THE GAME AS A MEANS OF DEVELOPMENT CREATIVE ABILITIES AND INTELLIGENCE OF STUDENTS

В статье рассматривается влияние игры на развитие творческих способностей и интеллекта обучающихся, определение особого статуса игры в системе деятельности и развития ребенка на основе систематизации теоретических положений и передовой практики. Именно школе отводится основная роль в создании условий для формирования личностных качеств, развития творческих способностей и интеллекта, достижения каждым обучающимся своих собственных успеховThe article discusses the impact of the game on development creative abilities and intelligence of students, the definition of special status of the game in the system of activity and development of the child on the basis of systematization of theoretical positions and best practices. It is the school that plays the main role in creating the conditions for formation of personal qualities, development of creative abilities and intelligence's, achievements of each student of their own successe

Нові тренди кримінально-правової доктрини: рефлексія віктимологічних девіацій уразливості у глобальному інформаційному суспільстві

Савінова Н. А. Нові тренди кримінально-правової доктрини: рефлексія віктимологічних девіацій уразливості у глобальному інформаційному суспільстві / Н. А. Савінова // Про злочини та покарання: еволюція кримінально-правової доктрини : матеріали Міжнар. наук.-практ. конф., присвяченої 250-річчю трактату Чезаре Беккаріа (м. Одеса, 13 черв. 2014 р.) / редкол. : С. В. Ківалов (голов. ред.), В. О. Туляков (заст. голов ред.), Є. Л. Стрельцов (заст. голов ред.), Д. О. Балобанова ; МОН України, НУ ОЮА, ПРЦ НАПрН України, Одес. відділ. ГО «Всеукр. асоц. кримін. права». — Одеса : Юрид. л-ра, 2014. - С. 69-74

Kaliningrad vs. Königsberg: The Role of the Renaming Discussion for the Formation of the Kaliningrad Regional Identity

This thesis is dedicated to studying the current processes of the Kaliningrad Region's identity transformation by examining debates over restoration of Kaliningrad's historical name, Königsberg in regional media. The aim of the study is to find out how does the regional media contribute to the renaming debate, and how is the regional identity transformed within the discussion in the media. The material for the analysis is a collection of 24 articles from 5 regional media sources published in January-April 2013. Articles are examined using Fairclough's three-dimensional concept of analysis of media texts. This work provides an introduction into the socio-cultural background of the topic. It thoroughly investigates how text producers use genre of "letters to the editor" to influence their audiences in a certain way. It discovers the political dimension of the renaming debate by looking at standpoints of various political actors and their representations in the media texts. It defines central topics within the renaming discussion and examines argumentation of renaming supporters and their opponents. It identifies discourses influencing the process of transformation of the Kaliningrad Region's identity. The study has shown that some of regional media outlets prefer to keep the status quo, while others are interested in the further development of the renaming debate. The latter are trying to introduce new topics and fresh opinions to their audience. The analysis of argumentation has shown that some arguments have already lost their persuasive power since the beginning of the discussion in 1991, while new arguments are entering the scene. The most influential discourse is the discourse of Europeanness, which central idea is to become as close to the EU as it is possible, without being separated from Russia. It shows how the Kaliningrad Region attempts to utilize its position in-between the EU and Russia. Conducted study has demonstrated significance of borderlands as political actors in international relations and importance of analyzing political dynamics related to margins along with state-state dynamics

Analysis of the Internal Environment of the Pharmaceutical Distributor Operation in Russia Using SWOT Analysis

BACKGROUND: The general directions of the organization’s development should be clearly formulated, i.e., a business strategy should be developed in order to achieve the long-term competitive advantages in the operation of a pharmaceutical distributor with its own pharmacy warehouse in Russia. AIM: Identification of strengths and weaknesses, opportunities and threats in the operation of a pharmaceutical distributor with its own pharmacy warehouse. MATERIALS AND METHODS: The SWOT analysis was used to analyze the environment, which enabled a joint study of the external and internal environment. During the study, content analysis of secondary sources of information was used (data from the Federal State Statistics Service, DSM Group marketing agency), as well as sociological analysis. RESULTS AND DISCUSSION: During the SWOT analysis, ten factors were identified that ensured the normal functioning of the pharmaceutical distributor, as well as 11 negative factors were identified that negatively affected the operation of the pharmacy warehouse. The article presents qualitative description of the strengths and weaknesses. Ten factors were attributed to the favorable opportunities for the organization’s activities; seven positions were considered as threats to the activities of the distributor. It should be noted that all factors of external environment are in a state of strong mutual influence. A change in one of the factors necessarily leads to a change in other factors. Therefore, their study and analysis should not be carried out separately, but systematically, with tracking not only the actual changes in one factor but also the process how these changes will affect other factors. After identifying strengths and weaknesses, opportunities and threats, a table was compiled and all intersections were analyzed, i.e., all possible pairwise combinations that would help determining the future strategy. At present, the strategic goal of a number of wholesale companies in the pharmaceutical market is defined as increasing return on investment. CONCLUSION: In this article, SWOT analysis has been used to provide some suggestions on overcoming weaknesses and threats in the activities of a pharmaceutical distributor, as well as on proper use of strengths and opportunities. During the study, pharmaceutical industry practitioners discussed the impact of various economic factors, strengths, opportunities, weaknesses, and threats regarding the activities of pharmaceutical distributor, as well as related problems and prospects for the future

European subtype of tick-borne encephalitis virus. Literature review

This review is devoted to the European subtype of tick-borne encephalitis virus (TBEV). It summarizes and analyzes the information available at the scientific literature on the genetic and biological properties of strains of this virus subtype. A comparative analysis of the complete coding sequences of all currently recognized tick-borne flaviviruses was carried out. It was noted that the differences in TBEV strains included in the European subtype are minimal, which indicates a higher degree of their genetic homogeneity than in strains of the Far Eastern and Siberian subtypes. The level of differences in the genome of strains of the European subtype, depending on the region and the source of isolation, was analyzed. No relationship was found between the level of homology of nucleotide sequences of TBEV strains of the European subtype and the source of isolation. The proposed models for the evolution of TBE are described. The area of TBE of the European subtype in Eurasia is analyzed. The maps of the geographical distribution of the European subtype are presented. It shows the European subtype TBE is found in 14 regions of Russia. TBE of this subtype, as a rule, causes a disease with a milder course in comparison with TBE caused by a virus of the Far Eastern or Siberian subtypes. An analysis of the main vectors and reservoir hosts of the European subtype TBEV in Europe and in Siberia has been carried out. It is emphasized that in Eurasia the European TBEV circulates in territories that differ significantly in climatic conditions, relief, landscape, and characteristics of biotopes. However, analysis of scientific literature data showed that, despite these differences, it has a high degree of genome stability

The mouse anterior chamber angle and trabecular meshwork develop without cell death

BACKGROUND: The iridocorneal angle forms in the mammalian eye from undifferentiated mesenchyme between the root of the iris and cornea. A major component is the trabecular meshwork, consisting of extracellular matrix organized into a network of beams, covered in trabecular endothelial cells. Between the beams, channels lead to Schlemm's canal for the drainage of aqueous humor from the eye into the blood stream. Abnormal development of the iridocorneal angle that interferes with ocular fluid drainage can lead to glaucoma in humans. Little is known about the precise mechanisms underlying angle development. There are two main hypotheses. The first proposes that morphogenesis involves mainly cell differentiation, matrix deposition and assembly of the originally continuous mesenchymal mass into beams, channels and Schlemm's canal. The second, based primarily on rat studies, proposes that cell death and macrophages play an important role in forming channels and beams. Mice provide a potentially useful model to understand the origin and development of angle structures and how defective development leads to glaucoma. Few studies have assessed the normal structure and development of the mouse angle. We used light and electron microscopy and a cell death assay to define the sequence of events underlying formation of the angle structures in mice. RESULTS: The mouse angle structures and developmental sequence are similar to those in humans. Cell death was not detectable during the period of trabecular channel and beam formation. CONCLUSIONS: These results support morphogenic mechanisms involving organization of cellular and extracellular matrix components without cell death or atrophy