Anthropometric indices of Gambian children after one or three annual rounds of mass drug administration with azithromycin for trachoma control.

BACKGROUND: Mass drug administration (MDA) with azithromycin, carried out for the control of blinding trachoma, has been linked to reduced mortality in children. While the mechanism behind this reduction is unclear, it may be due, in part, to improved nutritional status via a potential reduction in the community burden of infectious disease. To determine whether MDA with azithromycin improves anthropometric indices at the community level, we measured the heights and weights of children aged 1 to 4 years in communities where one (single MDA arm) or three annual rounds (annual MDA arm) of azithromycin had been distributed. METHODS: Data collection took place three years after treatment in the single MDA arm and one year after the final round of treatment in the annual MDA arm. Mean height-for-age, weight-for-age and weight-for-height z scores were compared between treatment arms. RESULTS: No significant differences in mean height-for-age, weight-for-age or weight-for-height z scores were found between the annual MDA and single MDA arms, nor was there a significant reduction in prevalence of stunting, wasting or underweight between arms. CONCLUSIONS: Our data do not provide evidence that community MDA with azithromycin improved anthropometric outcomes of children in The Gambia. This may suggest reductions in mortality associated with azithromycin MDA are due to a mechanism other than improved nutritional status

HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease

Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify patients at increased risk for development of anti-drug antibodies would facilitate selection of therapy and use of preventative strategies.This article is freely available via Open Access. Click on Publisher URL to access the full-text

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Mobility and Biography

The subject of transnational lives has only recently gained importance in historical research. With its transnational approach to “mobility and biography,” this volume brings together research on aspects of mobility and biography across different times and spaces to open up new interdisciplinary perspectives. Networks, movements and the capacity to become socially or spatially mobile in and across Europe are not only analysed as structural factors, but rather seen as connected to concrete practices of mobility among different groups in the spheres of business, politics and the arts: from Jewish merchants via legal and financial advisors all the way to musicians

New Publication: Robert Brier’s Inspiring Article on the Recent Historiography on Human Rights

Robert Brier’s inspiring article Beyond the Quest for a “Breakthrough”: Reflections on the Recent Historiography on Human Rights has been published in the European History Yearbook 2015 and is available in open access. Abstract: Human rights have become a central object of international and global history, with research focusing on the question where the origins of the central position of human rights language in our own time lie. The aim of this article is to take stock of this debate and di..

Jüdische Erfahrungen und Loyalitätskonflikte im Ersten Weltkrieg

The First World War and the question of its impact on the negotiation of Jewish difference have for a long time been neglected and under-researched topics in the field of modern history. In this context, analyses of Jewish war experiences were either non-existent or stood in the shadow of the history of the Holocaust. This trend has been somewhat countered over the last years. But despite the fact that the dilemma between transnational Jewish solidarity and national (civic) loyalties has gained more attention among scholars working in the field of Jewish as well as general history, these studies remain within a national framework. Sarah Panter seeks to overcome these limitations and break new ground by writing the first systematic comparative and transnational history of war-time debates concerning the meanings and implications of Jewishness in German- and English-speaking countries

Neutral Spectators from a Distance? American Jews and the Outbreak of the First World War

As the First World War broke out in 1914, American Jews seemed far away from the upheaval in Europe. Yet their role as neutral spectators from the distance was questioned right from the outset because of their diverse transcultural entanglements with Europe. Seen from a specific Jewish perspective, the war bore the potential of becoming a fratricidal war. In particular at the Eastern front it was a likely scenario that Jewish soldiers fighting on either side would have to face each other in battle. For Jews, depending on how one defined Jewishness, could be regarded as citizens of a particular nation-state or multi-ethnic empire, as members of a transnational religious community or as members of an ethnic-national diaspora community. Against this background, this article attempts to shed fresh light on the still under-researched topic of American Jewish responses to the outbreak of the First World War. Although American Jewry in 1914 was made up of Jews with different socio-cultural backgrounds, they were often regarded as being pro-German. The war&rsquo;s impact and the pressures of conformity associated with these contested loyalties for American Jews did therefore not just unfold in and after 1917, but, as this article emphasizes, already in 1914