ISIS Facchinetti: A Nearly Zero Energy Retrofit in Italy

The research presented here is about the energy retrofit of an existing high school building close to Varese (Italy). As the building was designed in the 60's with a peculiar architectural language, it has been protected by the conservation authorities. However, the construction system in exposed concrete and the large expanses of single glass make the energy performance of the building very poor. The Provincia di Varese, owner of the building, decided to realize an exemplary retrofit project, which would be the first renovated educational building in Italy in line with the future scenario of Nearly Zero-Energy Building expected from 2019 (2021 for private buildings) by the European Directive 2010/31/UE. In this work energetic and payback analysis are developed to delineate three different preliminary scenarios of intervention. The process has always followed discussions with the conservation authorities, which contributed to the definition of realistic scenarios. Interesting results are obtained: a potential energy demand reduction of 70% can be obtained with the passive solutions proposed; in combination with active strategies (efficient mechanical systems and controls) and with the integration of photovoltaic panels (BiPV), the overall energy need of the building can be reduced to nearly zero

P14 282. Endocarditis protésica. experiencia de 20 años

ObjetivosRevisamos la experiencia de nuestro centro en endocarditis protésica (EP).Material y métodosEntre 1990–2010, se intervienen 62 casos, que representaron el 23% de 276 casos totales de endocarditis y 2,46% de pacientes valvulares (precoces 0,58% con 20 casos, tardías 1,68% con 42 casos). No hubo diferencias en tipo ni localización de las prótesis, ni en incidencia entre las dos décadas (2,59% en 1990–2000 y 2,32% en 2000–2010). Edad media 59 años. Gérmenes: S. viridans 20,9%; S. epidermidis 16,1%; S. aureus 11,6%; C. burnetii 9,6%; enterococos 8%; difteroides 6,4%; hongos 6,4%. En un 8% de los casos se encontraron gérmenes raros aislados, mientras que no se identificó germen en 12,9%. Se intervinieron de forma urgente el 30% de pacientes (19 casos, el 45% de formas precoces y el 23% de formas tardías).ResultadosLa mortalidad precoz fue del 16%, a expensas sobre todo de EP precoz (12%). La supervivencia global a 10 años fue del 50%, con diferencias entre los dos grupos (EP precoz 15%; EP tardía 66%). El 70% de supervivientes se encuentra actualmente en clase funcional I-II/IV.ConclusiónLa EP sigue teniendo una incidencia relativamente elevada en nuestro medio. La EP precoz tiene una mortalidad muy elevada. La cirugía de la EP tardía tiene muy buenos resultados a largo plazo

Contacts and behaviours of university students during the COVID-19 pandemic at the start of the 2020/2021 academic year

University students have unique living, learning and social arrangements which may have implications for infectious disease transmission. To address this data gap, we created CONQUEST (COroNavirus QUESTionnaire), a longitudinal online survey of contacts, behaviour, and COVID-19 symptoms for University of Bristol (UoB) staff/students. Here, we analyse results from 740 students providing 1261 unique records from the start of the 2020/2021 academic year (14/09/2020–01/11/2020), where COVID-19 outbreaks led to the self-isolation of all students in some halls of residences. Although most students reported lower daily contacts than in pre-COVID-19 studies, there was heterogeneity, with some reporting many (median = 2, mean = 6.1, standard deviation = 15.0; 8% had ≥ 20 contacts). Around 40% of students’ contacts were with individuals external to the university, indicating potential for transmission to non-students/staff. Only 61% of those reporting cardinal symptoms in the past week self-isolated, although 99% with a positive COVID-19 test during the 2 weeks before survey completion had self-isolated within the last week. Some students who self-isolated had many contacts (mean = 4.3, standard deviation = 10.6). Our results provide context to the COVID-19 outbreaks seen in universities and are available for modelling future outbreaks and informing policy

Comparative analysis of distinct phenotypes in gambling disorder based on gambling preferences

Background: studies examining gambling preferences have identified the importance of the type of gambling practiced on distinct individual profiles. The objectives were to compare clinical, psychopathological and personality variables between two different groups of individuals with a gambling disorder (strategic and non-strategic gamblers) and to evaluate the statistical prediction capacity of these preferences with respect to the severity of the disorder. Method: a total sample of 2010 treatment-seeking patients with a gambling disorder participated in this stand-alone study. All were recruited from a single Pathological Gambling Unit in Spain (1709 strategic and 301 non-strategic gamblers). The design of the study was cross-sectional and data were collected at the start of treatment. Data was analysed using logistic regression for binary outcomes and analysis of variance (ANOVA) for quantitative responses. Results: there were significant differences in several socio-demographic and clinical variables, as well as in personality traits (novelty seeking and cooperativeness). Multiple regression analysis showed harm avoidance and self-directedness were the main predictors of gambling severity and psychopathology, while age at assessment and age of onset of gambling behaviour were predictive of gambling severity. Strategic gambling (as opposed to non-strategic) was significantly associated with clinical outcomes, but the effect size of the relationships was small. Conclusions: it is possible to identify distinct phenotypes depending on the preference of gambling. While these phenotypes differ in relation to the severity of the gambling disorder, psychopathology and personality traits, they can be useful from a clinical and therapeutic perspective in enabling risk factors to be identified and prevention programs targeting specific individual profiles to be developed

TP25 218. Asistencia circulatoria de larga duración. Experiencia inicial

ObjetivosSe presenta la experiencia inicial en nuestro centro en el uso de dispositivos de asistencia circulatoria mecánica de larga duración, tanto en pacientes adultos como pediátricos. Han sido utilizadas tanto como puente a trasplante como terapia de destino.Material y métodosRecogemos la experiencia sobre 4 pacientes, 3 pediátricos y uno adulto. Los pacientes pediátricos fueron todos de sexo masculino, con una media de edad de 5,5 años. La etiología fue diferente en cada caso (coronaria izquierda anómala, miocardiopatía dilatada idiopática y miocarditis), recibiendo una asistencia de flujo pulsátil (1 ventricular izquierda y 2 biventriculares) como puente a trasplante. El paciente adulto es un varón de 72 años con una miocardiopatía hipertrófica con disfunción ventricular izquierda grave, utilizando una asistencia ventricular izquierda de flujo continuo con bomba magnética.ResultadosEncontramos un 100% de supervivencia. Los 3 pacientes pediátricos recibieron un tiempo medio de asistencia de 142 días (91–247), siendo los 3 trasplantados con éxito. Uno de ellos precisó de oxigenador de membrana extracorpórea (ECMO) postrasplante, siendo retirada en 7 días. Todos fueron dados de alta del hospital. Al año, uno de los pacientes ha fallecido, sobreviviendo los otros dos. La complicación más frecuente fue el sangrado en el sitio de canulación. El paciente adulto sigue actualmente ingresado en el hospital y ha presentado como complicación principal una hemorragia cerebral con secuelas neurológicas.ConclusionesLa asistencia ventricular de larga duración es una terapia segura y efectiva en pacientes con cardiopatías terminales, ya sea como puente a trasplante, recuperación o terapia de destino

Comparative analysis of distinct phenotypes in gambling disorder based on gambling preferences

Background: Studies examining gambling preferences have identified the importance of the type of gambling practiced on distinct individual profiles. The objectives were to compare clinical, psychopathological and personality variables between two different groups of individuals with a gambling disorder (strategic and non-strategic gamblers) and to evaluate the statistical prediction capacity of these preferences with respect to the severity of the disorder. Method: A total sample of 2010 treatment-seeking patients with a gambling disorder participated in this stand-alone study. All were recruited from a single Pathological Gambling Unit in Spain (1709 strategic and 301 non-strategic gamblers). The design of the study was cross-sectional and data were collected at the start of treatment. Data was analysed using logistic regression for binary outcomes and analysis of variance (ANOVA) for quantitative responses. Results: There were significant differences in several socio-demographic and clinical variables, as well as in personality traits (novelty seeking and cooperativeness). Multiple regression analysis showed harm avoidance and self-directedness were the main predictors of gambling severity and psychopathology, while age at assessment and age of onset of gambling behaviour were predictive of gambling severity. Strategic gambling (as opposed to non-strategic) was significantly associated with clinical outcomes, but the effect size of the relationships was small. Conclusions: It is possible to identify distinct phenotypes depending on the preference of gambling. While these phenotypes differ in relation to the severity of the gambling disorder, psychopathology and personality traits, they can be useful from a clinical and therapeutic perspective in enabling risk factors to be identified and prevention programs targeting specific individual profiles to be developed

University students and staff able to maintain low daily contact numbers during various COVID-19 guideline periods

UK universities re-opened in September 2020, amidst the coronavirus epidemic. During the first term, various national social distancing measures were introduced, including banning groups of >6 people and the second lockdown in November; however, outbreaks among university students occurred. We aimed to measure the University of Bristol staff and student contact patterns via an online, longitudinal survey capturing self-reported contacts on the previous day. We investigated the change in contacts associated with COVID-19 guidance periods: post-first lockdown (23/06/2020–03/07/2020), relaxed guidance period (04/07/2020–13/09/2020), ‘rule-of-six’ period (14/09/2020–04/11/2020) and the second lockdown (05/11/2020–25/11/2020). In total, 722 staff (4199 responses) and 738 students (1906 responses) were included in the study. For staff, daily contacts were higher in the relaxed guidance and ‘rule-of-six’ periods than the post-first lockdown and second lockdown. Mean student contacts dropped between the ‘rule-of-six’ and second lockdown periods. For both staff and students, the proportion meeting with groups larger than six dropped between the ‘rule-of-six’ period and the second lockdown period, although was higher for students than for staff. Our results suggest university staff and students responded to national guidance by altering their social contacts. Most contacts during the second lockdown were household contacts. The response in staff and students was similar, suggesting that students can adhere to social distancing guidance while at university. The number of contacts recorded for both staff and students were much lower than those recorded by previous surveys in the UK conducted before the COVID-19 pandemic

Comparative analysis of distinct phenotypes in gambling disorder based on gambling preferences

Studies examining gambling preferences have identified the importance of the type of gambling practiced on distinct individual profiles. The objectives were to compare clinical, psychopathological and personality variables between two different groups of individuals with a gambling disorder (strategic and non-strategic gamblers) and to evaluate the statistical prediction capacity of these preferences with respect to the severity of the disorder. A total sample of 2010 treatment-seeking patients with a gambling disorder participated in this stand-alone study. All were recruited from a single Pathological Gambling Unit in Spain (1709 strategic and 301 non-strategic gamblers). The design of the study was cross-sectional and data were collected at the start of treatment. Data was analysed using logistic regression for binary outcomes and analysis of variance (ANOVA) for quantitative responses. There were significant differences in several socio-demographic and clinical variables, as well as in personality traits (novelty seeking and cooperativeness). Multiple regression analysis showed harm avoidance and self-directedness were the main predictors of gambling severity and psychopathology, while age at assessment and age of onset of gambling behaviour were predictive of gambling severity. Strategic gambling (as opposed to non-strategic) was significantly associated with clinical outcomes, but the effect size of the relationships was small. It is possible to identify distinct phenotypes depending on the preference of gambling. While these phenotypes differ in relation to the severity of the gambling disorder, psychopathology and personality traits, they can be useful from a clinical and therapeutic perspective in enabling risk factors to be identified and prevention programs targeting specific individual profiles to be developed