Investigation of thin n-in-p planar pixel modules for the ATLAS upgrade

In view of the High Luminosity upgrade of the Large Hadron Collider (HL-LHC), planned to start around 2023-2025, the ATLAS experiment will undergo a replacement of the Inner Detector. A higher luminosity will imply higher irradiation levels and hence will demand more ra- diation hardness especially in the inner layers of the pixel system. The n-in-p silicon technology is a promising candidate to instrument this region, also thanks to its cost-effectiveness because it only requires a single sided processing in contrast to the n-in-n pixel technology presently employed in the LHC experiments. In addition, thin sensors were found to ensure radiation hardness at high fluences. An overview is given of recent results obtained with not irradiated and irradiated n-in-p planar pixel modules. The focus will be on n-in-p planar pixel sensors with an active thickness of 100 and 150 um recently produced at ADVACAM. To maximize the active area of the sensors, slim and active edges are implemented. The performance of these modules is investigated at beam tests and the results on edge efficiency will be shown

Knowledge-based entrepreneurship in Central and Eastern Europe: myth and reality

This paper summarises results of a survey of 304 knowledge based firms in six central and east European (CEE) countries. Knowledge-based entrepreneurs in CEE are not ‘gazelles’ (i.e., fast growing new technology based firms which have the potential to reshape the industrial landscape). They consist of distinct types of companies, of which new technology based firms (NTBFs) are only one. The key factor in KBE firms’ growth is most often firm specific capabilities which do not always involve R&D. Based on factor analysis we develop several taxonomies of KBEs which all point to a specific nature of knowledge based entrepreneurship in CEE. The networks of KBEs are broader and more frequently involve innovation system actors, including professional networks. For different types of KBEs different networks are important

Finance pathways for young innovative small‐ and medium‐size enterprises: a demand‐side examination of finance gaps and policy implications for the post‐global financial crisis finance escalator

The paper addresses the persistent finance gaps facing young, innovative SMEs, by examining the financing pathways of 40 UK businesses in a post global financial crisis (GFC) environment. Using a unique combination of finance escalator and resource-based view theories four propositions are tested by examining: (i) early and growth stage development; (ii) innovation R&D investment horizons; (iii) the management resource base; (iv) finance gaps and their implications. The paper finds that successful financing strategies are emerging, using a mix of bootstrapping, collaboration and new emerging post-GFC finance escalator funding, which is heavily reliant on government interventions. It also pinpoints remaining finance gaps and the need for more cohesive financing and support policy to address these

Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line

In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively. Shut off of EBNA2, either in the presence or absence of myc, leads to a significant increase in enzymatic activity and surface expression of ecto-5nucleotidase (CD73) as well as an increased adenosine receptor response in cyclic AMP formation. Shut off of myc expression has a small additional positive effect on CD73 activity. Among the four different subtypes of adenosine receptors, the A2a receptor exclusively is subject to regulation in this system, which is substantiated by pharmacologic data (specific agonists and inhibitors), as well as on the mRNA level. With upregulated CD73 and A2a, cells also respond to 5AMP with increased cyclic AMP formation. Turn on of EBNA2 has the reverse effect of repression of CD73 and A2a expression. The time course of both induction and repression of CD73 and A2a is rather slow

DEVELOPMENT AND OPTIMIZATION OF CARVEDILOL FORMULATION USING EXPERIMENTAL DESIGN

The aim of this paper was to develop and optimize the carvedilol tablets formulation using the full factorial design. The content of binder (PVP K30), content of disintegrant (crospovidone) and main compression force were used as the independent variables. Tablets were prepared by wet granulation. The percentage of released carvedilol from prepared formulation after 10 minutes was defined as the response. It has been found that formulation with the low content of binding agents (4.8%), high content of disintegrant (4.5%) and compression force of 50 N has the best profile of drug. The optimal formulation was defined based on implementation of pharmaceuticaltechnological tests (testing strength, friability, disintegrating, contents of drug substance, drug release profiles). The stability of the optimal formulation with carvedilol was estimated using the aging tests

Leak Detection and Localization through Demand Components Calibration

Success in the application of any model-based methodology (e.g., design, control, supervision) highly depends on the availability of a well-calibrated model. The calibration of water distribution networks needs to be performed online due to the continuous evolution of demands. During the calibration process, background leakages or bursts can be unintentionally incorporated to the demand model and treated as a system evolution (change in demands). This work proposes a leak-detection and localization approach to be coupled with a calibration methodology that identifies geographically distributed parameters. The approach proposed consists in comparing the calibrated parameters with their historical values to assess if changes in these parameters are caused by a system evolution or by the effect of leakage. The geographical distribution allows unexpected behavior of the calibrated parameters (e.g., abrupt changes, trends, etc.) to be associated with a specific zone in the network. The performance of the methodology proposed is tested on a real water distribution network using synthetic data. Tested scenarios include leaks occurring at different locations and ranging from 2.5 to 13% of the total consumption. Leakage is represented as pressure-dependent demand simulated as emitter flows at the network nodes. Results show that even considering a low number of sensors, leaks with an effect on parameters higher than the parameters’ uncertainty can be correctly detected and located within 200 m.FP7 - ICT - 2012 - 318556 (EFFINET)European CommissionPolytechnic University of Cataloni

Explicit expressions for state estimation sensitivity analysis in water systems

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.The implementation of state estimation techniques to water systems enables the hydraulic state of a given network to be computed at any time. However, errors in both measurements and model parameters can severely affect the quality of the state estimate, thus sensitivity analysis is crucial to assess its performance. The aim of this paper is to provide general explicit expressions for the sensitivities of the objective function and the primal variables of the state estimation problem with respect to both measurements and roughness parameters based on the perturbation of the Karush-Kuhn-Tucker (KKT) conditions. Additionally, among all the possible applications of sensitivity analysis, two specific forms of such analysis for water systems are presented: identifiability of roughness parameters, and linear state estimate approximation. The merit of these applications is illustrated by means of a case study, which highlights the usefulness of compact sensitivity formulae to further understanding of state estimation solutions

Patterns of Northern Ireland trade by destination, product and business characteristics: 2012 to 2016

New figures show that Northern Irish businesses conducted most international trade with the Republic of Ireland, accounting for around 27% of exports and 23% of imports; however, a separate data source, which includes intra-country trade, highlights that the rest of the UK remains Northern Ireland’s biggest market. More than 50% of Northern Ireland’s goods exports went to just two countries, the Republic of Ireland and the USA; the Republic of Ireland was the most important destination for food and live animals, while the USA was the most important destination for machinery and transport. Food and live animals represented around 33% of the total Northern Irish exports going to the Republic of Ireland, of which the top sub-category was milk and cream products. Almost 70% of exporting businesses in Northern Ireland were small (employing 0 to 49 workers), selling a small number of products to a few markets. Domestic businesses in Northern Ireland were less diversified in terms of products and markets compared with foreign-owned businesses. The biggest proportion of two-way trade in similar products was in food and live animals, suggesting integration of supply-chains in this category

New Evidences on Domestication of the Horse (Equus Ferus Caballus) and Origine of Domestic Mountain Pony

The results of draft genome research of permafrost horse bone dated approximately 560-780 (kyr BP) have been published recently. According to the data representing the oldest full genome sequence compared to the modern genomes of domesticated horse, Przewalskii and donkey it was suggested that the Equus lineage gave rise to contemporary horses, zebras and donkeys some 4.0 to 4.5 million years ago, twice increasing the assumed time to the common ancestor. Upon the phylogenetic and divergence analyses it was estimated that the Przewalskii and domestic horse populations diverged some 38-72 kyr BP and that there are no evidences that admixtures between Przewalskii and domestic horse populations occurred post-divergently thus Przewalskii’s involvement in the process of horse domestication has been excluded. The new data on ancient equide genome question the conventional theory on the origin of Domestic mountain pony. Upon the protein variability of the Domestic mountain pony the influence of diluvial genome on the population was confirmed and this finding differed from the conventional theory stating E. f. Przewalskii and E. ferus caballus as ancestors of the autochthonous population. The role of different ancestral horses in evolution of our autochthonous population is therefore unclear. The questions emerging from the most recent genetic and proteomic research in concern with the autochthonous populations are presented in the paper

Characterisation of novel thin n-in-p planar pixel modules for the ATLAS Inner Tracker upgrade

In view of the high luminosity phase of the LHC (HL-LHC) to start operation around 2026, a major upgrade of the tracker system for the ATLAS experiment is in preparation. The expected neutron equivalent fluence of up to 2.4 * 1e16 1 MeV neq./cm2 at the innermost layer of the pixel detector poses the most severe challenge. Thanks to their low material budget and high charge collection efficiency after irradiation, modules made of thin planar pixel sensors are promising candidates to instrument these layers. To optimise the sensor layout for the decreased pixel cell size of 50 * 50 {\mu}m2, TCAD device simulations are being performed to investigate the charge collection efficiency before and after irradiation. In addition, sensors of 100-150 {\mu}m thickness, interconnected to FE-I4 read-out chips featuring the previous generation pixel cell size of 50 * 250 {\mu}m2, are characterised with testbeams at the CERN-SPS and DESY facilities. The performance of sensors with various designs, irradiated up to a fluence of 1 * 1e16 neq./cm2, is compared in terms of charge collection and hit efficiency. A replacement of the two innermost pixel layers is foreseen during the lifetime of HL-LHC. The replacement will require several months of intervention, during which the remaining detector modules cannot be cooled. They are kept at room temperature, thus inducing an annealing. The performance of irradiated modules will be investigated with testbeam campaigns and the method of accelerated annealing at higher temperatures.Comment: 11 pages, 10 figures, proceedings of the PSD Conference 201