Pemanfaatan Media Komunikasi Prima Tani, Aksesibilitas Kelembagaan Tani, dan Persepsi Petani Tentang Teknologi Agribisnis Industrial Pedesaan

This research aims to know the relation between Prima Tani media communications and accessibility of farmerinstitution with farmer perception about technology introduction of Rural Agribusiness Industrial. In this research tofind characteristic personal, Prima Tani of media communications and accessibility of farmer institution influencingfarmer perception about technology introduction of Rural Agribusiness Industrial in province of West Java and SouthSulawesi. Result of research indicates: nonformal education has correlation with perception of cooperator farmer inWest Java. Ages, formal and nonformal education has negative correlation with perception of noncooperator farmerin West Java at economic and social aspect. In South Sulawesi, formal education and experience of farm hascorrelation with perception of cooperator farmer at economic aspect, average income and land use field hascorrelation with social aspect. Average income and land use status has negative correlation with noncooperatorfarmer perception in social aspect and land use status at social aspect, land use status has correlation withnoncooperator farmer perception at economic aspect. In West Java, spread out technology and clinic agribusinesshas correlation with perception of cooperator farmer with biophysic and economic aspect. Prima Tani mediacommunications has correlation with biophysic and social aspect. Spread out technological and Prima Tani mediacommunication has correlation with perception of noncooperator farmer in West Java at social aspect, clinicagribusiness has correlation with noncooperator farmer in economic aspect. In South Sulawesi, spread outtechnological has correlation with biophysic and social aspect. Prima Tani media communications and clinicagribusiness has correlation with perception of cooperator farmer at social and economic aspect. In West Java,accessibility of farmer institution has correlation with perception of cooperator farmer in biophysic, social andeconomic aspect. Accessibility of farmer institution has correlation with noncooperator farmer perception in socialand economic aspect. In South Sulawesi, accessibility of farmer institution has correlation with cooperator farmerperception in social and biophysic aspect

Combined Tide and Storm Influence on Facies Sedimentation of Miocene Miri Formation, Sarawak

This study was conducted on the sedimentary rocks belonging to the Miri Formation (Middle – Late Miocene). The primary objective of the present study is to provide additional interpretation on the stratigraphy of the Miri Formation in the Miri Field based on the new information gathered from new outcrops in the area. Five outcrops were examined in detail on sedimentology and stratigraphy. Based on lithology, sedimentary structures, bedding geometry and traces fossil, the sediments of the Miri Formation were grouped into fourteen lithofacies. Influence of tide and storm during the depositional processes of the formation were indicated by the group of two main facies associations which are: (i) tide-dominated estuary; and (ii) wave-and-storm dominated facies associations. The tide-dominated estuary system of the Miri Formation are includes variety of sub environments: estuary mouth or tidal channel and sand bars (characterized by trough cross-stratified sandstone with mud drapes facies), estuary channel or upper flow regime of sand flat (characterized by parallel stratified sandstone with mud-laminas facies), mixed-tidal flat (characterized by wavy and flaser bedded sandstone facies), and mud-tidal flat (characterized by rhythmic stratified sandstone-mudstone and lenticular bedding facies). The wave-and-storm dominated varied from lower to middle shoreface (characterized by hummocky cross-stratified sandstone and rhythmic parallel stratified sandstone and laminated siltstone facies), upper shoreface (characterized by swaley cross-stratified sandstone), lower shoreface (interbedded to bioturbated sandstone and siltstone facies), and offshore transitional (characterized by bioturbated sandstone and mudstone interbedding with parallel to hummocky cross-stratified sandstone facies). Penelitian ini dilakukan pada batuan sedimen penyusun Formasi Miri (Miosen Tengah - Akhir). Tujuan penelitian ini adalah untuk mendapatkan interpretasi tambahan pada stratigrafi Formasi Miri di Lapangan Miri berdasarkan informasi baru yang dikumpulkan dari singkapan batuan baru di daerah tersebut. Lima singkapan tersebut diteliti secara rinci berdasarkan aspek sedimentologi dan stratigrafi. Berdasarkan litologi, struktur sedimen, geometri perlapisan dan fosil jejak, sedimen penyusun Formasi Miri dikelompokkan ke dalam empat belas litofasies. Pengaruh pasang surut dan badai selama proses pengendapan formasi diindikasikan dari adanya dua kelompok gabungan fasies utama antara lain: (i) didominasi oleh pasang-surut muara, dan (ii) didominasi oleh gabungan fasies gelombang dan badai. Sistem yang didominasi pasang surut muara pada Formasi Miri meliputi variasi sub-lingkungan: mulut muara atau alur pasang surut, dan gosong sungai (dicirikan oleh fasies batupasir dengan perlapisan saling silang dengan lempung yang mengapung), alur muara atau rezim aliran bagian atas dari dataran pasir (dicirikan oleh fasies batupasir berlapis paralel dengan lumpur berlapis), campuran pasang surut normal (dicirikan oleh fasies batupasir berlapis), dan lumpur pasang surut normal (dicirikan oleh fasies batupasir berlapis ritmik-batulumpur dan perlapisan lenticular). Dominasi pengaruh gelombang dan badai bervariasi dari rendah ke menengah (dicirikan oleh fasies batupasir berlapis silang yang hummocky dan batupasir berlapis paralel berulang dan batulanau berlapis), muka pantai bagian atas (dicirikan oleh batupasir berlapis silang yang swaley), muka pantai bagian bawah (fasies batupasir dan batulanau yang bersisipan sampai bioturtbasi), dan transisi lepas pantai (dicirikan oleh fasies batupasir bioturbasi dan batulumpur yang bersisipan dengan batupasir berlapis paralel sampai berlapis silang yang hummocky)

Pemanfaatan Media Komunikasi Prima Tani, Aksesibilitas Kelembagaan Tani, dan Persepsi Petani tentang Teknologi Agribisnis Industrial Pedesaan

This research aims to know the relation between Prima Tani media communications and accessibility of farmerinstitution with farmer perception about technology introduction of Rural Agribusiness Industrial. In this research tofind characteristic personal, Prima Tani of media communications and accessibility of farmer institution influencingfarmer perception about technology introduction of Rural Agribusiness Industrial in province of West Java and SouthSulawesi. Result of research indicates: nonformal education has correlation with perception of cooperator farmer inWest Java. Ages, formal and nonformal education has negative correlation with perception of noncooperator farmerin West Java at economic and social aspect. In South Sulawesi, formal education and experience of farm hascorrelation with perception of cooperator farmer at economic aspect, average income and land use field hascorrelation with social aspect. Average income and land use status has negative correlation with noncooperatorfarmer perception in social aspect and land use status at social aspect, land use status has correlation withnoncooperator farmer perception at economic aspect. In West Java, spread out technology and clinic agribusinesshas correlation with perception of cooperator farmer with biophysic and economic aspect. Prima Tani mediacommunications has correlation with biophysic and social aspect. Spread out technological and Prima Tani mediacommunication has correlation with perception of noncooperator farmer in West Java at social aspect, clinicagribusiness has correlation with noncooperator farmer in economic aspect. In South Sulawesi, spread outtechnological has correlation with biophysic and social aspect. Prima Tani media communications and clinicagribusiness has correlation with perception of cooperator farmer at social and economic aspect. In West Java,accessibility of farmer institution has correlation with perception of cooperator farmer in biophysic, social andeconomic aspect. Accessibility of farmer institution has correlation with noncooperator farmer perception in socialand economic aspect. In South Sulawesi, accessibility of farmer institution has correlation with cooperator farmerperception in social and biophysic aspect

Comprehensive biomarker analyses identifies HER2, EGFR, MET RNA expression and thymidylate synthase 5'UTR SNP as predictors of benefit from S-1 adjuvant chemotherapy in Japanese patients with stage II/III gastric cancer

Purpose: A comprehensive molecular analysis was conducted to identify prognostic and predictive markers for adjuvant S-1 chemotherapy in stage II/III Japanese gastric cancer (GC) patients and to evaluate their potential suitability for alternative cytotoxic or targeted drugs. Experimental Design: We investigated genetic polymorphisms of enzymes potentially involved in 5-fluoruracil (5-FU) metabolism as well as platinum resistance, previously identified genomic subtypes potentially predicting 5-FU benefit, and mRNA expression levels of receptor tyrosine kinases and KRAS as potential treatment targets in a single institution cohort of 252 stage II/III GC patients treated with or without S-1 after D2 gastrectomy. Results: 88% and 62% GC had a potentially 5-FU sensitive phenotype by SNP analyses of TS 3'UTR, and TS 5'UTR, respectively. 24%, 46%, 40%, 5%, and 44% GC had a potentially platinum sensitive phenotype by SNP analyses of GSTP1, ERCC1 rs11615, ERCC1 rs3212986, ERCC2, and XRCC1, respectively. High HER2, EGFR, FGFR2, or MET mRNA expression was observed in 49%, 66%, 72%, and 54% GC, respectively. High HER2 expression was the only significant prognosticator (HR=3.912, 95%CI: 1.706-8.973, p=0.0005). High HER2 (p=0.031), low EGFR (p=0.124), high MET (p=0.165) RNA expression, and TS 5'UTR subtype 2R/2R, 2R/3C, or 3C (p=0.058) were significant independent predictors for S-1 resistance. Conclusions: The present study suggests that platinum-based or RTK targeted agents could be alternative treatment options for a substantial subgroup of Japanese GC patients currently treated with S-1. HER2, EGFR, MET, and TS 5'UTR SNP appear to be promising predictive markers for S-1 resistance warranting validation in an independent GC series

DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: A comprehensive profiling approach

10.1186/1471-230X-14-55BMC Gastroenterology141-BGMA

Clinical Potential of DNA Methylation in Gastric Cancer: A Meta-Analysis

Background: Accumulating evidence indicates aberrant DNA methylation is involved in gastric tumourigenesis, suggesting it may be a useful clinical biomarker for the disease. The aim of this study was to consolidate and summarize published data on the potential of methylation in gastric cancer (GC) risk prediction, prognostication and prediction of treatment response. Methods: Relevant studies were identified from PubMed using a systematic search approach. Results were summarized by meta-analysis. Mantel-Haenszel odds ratios were computed for each methylation event assuming the random-effects model. Results: A review of 589 retrieved publications identified 415 relevant articles, including 143 case-control studies on gene methylation of 142 individual genes in GC clinical samples. A total of 77 genes were significantly differentially methylated between tumour and normal gastric tissue from GC subjects, of which data on 62 was derived from single studies. Methylation of 15, 4 and 7 genes in normal gastric tissue, plasma and serum respectively was significantly different in frequency between GC and non-cancer subjects. A prognostic significance was reported for 18 genes and predictive significance was reported for p16 methylation, although many inconsistent findings were also observed. No bias due to assay, use of fixed tissue or CpG sites analysed was detected, however a slight bias towards publication of positive findings was observed

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation