Synthesis and SomeReactions of 3-Methyl-4-aryl-1-phenyl-1H- pyrazolo[3,4-dipyrimidine-6-thiols

3-Methyl-4-aryl-1-phenyl-1H -pyrazolo[3,4-d]-pyrimidine-6-thiols( 11)were synthesised by the raction of thiourea with 3-methyl-\u27 -1-phenyl-4-arylidene-2-pyrazolin-5-ones(1) in ethanolic solution of potassium hydroxide. The mechanism of this reaction is discussed and further transformation of the products with different reagents (S-methylation, substitution of SR-group by arylamines, hydrazine, and azide) was carried out

Synthesis of Fused Heterocyclic Derivatives from 5-Ethyl-3-Hydrazino-5H-1,2,4-Triazino[5,6-b]Indole

5-Ethyl-3-hydrazino-5H-1,2,4-triazino[5,6-b ]indole II was used for the synthesis of various heterocyclic derivatives. This was performed by reaction of its 3-hydrazino group with different reagents such as acid anhydrides, ethylacetate, diethyl oxalate, thioglycolic acid, aroyl esters and acid chlorides. The structure of the products was confirmed by different spectroscopic and analytical methods

Age, Growth and Mortality of Atlantic chub mackerel, Scomber colias Gmelin, 1789 in the Mediterranean Waters of Morocco

This work is a study of growth aspects and mortality of the Atlantic chub mackerel, Scomber colia, from the Mediterranean Moroccan coast. A total of 845 specimens were collected from commercial catches in M'diq Bay, whose total length ranged between 16.4 and 35.9 cm. The length-weight relationship was W = 0.0019 TL3.4527 (r = 0.97) for the whole population. The Atlantic chub mackerel displays positive allometric growth. Otolith edge analysis indicated that opaque zones were formed between April and September and translucent ones during the remaining months of the year. The oldest individuals in the sample were 5 years old for both sexes. Von Bertalanffy growth parameters estimated for this species were: L∞ = 37.30 cm, k = 0.26 year-1 and t0 = - 2.19 year. The difference in growth between sexes is not significant. The estimated natural mortality was 0.59 per year

Nuevas aportaciones a la flora algal de las costas marroquíes

Nouveaux apports à la flore algale des côtes marocaines Palabras clave. Marruecos, macroalgas marinas. Mots clés. Maroc, macroalgues marine

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Plan de marketing. Lanzamiento de un nuevo producto Voramar

Treball de Final de Màster Universitari en Màrqueting i Investigació de Mercats. Codi: SRB100. Curs acadèmic 2017-2018

Synthesis of Fused Heterocyclic Derivatives from 5-Ethyl-3-Hydrazino-5H-1,2,4-Triazino[5,6-b]Indole

5-Ethyl-3-hydrazino-5H-1,2,4-triazino[5,6-b ]indole II was used for the synthesis of various heterocyclic derivatives. This was performed by reaction of its 3-hydrazino group with different reagents such as acid anhydrides, ethylacetate, diethyl oxalate, thioglycolic acid, aroyl esters and acid chlorides. The structure of the products was confirmed by different spectroscopic and analytical methods