The Role of Subjective Temporality in Future-Oriented Mental Time Travel

In this chapter we examine the tendency to view future-oriented mental time travel as a unitary faculty that, despite task-driven surface variation, ultimately reduces to a common phenomenological state. We review evidence that FMTT is neither unitary nor beholden to episodic memory: Rather, it is varied both in its memorial underpinnings and experiential realization. We conclude that the phenomenological diversity characterizing FMTT is dependent not on the type of memory activated during task performance, but on the kind of subjective temporality associated with the memory in play

Rechtsphilosophische Aufsätze

Photomechanical reprint of papers & review articles from 1974 to 1992 mostly in German, some in Swedish or Danish: AUFSÄTZE ‘Beiträge zu den Beziehungen zwischen Gustav Radbruch & Georg Lukács’ [1979] / ‘Die Entwicklung des rechtstheoretischen Denkens in der Ungarischen Räterepublik’ [1969] / ‘Die Kodifikation & ihr Verfall in der Entwicklungsgeschichte der bürgerlichen Demokratie’ [1978] / ‘Rationalitet och rättens objektifiering’ [1975] / ‘Utopi og Kodifikation’ [1976] / ‘Historisches Wesen & aktuelle Bedeutung der Kodifikation’ [1977] / ‘Rechtssetzung als Objektivationsprozesses’ [1979] / ‘Die ministerielle Begründung in rechtsphilosophischer Sicht’ [1977] / ‘Moderne Staatlichkeit & modernes formales Recht’ [1982] / ‘Leibniz & die Frage der rechtlichen Systembildung’ [1973] / ‘Der Systemcharacter des Rechts’ [1979] / ‘Die grundlegende Gesellschaftlichkeit der Rechtsanwendung’ [1978] / ‘Über die Rechtsanwendung (Ontologische Überlegungen)’ [1986] / ‘Recht & Rechtsverwirklichung (»Juristischer Weltbild«, Subsumption & Manipulation)’ [1979] / ‘Hans Kelsens Rechtsanwendungslehre (Entwicklung, Mehrdeutigkeiten, offene Probleme, Perspektiven)’ [1986] / ‘Geltung des Rechts – Wirksamkeit des Rechts’ [1978] / ‘Heterogeneität & Geltung des Rechts’ [1979] / ‘Hans Kelsens’ Reine Rechtslehre – gestern, heute, morgen’ [1988] / ‘Für die Selbständigkeit der Rechtspolitik’ [1985] / ‘Die Gewaltenteilung (Ideologie & Utopie im politischen Denken)’ [1984] / ‘Rechtskultur – Denkkultur’ [1988] // ZUSAMMENFASSUNGEN / REZENSIONEN [by & on the author

Well-Being in the Christian Tradition

This paper discusses well-being in the Christian tradition

Combining bleach and mild predigestion improves ancient DNA recovery from bones.

The feasibility of genome-scale studies from archaeological material remains critically dependent on the ability to access endogenous, authentic DNA. In the majority of cases, this represents a few per cent of the DNA extract, at most. A number of specific pre-extraction protocols for bone powder aimed to improve ancient DNA recovery before library amplification have recently been developed. Here, we test the effects of combining two of such protocols, a bleach wash and a predigestion step, on 12 bone samples of Atlantic cod and domestic horse aged 750-1350 cal. years before present. Using high-throughput sequencing, we show that combined together, bleach wash and predigestion consistently yield DNA libraries with higher endogenous content than either of these methods alone. Additionally, the molecular complexity of these libraries is improved and endogenous DNA templates show larger size distributions. Other library characteristics, such as DNA damage profiles or the composition of microbial communities, are little affected by the pre-extraction protocols. Application of the combined protocol presented in this study will facilitate the genetic analysis of an increasing number of ancient remains and will reduce the cost of whole-genome sequencing

Less effective selection leads to larger genomes

International audienceThe evolutionary origin of the striking genome size variations found in eukaryotes remains enigmatic. The effective size of populations, by controlling selection efficacy, is expected to be a key parameter underlying genome size evolution. However, this hypothesis has proved difficult to investigate using empirical datasets. Here, we tested this hypothesis using twenty-two de novo transcriptomes and low-coverage genomes of asellid isopods, which represent eleven independent habitat shifts from surface water to resource-poor groundwater. We show that these habitat shifts are associated with higher transcriptome-wide dN/dS. After ruling out the role of positive selection and pseudogenization, we show that these transcriptome-wide dN/dS increases are the consequence of a reduction in selection efficacy imposed by the smaller effective population size of subterranean species. This reduction is paralleled by an important increase in genome size (25% increase on average), an increase also confirmed in subterranean decapods and mollusks. We also control for an adaptive impact of genome size on life history traits but find no correlation between body size, or growth rate, and genome size. We show instead that the independent increases in genome size measured in subterranean isopods are the direct consequence of increasing invasion rates by repeated elements, which are less efficiently purged out by purifying selection. Contrary to selection efficacy, polymorphism is not correlated to genome size. We propose that recent demographic fluctuations and the difficulty to observe polymorphism variations in polymorphism-poor species can obfuscate the link between effective population size and genome size when polymorphism data is used alone

Hétérogénéité des ascendances mésolithiques et steppiques dans des génomes d’individus du Néolithique et du Campaniforme du territoire français

Les transitions archéologiques se caractérisent notamment par d’importants changements démographiques et sociétaux, qui peuvent avoir des répercussions à l’échelle du génome des individus. Ainsi, la transition du Néolithique à l’âge du Bronze s’est accompagnée de contributions génomiques massives d’éleveurs originaires des steppes pontico-caspiennes aux populations locales, ces dernières résultant d’interactions complexes entre chasseurs-cueilleurs indigènes et agriculteurs d’ascendance anato..

Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities

The first farmers from Central Europe reveal a genetic affinity to modern-day populations from the Near East and Anatolia, which suggests a significant demographic input from this area during the early Neolithic

From cheek swabs to consensus sequences : an A to Z protocol for high-throughput DNA sequencing of complete human mitochondrial genomes

Background: Next-generation DNA sequencing (NGS) technologies have made huge impacts in many fields of biological research, but especially in evolutionary biology. One area where NGS has shown potential is for high-throughput sequencing of complete mtDNA genomes (of humans and other animals). Despite the increasing use of NGS technologies and a better appreciation of their importance in answering biological questions, there remain significant obstacles to the successful implementation of NGS-based projects, especially for new users. Results: Here we present an ‘A to Z’ protocol for obtaining complete human mitochondrial (mtDNA) genomes – from DNA extraction to consensus sequence. Although designed for use on humans, this protocol could also be used to sequence small, organellar genomes from other species, and also nuclear loci. This protocol includes DNA extraction, PCR amplification, fragmentation of PCR products, barcoding of fragments, sequencing using the 454 GS FLX platform, and a complete bioinformatics pipeline (primer removal, reference-based mapping, output of coverage plots and SNP calling). Conclusions: All steps in this protocol are designed to be straightforward to implement, especially for researchers who are undertaking next-generation sequencing for the first time. The molecular steps are scalable to large numbers (hundreds) of individuals and all steps post-DNA extraction can be carried out in 96-well plate format. Also, the protocol has been assembled so that individual ‘modules’ can be swapped out to suit available resources

Ancient genomics

The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.No Full Tex