Successful treatment of refractory gastrointestinal bleeding by systemic (oral) ankaferd blood stopper in a patient with Glanzmann thrombasthenia

Background: Glanzmann Thrombasthenia (GT) is a genetic platelet dysfunction and a life threatening disease. Ankaferd Blood Stopper (ABS) is a topical hemostatic agent of herbal origin which has been recently made available for clinical use. Its hemostatic effect is independent from blood clotting factors and occurs as a result of the aggregation of focal red blood cells by an encapsulated protein web. Case Report: In this paper, a patient with GT is presented in whom 3 months of gastrointestinal bleeding refractory to all medical therapies was controlled within a short time of using oral ABS. Conclusion: The difference between this patient and other cases presented in the medical literature is the oral use of ABS. Thus, this patient may contribute to the medical community in showing the safety and efficacy of systemic (oral) ABS in patients with disorders of coagulation. However, there is a need for more patient experiences. © Trakya University Faculty of Medicine

KUR’AN KURSLARI ÖĞRETİCİ KİTABINDAKİ ETKİNLİK UYGULAMALARININ ÖĞRETİCİ GÖRÜŞLERİ DOĞRULTUSUNDA İNCELENMESİ

Diyanet İşleri Başkanlığı 2013-2014 eğitim öğretim yılında “4-6 Yaş Din Eğitimi Projesi” kapsamında yeni bir misyon daha üstlenmiş ve 4-6 yaş grubu Kur’an kurslarıyla hedef kitlesini farklılaştırmıştır. 4-6 yaş grubu Kur’an kursları programında öğretici rehberliğinde, öğrenci merkezli, öğrencinin yaparak ve yaşayarak öğrenebileceği, etkinlik temelli öğretim yöntemine göre düzenlenmiş muhtelif etkinlikler uygulandığı görülmüştür. 4-6 yaş grubu Kur’an kursları öğretici kitaplarındaki uygulamaların incelenmesini amaçlayan bu çalışma, karma araştırma desenine göre yapılmıştır. Araştırmada; Kur’an öğrenmeye yönelik etkinlik ve materyallerin yeterli olmadığı, ilkokula hazırlayıcı uygulamaların yetersiz olduğu, etkinliklerin birbirinin tekrarı niteliğinde olduğu ve öğrenci yaş seviyeleri ihmal edildiğinden öğreticilerin alternatif etkinlik üretmekte güçlük yaşadıkları sonuçlarına ulaşılmıştır

Possible role of GADD45γ methylation in diffuse large B-cell Lymphoma: Does it affect the progression and tissue involvement?

Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among adults and is characterized by heterogeneous clinical, immunophenotypic, and genetic features. Different mechanisms deregulating cell cycle and apoptosis play a role in the pathogenesis of DLBCL. Growth arrest DNA damage-inducible 45 (GADD45γ) is an important gene family involved in these mechanisms. The aims of this study are to determine the frequency of GADD45γ methylation, to evaluate the correlation between GADD45γ methylation and protein expression, and to investigate the relation between methylation status and clinicopathologic parameters in DLBCL tissues and reactive lymphoid node tissues from patients with reactive lymphoid hyperplasia. Materials and Methods: Thirty-six tissue samples of DLBCL and 40 nonmalignant reactive lymphoid node tissues were analyzed in this study. Methylation-sensitive high-resolution melting analysis was used for the determination of GADD45γ methylation status. The GADD45γ protein expression was determined by immunohistochemistry. Results: GADD45γ methylation was frequent (50.0%) in DLBCL. It was also significantly higher in advanced-stage tumors compared with early-stage (p=0.041). In contrast, unmethylated GADD45γ was associated with nodal involvement as the primary anatomical site (p=0.040). Conclusion: The results of this study show that, in contrast to solid tumors, the frequency of GADD45γ methylation is higher and this epigenetic alteration of GADD45γ may be associated with progression in DLBCL. In addition, nodal involvement is more likely to be present in patients with unmethylated GADD45γ. © 2015 Turkish Society of Hematology. All rights reserved

An Equifinality Energy Management Framework in Terms of Benchmarking Practices and Expectations: The EnerMan Project Outlook

Background: The Industry 4.0 wave is leading the changes in existing manufacturing and industrial processes across the world. This is especially important in the formulation of the smart-factory concept with an outlook to energy sustainable processes. In viewing and identifying the foundational elements of such a transformation, the initial conditions and current practices in a cross-sectoral manner is considered a first, yet crucial step in the EU-funded project EnerMan. Methods: In this paper, we identify and analyse the key common features and characteristics of industrial practices set in a perspective of similar and identical functions with a focus to three key energy areas: sustainability, management, and footprint. The examination of different industrial sector cases is performed via distributed questionnaires and then viewed under the prism of the equifinality state via a text-mining analysis approach. Results: identification of common themes and benchmarking of current practices in a cross-industry manner led to the creation of a common systemic framework within energy management related aspects, which is hereby presented. Conclusions: use of an equifinality approach in energy management practices should be further pursued to open up new methods of ideation and innovation and communicate systems’ design in tandem with each industrial set goals

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Post-revolution Iran's regime paradigm and its foreign policy trend

Bu çalışma, İran'da Şiî teolojiden İslâmcı ideolojiye geçiş sürecini ve İran'ın düşünsel sekülerleşmesini çözümlemektedir. Dolayısıyla bu örüntünün bir sonucu olan mevcut siyasi rejimin ideolojik paradigmasını ve bu ideolojik paradigmaya sahip iktidar ile rejim-karşıtı dinî muhalefet arasındaki çatışma ilişkisini entelektüel düzlemde analiz etmektedir. Ayrıca, bu çalışmada İslam Devrimi'nden günümüze Şiîliği bir devrim ideolojisi haline getiren, dönemsel olarak değişmekle birlikte, Şiî yayılmacılığına dayalı karşı-denge kurma amacını taşıyan İran'ın dış politika stratejisi olarak "güvenlik-otonomi arayışı" analiz edilmektedir. Günümüzde İran, ABD'nin Irak işgali ile bu bölgede etkinliğini zirveye ulaştırmış ve Arap Baharı süreci ile birlikte ortaya çıkan bölgesel sistemde yayılmacı politikalarına yeni bir alan bulmuştur. Bu süreçte bölgede İran'ın ne derece etkin olabileceği tartışılırken; "Şiî Hilali" tartışmaları yeniden gündeme gelmiştir. İran'ın Ortadoğu'yu mezhep temelinde şekillendirmeye çalıştığı tezine dayanan söz konusu yaklaşım, bu çalışmada sivik din ve politik kültür olarak İran Şiîliğinin temellerine inilerek incelenmektedir. Ayrıca, İran'ın Şiî yayılmacılığının ABD'nin Irak müdahalesinden Arap Baharına uzanan süreçte Bağdat, Şam, Beyrut ve Sana'da pragmatist kaygılarla nasıl jeopolitik bir amaca dönüştüğü analiz edilmektedir.This study analyses the transition period from Iran Shia teology to Islamist ideology and Iran's intellectual secularization. Therefore it analyses, on an intellectual level, the ideologic paradigm of the present politic regime which appeared as a result of this transition and the conflict between the said regime and the opposing groups. This study also analyses "struggle for security-autonomy" which is deemed to be Iran's diplomatic strategy which, from time to time, is aiming to structure a counter balance on the basis of Shia irrendetizm and which is defined to be a key factor, during the period starting from the date of Islamic revolution until today, transformed Shia into a revolution ideology. Today's Iran brought its domination in its region to the the highest level as a result of the US occupation of Iraq and finds a new basis for its expansionist policies in so-called Arab Spring regions. During the same period, the "Shia Crescent" has become an issue on one hand, while discussions on at which level Iran may dominate the region on the other. The aforementioned approach which centres the thesis of which Iran goes after the purpose of structuring the Middle East on sectarian policies basis, is examined hereby by getting into the roots of Shiitinazation which is deemed to be civil religion and politic culture of Iran society. It is also analysed in this study how the expansionism of Iran Shiitinazation become a geopolitical goal by the pragmatist worries in Baghdad, Damascus, Beirut and Sana during the period starting from intervention of Iraq until Arab Spring

Evaluating the Views of the School Principals, Concerning the Proficiency Level of Social Studies Teachers in Classroom Management

Bu araştırmanın amacı, sosyal bilgiler öğretmenlerinin sınıf yönetimi yeterliliklerini okul yöneticilerinin görüşleri doğrultusunda incelemektir. Araştırma, genel tarama modelinde betimsel bir çalışmadır. Araştırmaya ilişkin veriler, 2012-2013 eğitim-öğretim yılı bahar döneminde Diyarbakır’ın Ergani İlçesindeki devlet ortaokullarında görev yapan okul yöneticileri üzerinden elde edilmiştir. Veriler, "Sınıf Yönetimi Becerisini Değerlendirme Ölçeği" aracılığıyla toplanmıştır. Araştırma sonucunda, sosyal bilgiler öğretmenlerinin sınıf yönetimi yeterlilik düzeyleri okul yöneticileri tarafından “yeterli” seviyesinde gözlemlenmiştir. Okul yöneticilerinin görüşlerine göre, sosyal bilgiler öğretmenlerinin “etkinlik yönetimine” ilişkin yeterlilik düzeylerinin düşük düzeyde olduğu saptanmıştır. Ayrıca, yaş ve kıdem değişkenlerine göre, sosyal bilgiler öğretmenlerinin sınıf yönetimi yeterliliklerine ilişkin okul yöneticilerinin görüşlerinin anlamlı bir farklılık göstermediği gözlemlenmiştir. Dolayısıyla, sosyal bilgiler öğretmenlerinin sınıf yönetiminin “etkinlik yönetimi” boyutunda, kendilerini geliştirmelerine olanak sağlayacak çalışmalar yapılması önerilmektedir.The purpose of this study is to examine the classroom management competences of social studies teachers according to the opinions of school principals. The research is a descriptive study in the general survey model. The data related to the research were gathered from the school principals who work in state secondary schools in the Ergani District of Diyarbakır during the spring semester of 2012-2013 academic year. The data were gathered by the "Classroom Management Assessment Scale". As a result of the research, the classroom management proficiency levels of social studies teachers were observed by the school principals at the level of "sufficient". According to the opinions of the school principals, it was determined that the level of proficiency of social studies teachers regarding "activity management" was low. Additionally it was observed that the opinions of the school principals related to the classroom management competences of the social studies teachers did not show any significant difference according to the age and seniority variables. Therefore, it is recommended that social studies teachers should carry out studies that will enable them to improve themselves in the dimension of activity management of classroom management

Türkiye'de Dijital Vatandaşlıkla İlgili Yapılan Yüksek Lisans ve Doktora Tezlerinin İncelenmesi

Buçalışmanın amacı, Türkiye’de dijital vatandaşlık konusuyla ilgili hazırlanmışyüksek lisans ve doktora tezlerinin genel eğilimlerini ortaya çıkarmaktır.Araştırma, tarama modeline dayalı olarak yapılmıştır. Dijital vatandaşlığayönelik tezler, Yükseköğretim Kurulu Ulusal Tez Merkezi Veri Tabanındanfaydalanılarak elde edilmiştir. Bu doğrultuda, 2004-2017 yılları arasındahazırlanan 16 adet izinli tez, içerik analizi yöntemine dayalı olarakincelenmiştir. “Tez Çözümleme Formu” aracılığıyla elde edilen veriler, frekansve yüzde hesaplamalarıyla tablolaştırılarak yorumlanmıştır. Araştırmasonucunda, dijital vatandaşlıkla ilgili tezlerin çoğunluğunun eğitim bilimlerienstitüsü bünyesinde ve yüksek lisans seviyesinde çalışıldığı saptanmıştır.Ayrıca tezlerde en çok ilkokul ve ortaokul öğrencilerinin örneklem grubu olaraktercih edildiği, çalışmaların çoğunlukla karma (nicel nitel) ve nicelaraştırma yöntemine dayalı olarak yapıldığı ve veri toplama aracı olarak en çokölçeklerden faydalanıldığı saptanmıştır.Theaim of this study is to reveal general trends of master and doctoral thesesprepared related to digital citizenship in Turkey. The research was carried outin screening model. Theses related to the field of digital citizenship wereobtained from the Database of National Thesis Center of the Council of HigherEducation. In this direction, 16 authorized theses prepared between the yearsof 2004-2017, were examined based on content analysis method. The data obtainedthrough the “Thesis Analysis Form” was tabulated and interpreted with frequencyand percentage calculations. As a result of the research, it was determinedthat most of the theses related to digital citizenship were prepared at theinstitute of educational sciences and as a master thesis. Also it wasdetermined that primary and secondary school students were preferred mostly assampling group, researches were mostly done on the basis of mixed (quantitative qualitative)  and quantitative researchmethods and mostly scales were used as data tools. 

ACOUSTIC WAVE MODELLING USING TWO DIFFERENT NUMERICAL METHODS

This paper analyses various 2D acoustic wave propagation problems in the time domain BEM through geophysical environments. To this end the existing BEM code for the boundary nodes is expanded to optional internal nodes. Using appropriate and predominant temporal variations for the field quantities the time-related kernels are obtained explicitly. The BEM and FDM solutions presented are generated using synthetic seismograms and are seen to be stable. The qualitative agreement between the two methods is excellent