Chapter “Flex 2018” Cruise: an opportunity to assess phytoplankton chlorophyll fluorescence retrieval at different observative scales

The “FLEX 2018” cruise, organized by the CNR-ISMAR in frame of the ESA “FLEXSense Campaign 2018” and CMEMS project, provided a ground station for several bio-optical instruments that investigated the coastal waters of the Tyrrhenian Sea in June 2018. The field measurements were performed in time synergy with Sentinel 3A and Sentinel 3B satellites and HyPlant airborne imaging spectrometer. Active and passive fluorescence were investigated at different scales in coastal waters to support preparatory activities of the FLuorescence EXplorer (FLEX) satellite mission

“Flex 2018” Cruise: an opportunity to assess phytoplankton chlorophyll fluorescence retrieval at different observative scales

In frame of the European Space Agency’s (ESA) “FLEXSense Campaign 2018” and the Copernicus Marine Environment Monitoring Service (CMEMS) project, the Global Ocean Satellite monitoring and marine ecosystem study group (GOS) of the Italian National Research Council (CNR) organized the oceanographic cruise “FLEX 2018”. The CNR research vessel “Dallaporta” provided a ground station for several bio-optical instruments to investigate the coastal waters of the Tyrrhenian Sea (central Italy) in June 2018. The field measurements were performed in time synchrony with spaceborne (i.e. Sentinel 3A and Sentinel 3B satellites) and airborne (i.e. HyPlant airborne imaging spectrometer) observations, with the intent to contribute to calibration/validation activities for existing and future space mission developments. Particularly, active and passive fluorescence were investigated at different scales in aquatic ecosystems, to support preparatory activities of the FLuorescence EXplorer (FLEX) satellite mission to be launched in 2022. Results provide new insight on the sensitivity of Solar Induced Fluorescence (SIF) retrievals for atmospheric disturbances and other scale related aspects, and will eventually facilitate the implementation of robust retrieval schemes for the FLEX mission products. In addition, active fluorescence signals acquired from a LIDAR fluorosensor show a good agreement with SIF pattern retrieved by HyPlant and Sentinel-3 Ocean and Land Colour Instrument (OLCI). Our results demonstrate that the combination of active and passive fluorescence, together with the synergistic measurements from integrated platforms, is a promising approach to support the retrieval and interpretation of SIF in aquatic environments

Piaghe da decubito: adozione di un protocollo unico di terapia e valutazione della qualità del servizio offerto ai pazienti in assistenza domiciliare integrata presso il Presidio di Penne

The Penne Hospital Pharmacists have an important role in nursing home organization in order to distribution of medical devices and drugs required for prevention and treatment of pressure ulcers. In the first half of 2007 a questionnaire was drawn up by pharmacists and was submitted to 62 nursing home patients caregivers. The aim of this survey was to assess the problem and evaluate the quality of the services provided (the efficiency of the distribution, the Pharmacy, the health-care staff) for the prevention and treatment of pressure sores. The survey has resulted in the following: the service was activated in 83.3% of the cases in less than one week; an improvement of the condition of the pressure sores in 69.2% of the cases for the period of time analysed. In fact 60% of the patients were still suffering from bed ulcers at the time of discharge, due to the lack of movement; 90% of the interviewed declared to have received proper indications for home-care. However, the patients claimed a lack of nutritional directives due to the absence of a professional Nutritionist. This study led to the improvement the management and prevention of pressure sores through the drawing up of a unique therapeutic protocol according to the evidenced based medicine and through the evaluation of quality of services provided by Local Health Authority

Chapter “Flex 2018” Cruise: an opportunity to assess phytoplankton chlorophyll fluorescence retrieval at different observative scales

The “FLEX 2018” cruise, organized by the CNR-ISMAR in frame of the ESA “FLEXSense Campaign 2018” and CMEMS project, provided a ground station for several bio-optical instruments that investigated the coastal waters of the Tyrrhenian Sea in June 2018. The field measurements were performed in time synergy with Sentinel 3A and Sentinel 3B satellites and HyPlant airborne imaging spectrometer. Active and passive fluorescence were investigated at different scales in coastal waters to support preparatory activities of the FLuorescence EXplorer (FLEX) satellite mission

Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally diverse. However, the extent and determinants of neutrophil heterogeneity in humans remain unclear. We performed a comprehensive immunophenotypic and transcriptome analysis, at bulk and single-cell level, of neutrophils from healthy donors and patients undergoing stress myelopoiesis upon exposure to growth factors, transplantation of hematopoietic stem cells (HSC-T), development of pancreatic cancer, and viral infection. We uncover an extreme diversity of human neutrophils in vivo, reflecting the rates of cell mobilization, differentiation, and exposure to environmental signals. Integrated control of developmental and inducible transcriptional programs linked flexible granulopoietic outputs with elicitation of context-dependent functional responses. In this context, we detected an acute interferon (IFN) response in the blood of HSC-T patients that was mirrored by marked upregulation of IFN-stimulated genes in neutrophils but not in monocytes. Systematic characterization of human neutrophil plasticity may uncover clinically relevant biomarkers and support the development of diagnostic and therapeutic tools

Independent Quality Assessment of Essential Climate Variables: Lessons Learned from the Copernicus Climate Change Service

If climate services are to lead to effective use of climate information in decision-making to enable the transition to a climate-smart, climate-ready world, then the question of trust in the products and services is of paramount importance. The Copernicus Climate Change Service (C3S) has been actively grappling with how to build such trust: provision of demonstrably independent assessments of the quality of products, which was deemed an important element in such trust-building processes. C3S provides access to essential climate variables (ECVs) from multiple sources to a broad set of users ranging from scientists to private companies and decision-makers. Here we outline the approach ­undertaken to coherently assess the quality of a suite of observation- and reanalysis-based ECV products covering the atmosphere, ocean, land, and cryosphere. The assessment is based on four pillars: basic data checks, maturity of the datasets, fitness for purpose (scientific use cases and climate studies), and guidance to users. It is undertaken independently by scientific experts and presented alongside the datasets in a fully traceable, replicable, and transparent manner. The methodology deployed is detailed, and example assessments are given. These independent scientific quality assessments are intended to guide users to ensure they use tools and datasets that are fit for purpose to answer their specific needs rather than simply use the first product they alight on. This is the first such effort to develop and apply an assessment framework consistently to all ECVs. Lessons learned and future perspectives are outlined to potentially improve future assessment activities and thus climate services.This work is funded by European Copernicus Climate Change Service (C3S) implemented by European Centre for Medium-Range Weather Forecasts (ECMWF) under the service contract Independent Assessment on ECVs led by the National Research Council of Italy (CNR) with the service contract number as ECMWF/Copernicus/2017/C3S_511_CNR.Peer reviewe

Biobanking for COVID-19 research

Biobanks are imperative infrastructures, particularly during outbreaks, when there is an obligation to acquire and share knowledge as quick as possible to allow for implementation of science-based preventive, diagnostic, prognostic and therapeutic strategies