Green dyeing of polyamide with increased anti-UV properties

[Excerpt] Introduction: During the last few decades, ecological concerns related to the use of the synthetic dyes, have led to a greater motivation for the development of processes that use natural products. This strategy has been applied to improve theincreasingly necessary sustainability of wet textile processes.Natural dyes are available in nature in different shadesandthey can be exploited for coloring textilesandto improveother properties such as UV protection and antimicrobial activity. Among them, those obtained from eucalyptus leaves, mainly composed by tannins (gallic acid and ellagic acid) and flavonoids (quercetin and rutin), appear to be interesting for textile finishing applications. The eucalyptus leaves, arean abundant, inexpensiveand readily available forestresidue.However, despite the recognized properties of this type of compound, its use in polyamide dyeing was not reported in our literature review.The present study aimed to develop dyed polyamide 6 knittedfabrics with increased UV protection using a naturaleucalyptus leavesextract. [...]Authorswishing to acknowledge the Project UID/CTM/00264/2019 of 2C2T –Centro de Ciência e Tecnologia Têxtil, funded by National Founds through FCT/MCTES

Tecnosurveillance: the quality of medical devices in a hospital of the sentinel network

Neste trabalho realizou-se um estudo da qualidade dos produtos para a saúde em um Hospital da Rede Sentinela com o objetivo de subsidiar a ANVISA e melhorar a segurança na utilização destes produtos. O estudo teve caráter quantitativo e foi realizado no período de fevereiro de 2006 a maio de 2008. Foram analisados 376 produtos para a saúde. A ocorrência de queixas técnicas de artigos médico-hospitalares (197) foram maiores do que queixas técnicas de medicamentos (179). O principal problema encontrado nos artigos médico-hospitalares foi a ausência do produto ou parte dele da embalagem original (29%). Nas queixas técnicas de medicamentos, o desvio mais frequentemente encontrado foi a turvação da solução de medicamentos de administração por via parenteral (24%). Os resultados demonstram que apesar da legislação vigente, ainda existem produtos sendo comercializados fora dos padrões de qualidade. A tecnovigilância é um método eficaz que pode ser utilizado para colaborar na melhora da qualidade destes produtos.A study based on the quality of medical devices has been carried out in a Hospital of The Sentinel Network to subsidize the ANVISA and to evaluate and improve the security of theses products. It is a quantitative study and was held in period of February 2006 to May 2008. The analysis was based on 376 products with problems. The occurrences of technical complaints in medical devices (197) were higher than technical complaints in drugs (179). The main problem found in medical devices was the absence or part of the product of the original packaging (29%). In the drugs analyses, the most common problem were the turbidity of the solution from i.v. drugs (24%). The results show that despite of the legislation existing, many products are sold outside the standards of quality and tecnosurveillance is an effective method used to improve the quality of these products.Colegio de Farmacéuticos de la Provincia de Buenos Aire

ALMEIDA, Alfredo Wagner Berno de; MOURÃO, Laís. 2017. Questões agrárias no Maranhão contemporâneo

O livro Questões agrárias no Maranhão contemporâneo analisa as relações sociais camponesas impactadas por projetos desenvolvimentistas, no estado do Maranhão. Assim, ao contrário do que poderia parecer, o termo “contemporâneo”, presente no título, contém a ideia crítica que os organizadores deste livro invocam; o exercício proposto procura romper a própria temporalidade e seus limites. A novidade desse termo, segundo os autores, “atém-se a processos históricos, reais, que não correspondem a “..

A flow-through strategy using supported ionic liquids for L-asparaginase purification

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Synthesis, Bioavailability, and Cytotoxicity Studies

Funding Information: This work was supported by Portuguese funds from FCT/MCTES through the Associate Laboratory for Green Chemistry—LAQV (UIDB/50006/2020 and UIDP/50006/2020) and the project numbers PTDC/QUI-QOR/32406/2017 and PTDC/EAM-AMB/2023/2021. Ana R. Jesus and Ana Rita C. Duarte acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme, under grant agreement No ERC-2016-CoG 725034. Publisher Copyright: © 2023 by the authors.Thyroid diseases affect a considerable portion of the population, with hypothyroidism being one of the most commonly reported thyroid diseases. Levothyroxine (T4) is clinically used to treat hypothyroidism and suppress thyroid stimulating hormone secretion in other thyroid diseases. In this work, an attempt to improve T4 solubility is made through the synthesis of ionic liquids (ILs) based on this drug. In this context, [Na][T4] was combined with choline [Ch]+ and 1-(2-hydroxyethyl)-3-methylimidazolium [C2OHMiM]+ cations in order to prepare the desired T4-ILs. All compounds were characterized by NMR, ATR-FTIR, elemental analysis, and DSC, aiming to check their chemical structure, purities, and thermal properties. The serum, water, and PBS solubilities of the T4-ILs were compared to [Na][T4], as well as the permeability assays. It is important to note an improved adsorption capacity, in which no significant cytotoxicity was observed against L929 cells. [C2OHMiM][T4] seems to be a good alternative to the commercial levothyroxine sodium salt with promising bioavailability.publishersversionpublishe

Mycoplasma pneumoniae and/or Chlamydophila pneumoniae inoculation causing different aggravations in cholesterol-induced atherosclerosis in apoE KO male mice

<p>Abstract</p> <p>Background</p> <p><it>Chamydophila pneumoniae </it>(CP) and/or <it>Mycoplasma pneumoniae </it>(MP) are two bacteria detected in vulnerable atheromas. In this study we aimed to analyze whether CP and/or MP aggravates atherosclerosis induced by cholesterol-enriched diet in C57BL/6 apoE KO male mice. Thirty male apoE KO mice aged eight weeks fed by a diet containing 1% cholesterol until 32 weeks of age were divided into four groups: the first was inoculated with CP (n = 7), the second with MP (n = 12), the third with both CP + MP (n = 5), and the fourth with saline (sham n = 6). The animals were re-inoculated at 36 weeks of age, and sacrificed at 40 weeks of age. Two ascending aorta and one aortic arch segments were sampled. In the most severely obstructed segment, vessel diameter, plaque height, percentage of luminal obstruction and the degree of adventitial inflammation were analyzed. The plaque area/intimal surface ratio was obtained by measuring all three segments. The adventitial inflammation was semiquantified (0 absent, 1 mild, 2 moderate, and 3 diffuse).</p> <p>Results</p> <p>The mean and standard deviation of plaque height, % luminal obstruction, external diameter, the plaque area/intimal surface ratio and the adventitial inflammation values are the following for each group: MP (0.20 +/- 0.12 mm, 69 +/- 26%, 0.38 +/- 0.11 mm, 0.04 +/- 0.04 and 0.22 +/- 0.67), CP (0.23 +/- 0.08 mm, 90 +/- 26%, 0.37 +/- 0.08 mm, 0.04 +/- 0.03, and 0.44 +/- 0.53), MP + CP (18 +/- 0.08 mm, 84 +/- 4.0%, 0.35 +/- 0.25 mm, 0.03 +/- 0.03 and 1.33 +/- 0.82) and sham (0.08 +/- 0.09 mm, 42 +/- 46%, 0.30 +/- 0.10 mm, 0.02 +/- 0.03 and 0.71 ± 0.76). A wider area of plaque/intimal surface was observed in MP + CP inoculated groups (p = 0.07 and 0.06) as well as an increased plaque height in CP (p = 0.01) in comparison with sham group. There was also an increased luminal obstruction (p = 0.047) in CP inoculated group in comparison to sham group. Adventitial inflammation in MP + CP inoculated group was higher than MP, CP and the sham groups (p = 0.02).</p> <p>Conclusion</p> <p>Inoculation of CP, MP or both agents in C57BL/6 apoE KO male mice caused aggravation of experimental atherosclerosis induced by cholesterol-enriched diet, with distinct characteristics. CP inoculation increased the plaque height with positive vessel remodeling and co-inoculation of MP + CP caused the highest adventitial inflammation measures.</p

Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications : scaffold design and its performance when seeded with goat bone marrow stromal cells

Recent studies suggest that bone marrow stromal cells are a potential source of osteoblasts and chondrocytes and can be used to regenerate damaged tissues using a tissue-engineering (TE) approach. However, these strategies require the use of an appropriate scaffold architecture that can support the formation de novo of either bone and cartilage tissue, or both, as in the case of osteochondral defects. The later has been attracting a great deal of attention since it is considered a difficult goal to achieve. This work consisted on developing novel hydroxyapatite/chitosan (HA/CS) bilayered scaffold by combining a sintering and a freeze-drying technique, and aims to show the potential of such type of scaffolds for being used in TE of osteochondral defects. The developed HA/CS bilayered scaffolds were characterized by Fourier transform infra-red spectroscopy, X-ray diffraction analysis, micro-computed tomography, and scanning electron microscopy (SEM). Additionally, the mechanical properties of HA/CS bilayered scaffolds were assessed under compression. In vitro tests were also carried out, in order to study the water-uptake and weight loss profile of the HA/CS bilayered scaffolds. This was done by means of soaking the scaffolds into a phosphate buffered saline for 1 up to 30 days. The intrinsic cytotoxicity of the HA scaffolds and HA/CS bilayered scaffolds extract fluids was investigated by carrying out a cellular viability assay (MTS test) using Mouse fibroblastic-like cells. Results have shown that materials do not exert any cytotoxic effect. Complementarily, in vitro (phase I) cell culture studies were carried out to evaluate the capacity of HA and CS layers to separately, support the growth and differentiation of goat marrow stromal cells (GBMCs) into osteoblasts and chondrocytes, respectively. Cell adhesion and morphology were analysed by SEM while the cell viability and proliferation were assessed by MTS test and DNA quantification. The chondrogenic differentiation of GBMCs was evaluated measuring the glucosaminoglycans synthesis. Data showed that GBMCs were able to adhere, proliferate and osteogenic differentiation was evaluated by alkaline phosphatase activity and immunocytochemistry assays after 14 days in osteogenic medium and into chondrocytes after 21 days in culture with chondrogenic medium. The obtained results concerning the physicochemical and biological properties of the developed HA/CS bilayered scaffolds, show that these constructs exhibit great potential for their use in TE strategies leading to the formation of adequate tissue substitutes for the regeneration of osteochondral defects