La organización de la justicia real ordinaria en la Corona de Castilla durante la Edad Moderna

Apuntes sobre los medios institucionales y humanos empleados por la Corona de Castilla en la administración de justicia y en la persecución de delitos

Ciudades con atributos: conectividad, accesibilidad y movilidad

Se plantea en este artículo una crítica acerca de los sentidos de algunos conceptos habituales en el urbanismo y directamente relacionados con la correspondencia entre espacios urbanos e infraestructuras de transporte. Los autores se interesan especialmente por los significados y usos de acepciones tales como conectividad, accesibilidad y movilidad. Abriendo el debate terminológico y elucidando la perspectiva del análisis teórico, esta contribución combina unas notas sobre la movilidad urbana sostenible y el planeamiento orientado por la política de transporte urbano.In this article a critique is laid out about the senses of some habitual concepts in the urbanism and directly related to the correspondence between urban spaces and infrastructures of transport. The authors are especially interested in the meanings and uses of such meanings as connectivity, accessibility and mobility. Opening the terminological debate and elucidating the perspective of the theoretical analysis, this contribution combines a few notes on the urban sustainable mobility and the Transit-Oriented Development

Combined analysis of genome-wide expression and copy number profiles to identify key altered genomic regions in cancer

This is an open access article distributed under the terms of the Creative Commons Attribution License.-- Proceedings of the International Conference of the Brazilian Association for Bioinformatics and Computational Biology (X-meeting 2011).[Background]: Analysis of DNA copy number alterations and gene expression changes in human samples have been used to find potential target genes in complex diseases. Recent studies have combined these two types of data using different strategies, but focusing on finding gene-based relationships. However, it has been proposed that these data can be used to identify key genomic regions, which may enclose causal genes under the assumption that disease-associated gene expression changes are caused by genomic alterations. [Results]: Following this proposal, we undertake a new integrative analysis of genome-wide expression and copy number datasets. The analysis is based on the combined location of both types of signals along the genome. Our approach takes into account the genomic location in the copy number (CN) analysis and also in the gene expression (GE) analysis. To achieve this we apply a segmentation algorithm to both types of data using paired samples. Then, we perform a correlation analysis and a frequency analysis of the gene loci in the segmented CN regions and the segmented GE regions; selecting in both cases the statistically significant loci. In this way, we find CN alterations that show strong correspondence with GE changes. We applied our method to a human dataset of 64 Glioblastoma Multiforme samples finding key loci and hotspots that correspond to major alterations previously described for this type of tumors. [Conclusions]: Identification of key altered genomic loci constitutes a first step to find the genes that drive the alteration in a malignant state. These driver genes can be found in regions that show high correlation in copy number alterations and expression changesThis work has been supported by funds provided by the Local Government Junta de Castilla y León (JCyL, ref. project: CSI07A09), by the Spanish Government (ISCiii, ref. project PS09/00843) and by the European Commission (Research Grant ref. FP7-HEALTH-2007-223411). SA thanks the JCyL and the European Social Fund (ESF-EU) for a research grant.Peer Reviewe

Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle

Transcriptional and functional analysis reveals that the H-Ras and N-Ras isoforms have different roles in the initial phases of the mouse cell cycl

Corpo, mídia e mercado: o corpo objeto de discurso publicitário

O corpo na relação com a mídia e com mercado é o foco deste texto. O objetivo do trabalho é identificar essa relação via uma abordagem do corpo do ponto de vista dos discursos que o propõem, evidenciam e o promove. Nota-se que, atualmente, um ideal de corpo e de beleza é cada vez mais veiculado massivamente pelo aparato publicitário da mídia. O corpo tornou-se assim, alvo privilegiado da mídia e o principal “cartão de visita” na cultura contemporânea

La justicia penal de los Austrias en la Corona de Castilla

En este libro se presenta cual era la justicia penal en la Corona de Castilla bajo los Austrias (1517-1700), matizando su mayor singularidad : la de inscribirse en un régimen de desigualdad social