b><i>Results:</i></b> Levels of IL-6 and IL-8 were 26-fold (p = 0.001) and 6-fold higher (p = 0.001) in vitreous than in plasma in PDR. Vitreous IL-10 (p = 0.004), sPECAM-1, sE-selectin, sICAM-1 and sVCAM-1 were higher in PDR than controls (p = 0.001 for all). Adhesion molecule concentrations in vitreous in PDR were less than 10% of those in plasma. IL-10 was lower in vitreous than plasma (3.0 vs. 12.8 pg/ml, p = 0.007), and the vitreous IL-10/IL-8 ratio was significantly lower in PDR than in controls (0.10 vs. 0.55 pg/ml, p = 0.003). <b><i>Conclusion:</i></b> The elevated IL-6 and IL-8 levels in vitreous, but not in plasma, are evidence favouring local over systemic inflammation in PDR. Furthermore, there was imbalance between inflammatory and anti-inflammatory cytokines in the vitreous